Abstract
This paper presents a study of circumstellar debris around Sun-like stars using data from the Herschel DEBRIS Key Programme. DEBRIS is an unbiased survey comprising the nearest ∼90 stars of ...each spectral type A-M. Analysis of the 275 F-K stars shows that excess emission from a debris disc was detected around 47 stars, giving a detection rate of 17.1$^{+2.6}_{-2.3}$ per cent, with lower rates for later spectral types. For each target a blackbody spectrum was fitted to the dust emission to determine its fractional luminosity and temperature. The derived underlying distribution of fractional luminosity versus blackbody radius in the population showed that most detected discs are concentrated at f ∼ 10−5 and at temperatures corresponding to blackbody radii 7–40 au, which scales to ∼40 au for realistic dust properties (similar to the current Kuiper belt). Two outlying populations are also evident; five stars have exceptionally bright emission ( f > 5 × 10−5), and one has unusually hot dust <4 au. The excess emission distributions at all wavelengths were fitted with a steady-state evolution model, showing that these are compatible with all stars being born with a narrow belt that then undergoes collisional grinding. However, the model cannot explain the hot dust systems – likely originating in transient events – and bright emission systems – arising potentially from atypically massive discs or recent stirring. The emission from the present-day Kuiper belt is predicted to be close to the median of the population, suggesting that half of stars have either depleted their Kuiper belts (similar to the Solar system) or had a lower planetesimal formation efficiency.
Dramatic global increases in future numbers of people with dementia have been predicted. No multicentre population-based study powered to detect changes over time has reported dementia incidence. MRC ...Cognitive Function and Ageing Study (CFAS) undertook baseline interviews in populations aged 65+ years in England and Wales (1989-1994). Three areas (CFAS I) were selected for new sampling two decades later (2008-2011) with same geographical boundaries, sampling and approach methods (CFAS II). At 2 years CFAS I interviewed 5,156 (76% response) with 5,288 interviewed in CFAS II (74% response). Here we report a 20% drop in incidence (95% CI: 0-40%), driven by a reduction in men across all ages above 65. In the UK we estimate 209,600 new dementia cases per year. This study was uniquely designed to test for differences across geography and time. A reduction of age-specific incidence means that the numbers of people estimated to develop dementia in any year has remained relatively stable.
The Herschel DEBRIS (Disc Emission via a Bias-free Reconnaissance in the Infrared/Submillimetre) survey brings us a unique perspective on the study of debris discs around main-sequence A-type stars. ...Bias-free by design, the survey offers a remarkable data set with which to investigate the cold disc properties. The statistical analysis of the 100 and 160 μm data for 86 main-sequence A stars yields a lower than previously found debris disc rate. Considering better than 3σ excess sources, we find a detection rate ≥24 ± 5 per cent at 100 μm which is similar to the debris disc rate around main-sequence F/G/K-spectral type stars. While the 100 and 160 μm excesses slowly decline with time, debris discs with large excesses are found around some of the oldest A stars in our sample, evidence that the debris phenomenon can survive throughout the length of the main sequence (∼1 Gyr). Debris discs are predominantly detected around the youngest and hottest stars in our sample. Stellar properties such as metallicity are found to have no effect on the debris disc incidence. Debris discs are found around A stars in single systems and multiple systems at similar rates. While tight and wide binaries (<1 and >100 au, respectively) host debris discs with a similar frequency and global properties, no intermediate separation debris systems were detected in our sample.
We statistically evaluated the relative orientation between gas column density structures, inferred from Herschel submillimetre observations, and the magnetic field projected on the plane of sky, ...inferred from polarized thermal emission of Galactic dust observed by the Balloon-borne Large-Aperture Submillimetre Telescope for Polarimetry (BLASTPol) at 250, 350, and 500 μm, towards the Vela C molecular complex. First, we find very good agreement between the polarization orientations in the three wavelength-bands, suggesting that, at the considered common angular resolution of 3.́0 that corresponds to a physical scale of approximately 0.61 pc, the inferred magnetic field orientation is not significantly affected by temperature or dust grain alignment effects. Second, we find that the relative orientation between gas column density structures and the magnetic field changes progressively with increasing gas column density, from mostly parallel or having no preferred orientation at low column densities to mostly perpendicular at the highest column densities. This observation is in agreement with previous studies by the Planck collaboration towards more nearby molecular clouds. Finally, we find a correspondencebetween (a) the trends in relative orientation between the column density structures and the projected magnetic field; and (b) the shape of the column density probability distribution functions (PDFs). In the sub-regions of Vela C dominated by one clear filamentary structure, or “ridges”, where the high-column density tails of the PDFs are flatter, we find a sharp transition from preferentially parallel or having no preferred relative orientation at low column densities to preferentially perpendicular at highest column densities. In the sub-regions of Vela C dominated by several filamentary structures with multiple orientations, or “nests”, where the maximum values of the column density are smaller than in the ridge-like sub-regions and the high-column density tails of the PDFs are steeper, such a transition is also present, but it is clearly less sharp than in the ridge-like sub-regions. Both of these results suggest that the magnetic field is dynamically important for the formation of density structures in this region.
The High Resolution Fly's Eye (HiRes) experiment has observed the Greisen-Zatsepin-Kuzmin suppression (called the GZK cutoff) with a statistical significance of five standard deviations. HiRes' ...measurement of the flux of ultrahigh energy cosmic rays shows a sharp suppression at an energy of 6 x 10(19) eV, consistent with the expected cutoff energy. We observe the ankle of the cosmic-ray energy spectrum as well, at an energy of 4 x 10(18) eV. We describe the experiment, data collection, and analysis and estimate the systematic uncertainties. The results are presented and the calculation of the statistical significance of our observation is described.
Abstract
Limited information is available about the effect of mid-pregnancy viral infections on the placental expression of efflux transporters and offspring behavior. We hypothesized that maternal ...exposure to polyinosinic-polycytidylic acid poly(I:C), a synthetic double-stranded RNA viral mimic, would impair placental cell turnover, the expression of selected ABC transporters and adult offspring behavior. C57BL/6 mice were administered poly(I:C) (10 mg/Kg;ip) or vehicle at gestational day (GD) 13.5 (mid-pregnancy). Dams were euthanized for blood collection 4 h after injection, fetal and placental collection at GD18.5 or allowed to deliver spontaneously at term. At GD 13.5, poly(I:C) induced an acute pro-inflammatory response characterized by an increase in maternal plasma levels of IL-6, CXCL-1 and CCL-2/MCP-1. At GD 18.5, poly(I:C) decreased cell proliferation/death in the labyrinthine and increased cell death in the junctional zones, characterizing a disruption of placental cell turnover. Abca1 and Abcg1 immunolabelling was decreased in the labyrinthine zone, whereas Abca1, Abcg1 and breast cancer resistance transporter (Bcrp) expression increased in the junctional zone. Moreover, adult offspring showed motor and cognitive impairments in the Rotarod and T-water maze tests. These results indicate that viral infection during mid-pregnancy may disrupt relevant placental efflux transporters, as well as placental cell turnover and offspring behavior in adult life.
We present resolved Herschel images of a circumbinary debris disc in the 99 Herculis system. The primary is a late F-type star. The binary orbit is well characterized and we conclude that the disc is ...misaligned with the binary plane. Two different models can explain the observed structure. The first model is a ring of polar orbits that move in a plane perpendicular to the binary pericentre direction. We favour this interpretation because it includes the effect of secular perturbations and the disc can survive for Gyr time-scales. The second model is a misaligned ring. Because there is an ambiguity in the orientation of the ring, which could be reflected in the sky plane, this ring either has near-polar orbits similar to the first model or has a 30° misalignment. The misaligned ring, interpreted as the result of a recent collision, is shown to be implausible from constraints on the collisional and dynamical evolution. Because disc+star systems with separations similar to 99 Herculis should form coplanar, possible formation scenarios involve either a close stellar encounter or binary exchange in the presence of circumstellar and/or circumbinary discs. Discovery and characterization of systems like 99 Herculis will help understand processes that result in planetary system misalignment around both single and multiple stars.
Discs of dusty debris around main-sequence stars indicate fragmentation of orbiting planetesimals, and for a few A-type stars, a gas component is also seen that may come from collisionally released ...volatiles. Here we find the sixth example of a CO-hosting disc, around the ∼30 Myr-old A0-star HD 32997. Two more of these CO-hosting stars, HD 21997 and 49 Cet, have also been imaged in dust with SCUBA-2 within the SCUBA-2 Survey of Nearby Stars project. A census of 27 A-type debris hosts within 125 pc now shows 7/16 detections of carbon-bearing gas within the 5–50 Myr epoch, with no detections in 11 older systems. Such a prolonged period of high fragmentation rates corresponds quite well to the epoch when most of the Earth was assembled from planetesimal collisions. Recent models propose that collisional products can be spatially asymmetric if they originate at one location in the disc, with CO particularly exhibiting this behaviour as it can photodissociate in less than an orbital period. Of the six CO-hosting systems, only β Pic is in clear support of this hypothesis. However, radiative transfer modelling with the ProDiMo code shows that the CO is also hard to explain in a proto-planetary disc context.
Whether mild cognitive impairment (MCI) has a distinct neuropathological profile that reflects an intermediate state between no cognitive impairment and dementia is not clear. Identifying which ...biological events occur at the earliest stage of progressive disease and which are secondary to the neuropathological process is important for understating pathological pathways and for targeted disease prevention. Many studies have now reported on the neurobiology of this intermediate stage. In this systematic review, we synthesize current evidence on the neuropathological profile of MCI. A total of 162 studies were identified with varied definition of MCI, settings ranging from population to specialist clinics and a wide range of objectives. From these studies, it is clear that MCI is neuropathologically complex and cannot be understood within a single framework. Pathological changes identified include plaque and tangle formation, vascular pathologies, neurochemical deficits, cellular injury, inflammation, oxidative stress, mitochondrial changes, changes in genomic activity, synaptic dysfunction, disturbed protein metabolism and disrupted metabolic homeostasis. Determining which factors primarily drive neurodegeneration and dementia and which are secondary features of disease progression still requires further research. Standardization of the definition of MCI and reporting of pathology would greatly assist in building an integrated picture of the clinical and neuropathological profile of MCI.
PURPOSE:Accelerometers are recognized as a valid and objective tool to assess free-living physical activity. Despite the widespread use of accelerometers, there is no standardized way to process and ...summarize data from them, which limits our ability to compare results across studies. This paper a) reviews decision rules researchers have used in the past, b) compares the impact of using different decision rules on a common data set, and c) identifies issues to consider for accelerometer data reduction.
METHODS:The methods sections of studies published in 2003 and 2004 were reviewed to determine what decision rules previous researchers have used to identify wearing period, minimal wear requirement for a valid day, spurious data, number of days used to calculate the outcome variables, and extract bouts of moderate to vigorous physical activity (MVPA). For this study, four data reduction algorithms that employ different decision rules were used to analyze the same data set.
RESULTS:The review showed that among studies that reported their decision rules, much variability was observed. Overall, the analyses suggested that using different algorithms impacted several important outcome variables. The most stringent algorithm yielded significantly lower wearing time, the lowest activity counts per minute and counts per day, and fewer minutes of MVPA per day. An exploratory sensitivity analysis revealed that the most stringent inclusion criterion had an impact on sample size and wearing time, which in turn affected many outcome variables.
CONCLUSIONS:These findings suggest that the decision rules employed to process accelerometer data have a significant impact on important outcome variables. Until guidelines are developed, it will remain difficult to compare findings across studies.
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