The Posttraumatic Stress Disorder Checklist (PCL) is a widely used DSM‐correspondent self‐report measure of PTSD symptoms. The PCL was recently revised to reflect DSM‐5 changes to the PTSD criteria. ...In this article, the authors describe the development and initial psychometric evaluation of the PCL for DSM‐5 (PCL‐5). Psychometric properties of the PCL‐5 were examined in 2 studies involving trauma‐exposed college students. In Study 1 (N = 278), PCL‐5 scores exhibited strong internal consistency (α = .94), test‐retest reliability (r = .82), and convergent (rs = .74 to .85) and discriminant (rs = .31 to .60) validity. In addition, confirmatory factor analyses indicated adequate fit with the DSM‐5 4‐factor model, χ2(164) = 455.83, p < .001, standardized root mean square residual (SRMR) = .07, root mean squared error of approximation (RMSEA) = .08, comparative fit index (CFI) = .86, and Tucker‐Lewis index (TLI) = .84, and superior fit with recently proposed 6‐factor, χ2 (164) = 318.37, p < .001, SRMR = .05, RMSEA = .06, CFI = .92, and TLI = .90, and 7‐factor, χ2 (164) = 291.32, p < .001, SRMR = .05, RMSEA = .06, CFI = .93, and TLI = .91, models. In Study 2 (N = 558), PCL‐5 scores demonstrated similarly strong reliability and validity. Overall, results indicate that the PCL‐5 is a psychometrically sound measure of PTSD symptoms. Implications for use of the PCL‐5 in a variety of assessment contexts are discussed.
Resumen
Spanish s by the Asociacion Chilena de Estres Traumatico
Lista de verificación del Trastorno por Estrés Postraumatico para el
DSM‐5
La lista de verificación del Trastorno por Estrés Post‐Traumático (LVP o PCL por sus siglas en ingles: Posttraumatic Stress Disorder Checklist) es una medida DSM‐correspondiente de auto‐reporte de síntomas de TEPT ampliamente usada. La LVP fue recientemente revisada para reflejar los cambios DSM‐5 a los criterios de TEPT. Este artículo describe el desarrollo y evaluación psicométrica inicial de LVP para DSM‐5 (LVP‐5). Fueron examinadas propiedades psicométricas de LVP‐5 en dos estudios que involucraron estudiantes universitarios expuestos a trauma. En el estudio 1 (N = 278) las puntuaciones LVP‐ 5 exhibían fuerte consistencia interna (a = .94), y confiabilidad test‐re‐test (r = .82), y convergente (rs = .74 a .85) y validez discriminativa (rs = .31 a .60). Adicionalmente, análisis factoriales confirmatorios indicaron un ajuste adecuado con el modelo cuatro‐factores DSM‐5, Χ2 (164) = 455.83, p < .001; raíz cuadrada media estandarizada residual (RMER) = .07; error cuadrado medio de aproximación (ECMA) = .08; Índice de Ajuste Comparativo (IAC) = .86; y el Índice Tucker‐Lewis (ITL) = .84, y ajuste superior con el recientemente propuesto seis‐ (Χ2 (164) = 318.37, p < .001; RMER = .05; ECMA = .06; IAC = .92; y ITL = .90 y siete‐ (Χ2 (164) = 291.32, p < .001; RMER = .05; ECMA = 0.6; IAC = .93; y ITL = .91) modelos factoriales. En el Estudio 2 (N = 558) las puntuaciones LVP‐5 demostraron similarmente fuerte confiabilidad y validez. En general, los resultados indican que el LVP‐5 es una medida psicométrica sólida de TEPT. Son discutidas las implicaciones para el uso de LVP‐5 en una variedad de contextos de evaluación.
抽象
Traditional and Simplified Chinese s by AsianSTSS
標題 : DSM‐5的創傷後壓力症檢查表(PCL‐5)發展和初步心理測量評估
撮要: 與《精神疾病診斷與統計手冊》對應的創傷後壓力症檢查表(PCL)是普遍為人使用的PTSD症狀自評測量工具༌其最近因配合DSM‐5對PTSD診斷準則的修改而更新。本論文描述PCL(PCL‐5)為配合DSM‐5作出的發展和PCL‐5的初步心理測量評估༌利用兩項有關受創大學生的研究檢視PCL‐5的心理測量特性。研究一(N = 278)的PCL‐5分數反映強的內部一致性(α = .94)、重測信度(r = .82)、匯聚(rs = .74 至 .85)及判別效度(rs = .31 至 .60)。驗證性因數分析亦顯示PCL‐5跟DSM‐5的四因素模型有足夠適配度༌χ2 (164) = 455.83, p < .001༌
標準化殘差均方根 (SRMR) = .07༌漸進誤差均方根(RMSEA) = .08༌比較適配指數 (CFI) = .86༌Tucker Lewis指數(TLI) = .84༛並與最近提出的六因素模型(χ2 (164) = 318.37, p < .001; SRMR = .05; RMSEA = .06; CFI = .92; and TLI = .90)及七因素模型(χ2 (164) = 291.32, p < .001; SRMR = .05; RMSEA = .06; CFI = .93; and TLI = .91)有優越適配度。研究二(N = 558)的PCL‐5分數反映相近強度的信度和效度。整體結果反映PCL‐5是測量PTSD的好方法。論文亦討論到在各種評估情境下使用PCL‐5的意味。
标题 : DSM‐5的创伤后压力症检查表(PCL‐5)发展和初步心理测量评估
撮要: 与《精神疾病诊断与统计手册》对应的创伤后压力症检查表(PCL)是普遍为人使用的PTSD症状自评测量工具༌其最近因配合DSM‐5对PTSD诊断准则的修改而更新。本论文描述PCL(PCL‐5)为配合DSM‐5作出的发展和PCL‐5的初步心理测量评估༌利用两项有关受创大学生的研究检视PCL‐5的心理测量特性。研究一(N = 278)的PCL‐5分数反映强的内部一致性(α = .94)、重测信度(r = .82)、汇聚(rs = .74 至 .85)及判别效度(rs = .31 至 .60)。验证性因子分析亦显示PCL‐5跟DSM‐5的四因素模型有足够适配度༌χ2 (164) = 455.83, p < .001༌
标准化残差均方根 (SRMR) = .07༌渐进误差均方根(RMSEA) = .08༌比较适配指数 (CFI) = .86༌Tucker Lewis指数(TLI) = .84༛并与最近提出的六因素模型(χ2 (164) = 318.37, p < .001; SRMR = .05; RMSEA = .06; CFI = .92; and TLI = .90)及七因素模型(χ2 (164) = 291.32, p < .001; SRMR = .05; RMSEA = .06; CFI = .93; and TLI = .91)有优越适配度。研究二(N = 558)的PCL‐5分数反映相近强度的信度和效度。整体结果反映PCL‐5是测量PTSD的好方法。论文亦讨论到在各种评估情境下使用PCL‐5的意味。
Although social sciences such as anthropology are often thought to have been organized as academic specialties in the nineteenth century, the ideas upon which these disciplines were founded actually ...developed centuries earlier. In fact, the foundational concepts can be traced at least as far back as the sixteenth century, when contact with unfamiliar peoples in the New World led Europeans to create ways of describing and understanding social similarities and differences among humans.Early Anthropology in the Sixteenth and Seventeenth Centuriesexamines the history of some of the ideas adopted to help understand the origin of culture, the diversity of traits, the significance of similarities, the sequence of high civilizations, the course of cultural change, and the theory of social evolution. It is a book that not only illuminates the thinking of a bygone age but also sheds light on the sources of attitudes still prevalent today.
Herpes simplex virus type 1 (HSV-1) commonly causes orolabial ulcers, while HSV-2 commonly causes genital ulcers. However, HSV-1 is an increasing cause of genital infection. Previously, the World ...Health Organization estimated the global burden of HSV-2 for 2003 and for 2012. The global burden of HSV-1 has not been estimated.
We fitted a constant-incidence model to pooled HSV-1 prevalence data from literature searches for 6 World Health Organization regions and used 2012 population data to derive global numbers of 0-49-year-olds with prevalent and incident HSV-1 infection. To estimate genital HSV-1, we applied values for the proportion of incident infections that are genital.
We estimated that 3709 million people (range: 3440-3878 million) aged 0-49 years had prevalent HSV-1 infection in 2012 (67%), with highest prevalence in Africa, South-East Asia and Western Pacific. Assuming 50% of incident infections among 15-49-year-olds are genital, an estimated 140 million (range: 67-212 million) people had prevalent genital HSV-1 infection, most of which occurred in the Americas, Europe and Western Pacific.
The global burden of HSV-1 infection is huge. Genital HSV-1 burden can be substantial but varies widely by region. Future control efforts, including development of HSV vaccines, should consider the epidemiology of HSV-1 in addition to HSV-2, and especially the relative contribution of HSV-1 to genital infection.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
In the United States, racial/ethnic inequalities in obesity are well-documented, particularly among women. Using the Chicago Community Adult Health Study, a probability-based sample in 2001–2003 ...(N = 3105), we examined the roles of discrimination and vigilance in racial inequalities in two weight-related measures, body mass index (BMI) and waist circumference (WC), viewed through a cultural racism lens. Cultural racism creates a social environment in which Black Americans bear the stigma burden of their racial group while White Americans are allowed to view themselves as individuals. We propose that in this context, interpersonal discrimination holds a different meaning for Blacks and Whites, while vigilance captures the coping style for Blacks who carry the stigma burden of the racial group. By placing discrimination and vigilance within the context of cultural racism, we operationalize existing survey measures and utilize statistical models to clarify the ambiguous associations between discrimination and weight-related inequalities in the extant literature. Multivariate models were estimated for BMI and WC separately and were stratified by gender. Black women had higher mean BMI and WC than any other group, as well as highest levels of vigilance. White women did not show an association between vigilance and WC but did show a strong positive association between discrimination and WC. Conversely, Black women displayed an association between vigilance and WC, but not between discrimination and WC. These results demonstrate that vigilance and discrimination may hold different meanings for obesity by ethnoracial group that are concealed when all women are examined together and viewed without considering a cultural racism lens.
•With cultural racism, vigilance and discrimination hold different meanings by race.•Vigilance (not discrimination) was related to waist circumference for Black women.•Discrimination (not vigilance) was related to waist circumference for White women.
Synaptic loss and deficits in functional connectivity are hypothesized to contribute to symptoms associated with major depressive disorder (MDD) and post-traumatic stress disorder (PTSD). The ...synaptic vesicle glycoprotein 2A (SV2A) can be used to index the number of nerve terminals, an indirect estimate of synaptic density. Here, we used positron emission tomography (PET) with the SV2A radioligand
CUCB-J to examine synaptic density in n = 26 unmedicated individuals with MDD, PTSD, or comorbid MDD/PTSD. The severity of depressive symptoms was inversely correlated with SV2A density, and individuals with high levels of depression showing lower SV2A density compared to healthy controls (n = 21). SV2A density was also associated with aberrant network function, as measured by magnetic resonance imaging (MRI) functional connectivity. This is the first in vivo evidence linking lower synaptic density to network alterations and symptoms of depression. Our findings provide further incentive to evaluate interventions that restore synaptic connections to treat depression.
The objective of this study is to estimate life expectancies of HIV-positive patients conditional on response to antiretroviral therapy (ART).
Patients aged more than 20 years who started ART during ...2000-2010 (excluding IDU) in HIV clinics contributing to the UK CHIC Study were followed for mortality until 2012. We determined the latest CD4 cell count and viral load before ART and in each of years 1-5 of ART. For each duration of ART, life tables based on estimated mortality rates by sex, age, latest CD4 cell count and viral suppression (HIV-1 RNA <400 copies/ml), were used to estimate expected age at death for ages 20-85 years.
Of 21 388 patients who started ART, 961 (4.5%) died during 110 697 person-years. At start of ART, expected age at death 95% confidence interval (CI) of 35-year-old men with CD4 cell count less than 200, 200-349, at least 350 cells/μl was 71 (68-73), 78 (74-82) and 77 (72-81) years, respectively, compared with 78 years for men in the general UK population. Thirty-five-year-old men who increased their CD4 cell count in the first year of ART from less than 200 to 200-349 or at least 350 cells/μl and achieved viral suppression gained 7 and 10 years, respectively. After 5 years on ART, expected age at death of 35-year-old men varied from 54 (48-61) (CD4 cell count <200 cells/μl and no viral suppression) to 80 (76-83) years (CD4 cell count ≥350 cells/μl and viral suppression).
Successfully treated HIV-positive individuals have a normal life expectancy. Patients who started ART with a low CD4 cell count significantly improve their life expectancy if they have a good CD4 cell count response and undetectable viral load.
Substantial reductions in adult mortality have been observed in South Africa since the mid-2000s, but there has been no formal evaluation of how much of this decline is attributable to the scale-up ...of antiretroviral treatment (ART), as previous models have not been calibrated to vital registration data. We developed a deterministic mathematical model to simulate the mortality trends that would have been expected in the absence of ART, and with earlier introduction of ART.
Model estimates of mortality rates in ART patients were obtained from the International Epidemiology Databases to Evaluate AIDS-Southern Africa (IeDEA-SA) collaboration. The model was calibrated to HIV prevalence data (1997-2013) and mortality data from the South African vital registration system (1997-2014), using a Bayesian approach. In the 1985-2014 period, 2.70 million adult HIV-related deaths occurred in South Africa. Adult HIV deaths peaked at 231,000 per annum in 2006 and declined to 95,000 in 2014, a reduction of 74.7% (95% CI: 73.3%-76.1%) compared to the scenario without ART. However, HIV mortality in 2014 was estimated to be 69% (95% CI: 46%-97%) higher in 2014 (161,000) if the model was calibrated only to HIV prevalence data. In the 2000-2014 period, the South African ART programme is estimated to have reduced the cumulative number of HIV deaths in adults by 1.72 million (95% CI: 1.58 million-1.84 million) and to have saved 6.15 million life years in adults (95% CI: 5.52 million-6.69 million). This compares with a potential saving of 8.80 million (95% CI: 7.90 million-9.59 million) life years that might have been achieved if South Africa had moved swiftly to implement WHO guidelines (2004-2013) and had achieved high levels of ART uptake in HIV-diagnosed individuals from 2004 onwards. The model is limited by its reliance on all-cause mortality data, given the lack of reliable cause-of-death reporting, and also does not allow for changes over time in tuberculosis control programmes and ART effectiveness.
ART has had a dramatic impact on adult mortality in South Africa, but delays in the rollout of ART, especially in the early stages of the ART programme, have contributed to substantial loss of life. This is the first study to our knowledge to calibrate a model of ART impact to population-level recorded death data in Africa; models that are not calibrated to population-level death data may overestimate HIV-related mortality.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
PDF
