To prospectively evaluate fine needle aspiration biopsy (FNAB) of pancreatic cystic lesions.
We performed a blind, prospective study on percutaneous aspirates from 28 radiographically identified ...cysts, including 6 inflammatory cysts (5 pseudocysts and 1 abscess), 4 serous cystadenomas, 1 cystic islet cell tumor, 5 mucinous cystic neoplasms, 6 mucinous cystadenocarcinomas and 6 nonpancreatic cysts.
Four of six (67%) cystadenocarcinomas were identified as malignant, and the other two, which lacked sufficient morphologic criteria for malignancy, as consistent with mucinous cystic neoplasm. Two of five mucinous cystic neoplasms were correctly classified. One, which contained atypical cells, did not appear to be mucinous on the ThinPrep, and one, which lacked an epithelial component, was suggested because of the presence of mucin in the background. The fifth one contained inflammatory cells only. One of four serous cystadenomas produced a diagnostic specimen. FNAB of the cystic islet cell tumor was nondiagnostic. Five of six inflammatory cysts (83%) were correctly diagnosed, whereas one case produced an acellular, nondiagnostic specimen. Six of 28 (23%) cases were nonpancreatic cysts, aspirated under the presumption that they were pancreatic cysts based on radiologic studies: only one case, a papillary cystadenocarcinoma of the stomach, was correctly diagnosed; the other five cases were nondiagnostic, and in two of these the assumption that the cysts were pancreatic in origin precluded an accurate classification.
FNAB of pancreatic cystic lesions can differentiate mucinous from nonmucinous pancreatic cysts and provide definitive evidence of malignancy. In some cases, serous cystadenomas can be diagnosed. Pseudocysts can be suspected on the basis of an inflammatory smear lacking both epithelial cells and background mucin, but this finding is not specific. Nonpancreatic lesions constitute a significant percentage of cases aspirated as pancreatic cysts and present a major pitfall in cytologic interpretation.
Bilateral Action for Right Whales Sayles, Jesse S.; Green, David M.; Kraus, Scott D. ...
Science (American Association for the Advancement of Science),
12/2005, Letnik:
310, Številka:
5754
Journal Article
Mucinous ductal ectasia of the pancreas MCDOWELL, R. K; GAZELLE, G. S; MURPHY, B. L ...
Journal of computer assisted tomography,
05/1997, Letnik:
21, Številka:
3
Journal Article
Recenzirano
Pancreatic mucinous ductal ectasia (MDE) is a recently described and poorly understood disorder, with few cases reported in the imaging literature. We undertook this study to describe the spectrum of ...CT and pancreatographic findings of MDE and to investigate the incidence of associated pancreatic malignancy.
The medical records, CT scans, and pancreatograms of 12 consecutive patients with pathologically proven MDE were retrospectively reviewed. There were nine men and three women, ranging in age from 37 to 72 years (mean 59 years).
Focal lesions involved primarily the uncinate (two patients) and head (eight patients) by CT imaging. The entire gland was involved in two patients. CT findings were variable and included focal pancreatic enlargement, a low attenuation or cystic mass, low attenuation of the entire gland, or marked ductal dilatation. Pancreatographic findings were more consistent, showing ductal dilatation with or without intraluminal filling defects, obstruction, or displacement. In all cases, findings at endoscopy were felt to be characteristic, with ductal dilatation, filling defects, or abundant mucus seen upon cannulation of the pancreatic duct. Carcinoma-in-situ was present in six cases, cellular atypia without malignancy in two, and in three cases the lesions were histologically benign. One case demonstrated invasive adenocarcinoma. No finding or group of findings on CT or pancreatography permitted differentiation between benign and malignant lesions.
MDE can present with a variety of appearances on CT, none of which is diagnostic. Pancreatography can be diagnostic if dilatation and intraluminal filling defects are seen. Carcinoma-in-situ, invasive adenocarcinoma, or cellular atypia is present in approximately 75%, but cannot be accurately diagnosed prospectively.
Novel β-sheet-forming peptide 33-mers, βpep peptides, have been designed by using a combination approach employing basic folding principles and incorporating short sequences from the β-sheet domains ...of anti-angiogenic proteins. One of these designed peptides (βpep-25), named anginex, was observed to be potently anti-angiogenic. Anginex specifically inhibits vascular endothelial cell proliferation and induces apoptosis in these cells, as shown by flow-cytometric detection of sub-diploid cells, TUNEL (terminal deoxyribonucleotidyl transferase-mediated dUTP-nick-end labelling) analysis and cell morphology. Anginex also inhibits endothelial cell adhesion to and migration on different extracellular matrix components. Inhibition of angiogenesis in vitro is demonstrated in the sprout-formation assay and in vivo in the chick embryo chorio-allantoic membrane angiogenesis assay. Comparison of active and inactive βpep sequences allows structure–function relationships to be deduced. Five hydrophobic residues and two lysines appear to be crucial to activity. This is the first report of a designed peptide having a well-defined biological function as a novel cytokine, which may be an effective anti-angiogenic agent for therapeutic use against various pathological disorders, such as neoplasia, rheumatoid arthritis, diabetic retinopathy and restenosis.
We report the discovery of a compact multi-planet system orbiting the relatively nearby (78pc) and bright (\(K=8.9\)) K-star, K2-266 (EPIC248435473). We identify up to six possible planets orbiting ...K2-266 with estimated periods of P\(_b\) = 0.66, P\(_{.02}\) = 6.1, P\(_c\) = 7.8, P\(_d\) = 14.7, P\(_e\) = 19.5, and P\(_{.06}\) = 56.7 days and radii of R\(_P\) = 3.3 R\(_{\oplus}\), 0.646 R\(_{\oplus}\), 0.705 R\(_{\oplus}\), 2.93 R\(_{\oplus}\), 2.73 R\(_{\oplus}\), and 0.90 R\(_{\oplus}\), respectively. We are able to confirm the planetary nature of two of these planets (d & e) from analyzing their transit timing variations (\(m_d= 8.9_{-3.8}^{+5.7} M_\oplus\) and \(m_e=14.3_{-5.0}^{+6.4} M_\oplus\)), confidently validate the planetary nature of two other planets (b & c), and classify the last two as planetary candidates (K2-266.02 & .06). From a simultaneous fit of all 6 possible planets, we find that K2-266 b's orbit has an inclination of 75.32\(^{\circ}\) while the other five planets have inclinations of 87-90\(^{\circ}\). This observed mutual misalignment may indicate that K2-266 b formed differently from the other planets in the system. The brightness of the host star and the relatively large size of the sub-Neptune sized planets d and e make them well-suited for atmospheric characterization efforts with facilities like the Hubble Space Telescope and upcoming James Webb Space Telescope. We also identify an 8.5-day transiting planet candidate orbiting EPIC248435395, a co-moving companion to K2-266.
Among the costs associated with timber harvesting in northern New England, those related to unused production capacity are among the most poorly understood. Yet research in other regions of the US ...suggests that idle logging capacity can impose significant costs on wood supply systems, including logging businesses and procurement organizations.
Mail surveys of logging business owners and representatives of wood consuming mills were used to understand unused logging capacity in the northern New England states: Maine, New Hampshire and Vermont. Over two-thirds of logging business owners said that they experienced unused production capacity in an "average" year. Weather, poor road conditions, equipment breakdowns, and mill-imposed quotas, were cited most often as causes of unused logging capacity. Results of this study have implications for logging businesses, procurement organizations, and wood supply system efficiency in northern New England.
