Abstract
We report the discovery of HIP-97166b (TOI-1255b), a transiting sub-Neptune on a 10.3 day orbit around a K0 dwarf 68 pc from Earth. This planet was identified in a systematic search of TESS ...Objects of Interest for planets with eccentric orbits, based on a mismatch between the observed transit duration and the expected duration for a circular orbit. We confirmed the planetary nature of HIP-97166b with ground-based radial-velocity measurements and measured a mass of
M
b
= 20 ± 2
M
⊕
along with a radius of
R
b
= 2.7 ± 0.1
R
⊕
from photometry. We detected an additional nontransiting planetary companion with
M
c
sin
i
= 10 ± 2
M
⊕
on a 16.8 day orbit. While the short transit duration of the inner planet initially suggested a high eccentricity, a joint RV-photometry analysis revealed a high impact parameter
b
= 0.84 ± 0.03 and a moderate eccentricity. Modeling the dynamics with the condition that the system remain stable over >10
5
orbits yielded eccentricity constraints
e
b
= 0.16 ± 0.03 and
e
c
< 0.25. The eccentricity we find for planet b is above average for the small population of sub-Neptunes with well-measured eccentricities. We explored the plausible formation pathways of this system, proposing an early instability and merger event to explain the high density of the inner planet at 5.3 ± 0.9 g cc
−1
as well as its moderate eccentricity and proximity to a 5:3 mean-motion resonance.
Publishing study protocols might reduce research waste because of unclear methods or incomplete reporting; on the other hand, there might be few additional benefits of publishing protocols for ...registered trials that are never completed or published. No study has investigated the proportion of published protocols associated with published results.
To estimate the proportion of published trial protocols for which there are not associated published results.
This cross-sectional study used stratified random sampling to identify registered clinical trials with protocols published between January 2011 and August 2022 and indexed in PubMed Central. Ongoing studies and those within 1 year of the primary completion date on ClinicalTrials.gov were excluded. Published results were sought from August 2022 to March 2023 by searching ClinicalTrials.gov, emailing authors, and using an automated tool, as well as through incidental discovery.
The primary outcome was a weighted estimate of the proportion of registered trials with published protocols that also had published main results. The proportion of trials with unpublished results was estimated using a weighted mean.
From 1500 citations that were screened, 308 clinical trial protocols were included, and it was found that 87 trials had not published their main results. Most included trials were investigator-initiated evaluations of nonregulated products. When published, results appeared a mean (SD) of 3.4 (2.0) years after protocol publications. With the use of a weighted mean, an estimated 4754 (95% CI, 4296-5226) eligible clinical trial protocols were published and indexed in PubMed Central between 2011 and 2022. In the weighted analysis, 1708 of those protocols (36%; 95% CI, 31%-41%) were not associated with publication of main results. In a sensitivity analysis excluding protocols published after 2019, an estimated 25% (95% CI, 20%-30%) of 3670 (95% CI, 3310-4032) protocol publications were not associated with publication of main results.
This cross-sectional study of clinical trial protocols published on PubMed Central between 2011 and 2022 suggests that many protocols were not associated with subsequent publication of results. The overall benefits of publishing study protocols might outweigh the research waste caused by unnecessary protocol publications.
The Imaging and Medical Beamline (IMBL) is a superconducting multipole wiggler-based beamline at the 3 GeV Australian Synchrotron operated by the Australian Nuclear Science and Technology ...Organisation (ANSTO). The beamline delivers hard X-rays in the 25–120 keV energy range and offers the potential for a range of biomedical X-ray applications, including radiotherapy and medical imaging experiments. One of the imaging modalities available at IMBL is propagation-based X-ray phase-contrast computed tomography (PCT). PCT produces superior results when imaging low-density materials such as soft tissue (e.g., breast mastectomies) and has the potential to be developed into a valuable medical imaging tool. We anticipate that PCT will be utilized for medical breast imaging in the near future with the advantage that it could provide better contrast than conventional X-ray absorption imaging. The unique properties of synchrotron X-ray sources such as high coherence, energy tunability, and high brightness are particularly well-suited for generating PCT data using very short exposure times on the order of less than 1 min. The coherence of synchrotron radiation allows for phase-contrast imaging with superior sensitivity to small differences in soft-tissue density. Here we also compare the results of PCT using two different detectors, as these unique source characteristics need to be complemented with a highly efficient detector. Moreover, the application of phase retrieval for PCT image reconstruction enables the use of noisier images, potentially significantly reducing the total dose received by patients during acquisition. This work is part of ongoing research into innovative tomographic methods aimed at the introduction of 3D X-ray medical imaging at the IMBL to improve the detection and diagnosis of breast cancer. Major progress in this area at the IMBL includes the characterization of a large number of mastectomy samples, both normal and cancerous, which have been scanned at clinically acceptable radiation dose levels and evaluated by expert radiologists with respect to both image quality and cancer diagnosis.
Abstract The Transiting Exoplanet Survey Satellite (TESS) continues to increase dramatically the number of known transiting exoplanets, and is optimal for monitoring bright stars amenable to radial ...velocity (RV) and atmospheric follow-up observations. TOI-1386 is a solar-type (G5V) star that was detected via TESS photometry to exhibit transit signatures in three sectors with a period of 25.84 days. We conducted follow-up RV observations using Keck/High Resolution Echelle Spectrometer (HIRES) as part of the TESS–Keck Survey, collecting 64 RV measurements of TOI-1386 with the HIRES spectrograph over 2.5 yr. Our combined fit of the TOI-1386 photometry and RV data confirm the planetary nature of the detected TESS signal, and provide a mass and radius for planet b of 0.148 ± 0.019 M J and 0.540 ± 0.017 R J , respectively, marking TOI-1386 b as a warm sub-Saturn planet. Our RV data further reveal an additional outer companion, TOI-1386 c, with an estimated orbital period of 227.6 days and a minimum mass of 0.309 ± 0.038 M J . The dynamical modeling of the system shows that the measured system architecture is long-term stable, although there may be substantial eccentricity oscillations of the inner planet due to the dynamical influence of the outer planet.
Abstract
We present the discovery of two nearly identically sized sub-Neptune transiting planets orbiting HD 63935, a bright (
V
= 8.6 mag), Sun-like (
T
eff
= 5560 K) star at 49 pc. TESS identified ...the first planet, HD 63935 b (TOI-509.01), in Sectors 7 and 34. We identified the second signal (HD 63935 c) in Keck High Resolution Echelle Spectrometer and Lick Automated Planet Finder radial velocity data as part of our follow-up campaign. It was subsequently confirmed with TESS photometry in Sector 34 as TOI-509.02. Our analysis of the photometric and radial velocity data yielded a robust detection of both planets with periods of 9.0600 ± 0.007 and 21.40 ± 0.0019 days, radii of 2.99 ± 0.14 and 2.90 ± 0.13
R
⊕
, and masses of 10.8 ± 1.8 and 11.1 ± 2.4
M
⊕
. We calculated densities for planets b and c consistent with a few percent of the planet mass in hydrogen/helium envelopes. We also describe our survey’s efforts to choose the best targets for James Webb Space Telescope atmospheric follow-up. These efforts suggest that HD 63935 b has the most clearly visible atmosphere of its class. It is the best target for transmission spectroscopy (ranked by the transmission spectroscopy metric, a proxy for atmospheric observability) in the so far uncharacterized parameter space comprising sub-Neptune-sized (2.6
R
⊕
<
R
p
< 4
R
⊕
), moderately irradiated (100
F
⊕
<
F
p
< 1000
F
⊕
) planets around G stars. Planet c is also a viable target for transmission spectroscopy, and given the indistinguishable masses and radii of the two planets, the system serves as a natural laboratory for examining the processes that shape the evolution of sub-Neptune planets.
Results are presented of a recent experiment at the Imaging and Medical beamline of the Australian Synchrotron intended to contribute to the implementation of low‐dose high‐sensitivity ...three‐dimensional mammographic phase‐contrast imaging, initially at synchrotrons and subsequently in hospitals and medical imaging clinics. The effect of such imaging parameters as X‐ray energy, source size, detector resolution, sample‐to‐detector distance, scanning and data processing strategies in the case of propagation‐based phase‐contrast computed tomography (CT) have been tested, quantified, evaluated and optimized using a plastic phantom simulating relevant breast‐tissue characteristics. Analysis of the data collected using a Hamamatsu CMOS Flat Panel Sensor, with a pixel size of 100 µm, revealed the presence of propagation‐based phase contrast and demonstrated significant improvement of the quality of phase‐contrast CT imaging compared with conventional (absorption‐based) CT, at medically acceptable radiation doses.
To prospectively compare the accuracy of ultrasonography (US) with that of supine chest radiography in the detection of traumatic pneumothoraces, with computed tomography (CT) as the reference ...standard.
Thoracic US, supine chest radiography, and CT were performed to assess for pneumothorax in 27 patients who sustained blunt thoracic trauma. US and radiographic findings were compared with CT findings, the reference standard, for pneumothorax detection. For the purpose of this study, the sonographers were blinded to the radiographic and CT findings.
Eleven of 27 patients had pneumothorax at CT. All 11 of these pneumothoraces were detected at US, and four were seen at supine chest radiography. In the one false-positive US case, the patient was shown to have substantial bullous emphysema at CT. Sensitivity and negative predictive value of US were 100% (11 of 11 and 15 of 15 patients, respectively), specificity was 94% (15 of 16 patients), and positive predictive value was 92% (11 of 12 patients). Chest radiography had 36% (four of 11 patients) sensitivity, 100% (16 of 16 patients) specificity, a 100% (four of four patients) positive predictive value, and a 70% (16 of 23 patients) negative predictive value.
In this study, US was more sensitive than supine chest radiography and as sensitive as CT in the detection of traumatic pneumothoraces.
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