Background and Objective
It is documented that low protein and amino-acid dietary intake is related to poorer cognitive health and increased risk of dementia. Degradation of the neuromodulatory ...pathways, (comprising the cholinergic, dopaminergic, serotoninergic and noradrenergic systems) is observed in neurodegenerative diseases and impairs the proper biosynthesis of key neuromodulators from micro-nutrients and amino acids. How these micro-nutrients are linked to neuromodulatory pathways in healthy adults is less studied. The Locus Coeruleus–Noradrenergic System (LC-NA) is the earliest subcortical structure affected in Alzheimer’s disease, showing marked neurodegeneration, but is also sensitive for age-related changes. The LC-NA system is critical for supporting attention and cognitive control, functions that are enhanced both by tyrosine administration and chronic tyrosine intake. The purpose of this study was to 1) investigate whether the dietary intake of tyrosine, the key precursor for noradrenaline (NA), is related to LC signal intensity 2) whether LC mediates the reported association between tyrosine intake and higher cognitive performance (measured with Trail Making Test–TMT), and 3) whether LC signal intensity relates to an objective measure of brain maintenance (BrainPAD).
Methods
The analyses included 398 3T MRIs of healthy participants from the Berlin Aging Study II to investigate the relationship between LC signal intensity and habitual dietary tyrosine intake-daily average (HD-Tyr-IDA - measured with Food Frequency Questionnaire - FFQ). As a control procedure, the same analyses were repeated on other main seeds of the neuromodulators’ subcortical system (Dorsal and Medial Raphe, Ventral Tegmental Area and Nucleus Basalis of Meynert). In the same way, the relationships between the five nuclei and BrainPAD were tested.
Results
Results show that HD-Tyr-IDA is positively associated with LC signal intensity. Similarly, LC disproportionally relates to better brain maintenance (BrainPAD). Mediation analyses reveal that only LC, relative to the other nuclei tested, mediates the relationship between HD-Tyr-IDA I and performance in the TMT and between HD-Tyr-IDA and BrainPAD.
Conclusions
These findings provide the first evidence linking tyrosine intake with LC-NA system signal intensity and its correlation with neuropsychological performance. This study strengthens the role of diet for maintaining brain and cognitive health and supports the noradrenergic theory of cognitive reserve. Within this framework, adequate tyrosine intake might increase the resilience of LC-NA system functioning, by preventing degeneration and supporting noradrenergic metabolism required for LC function and neuropsychological performance.
Alcohol's effects on sexual perception Abbey, A; Zawacki, T; McAuslan, P
Journal of studies on alcohol,
09/2000, Letnik:
61, Številka:
5
Journal Article
Odprti dostop
This study examines hypotheses about alcohol's effects on sexual judgments based on both alcohol and misperception theories. It was hypothesized that gender, alcohol consumption and alcohol ...expectancy set would influence perceptions of sexuality.
Participants were unacquainted women and men (88 dyads) who interacted for 15 minutes within the context of the balanced placebo design. After the conversation ended, participants answered questions about their behavior and their partners' behavior. Conversations were videotaped and coded by trained raters.
Men perceived their female partner and themselves as behaving more sexually than women perceived their male partner and themselves. When alcohol was consumed, both women and men were perceived as behaving more sexually and in a more disinhibited manner than when alcohol was not consumed. Ratings made by members of white and black dyads were largely comparable. Trained observers coded participants' use of active attention and dating availability cues. Both types of cues interacted with alcohol consumption such that intoxicated participants exaggerated the meaning of strong (dating availability) cues and ignored the meaning of ambiguous (active attention) cues when making sexual judgments.
Supporting past research on gender differences in perceptions of sexuality, men were more sexually attracted to their opposite-sex partner than women were. Both women's and men's sexual judgments were influenced by alcohol consumption but not by alcohol expectancy set. Intoxicated participants' responses to their partners' behavioral cues supported cognitive impairment models of alcohol's effects. The implications of these findings for theories about alcohol's effects on sexuality and for prevention programming are discussed.
Autonomous Vehicle (AV) research has focused on public acceptance of and intention to use AVs, with trust emerging as important to these variables. Research on AV trust has centered on trust in ...vehicle performance. However, trust evaluation may include AV manufacturers and developers, and regulation pertaining to AVs; thus, we expand our measurement of trust to include beliefs based on manufacturers and regulation. In this experiment, we manipulate information regarding manufacturer focus (i.e., an emphasis on standards, regulations, and research (SRR) versus speed to market) to determine its effect on trust. When information focused on SRR, we found higher levels of trust in AV performance and in manufacturers, compared to when it focused on speed to market. In addition, information regarding passenger control (i.e., the ability to take over for the vehicle and to determine privacy settings) was manipulated to yield either high or low passenger control conditions. Behavioral Intention (BI) to use AVs was lowest when speed to market was emphasized and when passenger control was low. Furthermore, trust was tested as a mediator between perceived risk and BI. Trust in AV performance partially mediated the relationship between perceived AV performance risk and BI. In addition, trust in AV regulation partially mediated the relationship between AV privacy/security risk and BI. Researchers should continue to examine trust beyond the AV itself to encompass trust in manufacturers and regulations. Those designing and marketing AVs should carefully consider decisions that influence manufacturer/developer reputation and passenger control due to their effect on intention to use AVs.
The problem of estimating an unknown force driving a linear oscillator is revisited. When using linear measurement, feedback is often cited as a mechanism to enhance bandwidth, sensitivity or ...resolution. We show that as long as the oscillator dynamics are known, there exists a real-time estimation strategy that reproduces the same measurement record as any arbitrary feedback protocol. Consequently some form of nonlinearity is required to gain any advantage beyond estimation alone. This result holds true in both quantum and classical systems, with nonstationary forces and feedback, and in the general case of non-Gaussian and correlated noise. Recently, feedback enhanced incoherent force resolution has been demonstrated E. Gavartin, P. Verlot, and T. J. Kippenberg, Nat. Nano. 7, 509 (2012), with the enhancement attributed to a feedback induced modification of the mechanical susceptibility. As a proof-of-principle, we experimentally reproduce this result through straightforward filtering.
We report measurements of discrete excitation-induced frequency shifts on the 7F0→5D0 transition of the Eu+ center in La:Lu:EuCl3·6D2O resulting from the optical excitation of neighboring Eu3+ ions. ...Shifts of up to 46.081±0.005 MHz were observed. The magnitude of the interaction between neighboring ions was found to be significantly larger than expected from the electric dipole-dipole mechanism often observed in rare earth systems. We show that a large network of interacting and individually addressable centers can be created by lightly doping crystals otherwise stoichiometric in the optically active rare earth ion, and that this network could be used to implement a quantum processor with more than ten qubits.
Approximately half of all sexual assaults are associated with either the perpetrator's alcohol consumption, the victim's alcohol consumption, or both. Although the emphasis of this review is on ...alcohol-involved sexual assaults, their unique aspects can only be evaluated by comparing them to other types of sexual assault. Theoretical perspectives on sexual assault that focus on characteristics of the perpetrator, the victim, and the situation are described. A number of personality traits, attitudes, and past experiences have been systematically linked to sexual assault perpetration, including beliefs about alcohol and heavy drinking. In contrast, only a few experiences have been significantly related to sexual assault victimization, including childhood sexual abuse and heavy drinking. There is support for both psychological and pharmacological mechanisms linking alcohol and sexual assault. Beliefs about alcohol's effects reinforce stereotypes about gender roles and can exacerbate their influence on perpetrators' actions. Alcohol's effects on cognitive and motor skills also contribute to sexual assault through their effects on perpetrators' and victims' ability to process and react to each other's verbal and nonverbal behavior. Limitations with existing research and methodological challenges associated with conducting research on this topic are described. Suggestions are made for future research which can inform prevention and treatment programs.
Task-free functional connectivity in animal models provides an experimental framework to examine connectivity phenomena under controlled conditions and allows for comparisons with data modalities ...collected under invasive or terminal procedures. Currently, animal acquisitions are performed with varying protocols and analyses that hamper result comparison and integration. Here we introduce StandardRat, a consensus rat functional magnetic resonance imaging acquisition protocol tested across 20 centers. To develop this protocol with optimized acquisition and processing parameters, we initially aggregated 65 functional imaging datasets acquired from rats across 46 centers. We developed a reproducible pipeline for analyzing rat data acquired with diverse protocols and determined experimental and processing parameters associated with the robust detection of functional connectivity across centers. We show that the standardized protocol enhances biologically plausible functional connectivity patterns relative to previous acquisitions. The protocol and processing pipeline described here is openly shared with the neuroimaging community to promote interoperability and cooperation toward tackling the most important challenges in neuroscience.
Purpose
This study contributes to the ecological validity of resume research by systematically examining the impression management (IM) content of actual resumes and cover letters and empirically ...testing the effect on applicant evaluation.
Design/methodology/approach
A content analysis of the frequency and intensity of IM tactic use in 60 resumes and cover letters was completed (Study 1). Next, an experiment was conducted in which IM tactic use was manipulated and the effect on applicant evaluation examined, using a sample of MTurk workers as evaluators (Study 2).
Findings
In Study 1, four self-promotion categories, three ingratiation categories, and one hybrid category were delineated. In Study 2, ingratiation and lower intensity self-promotion were found to increase perceptions of job and organization fit.
Implications
Employers should be aware that resumes and cover letters contain IM tactics that may influence applicant evaluation. In addition, employment training programs might communicate the benefits of using ingratiation and lower intensity self-promotion, while emphasizing the importance of accurately conveying one’s qualifications. Furthermore, the present taxonomy of IM resume content might be applied to resume database search engines to identify and index IM tactic use.
Originality/value
This research is the first to develop a taxonomy of IM tactics based on actual resumes and cover letters and may facilitate more comprehensive manipulations of IM tactic use and better integration of IM research across the selection process.
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