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zadetkov: 356
1.
  • Structure and function of f... Structure and function of factor XI
    Emsley, Jonas; McEwan, Paul A.; Gailani, David Blood, 04/2010, Letnik: 115, Številka: 13
    Journal Article
    Recenzirano
    Odprti dostop

    Factor XI (FXI) is the zymogen of an enzyme (FXIa) that contributes to hemostasis by activating factor IX. Although bleeding associated with FXI deficiency is relatively mild, there has been ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP

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2.
  • Nix is a selective autophag... Nix is a selective autophagy receptor for mitochondrial clearance
    Novak, Ivana; Kirkin, Vladimir; McEwan, David G ... EMBO reports, January 2010, Letnik: 11, Številka: 1
    Journal Article
    Recenzirano
    Odprti dostop

    Autophagy is the cellular homeostatic pathway that delivers large cytosolic materials for degradation in the lysosome. Recent evidence indicates that autophagy mediates selective removal of protein ...
Celotno besedilo
Dostopno za: FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK

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3.
  • Structural correlations in ... Structural correlations in the family of small leucine-rich repeat proteins and proteoglycans
    McEwan, Paul A.; Scott, Paul G.; Bishop, Paul N. ... Journal of structural biology, 08/2006, Letnik: 155, Številka: 2
    Journal Article
    Recenzirano

    The family of small leucine-rich repeat proteins and proteoglycans (SLRPs) contains several extracellular matrix molecules that are structurally related by a protein core composed of leucine-rich ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
4.
  • Crystal Structure of the Di... Crystal Structure of the Dimeric Protein Core of Decorin, the Archetypal Small Leucine-Rich Repeat Proteoglycan
    Scott, Paul G.; McEwan, Paul A.; Dodd, Carole M. ... Proceedings of the National Academy of Sciences - PNAS, 11/2004, Letnik: 101, Številka: 44
    Journal Article
    Recenzirano
    Odprti dostop

    Decorin is a ubiquitous extracellular matrix proteoglycan with a variety of important biological functions that are mediated by its interactions with extracellular matrix proteins, cytokines, and ...
Celotno besedilo
Dostopno za: BFBNIB, NMLJ, NUK, PNG, SAZU, UL, UM, UPUK

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5.
  • Fragment Molecular Orbital ... Fragment Molecular Orbital Method Applied to Lead Optimization of Novel Interleukin‑2 Inducible T‑Cell Kinase (ITK) Inhibitors
    Heifetz, Alexander; Trani, Giancarlo; Aldeghi, Matteo ... Journal of medicinal chemistry, 05/2016, Letnik: 59, Številka: 9
    Journal Article
    Recenzirano

    Inhibition of inducible T-cell kinase (ITK), a nonreceptor tyrosine kinase, may represent a novel treatment for allergic asthma. In our previous reports, we described the discovery of ...
Celotno besedilo
Dostopno za: PNG, UM
6.
  • Leucine-rich repeat protein... Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia
    Wadelin, Frances; Fulton, Joel; McEwan, Paul A ... Molecular cancer, 08/2010, Letnik: 9, Številka: 1
    Journal Article
    Recenzirano
    Odprti dostop

    PRAME/MAPE/OIP4 is a germinal tissue-specific gene that is also expressed at high levels in haematological malignancies and solid tumours. The physiological functions of PRAME in normal and tumour ...
Celotno besedilo
Dostopno za: DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK

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7.
  • Sebetralstat (KVD900): A Po... Sebetralstat (KVD900): A Potent and Selective Small Molecule Plasma Kallikrein Inhibitor Featuring a Novel P1 Group as a Potential Oral On-Demand Treatment for Hereditary Angioedema
    Davie, Rebecca L.; Edwards, Hannah J.; Evans, D. Michael ... Journal of medicinal chemistry, 10/2022, Letnik: 65, Številka: 20
    Journal Article
    Recenzirano
    Odprti dostop

    Hereditary angioedema (HAE) is a rare genetic disorder in which patients experience sudden onset of swelling in various locations of the body. HAE is associated with uncontrolled plasma kallikrein ...
Celotno besedilo
Dostopno za: PNG, UM
8.
  • Crystal structure of the fa... Crystal structure of the factor XI zymogen reveals a pathway for transactivation
    Emsley, Jonas; Papagrigoriou, Evangelos; McEwan, Paul A ... Nature structural & molecular biology, 06/2006, Letnik: 13, Številka: 6
    Journal Article
    Recenzirano

    Factor XI (FXI), a coagulation protein essential to normal hemostasis, circulates as a disulfide-linked dimer. Here we report the full-length FXI zymogen crystal structure, revealing that the ...
Celotno besedilo
Dostopno za: DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
9.
  • Scaffold-Hopping Approach T... Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase
    Blaquiere, Nicole; Castanedo, Georgette M; Burch, Jason D ... Journal of medicinal chemistry, 08/2018, Letnik: 61, Številka: 15
    Journal Article
    Recenzirano

    NF-κB-inducing kinase (NIK) is a protein kinase central to the noncanonical NF-κB pathway downstream from multiple TNF receptor family members, including BAFF, which has been associated with B cell ...
Celotno besedilo
Dostopno za: PNG, UM
10.
  • Optimization and Mechanisti... Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1α
    Mak, Victor W.; Patel, Akash M.; Yen, Rose ... Journal of medicinal chemistry, 08/2022, Letnik: 65, Številka: 15
    Journal Article
    Recenzirano

    Activation of PKG1α is a compelling strategy for the treatment of cardiovascular diseases. As the main effector of cyclic guanosine monophosphate (cGMP), activation of PKG1α induces smooth muscle ...
Celotno besedilo
Dostopno za: PNG, UM
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zadetkov: 356

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