•A refined version of the free-streaming model for ELM dynamics was developed.•This model includes recycling during ELMs and was validated against DIII-D data.•A particle recycling coefficient of ...0.96 provides good agreement with the data set.•This model was extended to predict W erosion, also benchmarked with measurements.•A strong density dependence of the WI 400.8 nm S/XB coefficient was identified.
A refined version of the Fundamenksi-Moulton 'free-streaming' model (FSM) for the dynamics of divertor density, particle flux, and heat flux during edge localized modes (ELMs) is presented. This model depends only on inter-ELM pedestal and divertor conditions and, crucially, incorporates particle recycling: a FSM with recycling model, FSRM. The effective particle recycling coefficient, Reff, is the only empirical fitting parameter in the FSRM. The predictions of the FSRM are systematically tested against a DIII-D database of ELM ion and energy fluence measurements and are shown to be consistent with the model across a wide range of pedestal and divertor conditions using a constant value of 0.96 for Reff . Predictions for W sputtering during ELMs are developed based on the FSRM. It is concluded that energetic free-streaming D+ ions and C6+ impurities are the dominant contributors to the intra-ELM gross erosion of W in the DIII-D divertor, i.e., recycling ions and impurities have relatively little impact on the total W sputtering rate. These calculations are also shown to be consistent with spectroscopic measurements of W gross erosion for three different pedestal conditions after incorporating the strong electron density dependence of the WI 400.8 nm ionizations/photon (S/XB) coefficient.
Pathological changes in the Alzheimer's disease (AD) brain include amyoid-β (Aβ) plaques, and neurofibrillary tangles, as well as neuronal death and synaptic loss. Matrix metalloproteinases MMP-2 and ...MMP-9 are known to degrade Aβ, and their expressions are increased in the AD brain, in particular in the astrocytes surrounding amyloid plaque. To investigate a possible association between plasma metalloproteinases and AD, we quantified MMP-2 and MMP-9 activities in the plasma of healthy controls (HC, n = 56), cases with mild cognitive impairment (MCI, n = 45), and AD (n = 50). All cases had previously been imaged with Pittsburgh compound B (PiB) and had a Mini-Mental Status Examination (MMSE) assessment. MMP-2 and MMP-9 activity was determined using gelatine-zymography. There was a significant 1.5-fold decrease in MMP-2 activity in the AD group compared to HC (p < 0.001) and a 1.4-fold decrease compared to MCI (p < 0.01). There was no difference in MMP-9 levels between the three groups. A positive correlation was identified between MMP-2 plasma activity and MMSE score (r = 0.16, p < 0.05), but there was no association with PiB. This is the first report of a change in MMP-2 activity in AD plasma and these findings may provide some insight into AD pathogenesis.
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Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
•The first detailed experimental verification of polar ion impact angle distribution (IAD).•Specially fabricated micro-trenches were exposed to L-mode D plasmas at DIII-D DiMES.•Calculated polar and ...azimuthal IADs were combined with a Monte-Carlo MPR code.•MPR revealed the areal erosion yield on the trench floor due to D sputtering.•Good agreement between MPR erosion and EDS net C deposition profiles was seen.•Such agreement strongly verifies the IADs, and the modeling of the Chodura sheath.
We report the first detailed experimental verification of the polar deuterium ion impact angle distribution (IAD) on the DIII-D divertor surface in L-mode plasmas using micro-engineered trenches in samples mounted on the DiMES probe. These trenches were fabricated via focused ion beam (FIB) milling of a silicon surface partially coated with aluminum. The sample surfaces were exposed to eight repeat L-mode deuterium discharges (30 s total exposure time). The samples were examined by scanning electron microscopy (SEM), which revealed changes on the trench floor due to material deposition and evidence for shadowing of the incident deuterium ions by the trench walls. The areal distribution of carbon and aluminum deposition was measured by energy-dispersive X-ray spectroscopy (EDS). One-dimensional profiles of this deposition are in agreement with net erosion profiles calculated from a Monte Carlo micro-patterning and roughness (MPR) code for ion sputtering using as input the polar and azimuthal deuterium IADs reported previously (Chrobak et al., Nucl. Fusion 58, 106019 (2018)). The deposition profiles verified the characteristic shape of the polar IADs, which have a broad maximum from 79° to 86°, over the experimental range of 68°–83°, where 0° is the surface normal direction.
Two new studies report the results of genome-wide association analysis for androgenetic alopecia. The two major genetic loci identified set the scene for understanding the molecular basis of common ...male-pattern baldness. PUBLICATION ABSTRACT
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
The CP properties of the coupling between the Higgs boson and the top quark are investigated using 139 fb−1 of proton–proton collision data recorded by the ATLAS experiment at the LHC at a ...centre-of-mass energy of s=13 TeV. The CP structure of the top quark–Higgs boson Yukawa coupling is probed in events with a Higgs boson decaying into a pair of b-quarks and produced in association with either a pair of top quarks, tt¯H, or a single top quark, tH. Events containing one or two electrons or muons are used for the measurement. Multivariate techniques are used to select regions enriched in tt¯H and tH events, where dedicated CP-sensitive observables are exploited. In an extension of the Standard Model (SM) with a CP-odd admixture in the top–Higgs Yukawa coupling, the mixing angle between CP-even and CP-odd couplings is measured to be α=11−73∘∘+52∘, compatible with the SM prediction corresponding to α=0.
UEDGE simulations highlight the role of cross-field drifts on the onset of detached conditions, and new calibrated divertor vacuum ultra violet (VUV) spectroscopy is used to challenge the predictions ...of radiative constituents in these simulations. UEDGE simulations for DIII-D H-mode plasmas with the open divertor with the ion ∇B-drift towards the X-point show a bifurcated onset of the low field side (LFS) divertor detachment, consistent with experimentally observed step-like detachment onset (Jaervinen A.E. et al 2018 Phys. Rev. Lett. 121 075001). The divertor plasma in the simulations exhibits hysteresis in upstream separatrix density between attached and detached solution branches. Reducing the drift magnitude by a factor of 3 eliminates the step-like detachment onset in the simulations, confirming the strong role of drifts in the bifurcated detachment onset. When measured local plasma densities and temperatures are within proximity of predicted values in the simulations, there is no shortfall of the local emission of the dominant resonant radiating lines. However, the simulations systematically predict a factor of two lower total integrated radiated power than measured by the bolometer with the difference lost through radial heat flow out of the computational domain. Even though there is no shortfall in the emission of the dominant lines, a shortfall of total radiated power can be caused by underpredicted spatial extent of the radiation front, indicating a potential upstream or divertor transport physics origin for the radiation shortfall, or shortfall of radiated power in the spectrum between the dominant lines. In addition to the underpredicted spatial extent, in detached conditions, the simulations overpredict the peak radiation and dominant carbon lines near the X-point, which can be alleviated by manually increasing divertor diffusivity in the simulations, highlighting the ad hoc cross-field transport as one of the key limitations of the predictive capability of these divertor fluid codes.
Traditionally, Pitot rake test models have been used to take time- and spatially resolved impact pressure measurements in impulse facilities for flow characterisation. When expansion tubes are used ...for the study of hypervelocity planetary entry phenomena, generally the post-shock flow in the test section strongly radiates. This paper outlines a simple method which uses a high-speed camera in addition to a conventional Pitot rake to improve estimates of experimental test time and core flow size by imaging post-shock radiative emission over the probes in the Pitot rake. This method can also be used with specific narrow bandpass optical filters to examine when the emission from key species remains constant in the test flow in both time and space. The selection and suitability of various optical filters for a high-enthalpy Earth entry scenario are examined in this paper, as well as the effect of radiation from flow contamination. Experimentally, it was found that the radiative emission generally rises quite abruptly at the end of the test time and sometimes in situations where the pressure remains constant. It was also seen that different optical filters focusing on different spectral features can show their abrupt rise at different times, giving differing values for the end of the test time. Unfiltered measurements were found to be compromised by contaminant radiative emission which was seen to be randomly distributed in time and space towards the end of the test time.
The production yield of Z bosons is measured in the electron and muon decay channels in Pb+Pb collisions at sNN=5.02 TeV with the ATLAS detector. Data from the 2015 LHC run corresponding to an ...integrated luminosity of 0.49 nb−1 are used for the analysis. The Z boson yield, normalised by the total number of minimum-bias events and the mean nuclear thickness function, is measured as a function of dilepton rapidity and event centrality. The measurements in Pb+Pb collisions are compared with similar measurements made in proton–proton collisions at the same centre-of-mass energy. The nuclear modification factor is found to be consistent with unity for all centrality intervals. The results are compared with theoretical predictions obtained at next-to-leading order using nucleon and nuclear parton distribution functions. The normalised Z boson yields in Pb+Pb collisions lie 1–3σ above the predictions. The nuclear modification factor measured as a function of rapidity agrees with unity and is consistent with a next-to-leading-order QCD calculation including the isospin effect.
(Abstracted from N Engl J Med 2023;388(23):2132–2144) Gestational diabetes mellitus is a common pregnancy complication. It is associated with adverse outcomes, including preeclampsia, obstetrical ...intervention, large-for-gestational-age neonates, shoulder dystocia, birth trauma, and neonatal hypoglycemia. Cohort studies have found that women with hyperglycemia before 20 weeks of gestation are more likely to experience accelerated fetal growth by 24 to 28 weeks than those diagnosed with GDM later in pregnancy.
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