•R134a flow boiling 3D simulations were performed in smooth tubes using ANSYS fluent.•Effect of saturation condition, heat and mass flux was studied at varying diameter.•Heat transfer and pressure ...drop results are in dimensional and non-dimensional forms.•Results agree well with relevant correlations and experiments with low deviations.•Findings contribute to understanding flow boiling and optimizing heat exchangers.
Three-dimensional transient simulations using ANSYS Fluentʼs mixture multiphase model was conducted to investigate the impact of heat flux, mass flux, and saturation temperature variations on pressure drop behaviour and heat transfer characteristics during flow boiling of R134a refrigerant in smooth horizontal tubes of different diameters. The simulations employ an implicit numerical method to solve the governing equations, with relevant source terms for mass and energy transfer, incorporating the continuum surface force (CSF) and shear stress transport (SST) κ-ω models to account for surface tension and flow turbulence respectively. The results are presented in both dimensional (heat transfer coefficient and pressure drop) and non-dimensional (Nusselt number and two-phase frictional factor) forms. The Nusselt number shows a direct relationship with the Reynolds number, while the two-phase friction factor exhibits different behaviour. At higher vapor quality, mass flux significantly affects heat transfer performance and pressure drop. Heat flux plays a crucial role in heat transfer, but its impact on pressure drop is negligible. Higher saturation temperatures enhance heat transfer while reducing pressure gradients. The obtained results demonstrate good agreement with existing correlations, with mean absolute deviations (MAD) as low as 1.2 % for the heat transfer coefficient and 23.7 % for the pressure drop behaviour. This highlights the model's accuracy in predicting flow boiling behaviour of R134a in smooth horizontal channels, providing valuable insights for thermal analysis. The findings contribute to the understanding of flow boiling processes and aid in designing and optimizing efficient heat exchangers for various engineering applications.
Remote self-assessment of the revised amyotrophic lateral sclerosis functional rating scale (ALSFRS-R) using digital data capture was investigated for its feasibility as an add-on to ALSFRS-R ...assessments during multidisciplinary clinic visits.
From August 2017 to December 2021, at 12 ALS centers in Germany, an observational study on remote assessment of the ALSFRS-R was performed. In addition to the assessment of ALSFRS-R during clinic visits, patients were offered a digital self-assessment of the ALSFRS-R - either on a computer or on a mobile application ("ALS-App").
An estimated multicenter cohort of 4,670 ALS patients received care at participating ALS centers. Of these patients, 971 remotely submitted the ALSFRS-R, representing 21% of the multicenter cohort. Of those who opted for remote assessment, 53.7% (n = 521) completed a minimum of 4 ALSFRS-R per year with a mean number of 10.9 assessments per year. Different assessment frequencies were found for patients using a computer (7.9 per year, n = 857) and mobile app (14.6 per year, n = 234). Patients doing remote assessments were more likely to be male and less functionally impaired but many patients with severe disability managed to complete it themselves or with a caregiver (35% of remote ALSFRS-R cohort in King's Stage 4).
In a dedicated ALS center setting remote digital self-assessment of ALSFRS-R can provide substantial data which is complementary and potentially an alternative to clinic assessments and could be used for research purposes and person-level patient management. Addressing barriers relating to patient uptake and adherence are key to its success.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
This paper presents a geometric optimisation of conjugate cooling channels in forced convection with internal heat generation. Two configurations were studied; circular channels and square channels. ...The configurations were optimised in such a way that the peak temperatures were minimised subject to the constraint of fixed total global volume. The fluid was forced through the cooling channels by the pressure difference across the channels. The structure has one degree of freedom as design variable: channel hydraulic diameter and once the optimal channel hydraulic diameter is found, optimal elemental volume and channel-to-channel spacing result. A gradient-based optimisation algorithm is applied in order to search for the best and optimal geometric configurations that improve thermal performance by minimising thermal resistance for a wide range of dimensionless pressure difference. This optimiser adequately handles the numerical objective function obtained from CFD simulations. The results obtained show the behaviour of the applied pressure difference on the optimised geometry. There are unique optimal design variables for a given pressure difference. The numerical results obtained are in agreement with the theoretical formulation using scale analysis and method of intersection of asymptotes.
•Kalman filter and a heuristic model are used to identify false diagnostics.•False interferometry signals can reliably be detected in real-time on AUG.•States of a nonlinear distributed system are ...estimated amid corrupted diagnostics.
Plasma density is one of the key quantities that need to be controlled in real-time as it scales directly with fusion power and, if left uncontrolled, density limits can be reached leading to a disruption. On ASDEX Upgrade (AUG), the real-time measurements are the line-integrated density, measured by the interferometers, and the average density derived from the bremsstrahlung measured by spectroscopy. For control, these measurements are used to reconstruct the radial density profile using an extended Kalman filter (EKF). However, in discharges where ion cyclotron resonance heating (ICRH) is used, the measurements from the interferometers are corrupted and the reconstructed density is false. In this paper, the existing EKF implementation is improved, implemented and experimentally verified on AUG. The new EKF includes a new particle transport model in the prediction model RAPDENS as well as a new representation of ionization and recombination. Furthermore, an algorithm was introduced that is capable of detecting the corrupt diagnostics; this algorithm is based on the rate of change of the innovation residual. The changes to the RAPDENS observer resulted in better density reconstruction in ICRH discharges where corrupt measurement occur. The new version has been implemented on the real-time control system at AUG and functions properly in ICRH discharges.
This paper presents a three-dimensional geometric optimisation of cooling channels in forced convection of a vascularised material with the localised self-cooling property subjected to a heat flux. A ...square configuration was studied with different porosities. Analytical and numerical solutions were provided. The geometrical configuration was optimised in such a way that the peak temperature was minimised at every point in the solid body. The optimisation was subject to the constraint of a fixed global volume of solid material, but the elemental volume was allowed to morph. The solid material was subject to a heat flux on one side and the cooling fluid was forced through the channels from the opposite direction with a specified pressure difference. The structure had three degrees of freedom as design variables: the elemental volume, channel hydraulic diameter and channel-to-channel spacing. A gradient-based optimisation algorithm was used to determine the optimal geometry that gave the lowest thermal resistance. This optimiser adequately handled the numerical objective function obtained from numerical simulations of the fluid flow and heat transfer. The numerical results obtained were in agreement with a theoretical formulation using scale analysis and the method of intersection of asymptotes. The results obtained show that as the pressure difference increases, the minimised thermal resistance decreases. The results also show the behaviour of the applied pressure difference on the optimised geometry. The use of the optimiser made the numerical results to be more robust with respect to the optimum internal configurations of the flow systems and the dimensionless pressure difference.
Context.
The combination of high-contrast imaging with spectroscopy and polarimetry offers a pathway to studying the grain distribution and properties of debris disks in exquisite detail. Here, we ...focus on the case of a gas-rich debris disk around HD 141569A, which features a multiple-ring morphology first identified with SPHERE in the near-infrared.
Aims.
We obtained polarimetric differential imaging with SPHERE in the
H
-band to compare the scattering properties of the innermost ring at 44 au with former observations in total intensity with the same instrument. In polarimetric imaging, we observed that the intensity of the ring peaks in the south-east, mostly in the forward direction, whereas in total intensity imaging, the ring is detected only at the south. This noticeable characteristic suggests a non-uniform dust density in the ring. With these two sets of images, we aim to study the distribution of the dust to solve for the actual dust distribution.
Methods.
We implemented a density function varying azimuthally along the ring and generated synthetic images both in polarimetry and in total intensity, which are then compared to the actual data. The search for the best-fit model was performed both with a grid-based and an MCMC approach. Using the outcome of this modelization, we further measured the polarized scattering phase function for the observed scattering angle between 33° and 147° as well as the spectral reflectance of the southern part of the ring between 0.98 and 2.1 μm. We tentatively derived the grain properties by comparing these quantities with MCFOST models and assuming Mie scattering.
Results.
We find that the dust density peaks in the south-west at an azimuthal angle of 220°~238° with a rather broad width of 61°~127°. The difference in the intensity distributions observed in polarimetry and total intensity is the result of this particular morphology. Although there are still uncertainties that remain in the determination of the anisotropic scattering factor, the implementation of an azimuthal density variation to fit the data proved to be robust. Upon elaborating on the origin of this dust density distribution, we conclude that it could be the result of a massive collision when we account for the effect of the high gas mass that is present in the system on the dynamics of grains. In terms of grain composition, our preliminary interpretation indicates a mixture of porous sub-micron sized astro-silicate and carbonaceous grains.
Conclusions.
The SPHERE observations have allowed, for the first time, for meaningful constraints to be placed on the dust distribution beyond the standard picture of a uniform ring-like debris disk. However, future studies with a multiwavelength approach and additional detailed modeling would be required to better characterize the grain properties in the HD 141569 system.
Corynebacterium pseudotuberculosis, a facultative intracellular bacterial pathogen, is the etiological agent of caseous lymphadenitis (CLA), an infectious disease that affects sheep and goats and it ...is responsible for significant economic losses. The disease is characterized mainly by bacteria-induced caseous necrosis in lymphatic glands. New vaccines are needed for reliable control and management of CLA. Thus, the putative virulence factors SpaC, SodC, NanH, and PknG from C. pseudotuberculosis FRC41 may represent new target proteins for vaccine development and pathogenicity studies.
SpaC, PknG and NanH presented better vaccine potential than SodC after in silico analyses. A total of 136 B and T cell epitopes were predicted from the four putative virulence factors. A cluster analysis was performed to evaluate the redundancy degree among the sequences of the predicted epitopes; 57 clusters were formed, most of them (34) were single clusters. Two clusters from PknG and one from SpaC grouped epitopes for B and T-cell (MHC I and II). These epitopes can thus potentially stimulate a complete immune response (humoral and cellular) against C. pseudotuberculosis. Several other clusters, including two from NanH, grouped B-cell epitopes with either MHC I or II epitopes. The four target proteins were expressed in Escherichia coli. A purification protocol was developed for PknG expression.
In silico analyses show that the putative virulence factors SpaC, PknG and NanH present good potential for CLA vaccine development. Target proteins were successfully expressed in E. coli. A protocol for PknG purification is described.
Objectives
To investigate factors that predict speed of recovery and long‐term CD4 cell count in HIV‐1 seroconverters initiating combination antiretroviral therapy (cART), and to quantify the ...influence of very early treatment initiation. We make use of all pre‐treatment CD4 counts, because analyses using only a single observation at initiation may be subject to biases.
Methods
We used data from the CASCADE (Concerted Action on SeroConversion to AIDS and Death in Europe) multinational cohort collaboration of HIV‐1 seroconverters. We analysed pre‐ and post‐treatment data of patients with seroconversion dates estimated January 2003–March 2014 (n = 7600 for primary analysis) using a statistical model in which the characteristics of recovery in CD4 counts are determined by multiple predictive factors. Secondary analyses were performed incorporating uncertainty in the exact timing of seroconversion to allow more precise estimation of the benefit of very early treatment initiation.
Results
‘True’ CD4 count at cART initiation was the strongest predictor of CD4 count beyond 3 years on cART. Allowing for lack of complete certainty in the date of seroconversion, CD4 recovery was more rapid for patients in whom treatment was initiated within 4 months. For a given CD4 count, higher viral load (VL) at initiation was strongly associated with higher post‐treatment CD4 recovery. For other patient and drug characteristics, associations with recovery were statistically significant but small in magnitude.
Conclusions
CD4 count at cART initiation is the most important factor in predicting post‐treatment recovery, but VL provides substantial additional information. If cART is initiated in the first 4 months following seroconversion, recovery of CD4 counts appears to be more rapid.
Abstract Background The co-morbidity of cystic fibrosis (CF) and celiac disease (CD) has been reported sporadically since the 1960s. To our knowledge, this is the first time a systematic screening is ...performed in a large cohort of CF patients. Methods Transglutaminase-IgA (TGA), endomysium-IgA (EMA) and total IgA in serum were measured in 790 CF patients (48% females, 86% with pancreatic insufficiency). Six patients were diagnosed with CD prior to the study, all receiving a gluten-free diet. Patients with elevated TGA (> 50 Units/mL) and a positive EMA test were offered a gastroscopy obtaining mucosal biopsies from the duodenum. Results Four new cases of CD were diagnosed. Two additional patients had positive serological tests, but normal biopsies. In total, 10 cases of CD (1.2%, 1:83) indicate a prevalence rate about three times higher than the general prevalence of CD in Norway and Sweden. No CD patients were detected in the Danish CF cohort. Patients diagnosed with untreated CD reported symptoms typical of both CF and CD (poor weight gain, loose and/or fatty stools, fatigue, irritability, abdominal pain). They improved after introduction of a gluten-free diet. Conclusions Systematic screening for CD in a Scandinavian cohort of CF patients revealed a higher prevalence of CD than in the general population. Clinical signs of CD are difficult to differentiate from CF with malabsorption, and patients may go undiagnosed for a long time. In a population where CD is common we recommend screening for CD in patients with CF.
This paper presents the development of the three-dimensional flow architecture of conjugate cooling channels in forced convection with internal heat generation within the solid for an array of ...circular cooling channels with different flow orientation. Three flow orientations were studied: array of channels with parallel flow; array of channels in which the flow in every second row is in a counter direction with its neighbours, and flows in all the arrays of channels are in counter flow relative to each other. The geometric configurations were determined in such a way that the peak temperature was minimised subject to the constraint of fixed global volume of solid material. The degrees of freedom of the design were hydraulic diameter and channel to channel spacing. A gradient-based optimisation algorithm was applied to search for the best optimal geometric configurations that improve thermal performance by minimising thermal resistance for a wide range of dimensionless pressure differences. The effect of porosities, applied pressure difference, flow orientation and heat generation rate on the optimal hydraulic diameter and channel to channel spacing is reported. The results show that the effects of dimensionless pressure drop on minimum thermal resistance were consistent with those obtained in the open literature.
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