High energy gamma-rays from the 116Sn + 24Mg reaction at 23A MeV were measured using the MEDEA detector at LNS – INFN Catania. Combining this new data with previous measurements yields a detailed ...view of the quenching of the Giant Dipole Resonance as a function of excitation energy in nuclei of mass A in the range 120÷132. The transition towards the disappearance of the dipole strength, which occurs around 230 MeV excitation energy, appears to be remarkably sharp. Current phenomenological models give qualitative explanations for the quenching but cannot reproduce its detailed features.
Background
It is well established that females and persons of racial and ethnic minorities are frequently underrepresented in clinical trials. These disparities are potentially important aspects of ...evidence-based formulary management and drug utilization review (DUR) processes.
Objective
The purpose of this study was to review the demographic composition of pivotal trials and post-approval study requirements for recent FDA-approved drugs, analyzing the representation of minority groups and its generalizability to the US population or corresponding disease state.
Methods
Drugs approved between July 2019 and June 2020 were identified and demographic data including race, ethnicity, and sex was extracted from their pivotal trials. Demographic data was compared to US demographics and/or the disease state demographics for the respective approved drug.
Results
There were a total of 85 drugs and 142 pivotal trials included in the study. Compared to the estimated US population, the minority groups with a statistically significant underrepresentation across all pivotal trials included Black or African Americans and American Indian or Alaska Natives. The Hispanic/Latinx population had a statistically significant underrepresentation in 55.4% of trials. Females had a statistically significant underrepresentation in 21.2% of trials when compared to the disease state demographics of the respective approved drug.
Conclusion and Relevance
Persons of minorities are underrepresented in the generation of evidence of safety and efficacy for many new drugs. Formulary management and DUR offer an integrated strategic opportunity for the clinical community to formally and carefully consider the data on sex, race, and ethnicity to address disparities in health care.
Letter of intent for KM3NeT 2.0 Adrián-Martínez, S; Aharonian, F; Aiello, S ...
Journal of physics. G, Nuclear and particle physics,
08/2016, Letnik:
43, Številka:
8
Journal Article, Publication
Recenzirano
Odprti dostop
The main objectives of the KM3NeT Collaboration are (i) the discovery and subsequent observation of high-energy neutrino sources in the Universe and (ii) the determination of the mass hierarchy of ...neutrinos. These objectives are strongly motivated by two recent important discoveries, namely: (1) the high-energy astrophysical neutrino signal reported by IceCube and (2) the sizable contribution of electron neutrinos to the third neutrino mass eigenstate as reported by Daya Bay, Reno and others. To meet these objectives, the KM3NeT Collaboration plans to build a new Research Infrastructure consisting of a network of deep-sea neutrino telescopes in the Mediterranean Sea. A phased and distributed implementation is pursued which maximises the access to regional funds, the availability of human resources and the synergistic opportunities for the Earth and sea sciences community. Three suitable deep-sea sites are selected, namely off-shore Toulon (France), Capo Passero (Sicily, Italy) and Pylos (Peloponnese, Greece). The infrastructure will consist of three so-called building blocks. A building block comprises 115 strings, each string comprises 18 optical modules and each optical module comprises 31 photo-multiplier tubes. Each building block thus constitutes a three-dimensional array of photo sensors that can be used to detect the Cherenkov light produced by relativistic particles emerging from neutrino interactions. Two building blocks will be sparsely configured to fully explore the IceCube signal with similar instrumented volume, different methodology, improved resolution and complementary field of view, including the galactic plane. One building block will be densely configured to precisely measure atmospheric neutrino oscillations.
The NEMO project: A status report Taiuti, M.; Aiello, S.; Ameli, F. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
01/2011, Letnik:
626
Journal Article
Recenzirano
The latest results and the activities towards the construction of a km
3 Cherenkov neutrino detector carried out by the NEMO Collaboration are described. Long-term exploration of a 3500
m deep-sea ...site close to the Sicilian coast has shown that it is optimal for the installation of the detector. The NEMO Phase-1 project has validated several technologies proposed for the construction of the km
3 detector on a test site at 2000
m depth. The new infrastructure on the candidate Capo Passero site set up as part of the Phase-2 project will provide the possibility to test detector components at 3500
m depth.
The NEMO Collaboration installed and operated an underwater detector including prototypes of the critical elements of a possible underwater km
3 neutrino telescope: a four-floor tower (called ...Mini-Tower) and a Junction Box. The detector was developed to test some of the main systems of the km
3 detector, including the data transmission, the power distribution, the timing calibration and the acoustic positioning systems as well as to verify the capabilities of a single tridimensional detection structure to reconstruct muon tracks. We present results of the analysis of the data collected with the NEMO Mini-Tower. The position of photomultiplier tubes (PMTs) is determined through the acoustic position system. Signals detected with PMTs are used to reconstruct the tracks of atmospheric muons. The angular distribution of atmospheric muons was measured and results compared to Monte Carlo simulations.
KM3NeT will be a network of deep-sea neutrino telescopes in the Mediterranean Sea. The KM3NeT/ARCA detector, to be installed at the Capo Passero site (Italy), is optimised for the detection of ...high-energy neutrinos of cosmic origin. Thanks to its geographical location on the Northern hemisphere, KM3NeT/ARCA can observe upgoing neutrinos from most of the Galactic Plane, including the Galactic Centre. Given its effective area and excellent pointing resolution, KM3NeT/ARCA will measure or significantly constrain the neutrino flux from potential astrophysical neutrino sources. At the same time, it will test flux predictions based on gamma-ray measurements and the assumption that the gamma-ray flux is of hadronic origin. Assuming this scenario, discovery potentials and sensitivities for a selected list of Galactic sources and to generic point sources with an E−2 spectrum are presented. These spectra are assumed to be time independent. The results indicate that an observation with 3σ significance is possible in about six years of operation for the most intense sources, such as Supernovae Remnants RX J1713.7-3946 and Vela Jr. If no signal will be found during this time, the fraction of the gamma-ray flux coming from hadronic processes can be constrained to be below 50% for these two objects.
A 13-inch Optical Module (OM) containing a large-area (10-inch) photomultiplier was designed as part of Phase-2 of the NEMO project. An intense R&D activity on the photomultipliers, the voltage ...supply boards, the optical coupling as well as the study of the influences of the Earth's magnetic field has driven the choice of each single component of the OM. Following a well-established production procedure, 32 OMs were assembled and their functionality tested. The design, the testing and the production phases are thoroughly described in this paper.
ANTARES: The first undersea neutrino telescope Ageron, M.; Anghinolfi, M.; Ardid, M. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
11/2011, Letnik:
656, Številka:
1
Journal Article
Recenzirano
Odprti dostop
The ANTARES Neutrino Telescope was completed in May 2008 and is the first operational Neutrino Telescope in the Mediterranean Sea. The main purpose of the detector is to perform neutrino astronomy ...and the apparatus also offers facilities for marine and Earth sciences. This paper describes the design, the construction and the installation of the telescope in the deep sea, offshore from Toulon in France. An illustration of the detector performance is given.
The next generation of water Cherenkov neutrino telescopes in the Mediterranean Sea are under construction offshore France (KM3NeT/ORCA) and Sicily (KM3NeT/ARCA). The KM3NeT/ORCA detector features an ...energy detection threshold which allows to collect atmospheric neutrinos to study flavour oscillation. This paper reports the KM3NeT/ORCA sensitivity to this phenomenon. The event reconstruction, selection and classification are described. The sensitivity to determine the neutrino mass ordering was evaluated and found to be 4.4
σ
if the true ordering is normal and 2.3
σ
if inverted, after 3 years of data taking. The precision to measure
Δ
m
32
2
and
θ
23
were also estimated and found to be
85
.
10
-
6
eV
2
and
(
-
3.1
+
1.9
)
∘
for normal neutrino mass ordering and,
75
.
10
-
6
eV
2
and
(
-
7.0
+
2.0
)
∘
for inverted ordering. Finally, a unitarity test of the leptonic mixing matrix by measuring the rate of tau neutrinos is described. Three years of data taking were found to be sufficient to exclude
event rate variations larger than 20% at
3
σ
level.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
In March 2013, the NEMO Phase 2 tower has been successfully installed in the Capo Passero site, at a depth of 3500 m and 80 km off from the southern coast of Sicily. The unfurled tower is 450 m high; ...it is composed of 8 mechanical floors, for a total amount of 32 PMTs and various instruments for environmental measurements. The tower positioning is achieved by an acoustic system. The tower is continuously acquiring and transmitting all the measured signals to shore. Data reduction is completely performed in the Portopalo shore station by a dedicated computing facility connected to the persistent storage system at LNS, in Catania. Results from the last 9 months of acquisition will be presented. In particular, the analyzed optical rates, showing stable and low baseline values, are compatible with the contribution mainly of super(40)K light emission, with a small percentage of light bursts due to bioluminescence. These features reveal the optimal nature of the Capo Passero abyssal site to host a km super(3) -sized Neutrino Telescope.
PDF
