ABSTRACT
We investigate the evolution of the gas mass fraction for galaxies in the COSMOS field using submillimetre emission from dust at 850 μm. We use stacking methodologies on the 850 μm S2COSMOS ...map to derive the gas mass fraction of galaxies out to high redshifts, 0 ≤ z ≤ 5, for galaxies with stellar masses of $10^{9.5} \lt M_* (\rm M_{\odot }) \lt 10^{11.75}$. In comparison to previous literature studies we extend to higher redshifts, include more normal star-forming galaxies (on the main sequence), and also investigate the evolution of the gas mass fraction split by star-forming and passive galaxy populations. We find our stacking results broadly agree with scaling relations in the literature. We find tentative evidence for a peak in the gas mass fraction of galaxies at around z ∼ 2.5–3, just before the peak of the star formation history of the Universe. We find that passive galaxies are particularly devoid of gas, compared to the star-forming population. We find that even at high redshifts, high stellar mass galaxies still contain significant amounts of gas.
We describe and model the evolution of a recent landslide, tsunami, outburst flood, and sediment plume in the southern Coast Mountains, British Columbia, Canada. On November 28, 2020, about 18 ...million m3 of rock descended 1,000 m from a steep valley wall and traveled across the toe of a glacier before entering a 0.6 km2 glacier lake and producing >100‐m high run‐up. Water overtopped the lake outlet and scoured a 10‐km long channel before depositing debris on a 2‐km2 fan below the lake outlet. Floodwater, organic debris, and fine sediment entered a fjord where it produced a 60+km long sediment plume and altered turbidity, water temperature, and water chemistry for weeks. The outburst flood destroyed forest and salmon spawning habitat. Physically based models of the landslide, tsunami, and flood provide real‐time simulations of the event and can improve understanding of similar hazard cascades and the risk they pose.
Plain Language Summary
Glacier retreat exposes unstable slopes that can suddenly fail. We describe and model one such event with far‐reaching consequences. The landslide mass (50 million tonnes, equivalent to the combined mass of all Canadian automobiles) entered and suddenly drained a 0.6‐km2 alpine lake in the southern Coast Mountains of British Columbia. Displaced water destroyed salmon‐spawning habitat over a distance of 8.5 km and created a plume of sediment and organic matter more than 60 km from the head of the fjord into which the floodwaters discharged. Physically based models are able to simulate the hazard cascade, and such models could be used to improve hazard and risk assessments of these events under future climate change.
Key Points
Rapid glacier retreat created conditions that allowed a geohazard cascade to occur in a steep mountain valley
We describe and model a recent landslide, tsunami, and outburst flood that typifies a deglacial geohazard cascade
Future work should predict new glacial lakes and use physically based models to simulate the slope, tsunami, and outburst flood hazards
Abstract
We present a catalog (status 2022 July 1) of triple and higher-order systems identified containing exoplanets based on data from the literature, including various analyses. We explore ...statistical properties of the systems with a focus on both the stars and the planets. So far, about 30 triple systems and one to three quadruple systems, including (mildly) controversial cases, have been found. The total number of planets is close to 40. All planet-hosting triple-star systems are highly hierarchic, consisting of a quasi-binary complemented by a distant stellar component, which is in orbit about the common center of mass. Furthermore, the quadruple systems are in fact pairs of close binaries (“double–doubles”), with one binary harboring a planet. For the different types of star–planet systems, we introduce a template for the classifications of planetary orbital configurations in correspondence to the hierarchy of the system and the planetary host. The data show that almost all stars are main-sequence stars, as expected. However, the stellar primaries tend to be more massive (i.e., corresponding to spectral types A, F, and G) than expected from single-star statistics, a finding also valid for stellar secondaries but less pronounced. Tertiary stellar components are almost exclusively low-mass stars of spectral type M. Almost all planets have been discovered based on either the Radial Velocity method or the Transit method. Both gas giants (the dominant type) and terrestrial planets (including super-Earths) have been identified. We anticipate the expansion of this database in the light of future planetary search missions.
Abstract We use the Very Energetic Radiation Imaging telescope Array System (VERITAS) imaging air Cherenkov telescope array to obtain the first measured angular diameter of β UMa at visual ...wavelengths using stellar intensity interferometry (SII) and independently constrain the limb-darkened angular diameter. The age of the Ursa Major moving group has been assessed from the ages of its members, including nuclear member Merak ( β UMa), an A1-type subgiant, by comparing effective temperature and luminosity constraints to model stellar evolution tracks. Previous interferometric limb-darkened angular-diameter measurements of β UMa in the near-infrared (Center for High Angular Resolution Astronomy (CHARA) Array, 1.149 ± 0.014 mas) and mid-infrared (Keck Nuller, 1.08 ± 0.07 mas), together with the measured parallax and bolometric flux, have constrained the effective temperature. This paper presents current VERITAS-SII observation and analysis procedures to derive squared visibilities from correlation functions. We fit the resulting squared visibilities to find a limb-darkened angular diameter of 1.07 ± 0.04 (stat) ± 0.05 (sys) mas, using synthetic visibilities from a stellar atmosphere model that provides a good match to the spectrum of β UMa in the optical wave band. The VERITAS-SII limb-darkened angular diameter yields an effective temperature of 9700 ± 200 ± 200 K, consistent with ultraviolet spectrophotometry, and an age of 390 ± 29 ± 32 Myr, using MESA Isochrones and Stellar Tracks. This age is consistent with 408 ± 6 Myr from the CHARA Array angular diameter.
We examined stressors that have led to profound ecological changes in the Lake Ontario ecosystem and its fish community since 1970. The most notable changes have been reductions in phosphorus ...loading, invasion by Dreissena spp., fisheries management through stocking of exotic salmonids and control of sea lamprey (Petromyzon marinus), and fish harvest by anglers and double-crested cormorants (Phalacrocorax auritus). The response to these stressors has led to (i) declines in both algal photosynthesis and epilimnetic zooplankton production, (ii) decreases in alewife (Alosa pseudoharengus) abundance, (iii) declines in native Diporeia and lake whitefish (Coregonus clupeaformis), (iv) behavioral shifts in alewife spatial distribution benefitting native lake trout (Salvelinus namaycush), threespine stickleback (Gasterosteus aculeatus), and emerald shiner (Notropis atherinoides) populations, (v) dramatic increases in water clarity, (vi) predation impacts by cormorants on select fish species, and (vii) lake trout recruitment bottlenecks associated with alewife-induced thiamine deficiency. We expect stressor responses associated with anthropogenic forces like exotic species invasions and global climate warming to continue to impact the Lake Ontario ecosystem in the future and recommend continuous long-term ecological studies to enhance scientific understanding and management of this important resource.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The cavities beneath Antarctic ice shelves are among the least studied regions of the World Ocean, yet they are sites of globally important water mass transformations. Here we report results from a ...mission beneath Fimbul Ice Shelf of an autonomous underwater vehicle. The data reveal a spatially complex oceanographic environment, an ice base with widely varying roughness, and a cavity periodically exposed to water with a temperature significantly above the surface freezing point. The results of this, the briefest of glimpses of conditions in this extraordinary environment, are already reforming our view of the topographic and oceanographic conditions beneath ice shelves, holding out great promises for future missions from similar platforms.
Craniosynostosis, the premature ossification of cranial sutures, is a developmental disorder of the skull vault, occurring in approximately 1 in 2250 births. The causes are heterogeneous, with a ...monogenic basis identified in ~25% of patients. Using whole-genome sequencing, we identified a novel, de novo variant in BCL11B, c.7C>A, encoding an R3S substitution (p.R3S), in a male patient with coronal suture synostosis. BCL11B is a transcription factor that interacts directly with the nucleosome remodelling and deacetylation complex (NuRD) and polycomb-related complex 2 (PRC2) through the invariant proteins RBBP4 and RBBP7. The p.R3S substitution occurs within a conserved amino-terminal motif (RRKQxxP) of BCL11B and reduces interaction with both transcriptional complexes. Equilibrium binding studies and molecular dynamics simulations show that the p.R3S substitution disrupts ionic coordination between BCL11B and the RBBP4-MTA1 complex, a subassembly of the NuRD complex, and increases the conformational flexibility of Arg-4, Lys-5 and Gln-6 of BCL11B. These alterations collectively reduce the affinity of BCL11B p.R3S for the RBBP4-MTA1 complex by nearly an order of magnitude. We generated a mouse model of the BCL11B p.R3S substitution using a CRISPR-Cas9-based approach, and we report herein that these mice exhibit craniosynostosis of the coronal suture, as well as other cranial sutures. This finding provides strong evidence that the BCL11B p.R3S substitution is causally associated with craniosynostosis and confirms an important role for BCL11B in the maintenance of cranial suture patency.
Cystic Fibrosis (CF) is caused most often by removal of amino acid 508 (Phe508del, deltaF508) within CFTR, yet dozens of additional CFTR variants are known to give rise to CF and many variants in the ...genome are known to contribute to CF pathology. To address CFTR coding variants, we developed a sequence-to-structure-to-dynamic matrix for all amino acids of CFTR using 233 vertebrate species, CFTR structure within a lipid membrane, and 20 ns of molecular dynamic simulation to assess known variants from the CFTR1, CFTR2, ClinVar, TOPmed, gnomAD, and COSMIC databases. Surprisingly, we identify 18 variants of uncertain significance within CFTR from diverse populations that are heritable and a likely cause of CF that have been understudied due to nonexistence in Caucasian populations. In addition, 15 sites within the genome are known to modulate CF pathology, where we have identified one genome region (chr11:34754985-34836401) that contributes to CF through modulation of expression of a noncoding RNA in epithelial cells. These 15 sites are just the beginning of understanding comodifiers of CF, where utilization of eQTLs suggests many additional genomics of CFTR expressing cells that can be influenced by genomic background of CFTR variants. This work highlights that many additional insights of CF genetics are needed, particularly as pharmaceutical interventions increase in the coming years.
The orphan nuclear constitutive androstane receptor (CAR) is proposed to play a central role in the response to xenochemical stress. Identification of CAR target genes in humans has been limited by ...the lack of a selective CAR agonist. We report the identification of 6-(4-chlorophenyl)imidazo2,1-b1,3thiazole-5-carbaldehydeO-(3,4-dichlorobenzyl)oxime (CITCO) as a novel human CAR agonist with the following characteristics: (a) potent activity in an in vitro fluorescence-based CAR activation assay; (b) selectivity for CAR over other nuclear receptors, including the xenobiotic pregnane X receptor (PXR); (c) the ability to induce human CAR nuclear translocation; and (d) the ability to induce the prototypical CAR target gene CYP2B6 in primary human hepatocytes. Using primary cultures of human hepatocytes, the effects of CITCO on gene expression were compared with those of the PXR ligand rifampicin. The relative expression of a number of genes encoding proteins involved in various aspects of steroid and xenobiotic metabolism was analyzed. Notably, CAR and PXR activators differentially regulated the expression of several genes, demonstrating that these two nuclear receptors subserve overlapping but distinct biological functions in human hepatocytes.
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