•Support was found for the knowledge-is-power position relating to food label use.•Most studies focused on nutrition labels, few included claims and ingredient lists.•Nutrition knowledge supported ...food label use across a range of knowledge measures.•More research with representative samples and wider age ranges is needed.
Nutrition information on food labels is an important source of nutrition information but is typically underutilized by consumers. This review examined whether consumer nutrition knowledge is important for communication of nutrition information through labels on packaged foods. A cognitive processing model posits that consumers with prior knowledge are more likely to use label information effectively, that is, focus on salient information, understand information, and make healthful decisions based on this information. Consistent with this model, the review found that nutrition knowledge provides support for food label use. However, nutrition knowledge measures varied widely in terms of the dimensions they included and the extensiveness of the assessment. Relatively few studies investigated knowledge effects on the use of ingredient lists and claims, compared to nutrition facts labels. We also found an overreliance on convenience samples relying on younger adults, limiting our understanding of how knowledge supports food label use in later life. Future research should 1) investigate which dimensions, or forms, of nutrition knowledge are most critical to food label use and dietary decision making and 2) determine whether increases in nutrition knowledge can promote great use of nutrition information on food labels.
Research suggests that transgender people face high levels of discrimination in society, which may contribute to their disproportionate risk for poor health. However, little is known about whether ...gender nonconformity, as a visible marker of one's stigmatized status as a transgender individual, heightens trans people's experiences with discrimination and, in turn, their health. Using data from the largest survey of transgender adults in the United States, the National Transgender Discrimination Survey (N = 4,115), we examine the associations among gender nonconformity, transphobic discrimination, and health-harming behaviors (i.e., attempted suicide, drug I alcohol abuse, and smoking). The results suggest that gender nonconforming trans people face more discrimination and, in turn, are more likely to engage in health-harming behaviors than trans people who are gender conforming. Our findings highlight the important role of gender nonconformity in the social experiences and well-being of transgender people.
Background Food insecurity, limited access to adequate food, in adulthood is associated with poor health outcomes that suggest a pattern of accelerated aging. However, little is known about factors ...that impact food insecurity in midlife which in turn could help to identify potential pathways of accelerated aging. Methods Low-income adults (n = 17,866; 2014 National Health Interview Survey), ages 18 to 84, completed a 10-item food security module and answered questions regarding health challenges (chronic conditions and functional limitations) and financial worry. We used multinomial logistic regression for complex samples to assess the association of health challenges and financial worry with food insecurity status and determine whether these associations differed by age group, while adjusting for poverty, sex, race/ethnicity, education, family structure, social security, and food assistance. Results Food insecurity rates were highest in late- (37.5%) and early- (36.0%) midlife, relative to younger (33.7%) and older (20.2%) age groups and, furthermore, age moderated the relationship between food insecurity and both risk factors (interaction p-values < .05, for both). The effects of poor health were stronger in midlife relative to younger and older ages. Unlike younger and older adults, however, adults in midlife showed high levels of food insecurity regardless of financial worry. Conclusions Findings suggest that food insecurity in midlife may be more severe than previously thought. Greater efforts are needed to identify those at greatest risk and intervene early to slow premature aging.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Chronic illnesses are significant to individuals and costly to society. When systematically implemented, the well-established and tested Chronic Care Model (CCM) is shown to improve health outcomes ...for people with chronic conditions. Since the development of the original CCM, tremendous information management, communication, and technology advancements have been established. An opportunity exists to improve the time-honored CCM with clinically efficacious eHealth tools.
The first goal of this paper was to review research on eHealth tools that support self-management of chronic disease using the CCM. The second goal was to present a revised model, the eHealth Enhanced Chronic Care Model (eCCM), to show how eHealth tools can be used to increase efficiency of how patients manage their own chronic illnesses.
Using Theory Derivation processes, we identified a "parent theory", the Chronic Care Model, and conducted a thorough review of the literature using CINAHL, Medline, OVID, EMBASE PsychINFO, Science Direct, as well as government reports, industry reports, legislation using search terms "CCM or Chronic Care Model" AND "eHealth" or the specific identified components of eHealth. Additionally, "Chronic Illness Self-management support" AND "Technology" AND several identified eHealth tools were also used as search terms. We then used a review of the literature and specific components of the CCM to create the eCCM.
We identified 260 papers at the intersection of technology, chronic disease self-management support, the CCM, and eHealth and organized a high-quality subset (n=95) using the components of CCM, self-management support, delivery system design, clinical decision support, and clinical information systems. In general, results showed that eHealth tools make important contributions to chronic care and the CCM but that the model requires modification in several key areas. Specifically, (1) eHealth education is critical for self-care, (2) eHealth support needs to be placed within the context of community and enhanced with the benefits of the eCommunity or virtual communities, and (3) a complete feedback loop is needed to assure productive technology-based interactions between the patient and provider.
The revised model, eCCM, offers insight into the role of eHealth tools in self-management support for people with chronic conditions. Additional research and testing of the eCCM are the logical next steps.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Attitudes toward gay rights have liberalized over the past few decades, but scholars know less about the extent to which individuals in the United States exhibit subtle forms of prejudice toward ...lesbians and gays. To help address this issue, we offer a conceptualization of formal rights and informal privileges. Using original data from a nationally representative survey experiment, we examine whether people distinguish between formal rights (e.g., partnership benefits) and informal privileges (e.g., public displays of affection) in their attitudes toward same-sex couples. Results show that heterosexuals are as willing to extend formal rights to same-sex couples as they are to unmarried heterosexual couples. However, they are less willing to grant informal privileges. Lesbians and gays are more willing to extend formal rights to same-sex couples, but they too are sometimes more supportive of informal privileges for heterosexual couples. We also find that heterosexuals' attitudes toward marriage more closely align with their attitudes toward informal privileges than formal rights, whereas lesbians and gays view marriage similarly to both formal rights and informal privileges. Our findings highlight the need to examine multiple dimensions of sexual prejudice to help understand how informal types of prejudice persist as minority groups receive formal rights.
Understanding the effect of wildfire smoke exposure on human health represents a unique interdisciplinary challenge to the scientific community. Population health studies indicate that wildfire smoke ...is a risk to human health and increases the healthcare burden of smoke-impacted areas. However, wildfire smoke composition is complex and dynamic, making characterization and modeling difficult. Furthermore, current efforts to study the effect of wildfire smoke are limited by availability of air quality measures and inconsistent air quality reporting among researchers. To help address these issues, we conducted a substantive review of wildfire smoke effects on population health, wildfire smoke exposure in occupational health, and experimental wood smoke exposure. Our goal was to evaluate the current literature on wildfire smoke and highlight important gaps in research. In particular we emphasize long-term health effects of wildfire smoke, recovery following wildfire smoke exposure, and health consequences of exposure in children.
Conventional accounts of the U.S. constitution laud its checks and balances for diffusing power across many venues, limiting the potential for government oppression, and protecting political ...minorities. I refer to this as constitutional folk wisdom and contrast it with an American political economy approach of veto exceptionalism to better understand how the U.S. constitution shapes, and is shaped, by power relations. This analysis illustrates the volume and scope of veto exceptionalism and its implication for democratic participation and accountability, contrasts it with the virtues championed by the folk wisdom, and suggests how veto exceptionalism can help explain political outcomes and processes in American politics. I argue that the folk wisdom is not only inaccurate as a description of how power functions in the American “checks and balances” system; it is cultivated and utilized most frequently by powerful economic and racial actors that benefit from the anti-democratic and elitist features of the U.S. constitutional system.
SLFN11 sensitizes cancer cells to a broad range of DNA-targeted therapies. Here we show that, in response to replication stress induced by camptothecin, SLFN11 tightly binds chromatin at stressed ...replication foci via RPA1 together with the replication helicase subunit MCM3. Unlike ATR, SLFN11 neither interferes with the loading of CDC45 and PCNA nor inhibits the initiation of DNA replication but selectively blocks fork progression while inducing chromatin opening across replication initiation sites. The ATPase domain of SLFN11 is required for chromatin opening, replication block, and cell death but not for the tight binding of SLFN11 to chromatin. Replication stress by the CHK1 inhibitor Prexasertib also recruits SLFN11 to nascent replicating DNA together with CDC45 and PCNA. We conclude that SLFN11 is recruited to stressed replication forks carrying extended RPA filaments where it blocks replication by changing chromatin structure across replication sites.
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•SLFN11 binds replication forks in response to replication stress•SLFN11 blocks replication regardless of ATR-CHK1 activity•SLFN11 opens chromatin in the near vicinity of replication initiation sites•By killing cells with defective replication, SLFN11 arises a guardian of the genome
SLFN11 is a dominant determinant of sensitivity to DNA-targeted therapies. Murai et al. show that SLFN11 is recruited to stressed replication forks, opens chromatin, and blocks replication when replication is perturbed by DNA damage or improperly activated by cell cycle checkpoint inhibition. SLFN11 emerges as a unique S-phase regulator.
Protein misfolding and aggregation are the hallmark of a number of diseases including Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and the prion ...diseases. In all cases, a naturally-occurring protein misfolds and forms aggregates that are thought to disrupt cell function through a wide range of mechanisms that are yet to be fully unraveled. Fourier transform infrared (FTIR) spectroscopy is a technique that is sensitive to the secondary structure of proteins and has been widely used to investigate the process of misfolding and aggregate formation. This review focuses on how FTIR spectroscopy and spectroscopic microscopy are being used to evaluate the structural changes in disease-related proteins both in vitro and directly within cells and tissues. Finally, ongoing technological advances will be presented that are enabling time-resolved FTIR imaging of protein aggregation directly within living cells, which can provide insight into the structural intermediates, time scale, and mechanisms of cell toxicity associated with aggregate formation. This article is part of a Special Issue entitled: FTIR in membrane proteins and peptide studies.
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► We review FTIR spectroscopy for evaluating the secondary structure of proteins. ► We describe its use for investigating protein misfolding and aggregation in vitro. ► New technology has enabled determination of aggregate structure in cells and tissue. ► Time-lapsed FTIR imaging of protein aggregation within living cells is demonstrated. ► Results can reveal the structural intermediates and mechanisms of cell toxicity.
Abstract
Background and Objectives
Scholars argue that volunteering enhances social, physical, and cognitive activities that are increasingly valued as people age, which in turn improves older ...adults’ well-being via a host of psychosocial and neurobiological mechanisms. This study explicitly tested older adults’ self-perceptions of aging as a mechanism underlying the mental health benefits of volunteering.
Research Design and Methods
Using 2-wave data from the Health and Retirement Study (2008/2010 for Wave 1 and 2012/2014 for Wave 2), we analyzed reports from a pooled sample of older adults aged 65 or older (N = 9,017). Participants reported on demographic characteristics, volunteer work (did not volunteer, 1–99 h/year, 100+ h/year), self-perceptions of aging, and depressive symptoms. We estimated an autoregressive cross-lagged panel model.
Results
Volunteering for 100 h or more per year was associated with older adults’ more positive and less negative self-perceptions of aging in the subsequent wave (i.e., 4 years later), which in turn predicted fewer depressive symptoms.
Discussion and Implications
This study suggests the promising role of volunteering in shaping older adults’ self-perceptions of aging on a sustained basis and refines our understanding of the benefits volunteering brings. Findings shed light on future interventions aimed at improving older adults’ adjustment to age-related changes and lessening ageism in society.
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