Gut microbiota of patients with Parkinson’s disease and healthy volunteers was analyzed by the method of high throughput 16S rRNA sequencing of bacterial genomes. In patients with Parkinson’s ...diseases, changes in the content of 9 genera and 15 species of microorganisms were revealed: reduced content of
Dorea
,
Bacteroides
,
Prevotella
,
Faecalibacterium
,
Bacteroides massiliensis
,
Stoquefichus massiliensis
,
Bacteroides coprocola
,
Blautia glucerasea
,
Dorea longicatena
,
Bacteroides dorei
,
Bacteroides plebeus
,
Prevotella copri
,
Coprococcus eutactus
, and
Ruminococcus callidus
, and increased content of
Christensenella
,
Catabacter
,
Lactobacillus
,
Oscillospira
,
Bifidobacterium
,
Christensenella minuta
,
Catabacter hongkongensis
,
Lactobacillus mucosae
,
Ruminococcus bromii
, and
Papillibacter cinnamivorans
. This microbiological pattern of gut microflora can trigger local inflammation followed by aggregation of α-synuclein and generation of Lewy bodies.
Energetic cosmic rays are the main source of ionization of the low-middle atmosphere, leading to associated changes in atmospheric properties. Via the hypothetical influence of ionization on aerosol ...growth and facilitated formation of clouds, this may be an important indirect link relating solar variability to climate. This effect is highly debated, however, since the proposed theoretical mechanisms still remain illusive and qualitative, and observational evidence is inconclusive and controversial. Therefore, important questions regarding the existence and magnitude of the effect, and particularly the fraction of aerosol particles that can form and grow, are still open. Here we present empirical evidence of the possible effect caused by cosmic rays upon polar stratospheric aerosols, based on a case study of an extreme solar energetic particle (SEP) event of 20 January 2005. Using aerosol data obtained over polar regions from different satellites with optical instruments that were operating during January 2005, such as the Stratospheric Aerosol and Gas Experiment III (SAGE III), and Optical Spectrograph and Infrared Imaging System (OSIRIS), we found a significant simultaneous change in aerosol properties in both the Southern and Northern Polar regions in temporal association with the SEP event. We speculate that ionization of the atmosphere, which was abnormally high in the lower stratosphere during the extreme SEP event, might have led to formation of new particles and/or growth of preexisting ultrafine particles in the polar stratospheric region. However, a detailed interpretation of the effect is left for subsequent studies. This is the first time high vertical resolution measurements have been used to discuss possible production of stratospheric aerosols under the influence of cosmic ray induced ionization. The observed effect is marginally detectable for the analyzed severe SEP event and can be undetectable for the majority of weak-moderate events. The present interpretation serves as a conservative upper limit of solar energetic particle effect upon polar stratospheric aerosols.
We retrieve ionization rates in the atmosphere caused by energetic electron precipitation from balloon observations in the polar atmosphere and compare them against ionization rates recommended for ...the Phase 6 of the Coupled Model Intercomparison Project. In our retrieval procedure, we consider the precipitating electrons with energies from about tens of keV to 5 MeV. Our simulations with 1‐D radiative‐convective model with interactive neutral and ion chemistry show that the difference of the Phase 6 of the Coupled Model Intercomparison Project and balloon‐based ionization rate can lead to underestimation of the NOx enhancement by more than 100% and ozone loss up to 25% in the mesosphere. The atmospheric response is different below 50 km due to considering highly energetic electrons, but it is not important because the absolute values of atmospheric impact is tiny. Ionization rates obtained from the balloon observations reveal a high variability.
Plain Language Summary
The main idea of our manuscript is to demonstrate that the atmospheric ionization rates (IR) can be successfully retrieved from the long‐term balloon observations of the energetic electron precipitation (EEP) events and used to evaluate the uncertainties of the other IR data sets, for example, IR recommended for the Phase 6 of the Coupled Model Intercomparison Project (CMIP6). IR obtained from the balloon observations reveal a high variability. This means that the time resolution used in CMIP6 probably is not enough to consider high frequency variability of the precipitating electron fluxes. Using 1‐D radiative‐convective model with neutral and ion chemistry, we compared the atmospheric response to the one particular EEP observed by balloons and presented in CMIP6 data. We show that the difference of the CMIP6 and balloon‐based IRs can lead to underestimation of the NOx enhancement by more than 100% and ozone loss by up to 25% in the mesosphere. Our results are new and needed for the understanding of the potential uncertainties in CMIP6 EEP forcing. Our paper will give inspiration for the continuation of the balloon measurements of EEP‐related processes using improved instruments.
Key Points
Ionization rates (IR) from energetic electron precipitation (EEP) are calculated using balloon observations and compared to the CMIP6 data set
The difference in the atmospheric response calculated with these two data sets can exceed 100% for NOx and reach 25% for O3
IR obtained from balloon measurements reveal a high temporal variability, which is absent in CMIP6 data
Numerous energetic electron precipitation events were recorded since 1963 in the atmosphere at polar latitudes in the course of regular measurements of charged particle fluxes in the Earth's ...atmosphere being performed by the Lebedev Physical Institute. The experimental data obtained represent the only uniform database in the world on electron precipitation events recorded directly in the atmosphere well below satellite orbits. The precipitating electrons are absorbed in the upper atmosphere. However, they generate X‐rays that can penetrate deep into the atmosphere sometimes down to altitudes of 20–35 km accessible to balloon measurements. These experimental data allow studying energy, temporal and spatial characteristics of electron precipitation events. In particular, based on PLANETOCOSMICS/GEANT4 we developed a method for evaluating the energy spectra of the primary flux of precipitating electrons. This method was used for evaluation of primary spectra of precipitating electrons assuming exponential energy distribution of incident electrons. Now, for the development of the method, we present the possibility of determining the energy spectra of electrons in the power‐law form, using new software RUSCOSMICS code. This new method, based on the GEANT4 software, makes it possible to describe the transport of precipitating electrons in the atmosphere taking into account the evolution of the energy and pitch‐angle distributions of electrons and X‐ray photons.
Key Points
We developed a new method of evaluation of energy spectra of primary flux of precipitating electrons
Knowledge of the spectrum is important for understanding the processes of acceleration and loss of electrons in the outer radiation belt
The method describes evolution of the energy and pitch‐angle distributions of electrons and X‐ray photons in the atmosphere
The main ionization source of the middle and low Earth's atmosphere is related to energetic particles coming from outer space. Usually it is ionization from cosmic rays that is always present in the ...atmosphere. But in a case of a very strong solar eruption, some solar energetic particles (SEPs) can reach middle/low atmosphere increasing the ionization rate up to some orders of magnitude at polar latitudes. We continue investigating such a special class of solar events and their possible applications for natural variations of the aerosol content. After the case study of the extreme SEP event of January 2005 and its possible effect upon polar stratospheric aerosols, here we analyze atmospheric applications of the sequence of several events that took place over autumn 1989. Using aerosol data obtained over polar regions from two satellites with space-borne optical instruments SAGE II and SAM II that were operating during September-October 1989, we found that an extreme major SEP event might have led to formation of new particles and/or growth of preexisting ultrafine particles in the polar stratospheric region. However, the effect of the additional ambient air ionization on the aerosol formation is minor, in comparison with temperature effect, and can take place only in the cold polar atmospheric conditions. The extra aerosol mass formed under the temperature effect allows attributing most of the changes to the "ion-aerosol clear sky mechanism".
This letter presents a summary of a phenomenological study of the response of the polar stratosphere to strong solar energetic particle (SEP) events corresponding to ground level enhancements (GLEs) ...of cosmic rays. This work is focused on evaluation of the possible influence of the atmospheric ionization caused by SEPs upon formation of aerosol particles in the stratosphere over polar regions. Following case studies of two major SEP/GLE events, in January 2005 and September 1989, and their possible effects on polar stratospheric aerosols, we present here the results of an analysis of variations of the daily profiles of the stratospheric aerosol parameters (aerosol extinction for different wavelengths, as well as Ångstrom exponent) for both polar hemispheres during SEP/GLE events of July 2000, April 2001 and October 2003, which form already five clear cases corresponding to extreme and strong SEP/GLE events. The obtained results suggest that an enhancement of ionization rate by a factor of about two in the polar region with night/cold/winter conditions can lead to the formation/growing of aerosol particles in the altitude range of 10-25 km. We also present a summary of the investigated effects based on the phenomenological study of the atmospheric application of extreme SEP events.
Understanding of aerosol sources that affect climate is an ongoing problem facing scientists as well as policymakers. The role of aerosols in local climate variability depends on a balance between ...light absorbing and scattering particles as well as on variability of environmental conditions. In this paper we investigate variability of aerosol content (both absorbing and scattering ultraviolet radiation) over continental Portugal in connection with aerosol sources (volcanic eruptions, dust events, wildfires and anthropogenic pollution). The effect of the aerosol on the climate is studied analyzing their contribution to variations of temperature, pressure, sunshine duration and precipitation over Portuguese regions. The present analysis is based on a developed modern multiple regression technique allowing us to build the statistical correlation models to determine both the main local aerosol sources and aerosol's influence on the climate of continental Portugal during 1978-1993. The analysis allows us to conclude that the main sources driving the variations of the aerosol content over studied locations are wildfires, mineral dust intrusions and anthropogenic pollution. The relations between the aerosol content variations and the atmospheric parameters depend on the level of urbanization of the studied region, the type of aerosol and the season. The most significant finding is the decrease of the daily maximum temperature (and diurnal temperature range) related to the decrease of sunshine duration observed during the summer periods of increased content of the absorbing aerosols in the atmosphere.
This paper presents some issues of diagnostics and repair of a technical system, which can be implemented in the course of studying the disciplines of the mathematical cycle. Mathematical models make ...it possible to evaluate reliability issues already at the design stage of a technical system. An algorithm for using Markov processes to study models of a technical system at the stages of diagnostics, line work, maintenance, and troubleshooting is considered.
Industrial shell and tube heat exchangers require often pipes of considerable length. The surface treatment of such tubes to enhance heat transfer parameters of the equipment must be cheap and simple ...in manufacturing. Two kinds of tube surface treatment are compared: sandblasting and machining. The tubes with OD = 10 mm, ID = 6 mm, and 625 mm long were tested within a bundle of horizontal tubes installed in a rectangular evaporator shell. Hot water pumped through bundle tubes used as a heat carrier. Refrigerant R21 at the pressure of
3 bara is used as working liquid. Tests have been performed at
numbers from 500 to 1500. The micro-rough tubes (machined duralumin tube, sandblasted copper tube) provide considerable heat transfer enhancement at transition to bubble boiling. At low heat fluxes (evaporation regime) heat transfer on these tubes are close to plain tubes.
To analyze the frequency of resumption of anticoagulant therapy (ACT) after major and clinically significant bleeding among AF patients who received oral anticoagulants and were observed in the ...Department of clinical problems of atherothrombosis from 1999 to 2019 within the retro-prospective register Regata-2, and to search for clinical factors associated with recurrence of hemorrhagic complications among patients who resumed anticoagulant therapy after a bleeding episode.
In cohort study of patients with high-risk AF with absolute indications for ACT we enrolled 290 AF patients (130 women and 160 men) aged 32 to 85 years (the average age was 65.188.89 years). During the follow-up period, 92 patients developed hemorrhagic complications, and 73 of them resumed ACT. 35 of the 73 patients who resumed ACT developed a relapse of major/clinically significant bleeding.
The frequency of resuming ACT after the first hemorrhagic complication increased over time from 75% in the period from 19992003 to 90% in the period 20152019. We were not able to establish an exact relationship between the presence of concomitant pathology and the decision to resume the ACT after bleeding. The only reliable reason for refusing to resume the ACT was the patients categorical reluctance. Among patients who had recurrent hemorrhagic complications, the total score on the Charleson comorbidity scale was significantly higher (4.232.01vs3.521.43;p=0.0425). Patients with recurrent bleeding were significantly more likely to suffer from CKD with a decrease in GFR less than 60 ml/min/1.73 sq. m, and also had a history of erosive and ulcerative lesions of the gastrointestinal tract. There was also a significant Association of recurrent bleeding with the use of proton pump inhibitors. Subgroups of patients who switched from warfarin to taking direct oral anticoagulants after the first bleeding and subsequent recurrent bleeding did not differ in basic clinical characteristics from patients without bleeding after changing the anticoagulant. According to multiple regression analysis, NSAIDs showed a tendency to develop a relapse of B/C bleeding on the background of direct oral anticoagulants in patients who underwent GO on the background of warfarin therapy (b=0.4524,p=0.0530).
During the 20-year follow-up, the frequency of all major and clinically significant bleeding was 2.6/100 patients-years, the frequency of first bleeding was 5.86/100 patients-years, while the frequency of repeated hemorrhagic complications was 7.06/100 patients-years. Patients with a high thromboembolic risk should receive anticoagulants, provided that the modifiable risk factors for bleeding are carefully corrected.
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