Display omitted
This work reviews fundamentals and the recent state-of-art achievements in the field of plasmonic biosensing based terahertz (THz) spectroscopy. Being nonpoisonous and nondestructive ...to the human tissues, THz signals offer promising, cost-effective, and real-time biodevices for practical pharmacological applications such as enzyme reaction analysis. Rapid developments in the field of THz plasmonics biosensors and immunosensors have brought many methodologies to employ the resonant subwavelength structures operating based on the fundamental physics of multipoles and asymmetric lineshape resonances. In the ongoing hunt for new and advanced THz plasmonic biosensors, the toroidal metasensors have emerged as excellent alternates and are introduced to be a very promising technology for THz immunosensing applications. Here, we provide examples of recently proposed THz plasmonic metasensors for the detection of thin films, chemical and biological substances. This review allows to compare the performance of various biosensing tools based on THz plasmonic approach and to understand the strategic role of toroidal metasensors in highly accurate and sensitive biosensors instrumentation. The possibility of using THz plasmonic biosensors based on toroidal technology in modern medical and clinical practices has been briefly discussed.
Display omitted
In the last 15 years, more than 50,000 papers with zinc oxide (ZnO) in the title are listed within ISI database. The outstanding popularity of ZnO has many reasons; the most important ...one appears to be its multi-functionality, resulting in applications in physics, chemistry, electrical engineering, material science, energy, textile, rubber, additive manufacturing, cosmetics, and pharmaceutical or medicine, as well as the ease to grow all kinds of nano- and microstructures. A key structure is the tetrapod-shaped ZnO (T-ZnO), which we want to focus on in this mini-review to demonstrate the remarkable properties and multifunctionality of ZnO and motivate why even much more research and applications are likely to come in near future. As T-ZnO came into focus again mainly during the last 10 years, the big data problem in T-ZnO is not as severe as in ZnO; nevertheless, a complete overview is impossible. However, this brief T-ZnO overview attempts to cover the scopes toward advanced technologies; nanoelectronics/optoelectronics sensing devices; multifunctional composites/coatings; novel biomedical engineering materials; versatile energy harvesting candidates; and unique structures for applications in chemistry, cosmetics, pharmaceuticals, food, agriculture, engineering technologies, and many others. The 3D nanotechnology is a current mainstream in materials science/nanotechnology research, and T-ZnO contributes to this field by its simple synthesis of porous networks as sacrificial templates for any desired new cellular materials.
The formation of bacterial biofilm is a major challenge in clinical applications. The main aim of this study is to describe the synthesis, characterization and biocidal potential of zinc oxide ...nanoparticles (NPs) against bacterial strain Pseudomonas aeruginosa. These nanoparticles were synthesized via soft chemical solution process in a very short time and their structural properties have been investigated in detail by using X-ray diffraction and transmission electron microscopy measurements. In this work, the potential of synthesized ZnO-NPs (∼ 10-15 nm) has been assessed in-vitro inhibition of bacteria and the formation of their biofilms was observed using the tissue culture plate assays. The crystal violet staining on biofilm formation and its optical density revealed the effect on biofilm inhibition. The NPs at a concentration of 100 µg/mL significantly inhibited the growth of bacteria and biofilm formation. The biofilm inhibition by ZnO-NPs was also confirmed via bio-transmission electron microscopy (Bio-TEM). The Bio-TEM analysis of ZnO-NPs treated bacteria confirmed the deformation and damage of cells. The bacterial growth in presence of NPs concluded the bactericidal ability of NPs in a concentration dependent manner. It has been speculated that the antibacterial activity of NPs as a surface coating material, could be a feasible approach for controlling the pathogens. Additionally, the obtained bacterial solution data is also in agreement with the results from statistical analytical methods.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Existing public health emergencies due to fatal/infectious diseases such as coronavirus disease (COVID-19) and monkeypox have raised the paradigm of 5th generation portable intelligent and ...multifunctional biosensors embedded on a single chip. The state-of-the-art 5th generation biosensors are concerned with integrating advanced functional materials with controllable physicochemical attributes and optimal machine processability. In this direction, 2D metal carbides and nitrides (MXenes), owing to their enhanced effective surface area, tunable physicochemical properties, and rich surface functionalities, have shown promising performances in biosensing flatlands. Moreover, their hybridization with diversified nanomaterials caters to their associated challenges for the commercialization of stability due to restacking and oxidation. MXenes and its hybrid biosensors have demonstrated intelligent and lab-on-chip prospects for determining diverse biomarkers/pathogens related to fatal and infectious diseases. Recently, on-site detection has been clubbed with solution-on-chip MXenes by interfacing biosensors with modern-age technologies, including 5G communication, internet-of-medical-things (IoMT), artificial intelligence (AI), and data clouding to progress toward hospital-on-chip (HOC) modules. This review comprehensively summarizes the state-of-the-art MXene fabrication, advancements in physicochemical properties to architect biosensors, and the progress of MXene-based lab-on-chip biosensors toward HOC solutions. Besides, it discusses sustainable aspects, practical challenges and alternative solutions associated with these modules to develop personalized and remote healthcare solutions for every individual in the world.
Display omitted
Display omitted
•Large scale synthesis of ZnO tetrapods by flame transport synthesis.•Eco-friendly extraction of activated carbon from sugarcane.•ZnO tetrapods-activated carbon based advance ...composite fabrication.•ZnO tetrapods-activated carbon composites as efficient Cr(VI) adsorbents.
Owing to its acute toxicity and mobility, the hexavalent chromium Cr(VI) in water and wastewater is an immense risk to the environment. Herein, ZnO-tetrapods/activated carbon (ZnO-T/AC) nanocomposite was synthesized as an adsorbent for an efficient decontamination of Cr(VI) from an aqueous medium. The tetrapodal ZnO was synthesized by flame transport synthesis (FTS) approach. The utilized activated carbon (AC) was successfully prepared from sugarcane bagasse with sodium hydroxide (NaOH) impregnation, followed by carbonization. Finally the ZnO-T/AC nanocomposite was synthesized by the hydrothermal method. The structural and chemical properties of the obtained nanocomposite (NC) were systematically characterized using X-ray diffraction (XRD) technique, scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR) spectroscopy and Brunauer–Emmett–Teller (BET) analysis. Batch experiments were performed with the AC, ZnO-T and ZnO-T/AC to study their maximum adsorption efficiency for the Cr(VI). The effect of operational parameters such as contact time, pH and adsorbent dosage on the removal of Cr(VI) were also investigated. Different kinetic models were employed to comprehend the adsorption mechanism. The removal efficiency (97%) of Cr(VI) using ZnO-T/AC adsorbent was achieved at pH 2. The synthesized nanocomposite showed significant potential for the decontamination of Cr(VI) and can be further explored at a large scale for the efficient removal of hazardous heavy metal ions from the industrial contaminates.
Cardio-vocal syndrome revisited Shivank; Mishra, Yogendra
Saudi Journal for Health Sciences,
2023, Letnik:
12, Številka:
1
Journal Article
Recenzirano
Odprti dostop
Ortner Syndrome or Cardiovocal Syndrome encompasses any cardiovascular cause causing vocal cord paralysis by compression of the recurrent laryngeal nerve along its pathway. Historically, it was ...described as a case of vocal cord paralysis due to an enlarged left atrium compressing on the left recurrent laryngeal nerve in mitral valve stenosis. We describe a case of 71 years male, who presented with insidious onset hoarseness of voice. Contrast-enhanced computed tomography neck and chest revealed two aneurysms from the arch of aorta compressing on the left recurrent laryngeal nerve. With other causes being ruled out, the diagnosis of Cardiovocal syndrome was retained.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Advanced wound scaffolds that integrate active substances to treat chronic wounds have gained significant recent attention. While wound scaffolds and advanced functionalities have previously been ...incorporated into one medical device, the wirelessly triggered release of active substances has remained the focus of many research endeavors. To combine multiple functions including light‐triggered activation, antiseptic, angiogenic, and moisturizing properties, a 3D printed hydrogel patch encapsulating vascular endothelial growth factor (VEGF) decorated with photoactive and antibacterial tetrapodal zinc oxide (t‐ZnO) microparticles is developed. To achieve the smart release of VEGF, t‐ZnO is modified by chemical treatment and activated through ultraviolet/visible light exposure. This process would also make the surface rough and improve protein adhesion. The elastic modulus and degradation behavior of the composite hydrogels, which must match the wound healing process, are adjusted by changing t‐ZnO concentrations. The t‐ZnO‐laden composite hydrogels can be printed with any desired micropattern to potentially create a modular elution of various growth factors. The VEGF‐decorated t‐ZnO‐laden hydrogel patches show low cytotoxicity and improved angiogenic properties while maintaining antibacterial functions in vitro. In vivo tests show promising results for the printed wound patches, with less immunogenicity and enhanced wound healing.
To treat chronic wounds, a smart wound scaffold based on growth factors decorated tetrapodal zinc oxide (t‑ZnO)‐laden 3D printed hydrogel patches, which possess light‐triggered activation, anti‐bacterial, angiogenic, and tissue regeneration properties is reported. Through in vivo tests, the multi‐functional wound scaffolds show less immunogenicity and enhance wound healing, which make them interesting candidates for future smart wound dressing platforms.
With increasing production and applications of nanostructured zinc oxide, e.g., for biomedical and consumer products, the question of safety is getting more and more important. Different morphologies ...of zinc oxide structures have been synthesized and accordingly investigated. In this study, we have particularly focused on nano-micro ZnO tetrapods (ZnO-T), because their large scale fabrication has been made possible by a newly introduced flame transport synthesis approach which will probably lead to several new applications. Moreover, ZnO-T provide a completely different morphology then classical spherical ZnO nanoparticles. To get a better understanding of parameters that affect the interactions between ZnO-T and mammalian cells, and thus their biocompatibility, we have examined the impact of cell culture conditions as well as of material properties on cytotoxicity. Our results demonstrate that the cell density of fibroblasts in culture along with their age, i.e., the number of preceding cell divisions, strongly affect the cytotoxic potency of ZnO-T. Concerning the material properties, the toxic potency of ZnO-T is found to be significantly lower than that of spherical ZnO nanoparticles. Furthermore, the morphology of the ZnO-T influenced cellular toxicity in contrast to surface charges modified by UV illumination or O2 treatment and to the material age. Finally, we have observed that direct contact between tetrapods and cells increases their toxicity compared to transwell culture models which allow only an indirect effect via released zinc ions. The results reveal several parameters that can be of importance for the assessment of ZnO-T toxicity in cell cultures and for particle development.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The laboratory waste produced in several parts of the world has scaled up the pollution and adverse effect on human health in the present era. The “3 R” (reduce, reuse, and recycle) scheme is adopted ...by many communities for efficiently recovering waste products and utilizing them for the production of energy. In the present work, the laboratory waste is collected and directly utilized for fabricating a laboratory waste-based triboelectric nanogenerator (LW-TENG) operating in vertical contact-separation mode. The substrate, electrode, and triboelectric layer are randomly selected from lab waste. The waste plastic petri dishes were extruded into thin filament wires for 3D printing of the substrate for the LW-TENG. The effective electrical output is generated by LW-TENG having a triboelectric layer plastic-glass delivering voltage of 185 V, current of 1.25μA, and power density of 8.1μW/cm2 across the load resistance of 500 MΩ. The positive and negative triboelectric layers are altered and the electrical output is systematically investigated. Additionally, the LW-TENG device is attached to various locations of the laboratory to demonstrate the energy harvesting from the mechanical motions. It is also utilized for demonstrating real-time applications that could be beneficial as a self-powered human tracking device (HSD) that tracks the location of the human during an emergency and self-powered exercise counter.
Display omitted
•Circular economy-Circumvention of laboratory waste to sustainable energy.•Straightforward and cost-effective 3D printing of plastics into devices.•Recycling of plastic wastes to develop LW-TENG device.•Demonstration of self-powered biomechanical energy harvesting applications.
Display omitted
Phase change materials (PCM) are largely assessed on their ability towards energy storage and their enthalpy efficiency of discharging the stored energy. Nevertheless, their ...applications are limited by the low thermal conductivity behaviour, despite their tunable transition temperature abilities. The present work demonstrates a novel concept to develop and explore PCM composite by embedding two unique zinc oxide tetrapod classes to engineer the heat transfer mechanism for potential utilization in thermal energy storage. Tetrapods embedded phase change material (TPCM) composite displayed up to 94% enhancement in thermal conductivity without compromising melting enthalpy. TPCM composite with high thermal conductivity, high heat capacity, broad photo-absorptivity, improved stability in isothermal conditions, and long thermal cycles offer attractive solutions for effective thermal energy storage, efficient solar energy harnessing, and thermal management. With demonstrated abilities, the developed TPCM composite material could play a significant role in the progress of renewable energy needs in future.
PDF
