Abstract Autism spectrum disorder (ASD) is characterized by social and communication impairments as well as restricted, repetitive behavior patterns. Despite the fact that ASD is reported worldwide, ...very little research exists examining ASD characteristics on a multinational scale. Cross-cultural comparisons are especially important for ASD, since cultural differences may impact the perception of symptoms. Identifying behaviors that are similarly reported as problematic across cultures as well as identifying behaviors in which there is cultural variation could aid in the development and refinement of more universally effective measures. The present study sought to examine similarities and differences in caregiver endorsement of symptom severity through scores on the Baby Infant Screen for Children with aUtIsm Traits (BISCUIT). The BISCUIT was utilized to examine ASD core symptomology in 250 toddlers diagnosed with ASD from Greece, Italy, Japan, Poland, and the United States. Significant differences in overall ASD symptom severity and endorsement were found between multinational groups. Implications of the results are discussed.
Large-scale physics experiments running at high interaction rates place a high demand on the data acquisition system (DAQ) responsible for transporting the data from the detector to the storage. The ...antiProton ANihilation at DArmstadt (PANDA) at the facility for anti-proton and ion research (FAIR) is one such experiment of the future that will not use fixed hardware triggers; instead, the event selection is based on real-time feature extraction, filtering, and high-level correlations. A firmware framework for such real-time data processing has been developed and tested with hardware setup for a PANDA Forward Tracker (FT) prototype. The solution is applicable for other detector subsystems based on the so-called Trigger Readout Board (TRB) data read-out system.
The design of straw tube detector modules developed for the PANDA Forward Tracker is presented. One module consists of 32 straws with 10 mm diameter, arranged in two staggered layers, and has a very ...low material budget of only 8.8ċ10−4X0. The overpressure of the working gas mixture of 1 bar makes the module self-supporting and enables the use of lightweight and compact support frames. Detection planes in the Forward Tracker consist of modules mounted closely, without gaps, next to each other on a support frame. A module can be mounted and dismounted from the frame without the need to remove the neighboring modules, enabling fast repairs. Technical details of the detector design and the assembly procedure of the straw tubes and the straw modules as well as results of performed tests of the modules are given.
The article is dedicated to the psychological aspects of the relationship of the organisms of patients suffering from malignisation, and neoplasms, for further study of the disease during the ...rehabilitation period after standard treatment. If during the treatment of neoplastic disease doctors are encountering with the consequences of illness then the rehabilitation team need to identify the reasons of the disease occurrence. This helps to give the patient rehabilitation in full to improve the life quality and to provide effective socialization. The article analyzes the problems of the psychological characteristics of the origin and course of cancer, psychosomatic theories to explain the origin of the tumor during the illness. Also theories of the models of the patient’s psychological reactions to the presence of the cancer were studied in the article. The rehabilitation period in the cancer patients should include technological methods of psychotherapy.
Summary
Introduction: The HPA‐15 antigen system is characterized by a low antigen expression on platelets. The antibodies against this antigen are implied in fetal/neonatal alloimmune ...thrombocytopenia (F/NAIT), post‐transfusion purpura, and refractoriness to platelet transfusions. Detection of these antibodies appears to be related to the level of HPA‐15 expression on the platelets used in the monoclonal antibody–specific immobilization of platelet antigen (MAIPA) assay.
Methods: We performed genotyping of 300 healthy blood donors for HPA‐15 by TaqMan real‐time PCR technology, and the HPA‐15 antigen expression was investigated in 13 HPA‐15aa and 19 HPA‐15bb individuals. We also investigated the relevance of HPA‐15 antigen expression on donor platelets used in MAIPA for antibody detection in 223 multitransfused hematological patients and 271 women with suspected F/NAIT.
Results: In Polish donors, the HPA‐15a allele frequencies were lower than the HPA‐15b (0.480 vs. 0.515). We identified three HPA‐15 expression groups: high (36.7 ± 8.36 MFI – eight cases), medium (19.5 ± 6.2 MFI – 21 cases), and low (6.5 ± 5.9 MFI – three cases). The HPA‐15 expression was stable over time. The HPA‐15aa and HPA‐15bb platelets with high antigen expression were used for anti‐HPA‐15 antibody detection; anti‐HPA‐15 antibodies were detected in 4/223 (1.8%) patients receiving multiple transfusions but in none of the 271 women with suspected F/NAIT. Further examination of the four sera by MAIPA with various platelets revealed the optical density in the assay to be closely related to the level of HPA‐15 antigen expression.
Conclusion: Anti‐HPA‐15 antibody detection should be based on carefully selected platelets with high HPA‐15 expression level.
Drift chamber with a c-shaped frame Smyrski, J.; Kolf, Ch; Adam, H.-H. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
04/2005, Letnik:
541, Številka:
3
Journal Article
Recenzirano
Odprti dostop
We present the construction of a planar drift chamber with wires stretched between two arms of a c-shaped aluminum frame. The special shape of the frame allows to extend the momentum acceptance of ...the COSY-11 detection system towards lower momenta without suppressing the high-momentum particles. The proposed design allows for construction of tracking detectors covering small angles with respect to the beam, which can be installed and removed without dismounting the beam-pipe. For a three-dimensional track reconstruction a computer code was developed using a simple algorithm of hit pre-selection.
We investigated methylation of DNA repetitive sequences (LINE-1 and BAGE) in peripheral blood leukocytes from first-episode schizophrenia (FES) patients and healthy controls (HCs) with respect to ...childhood adversities.
Patients were divided into two subgroups based on the history of childhood trauma - FES(+) and FES(-) subjects. The majority of HCs had a negative history of childhood trauma - HCs(-) subjects.
FES(+) patients had significantly lower LINE-1 methylation in comparison with FES(-) patients or HC(-) subjects. Emotional abuse and total trauma score predicted lower LINE-1 methylation in FES patients, while general trauma score was associated with lower BAGE methylation in HCs.
Childhood adversities might be associated with global DNA hypomethylation in adult FES patients.
Infection with Helicobacter pylori is the main aetiological factor for erosive gastritis and duodenal or gastric peptic ulcers often complicated with life‐threatening bleeding in patients with ...coagulation disorders. The aim of this prospective study was to evaluate the prevalence of Helicobacter pylori infection in haemophilia patients, and to assess the risk of gastrointestinal bleeding associated with this infection. From 2000 to 2002, 146 patients with haemophilia (129, haemophilia A; 13, haemophilia B), mean age, 39.9 years (±7.3), were investigated for H. pylori infection using IgG and IgA latex serological test. The control group included 100 men with no coagulation disorders, mean age, 40.9 years (±9.2). For 72 (49.3%) patients with haemophilia and 39 controls (39.0%) serological tests were positive indicating the presence of H. pylori infection (P =0.1112). A history of gastrointestinal bleeding was reported in 46 patients (31.5%) with haemophilia and in two control group patients (2.0%) (P < 0.0001). Gastrointestinal bleeding was significantly more frequent in patients with haemophilia infected with H. pylori (33/46; 71.7%) than in patients with no H. pylori infection (13/46; 28.3%; P = 0.0002). In conclusion, the prevalence of H. pylori infection in haemophilic patients in Poland is comparable with that in patients with no coagulation disorders. Helicobacter pylori infection is a risk factor for duodenal and gastric ulcer bleeding in haemophilia patients. In view of the high frequency of upper gastrointestinal bleeding associated with H. pylori infection, we believe that screening and eradication therapy are appropriate in haemophilia patients.
COSY-11, an internal experimental facility for threshold measurements Brauksiepe, S.; Grzonka, D.; Kilian, K. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
07/1996, Letnik:
376, Številka:
3
Journal Article
Recenzirano
The COSY-11 installation is an internal experiment at the cooler synchrotron and storage ring COSY Jülich. It has been designed for full geometrical acceptance close to threshold for meson production ...studies, especially in the 1 GeV/
c
2 mass range. The experimental setup makes use of a regular C-type COSY dipole magnet, following a cluster target, to separate reaction products from the beam and to analyze their momenta, thus allowing the observation of charged reaction products at small angles with beam energies close to threshold. Resonances will be identified by missing mass reconstructions from measured four-momenta of two outgoing protons in the predominantly studied pp → ppX reaction. In addition, charged mesons either produced directly or from decays of
X will be detected. The different components of the experimental facility are presented.
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