The diagnosis of Gaucher's disease is established by demonstration of reduced acid β-glucosidase activity in peripheral blood leukocytes. Genotyping at the glucocerebrosidase gene locus can give ...additional prognostic information and facilitate carrier detection. However, extreme phenotypic diversity precludes reliable prediction of prognosis in individual patients. Histological diagnosis of Gaucher's disease is unnecessary and can be misleading. A range of clinical, radiological and laboratory parameters are useful for staging disease activity which is central to achieving optimal timing to initiate enzyme therapy. Treatment should be individualized to obtain maximum therapeutic response. The recent introduction of chitotriosidase measurements has provided a valuable indicator of total cellular burden of storage cells. Serial measurements of chitotriosidase activity are useful for monitoring disease progression as well as response to therapy. A number of adjuvant therapies are available for use in conjunction with enzyme treatment. Special considerations apply to management of affected children.
Recent evidence suggest that allergen type 2 helper T cells (Th2) play a triggering role in the activation/recruitment of IgE antibody producing B cells, mast cells and eosinophils. Reduced microbial ...exposure in early life is responsible for a shift of Th1/Th2 balance in the immune system towards the pre-allergic Th2 response. The Th1 predominantly produce IFNgamma and delayed type hypersensitivity while Th2 secrete IL-4, IL-5, IL-6, IL-13 and regulate B cell and eosinophil mediated responses. To assess regulatory changes in the immune system, in patients with allergy and asthma, we studied the cytokine profile in serum in comparison with normal healthy controls.
A total of 170 patients with various allergies and asthmatic conditions were studied, for cytokines in the serum by ELISA using kits from Immunotech, and analyzed to identify the triggering factors or main contributors towards allergy and asthma.
Our study showed increase in the levels of IL-4, IL-5 and IL-6 in all groups which were non- significant. But the levels of IL-10, IL-13 and TNF alpha were highly significant. Besides, we found correlation of GM-CSF with IL-10. Significant correlation with different cytokines was observed. Most of these patients showed increase in IgE levels.
This study gives a better understanding of how cytokines are the mediators of balance of Th1 and Th2 immune responses and IgE synthesis is controlled by cytokines. Further studies will eventually lead to improved treatment strategies in the clinical management of IgE mediated allergy.
A Novel Implementation of an Interactive Smart Mirror Desai, Siddharth Anil; Mistry, Piran Delzad; Kahar, Jash Pramod ...
2021 6th International Conference on Communication and Electronics Systems (ICCES),
2021-July-8
Conference Proceeding
Finding new ways and devices to integrate with Home Automation Systems has led to the inception of the Smart Mirror. Every day, new technology has been developed, new robots, new functionalities not ...only meant to circumvent monotonous tasks of daily life, but also to make life more luxurious. An interactive smart mirror allows us to focus more on the important aspects of the day. In this paper, small and larger activities that steal time out of our busy schedules are mentioned. The smart mirror will allow you to essentially tailor your own experience and save your time while getting ready at any time of the day. The goal lies in filtering out the unimportant kinks in life and focusing you on you.
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