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zadetkov: 256
1.
  • PTEN and Other PtdIns(3,4,5... PTEN and Other PtdIns(3,4,5)P3 Lipid Phosphatases in Breast Cancer
    Csolle, Mariah P.; Ooms, Lisa M.; Papa, Antonella ... International journal of molecular sciences, 12/2020, Letnik: 21, Številka: 23
    Journal Article
    Recenzirano
    Odprti dostop

    The phosphoinositide 3-kinase (PI3K)/AKT signalling pathway is hyperactivated in ~70% of breast cancers. Class I PI3K generates PtdIns(3,4,5)P3 at the plasma membrane in response to growth factor ...
Celotno besedilo
Dostopno za: IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK

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2.
  • Autophagic lysosome reforma... Autophagic lysosome reformation in health and disease
    Nanayakkara, Randini; Gurung, Rajendra; Rodgers, Samuel J. ... Autophagy, 05/2023, Letnik: 19, Številka: 5
    Journal Article
    Recenzirano
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    Lysosomes are the primary degradative compartment within cells and there have been significant advances over the past decade toward understanding how lysosome homeostasis is maintained. Lysosome ...
Celotno besedilo
Dostopno za: BFBNIB, GIS, IJS, KISLJ, NUK, PNG, UL, UM, UPUK
3.
  • The Inositol Polyphosphate ... The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis
    Ooms, Lisa M.; Binge, Lauren C.; Davies, Elizabeth M. ... Cancer cell, 08/2015, Letnik: 28, Številka: 2
    Journal Article
    Recenzirano
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    Metastasis is the major cause of breast cancer mortality. Phosphoinositide 3-kinase (PI3K) generated PtdIns(3,4,5)P3 activates AKT, which promotes breast cancer cell proliferation and regulates ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP

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4.
  • INPP5E regulates phosphoino... INPP5E regulates phosphoinositide-dependent cilia transition zone function
    Dyson, Jennifer M; Conduit, Sarah E; Feeney, Sandra J ... The Journal of cell biology, 01/2017, Letnik: 216, Številka: 1
    Journal Article
    Recenzirano
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    Human ciliopathies, including Joubert syndrome (JBTS), arise from cilia dysfunction. The inositol polyphosphate 5-phosphatase INPP5E localizes to cilia and is mutated in JBTS. Murine Inpp5e ablation ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK

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5.
  • The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease
    Ooms, Lisa M; Horan, Kristy A; Rahman, Parvin ... Biochemical journal, 04/2009, Letnik: 419, Številka: 1
    Journal Article
    Recenzirano

    Phosphoinositides are membrane-bound signalling molecules that regulate cell proliferation and survival, cytoskeletal reorganization and vesicular trafficking by recruiting effector proteins to ...
Preverite dostopnost
6.
  • Persistent mTORC1 signaling... Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing
    Carroll, Bernadette; Nelson, Glyn; Rabanal-Ruiz, Yoana ... The Journal of cell biology, 07/2017, Letnik: 216, Številka: 7
    Journal Article
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    Mammalian target of rapamycin complex 1 (mTORC1) and cell senescence are intimately linked to each other and to organismal aging. Inhibition of mTORC1 is the best-known intervention to extend ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK

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7.
  • Intranasal Targeting of Hyp... Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity
    Dodd, Garron T.; Xirouchaki, Chrysovalantou E.; Eramo, Matthew ... Cell reports (Cambridge), 09/2019, Letnik: 28, Številka: 11
    Journal Article
    Recenzirano
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    The importance of hypothalamic leptin and insulin resistance in the development and maintenance of obesity remains unclear. The tyrosine phosphatases protein tyrosine phosphatase 1B (PTP1B) and ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP

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8.
  • Deterministic early endosom... Deterministic early endosomal maturations emerge from a stochastic trigger-and-convert mechanism
    York, Harrison M; Joshi, Kunaal; Wright, Charles S ... Nature communications, 08/2023, Letnik: 14, Številka: 1
    Journal Article
    Recenzirano
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    Endosomal maturation is critical for robust and timely cargo transport to specific cellular compartments. The most prominent model of early endosomal maturation involves a phosphoinositide-driven ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK
9.
  • Phosphoinositide 3-kinase a... Phosphoinositide 3-kinase and INPP4B in human breast cancer
    Bertucci, Micka C.; Mitchell, Christina A. Annals of the New York Academy of Sciences, March 2013, Letnik: 1280, Številka: 1
    Journal Article
    Recenzirano

    The PI3K/Akt signaling pathway is frequently increased in many human cancers, including breast cancer. Recent studies have identified INPP4B, which inhibits PI3K signaling, as an emerging tumor ...
Celotno besedilo
Dostopno za: BFBNIB, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UL, UM, UPUK
10.
  • INPP4B promotes PI3Kα-depen... INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer
    Rodgers, Samuel J.; Ooms, Lisa M.; Oorschot, Viola M. J. ... Nature communications, 05/2021, Letnik: 12, Številka: 1
    Journal Article
    Recenzirano
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    Abstract INPP4B suppresses PI3K/AKT signaling by converting PI(3,4)P 2 to PI(3)P and INPP4B inactivation is common in triple-negative breast cancer. Paradoxically, INPP4B is also a reported oncogene ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK

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zadetkov: 256

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