Summary Amyotrophic lateral sclerosis (known in the UK as motor neuron disease) is a devastating illness with uncertain pathogenesis. In this Seminar, we review its natural history, clinical ...features, diagnostic criteria, variant and mimic syndromes, genetic forms, and epidemiology. Several hypotheses about causes of the disorder are discussed, such as excitotoxicity and oxidant stress, and we review past and present putative disease-modifying treatments. Disease-management strategies, from telling the patient about their illness to end-of-life decisions and palliative care, are presented. We review options for control of the main symptoms of amyotrophic lateral sclerosis—including dysphagia, dysarthria, respiratory distress, pain, and psychological disorders—and care in the terminal phase. The need for good psychosocial and spiritual care of patients and families is emphasised. We conclude with an overview of some current major issues and future prospects, ranging from the search for disease markers to challenging developments such as stem-cell and gene therapy.
The Energetic Particle Detector (EPD) Investigation is one of 5 fields-and-particles investigations on the Magnetospheric Multiscale (MMS) mission. MMS comprises 4 spacecraft flying in close ...formation in highly elliptical, near-Earth-equatorial orbits targeting understanding of the fundamental physics of the important physical process called magnetic reconnection using Earth’s magnetosphere as a plasma laboratory. EPD comprises two sensor types, the Energetic Ion Spectrometer (EIS) with one instrument on each of the 4 spacecraft, and the Fly’s Eye Energetic Particle Spectrometer (FEEPS) with 2 instruments on each of the 4 spacecraft. EIS measures energetic ion energy, angle and elemental compositional distributions from a required low energy limit of 20 keV for protons and 45 keV for oxygen ions, up to >0.5 MeV (with capabilities to measure up to >1 MeV). FEEPS measures instantaneous all sky images of energetic electrons from 25 keV to >0.5 MeV, and also measures total ion energy distributions from 45 keV to >0.5 MeV to be used in conjunction with EIS to measure all sky ion distributions. In this report we describe the EPD investigation and the details of the EIS sensor. Specifically we describe EPD-level science objectives, the science and measurement requirements, and the challenges that the EPD team had in meeting these requirements. Here we also describe the design and operation of the EIS instruments, their calibrated performances, and the EIS in-flight and ground operations. Blake et al. (The Flys Eye Energetic Particle Spectrometer (FEEPS) contribution to the Energetic Particle Detector (EPD) investigation of the Magnetospheric Magnetoscale (MMS) Mission,
this issue
) describe the design and operation of the FEEPS instruments, their calibrated performances, and the FEEPS in-flight and ground operations. The MMS spacecraft will launch in early 2015, and over its 2-year mission will provide comprehensive measurements of magnetic reconnection at Earth’s magnetopause during the 18 months that comprise orbital phase 1, and magnetic reconnection within Earth’s magnetotail during the about 6 months that comprise orbital phase 2.
Abstract On 2022 September 5, Parker Solar Probe (Parker) observed a large solar energetic particle (SEP) event at the unprecedented distance of only 15 R S from the Sun. The observations from the ...Integrated Science Investigation of the Sun (IS⊙IS) obtained over the course of this event are remarkably rich, and an overview is presented here. IS⊙IS is capable of measuring ions from 20 keV to over 100 MeV nuc −1 and electrons from 30 keV to 6 MeV; here, we primarily focus on the proton and helium measurements above 80 keV. Among the surprising results are evidence of inverse velocity dispersion at energies above 1 MeV during the onset of the event, a sharp decrease in the energetic particle intensities at all energies at the interplanetary shock crossing, and repeated short durations of highly anisotropic sunward flow. Many changes in the SEP intensities, anisotropy, and spectral steepness are coincident with solar wind structure boundaries identified using the Parker solar wind magnetic field and plasma data. However, there are significant changes that are not correlated with any clearly visible solar wind variation. The observations presented here serve as an introduction to a complex event with numerous opportunities for future, more in-depth studies.
From 27 to 28 January 2009, the Cassini spacecraft remotely acquired combined observations of Saturn's southern aurorae at radio, ultraviolet, and infrared wavelengths, while monitoring ion ...injections in the middle magnetosphere from energetic neutral atoms. Simultaneous measurements included the sampling of a full planetary rotation, a relevant timescale to investigate auroral emissions driven by processes internal to the magnetosphere. In addition, this interval coincidentally matched a powerful substorm‐like event in the magnetotail, which induced an overall dawnside intensification of the magnetospheric and auroral activity. We comparatively analyze this unique set of measurements to reach a comprehensive view of kronian auroral processes over the investigated timescale. We identify three source regions for the atmospheric aurorae, including a main oval associated with the bulk of Saturn Kilometric Radiation (SKR), together with polar and equatorward emissions. These observations reveal the coexistence of corotational and subcorototational dynamics of emissions associated with the main auroral oval. Precisely, we show that the atmospheric main oval hosts short‐lived subcorotating isolated features together with a bright, longitudinally extended, corotating region locked at the southern SKR phase. We assign the substorm‐like event to a regular, internally driven, nightside ion injection possibly triggered by a plasmoid ejection. We also investigate the total auroral energy budget, from the power input to the atmosphere, characterized by precipitating electrons up to 20 keV, to its dissipation through the various radiating processes. Finally, through simulations, we confirm the search‐light nature of the SKR rotational modulation and we show that SKR arcs relate to isolated auroral spots. We characterize which radio sources are visible from the spacecraft and we estimate the fraction of visible southern power to a few percent. The resulting findings are discussed in the frame of pending questions as the persistence of a corotating field‐aligned current system within a subcorotating magnetospheric cold plasma, the occurrence of plasmoid activity, and the comparison of auroral fluxes radiated at different wavelengths.
Key Points
Auroral source regions
Rotational dynamics
Auroral energy budget
Abstract
We present analyses of 0.05–2 MeV ions from the 2022 February 16 energetic storm particle event observed by Parker Solar Probe's (PSP) IS⊙IS/EPI-Lo instrument at 0.35 au from the Sun. This ...event was characterized by an enhancement in ion fluxes from a quiet background, increasing gradually with time with a nearly flat spectrum, rising sharply near the arrival of the coronal mass ejection (CME)–driven shock, becoming nearly a power-law spectrum, then decaying exponentially afterward, with a rate that was independent of energy. From the observed fluxes, we determine diffusion coefficients, finding that far upstream of the shock the diffusion coefficients are nearly independent of energy, with a value of 10
20
cm
2
s
−1
. Near the shock, the diffusion coefficients are more than 1 order of magnitude smaller and increase nearly linearly with energy. We also determine the source of energetic particles, by comparing ratios of the intensities at the shock to estimates of the quiet-time intensity to predictions from diffusive shock acceleration theory. We conclude that the source of energetic ions is mostly the solar wind for this event. We also present potential interpretations of the near-exponential decay of the intensity behind the shock. One possibility we suggest is that the shock was overexpanding when it crossed PSP and the energetic particle intensity decreased behind the shock to fill the expanding volume. Overexpanding CMEs could well be more common closer to the Sun, and this is an example of such a case.
Juno obtained unique low‐altitude space environment measurements over Jupiter's poles on 27 August 2016. Here Jupiter Energetic‐particle Detector Instrument observations are presented for electrons ...(25–800 keV) and protons (10–1500 keV). We analyze magnetic field‐aligned electron angular beams over expected auroral regions that were sometimes symmetric (bidirectional) but more often strongly asymmetric. Included are variable but surprisingly persistent upward, monodirectional electron angular beams emerging from what we term the “polar cap,” poleward of the nominal auroral ovals. The energy spectra of all beams were monotonic and hard (not structured in energy), showing power law‐like distributions often extending beyond ~800 keV. Given highly variable downward energy fluxes (below 1 RJ altitudes within the loss cone) as high as 280 mW/m2, we suggest that mechanisms generating these beams are among the primary processes generating Jupiter's uniquely intense auroral emissions, distinct from what is typically observed at Earth.
Key Points
Upward, energy‐monotonic energetic electron angular beams are unexpectedly persistent over Jupiter's polar caps
Jupiter's aurora appears not to be associated with monoenergetic electron beams but with other processes
Jupiter's aurora is powered by the downward portion of bidirectional, energy‐monotonic electron angular beams and diffuse precipitation
Using Van Allen Probe observations of the inner magnetosphere during geomagnetic storms driven by interplanetary coronal mass ejections (ICMEs) and corotating interaction regions (CIRs), we ...characterize the impact of these drivers on the storm‐time ring current development. Using 25 ICME‐ and 35 CIR‐driven storms, we have determined the ring current pressure development during the prestorm, main, early‐recovery, and late‐recovery storm phases, as a function of magnetic local time, L shell and ion species (H+, He+, and O+) over the 100‐ to 600‐keV energy range. Consistent with previous results, we find that during the storm main phase, most of the ring current pressure in the inner magnetosphere is contributed by particles on open drift paths drifting duskward leading to a strong partial ring current. The largest difference between the ICME and CIR ring current responses during the storm main and early‐recovery phases is the difference in the response of the <~55‐keV O+ to these drivers. While the H+ pressure response shows similar source and convection patterns for ICME and CIR storms, the O+ pressure response is significantly stronger for ICME storms. The ICME O+ pressure increases more strongly than H+ with decreasing L and peaks at lower L shells than H+.
Key Points
During the storm main and early‐recovery phases, most of the ring current pressure is contributed by particles on open drift paths
The largest difference between ICME and CIR responses in the main and early recovery phase is the <~55‐keV O+ pressure contribution
During the storm main and early‐recovery phases, the plasma beta increases to values greater than ~1 for L > 4 for ICMEs and L > 4.5 for CIRs
Two wave packets of second harmonic poloidal Pc 4 waves with a wave frequency of ~7 mHz were detected by Van Allen Probe A at a radial distance of ~5.8 RE and magnetic local time of 13 hr near the ...magnetic equator, where plasmaspheric refilling was in progress. Proton butterfly distributions with energy dispersions were also measured at the same time; the proton fluxes at 10–30 keV oscillated with the same frequency as the Pc 4 waves. Using the ion sounding technique, we find that the Pc 4 waves propagated eastward with an azimuthal wave number (m number) of ~220 and ~260 for each wave packet, respectively. Such eastward propagating high‐m (m > 100) waves were seldom reported in previous studies. The condition of drift‐bounce resonance is well satisfied for the estimated m numbers in both events. Proton phase space density was also examined to understand the wave excitation mechanism. We obtained temporal variations of the energy and radial gradient of the proton phase space density and find that temporal intensification of the radial gradient can generate the two wave packets. The cold electron density around the spacecraft apogee was >100 cm−3 in the present events, and hence the eigenfrequency of the Pc 4 waves became lower. This causes the increase of the m number which satisfies the resonance condition of drift‐bounce resonance for 10–30 keV protons and meets the condition for destabilization due to gyrokinetic effect.
Key Points
The first direct observation of drift‐bounce resonance that excites eastward propagating second harmonic poloidal waves with high m number
These waves are excited by intensification of radial gradient of proton phase space density due to substorm injection
Cold electrons also contribute to the wave excitation by increasing the m number to satisfy gyro‐kinetic destabilization condition
Abstract High-energy neutral solar radiation in the form of γ -rays and neutrons is produced as secondary products in solar flares. The characteristics of this emission can provide key information ...regarding the energization of charged particles, particularly when primary particles remain trapped in the corona. The Integrated Science Investigation of the Sun (IS⊙IS) suite on Parker Solar Probe is composed of instruments primarily intended to measure energetic charged particles. However, the High Energy Telescope (HET) in IS⊙IS was also designed with a supplementary neutral mode intended to measure γ -rays and neutrons. HET observed its first clear solar γ -ray event in connection with a hard X-ray flare, the eruption of a coronal mass ejection, and a solar energetic particle event on 2022 September 5. The X-ray spectral shape was observed to harden over the course of the event, culminating with the observation of γ -rays by HET. A coincident enhancement in the lower-energy Energetic Particle Instrument (EPI-Lo) was also observed, likely produced by incident solar γ -rays despite the EPI-Lo instrument not having any special neutral measurement capabilities. We use Monte Carlo modeling to reconstruct the incident γ -ray spectrum based on the measured spectrum to demonstrate that the combination of IS⊙IS instruments can measure hard X-rays and γ -rays from ∼60 keV–7 MeV. Despite the fact that this is a supplemental science goal of the mission, the capability of the IS⊙IS instruments to measure γ -rays is important for the study of this population due to the very limited instruments currently observing the Sun in γ -rays.
Enabled by the comprehensive measurements from the Magnetic Electron Ion Spectrometer (MagEIS), Helium Oxygen Proton Electron mass spectrometer (HOPE), and Radiation Belt Storm Probes Ion Composition ...Experiment (RBSPICE) instruments onboard Van Allen Probes in the heart of the radiation belt, the relative contributions of ions with different energies and species to the ring current energy density and their dependence on the phases of geomagnetic storms are quantified. The results show that lower energy (<50 keV) protons enhance much more often and also decay much faster than higher‐energy protons. During the storm main phase, ions with energies <50 keV contribute more significantly to the ring current than those with higher energies; while the higher‐energy protons dominate during the recovery phase and quiet times. The enhancements of higher‐energy proton fluxes as well as energy content generally occur later than those of lower energy protons, which could be due to the inward radial diffusion. For the 29 March 2013 storm we investigated in detail that the contribution from O+ is ~25% of the ring current energy content during the main phase and the majority of that comes from <50 keV O+. This indicates that even during moderate geomagnetic storms the ionosphere is still an important contributor to the ring current ions. Using the Dessler‐Parker‐Sckopke relation, the contributions of ring current particles to the magnetic field depression during this geomagnetic storm are also calculated. The results show that the measured ring current ions contribute about half of the Dst depression.
Key Points
<50 keV ions contribute more to the ring current than those of higher energies at storm main phase
Flux increase of >50 keV protons usually occurs at recovery phase (could be due to radial diffusion)
Even during moderate storms <50 keV O+ still contributes significantly to the ring current energy
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