Patients with metastatic breast cancer (MBC) can derive clinical benefit from several subsequent lines of chemotherapy. However, in heavily pre-treated patients, agents with clinical activity, a ...favourable side effects profile and a convenient administration modality are preferred.
We retrospectively analyzed 110 patients with previously treated MBC, who received oral etoposide at the dose of 50 mg/day for 20 days in 28 days cycles, between 2003 and 2017. Because this was not a prospectively planned study, to describe the clinical performance of oral etoposide we adopted the approach suggested by Dzimitrowicz and colleagues (J Clin Oncol. 2016; 34:3511–17); Tumour Response (TR) was defined as the proportion of physician-reported clinical or imaging response; Prolonged Duration on Therapy (PDT) as the proportion of non-progressing patients whose treatment lasted more than 6 months. Furthermore, we evaluated median duration on therapy (TD) and median Overall Survival (OS) by the Kaplan Meier method.
The median number of previous chemotherapy lines was 5 (range 2–8). TR, PDT, median TD and median OS were 6.4%, 18.2% 4 (range 3.5–4.5) and 10.6 (range 8.4–12.8) months respectively. Interestingly, etoposide activity was unrelated to the number of previous lines and type of metastatic involvement. Oral etoposide was well tolerated with only two patients discontinuing therapy due to toxicity.
In this large, single Institution, real practice analysis oral etoposide is a valuable and safe option for pre-treated metastatic breast cancer patients and might be considered in patients failing other approaches, but still suitable for chemotherapy.
•Oral etoposide is a well-tolerated agent used in treatment of several types of neoplasms.•We retrospectively evaluated 110 pre-treated metastatic breast cancer patients receiving oraletoposide at our institution.•Oral etoposide was active and well tolerated in patients failing a median of 5 prior chemotherapy lines.•This real world study suggests that oral etoposide is a therapeutic option in pre-treated metastatic breast cancer patients.
Despite improvements in surgery and medical treatments, epithelial ovarian cancer (EOC) remains the most lethal gynaecological malignancy. Aim of this study is to investigate the preclinical ...immunotherapy activity of cytokine-induced killer lymphocytes (CIK) against epithelial ovarian cancers, focusing on platinum-resistant settings. We generated CIK ex vivo starting from human peripheral blood samples (PBMCs) collected from EOC patients. Their antitumor activity was tested in vitro and in vivo against platinum-resistant patient-derived ovarian cancer cells (pdOVCs) and a Patient Derived Xenograft (PDX), respectively. CIK were efficiently generated (48 fold median ex vivo expansion) from EOC patients; pdOVCs lines (n = 9) were successfully generated from metastatic ascites; the expression of CIK target molecules by pdOVC confirmed pre and post treatment in vitro with carboplatin. The results indicate that patient-derived CIK effectively killed autologous pdOVCs in vitro. Such intense activity was maintained against a subset of pdOVC that survived in vitro treatment with carboplatin. Moreover, CIK antitumor activity and tumor homing was confirmed in vivo within an EOC PDX model. Our preliminary data suggest that CIK are active in platinum resistant ovarian cancer models and should be therefore further investigated as a new therapeutic option in this extremely challenging setting.
Hypersensitivity reactions (HSRs) to platinum are an important issue in the treatment of patients (pts) with ovarian cancer (OC). Germline BRCA mutations have been proposed as a risk factor. We aimed ...at evaluating the incidence and severity of HSRs to platinum in OC pts. with known BRCA status.
We retrospectively analyzed 432 pts. from 5 Italian Centers. In addition, we performed a systematic review and meta-analysis of published series.
Four hundred nine pts. received at least one prior platinum-based treatment line: 314 were BRCA wild type (77%) and 95 were BRCA mutated (23%). There was no statistical difference in exposure to platinum. Incidence of any grade HSRs was higher among BRCA mutated pts. 9% vs 18%, p = 0.019 and the time-to-HSRs curves show that the risk increases with the duration of platinum exposure, in BRCA mutated pts. more than in BRCA wild type. A multivariable analysis showed that harboring a germline BRCA mutation was related to a higher incidence of HSRs (HR: 1.84, 95% CI 1.00–3.99, p = 0.05) while having received pegylated liposomal doxorubicin (PLD) was related to a lower incidence of HSRs (HR: 0.03 95% CI 0.004–0.22, p = 0.001). The systematic review confirmed the higher incidence of HSRs in BRCA mutated pts., though heterogeneity among series was significant.
In OC pts. with BRCA mutations, there is a significantly higher incidence of HSRs to carboplatin, not justified by longer drug exposure. On the other hand, PLD exerted a protective role in our series.
•Hypersensitivity reactions (HSRs) to carboplatin are frequent in pretreated ovarian cancer (OC) patients (pts).•The role of BRCA mutations (mut) as a risk factor has been suggested.•We demonstrate that BRCAmut pts. have an increased risk of HSRs which is not justified by longer drug exposure only.•Receiving pegylated liposomal doxorubicin was a protective factor in our series.•The meta-analysis of literature, though results are heterogeneous, confirms the role of BRCAmut in increasing HSRs risk.
In this paper, we focus on the archaeometric characterisation of some pottery remains dated to the 8th and early 7th centuries BC. The sherds examined come from excavations carried out by the ...Groningen Institute of Archaeology (GIA) on the
acropolis of Timpone della Motta, an archaeological site located in Francavilla Marittima, near the well-known Greek colony of Sybaris (Calabria, southern Italy). As the site was one of the most important sanctuaries in the area during the 8th century BC, pottery from the sanctuary is one of the main sources of evidence for cultural and technological transformations which occurred within the indigenous Oinotrian society. However, in order to evaluate the significance of the individual classes of pottery, their provenance needs to be better understood. A first step in this direction was to clarify which pottery classes were produced locally at Timpone della Motta. We focus here on three ceramic classes frequently found in the sanctuary: a) matt-painted pottery; b) Oinotrian-Euboean style; and c) colonial ware (
hydriskoi), for further information on the probable provenance area and the technological features of these ceramic categories.
A multi-analytical approach was used, including petrographic, mineralogical and chemical investigations by means of optical and scanning electron microscopy, X-ray powder diffraction (XRD) and X-ray fluorescence spectroscopy (XRF). The results are compared with those deriving from minero-chemical and granulometric characterisation of some clay sediments sampled from outcrops near the study site, representing the potential source of clay used for ceramic production in this area. Preliminary data indicate that the matt-painted and Oinotrian-Euboean sherds were probably locally produced, since their chemical composition markedly resembles that of the clay sediments. As regards the
hydriskoi, some chemical differences were observed with respect to local clays and the other two classes, perhaps indicating a different production centre for this type of pottery. However, local manufacture exploiting the Fe- and Mg-richer clay layers in the sampled outcrop cannot be excluded for this group.
►The multidisciplinary approach allowed to characterise three ceramic groups. ►Local production is therefore suggested. ►Some chemical differences were observed in the
hydriskos group. ►The differences might be indicative of a different local raw material or a different production. ►Almost all the examined sherds were fired at relatively high temperatures (>
850
°C).
CdTe and CdS are emerging as the most promising materials for thin film photovoltaics in the quest of the achievement of grid parity. The major challenge for the advancement of grid parity is the ...achievement of high quality at the same time as low fabrication cost. The present paper reports the results of the new deposition technique, Pulsed Plasma Deposition (PPD), for the growth of the CdTe layers on CdS/ZnO/quartz and quartz substrates. The PPD method allows to deposit at low temperature. The optical band gap of deposited layers is 1.50 eV, in perfect accord with the value reported in the literature for the crystalline cubic phase of the CdTe. The films are highly crystalline with a predominant cubic phase, a random orientation of the grains of the film and have an extremely low surface roughness of 4.6\pm0.7 nm r.m.s.. The low roughness, compared to traditional thermal deposition methods (close space sublimation and vapour transport) permits the reduction of the active absorber and n-type semiconductor layers resulting in a dramatic reduction of material usage and the relative deposition issues like safety, deposition rate and ultimately cost
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