In this paper, we present the analysis and results of a direct measurement of the cosmic-ray proton spectrum with the CALET instrument onboard the International Space Station, including the detailed ...assessment of systematic uncertainties. The observation period used in this analysis is from October 13, 2015 to August 31, 2018 (1054 days). We have achieved the very wide energy range necessary to carry out measurements of the spectrum from 50 GeV to 10 TeV covering, for the first time in space, with a single instrument the whole energy interval previously investigated in most cases in separate subranges by magnetic spectrometers (BESS-TeV, PAMELA, and AMS-02) and calorimetric instruments (ATIC, CREAM, and NUCLEON). The observed spectrum is consistent with AMS-02 but extends to nearly an order of magnitude higher energy, showing a very smooth transition of the power-law spectral index from -2.81±0.03 (50-500 GeV) neglecting solar modulation effects (or -2.87±0.06 including solar modulation effects in the lower energy region) to -2.56±0.04 (1-10 TeV), thereby confirming the existence of spectral hardening and providing evidence of a deviation from a single power law by more than 3σ.
Extended results on the cosmic-ray electron + positron spectrum from 11 GeV to 4.8 TeV are presented based on observations with the Calorimetric Electron Telescope (CALET) on the International Space ...Station utilizing the data up to November 2017. The analysis uses the full detector acceptance at high energies, approximately doubling the statistics compared to the previous result. CALET is an all-calorimetric instrument with a total thickness of 30 X_{0} at normal incidence and fine imaging capability, designed to achieve large proton rejection and excellent energy resolution well into the TeV energy region. The observed energy spectrum in the region below 1 TeV shows good agreement with Alpha Magnetic Spectrometer (AMS-02) data. In the energy region below ∼300 GeV, CALET's spectral index is found to be consistent with the AMS-02, Fermi Large Area Telescope (Fermi-LAT), and Dark Matter Particle Explorer (DAMPE), while from 300 to 600 GeV the spectrum is significantly softer than the spectra from the latter two experiments. The absolute flux of CALET is consistent with other experiments at around a few tens of GeV. However, it is lower than those of DAMPE and Fermi-LAT with the difference increasing up to several hundred GeV. The observed energy spectrum above ∼1 TeV suggests a flux suppression consistent within the errors with the results of DAMPE, while CALET does not observe any significant evidence for a narrow spectral feature in the energy region around 1.4 TeV. Our measured all-electron flux, including statistical errors and a detailed breakdown of the systematic errors, is tabulated in the Supplemental Material in order to allow more refined spectral analyses based on our data.
Completion of multiple dose vaccine schedules is crucial to ensure a protective immune response, and maximise vaccine cost-effectiveness. While barriers and facilitators to vaccine uptake have ...recently been reviewed, there is no comprehensive review of factors influencing subsequent adherence or completion, which is key to achieving vaccine effectiveness. This study identifies and summarises the literature on factors affecting completion of multi-dose vaccine schedules by adolescents.
Ten online databases and four websites were searched (February 2014). Studies with analysis of factors predicting completion of multi-dose vaccines were included. Study participants within 9-19 years of age were included in the review. The defined outcome was completion of the vaccine series within 1 year among those who received the first dose.
Overall, 6159 abstracts were screened, and 502 full texts were reviewed. Sixty one studies were eligible for this review. All except two were set in high-income countries. Included studies evaluated human papillomavirus vaccine, hepatitis A, hepatitis B, and varicella vaccines. Reported vaccine completion rates, among those who initiated vaccination, ranged from 27% to over 90%. Minority racial or ethnic groups and inadequate health insurance coverage were risk factors for low completion, irrespective of initiation rates. Parental healthcare seeking behaviour was positively associated with completion. Vaccine delivery in schools was associated with higher completion than delivery in the community or health facilities. Gender, prior healthcare use and socio-economic status rarely remained significant risks or protective factors in multivariate analysis.
Almost all studies investigating factors affecting completion have been carried out in developed countries and investigate a limited range of variables. Increased understanding of barriers to completion in adolescents will be invaluable to future new vaccine introductions and the further development of an adolescent health platform. PROSPERO reg# CRD42014006765.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The Red Sea has long been recognized as a region of high biodiversity and endemism. Despite this diversity and early history of scientific work, our understanding of the ecology of coral reefs in the ...Red Sea has lagged behind that of other large coral reef systems. We carried out a quantitative assessment of ISI-listed research published from the Red Sea in eight specific topics (apex predators, connectivity, coral bleaching, coral reproductive biology, herbivory, marine protected areas, non-coral invertebrates and reef-associated bacteria) and compared the amount of research conducted in the Red Sea to that from Australia’s Great Barrier Reef (GBR) and the Caribbean. On average, for these eight topics, the Red Sea had 1/6th the amount of research compared to the GBR and about 1/8th the amount of the Caribbean. Further, more than 50 % of the published research from the Red Sea originated from the Gulf of Aqaba, a small area (<2 % of the area of the Red Sea) in the far northern Red Sea. We summarize the general state of knowledge in these eight topics and highlight the areas of future research priorities for the Red Sea region. Notably, data that could inform science-based management approaches are badly lacking in most Red Sea countries. The Red Sea, as a geologically “young” sea located in one of the warmest regions of the world, has the potential to provide insight into pressing topics such as speciation processes as well as the capacity of reef systems and organisms to adapt to global climate change. As one of the world’s most biodiverse coral reef regions, the Red Sea may yet have a significant role to play in our understanding of coral reef ecology at a global scale.
Experimental autoimmune encephalomyelitis (EAE) is a prototype autoimmune disease mediated by type 1 helper T (TH1) cells and under the control of regulatory cells. Here we report that a synthetic ...glycolipid ligand for CD1d-restricted natural killer T (NKT) cells expressing the semi-invariant T-cell receptor (Valpha14+) is preventive against EAE. The ligand is an analogue of alpha-galactosylceramide (alpha-GC), a prototype NKT cell ligand, with a truncated sphingosine chain. alpha-GC causes NKT cells to produce both interferon (IFN)-gamma and interleukin (IL)-4 (refs 4, 5). However, this new ligand can induce a predominant production of IL-4 by the NKT cells. A single injection of this glycolipid, but not of alpha-GC, consistently induced TH2 bias of autoimmune T cells by causing NKT cells to produce IL-4, leading to suppression of EAE. The lack of polymorphism of CD1d and cross-reactive response of mouse and human NKT cells to the same ligand indicates that targeting NKT cells with this ligand may be an attractive means for intervening in human autoimmune diseases such as multiple sclerosis.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Aims. The path length distribution of Galactic cosmic rays (GCRs) is the fundamental ingredient for modeling the propagation process of GCRs based on the so-called weighted slab method. We try to ...derive this distribution numerically by taking into account the discreteness in both space and time of occurrences of supernova explosions where GCRs are suspected to be born. The resultant age distribution and ratio of B/C are to be compared with recent observations. Methods. We solve numerically the stochastic differential equations equivalent to the Parker diffusion-convection equation which describes the propagation process of GCR in the Galaxy. We assume the three-dimensional diffusion is an isotropic one without any free escape boundaries. We ignore any energy change of GCRs and the existence of the Galactic wind for simplicity. We also assume axisymmetric configurations for the density distributions of the interstellar matter and for the surface density of supernovae. We have calculated age and path length of GCR protons arriving at the solar system with this stochastic method. The obtained age is not the escape time of GCRs from the Galaxy as usually assumed, but the time spent by GCRs during their journey to the solar system from the supernova remnants where they were born. Results. The derived age and path length show a distribution spread in a wide range even for GCR protons arriving at the solar system with the same energy. The distributions show a cut-off at a lower range in age or path length depending on the energy of GCRs. These cut-offs clearly come from the discreteness of occurrence of supernovae. The mean age of GeV particles obtained from the distributions is consistent with the age obtained by direct observation of radioactive secondary nuclei. The energy dependence of the B/C ratio estimated with the path length distribution reproduces reliably the energy dependence of B/C obtained by recent observations in space.
Gamma‐ray glows are observational evidence of relativistic electron acceleration due to the electric field in thunderclouds. However, it is yet to be understood whether such relativistic electrons ...contribute to the initiation of lightning discharges. To tackle this question, we started the citizen science “Thundercloud Project,” where we map radiation measurements of glows from winter thunderclouds along Japan's sea coast area. We developed and deployed 58 compact gamma‐ray monitors at the end of 2021. On 30 December 2021, five monitors simultaneously detected a glow with its radiation distribution horizontally extending for 2 km. The glow terminated coinciding with a lightning flash at 04:08:34 JST, which was recorded by the two radio‐band lightning mapping systems, FALMA and DALMA. The initial discharges during the preliminary breakdown started above the glow, that is, in vicinity of the electron acceleration site. This result provides one example of possible connections between electron acceleration and lightning initiation.
Plain Language Summary
Thunderstorms are natural particle accelerators. The strong electric field inside thunderclouds accelerates relativistic electrons, which emit gamma rays via interaction with the atmosphere. High‐energy photons generated in this process have been observed as radiation enhancements called gamma‐ray glows. Winter thunderclouds along the sea of Japan are an ideal target for monitoring glows because their altitudes are usually sufficiently low for the generated gamma‐ray photons to reach the ground. We started a new citizen science “Thundercloud Project” in this area, where we distributed radiation detectors to citizen supporters to observe glows and to reveal their relationship with the aerological condition and lightning discharges. On 30 December 2021, five of those sensors detected a glow from a single thundercloud. Two of them recorded a sudden termination of the glow coinciding with a lightning flash, which was monitored by our two radio mapping systems of FALMA and DALMA. The initial discharges of the flash started at a location about 1.6 km above the glow region with an unusually fast downward progression. This paper is the first report of our citizen science project. We discuss the possibility that accelerated electrons contribute to the initiation of lightning discharges.
Key Points
We started the citizen science “Thundercloud Project,” a multi‐point observation campaign of gamma‐ray glows from thunderstorms
On 30 December 2021, five radiation monitors detected a 2‐km‐long size gamma‐ray glow, which suddenly terminated with a lightning flash
Two radio mapping systems of lightning identified the initiation of the discharges, which started at a location above the glow region
AIMS: To clarify the polyhydroxyalkanoate (PHA) accumulation potential and the PHA‐accumulating microbial community structure in activated sludge in municipal wastewater treatment plants (WWTPs) and ...to identify their influential factors. METHODS AND RESULTS: Nine activated sludge samples were collected from municipal WWTPs employing various biological treatment processes. In acetate‐fed 24‐h batch experiments under aerobic and nitrogen‐ and phosphorus‐limited conditions, polyhydroxybutyrate (PHB) content of activated sludge increased from 0–1·3 wt% to 7·9–24 wt%, with PHB yields of 0·22–0·50 C‐mol 3‐hydroxybutyrate (C‐mol acetate)⁻¹. Microbial community analyses found that activated sludge samples that accumulated >20 wt% of PHB after 24‐h PHA accumulation experiments had >5·0 × 10⁸ copies g⁻¹‐mixed liquor‐suspended solid of phaC genes. CONCLUSIONS: Results indicated that (i) activated sludge in municipal WWTPs can accumulate up to approx. 20 wt% of PHA without enrichment processes, (ii) PHA accumulation potential of activated sludge varied depending on the operational conditions (treatment processes) of WWTPs, and (iii) phaC gene number can provide a simple indication of PHA accumulation potential. SIGNIFICANCE AND IMPACT OF THE STUDY: This is the first study to compare the PHA accumulation potential and PHA‐accumulating microbial communities in activated sludge of various treatment processes. Our findings may be useful for enhancing the resource recovery potential of wastewater treatment systems.
Sputter-deposited MoS2 films have been often used as dry lubricant in various industrial fields, such as space applications. Most investigations have been focused on the reduction of the friction ...coefficient. However, mechanical components require not only stable lubricating films for friction reduction, but also excellent wear resistance for prolonged endurance life. Therefore, in this work, anti-wear properties of WS2/MoS2 nanometer-scale multilayers have been investigated, because a nanometer-scale multilayer film, so-called superlattice structured film, is expected to show good mechanical properties, such as high hardness and high stiffness, resulting in a low friction and long endurance lives. WS2/MoS2 nanometer-scale multilayer films have been prepared by multi-target RF sputtering. Single-layer MoS2 and WS2 films were also prepared for comparison. Ball-on-disk wear tests and nono-indentation tests were performed on the films grown onto Si substrates. WS2/MoS2 multilayer film showed a significantly improved tribological performance in air compared to the single-layer MoS2 or WS2 film, with an improvement in wear life of approximately seven times, and with a low friction coefficient of approximately 0.05.
Hippocampus-associated cognitive impairments are a common, highly conserved symptom of both schizophrenia (SCZ) and bipolar disorder (BPD). Although the hippocampus is likely an impacted region in ...SCZ/BPD patients, the molecular and cellular underpinnings of these impairments are difficult to identify. An emerging class of mouse models for these psychiatric diseases display similar cognitive impairments to those observed in human patients. The hippocampi of these mice possess a conserved pathophysiological alteration; we term the 'immature dentate gyrus' (iDG), characterized by increased numbers of calretinin-positive immature neuronal progenitors, a dearth of calbindin-positive mature neurons and (often) constitutively increased neurogenesis. Although these models provide a link between cellular dysfunction and behavioral alteration, limited translational validity exists linking the iDG to human pathophysiology. In this study, we report the initial identification of an iDG-like phenotype in the hippocampi of human SCZ/BPD patients. These findings suggest a new motif for the etiology of these diseases and link an emerging class of mouse models to the human disease condition.
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