Introduction and objective: In recent years, depression and diabetes have become more and more serious medical issues. The number of patients suffering from one or both of these disorders increases ...year by year, which significantly worsens their quality of life. The aim of the study is to present the current state of knowledge on the basic mechanisms and risk factors influencing the development of depression in patients with diabetes, as well as the bidirectional relationship between these illnesses. The study was based on a literature review and an analysis of publications available on PubMed and Google Scholar platforms. The search has been conducted with the use of a combination of keywords like: “diabetes type 1”, “diabetes type 2”, “depression”, “mental health”.
An abbreviated description of the state of knowledge: Every third patient with diabetes shows depressive symptoms. These psychological disorders are more common in people with type 1 diabetes. The most vulnerable group of patients are single women with low socioeconomic status and comorbidities. Numerous biochemical and psychosocial changes in the life of diabetic patients, significantly increase the risk of developing depression. The latest scientific reports also draw attention to the two-way relationship between diabetes and depression. The inclusion of cognitive-behavioral therapy brings positive results in managing diabetes with comorbid depression.
Summary: The available scientific data clearly shows the existence of psychological and biological links between these two disease entities. Appropriate diagnosis and treatment of depressive disorders can improve the course of diabetes.
Endothelial progenitor cells (EPCs) are a population of cells that circulate in the blood looking for areas of endothelial or vascular injury in order to repair them. Endothelial dysfunction is an ...important component of disorders with neurovascular involvement. Thus, the subject of involvement of EPCs in such conditions has been gaining increasing scientific interest in recent years. Overall, decreased levels of EPCs are associated with worse disease outcome. Moreover, their functionalities appear to decline with severity of disease. These findings inspired the application of EPCs as therapeutic targets and agents. So far, EPCs appear safe and promising based on the results of pre-clinical studies conducted on their use in the treatment of Alzheimer’s disease and ischemic stroke. In the case of the latter, human clinical trials have recently started to be performed in this subject and provided optimistic results thus far. Whereas in the case of migraine, existing findings pave the way for testing EPCs in in vitro studies. This review aims to thoroughly summarize current knowledge on the role EPCs in four disorders with neurovascular involvement, which are Alzheimer’s disease, cerebral small vessel disease, ischemic stroke and migraine, with a particular focus on the potential practical use of these cells as a treatment remedy.
ABSTRACT
Introduction and purpose: COVID-19 is a highly contagious disease that is caused by a new strain of SARS-CoV-2 coronavirus (type 2 acute respiratory syndrome virus). Globally, as of 14 July ...2021, there have been more than 4 million deaths and almost 190 million confirmed cases of infection. Mental health disorders are sets of behaviours, ways of thinking or perceiving and other mental activities and relations with other people which are a source of suffering or impediments to the individual functioning of the affected person. The most common mental health disorders are anxiety disorders, insomnia, depression and somatic disorders.
State of knowledge: The COVID-19 pandemic has disrupted people's lives around the world through the rapid spread of the disease, high mortality and negative health effects. Over time, there is growing public concern that health systems may become overburdened and that adequate medical care will not be available to everyone affected by the disease. There are also concerns that isolation and reduced mobility will be long-term with serious consequences for mental health and well-being.
Summary: There is already evidence of the negative psychological effects of the COVID-19 pandemic on children and adolescents, as well as the elderly who have been isolated, making these individuals more susceptible to developing long-term psychiatric disorders.
Introduction and objective. Depression is a disease that impairs daily functioning. According to research, as much as 27.2% of medical students suffer from depression or show depressive symptoms and ...11.1% of them experience suicidal ideation. The aim of the research was to investigate the occurrence of subjective feeling of depressive symptoms among Polish medical students during the course of their medical studies and to determine predictors of this phenomenon that are related to student’s environment. Material and method. A total of 1023 medical students from each year of medical education and different Polish universities took part in the study. The research tool was an author’s questionnaire. Obtained data was subjected to a statistical analysis. To assess the relationship between two variables, the chi-square test of independence was used. The level of significance was set at p < 0.05. Results. The statistical analysis showed that most respondents (52.79%) had noticed symptoms that might had pointed to depression during their medical studies. A statistically significant link was found between subjective feeling of depressive symptoms during the course of medical studies and: mother’s level of education, relationship with parents, relationship with siblings, relationship with friends, knowing a person that one could count on in a difficult situation, knowing a person in which one could trust with all their problems, frequent feelings of loneliness and feeling that one doesn’t participate in social gatherings often enough. Conclusions. The prevalence of subjective feeling of depressive symptoms among medical students is high. Results suggest that good relationships with others are important in prevention of depression.
Alzheimer's disease (AD) is a life-changing condition whose etiology is explained by several hypotheses. Recently, a new virus contributed to the evidence of viral involvement in AD: the severe acute ...respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the COVID-19 coronavirus disease. AD was found to be one of the most common COVID-19 comorbidities, and it was found to increase mortality from this disease as well. Moreover, AD patients were observed to present with the distinct clinical features of COVID-19, with delirium being prevalent in this group. The SARS-CoV-2 virus enters host cells through the angiotensin-converting enzyme 2 (ACE2) receptor. ACE2 is overexpressed in brains with AD, which thus increases the viral invasion. Furthermore, the inhibition of the ACE2 receptor by the SARS-CoV-2 virus may also decrease the brain-derived neurotrophic factor (BDNF), contributing to neurodegeneration. The ApoE ε4 allele, which increases the risk of AD, was found to facilitate the SARS-CoV-2 entry into cells. Furthermore, the neuroinflammation and oxidative stress existing in AD patients enhance the inflammatory response associated with COVID-19. Moreover, pandemic and associated social distancing measures negatively affected the mental health, cognitive function, and neuro-psychiatric symptoms of AD patients. This review comprehensively covers the links between COVID-19 and Alzheimer's disease, including clinical presentation, molecular mechanisms, and the effects of social distancing.
According to some authors, serum selenium levels are strongly associated with the severity of liver diseases, including liver cirrhosis. The aim of this study was to determine the relationship ...between the concentration of selenium and pro-inflammatory and profibrotic cytokines-interleukin-6 (IL-6) and growth differentiation factor 15 (GDF-15) in patients with alcoholic liver cirrhosis. The parameters studied were determined in the serum of 99 patients with alcoholic liver cirrhosis divided based on the severity of disease according to the Child-Turcotte-Pugh criteria. In patients with liver cirrhosis, the serum selenium concentration was statistically lower, whereas serum IL-6 and GDF-15 concentrations were higher than those in the control group. Moreover, the concentration of selenium negatively correlated with the levels of GDF-15 and IL-6. The above results may indicate a role of selenium deficiency in the pathogenesis and progression of alcoholic liver disease.
Introduction Breast cancer, with an estimated 1.67 million new cases diagnosed in 2012 (25% of all cancers), is the second most common neoplasm worldwide. It is also the most frequent proliferative ...process among women. Objective Evaluation of the level of students’ knowledge concerning risk factors and prophylaxis of breast cancer. Material and methods The study was conducted among randomly selected students of high schools from Lubelskie region between April and June 2017. Participation in the study was voluntary and anonymous. The study group consisted of 137 students. The study used the method of a diagnostic survey using a questionnaire constructed by the authors. The obtained results were statistically analyzed using the STATISTICA 13 program. The significance of intergroup differences was verified with Pearson chi-square test. Results The vast majority of students indicated the following main risk factors of breast cancer: family history, genetic predispositions, smoking and advanced age. In the respondents opinion, palpable tumor, changes in the size or shape of the breast and enlargement of axillar lymph nodes were the main symptoms of breast cancer. The Internet was indicated as the main source of breast cancer knowledge. Conclusions Interviewed students showed relatively low level of knowledge concerning problem of breast cancer risk factors. Young people use Internet as a main source of information about breast cancer and its prophylaxis. According to the results, it is necessary to mobilize health professionals, to promote rules for the prevention of breast cancer among young women. There is a need of new, wide, persuasive social campaigns from the area of breast cancer prevention.
Introduction Breast cancer, with an estimated 1.67 million new cases diagnosed in 2012 (25% of all cancers), is the second most common neoplasm worldwide. It is also the most frequent proliferative ...process among women. Objective Evaluation of the level of students’ knowledge concerning risk factors and prophylaxis of breast cancer. Material and methods The study was conducted among randomly selected students of high schools from Lubelskie region between April and June 2017. Participation in the study was voluntary and anonymous. The study group consisted of 137 students. The study used the method of a diagnostic survey using a questionnaire constructed by the authors. The obtained results were statistically analyzed using the STATISTICA 13 program. The significance of intergroup differences was verified with Pearson chi-square test. Results The vast majority of students indicated the following main risk factors of breast cancer: family history, genetic predispositions, smoking and advanced age. In the respondents opinion, palpable tumor, changes in the size or shape of the breast and enlargement of axillar lymph nodes were the main symptoms of breast cancer. The Internet was indicated as the main source of breast cancer knowledge. Conclusions Interviewed students showed relatively low level of knowledge concerning problem of breast cancer risk factors. Young people use Internet as a main source of information about breast cancer and its prophylaxis. According to the results, it is necessary to mobilize health professionals, to promote rules for the prevention of breast cancer among young women. There is a need of new, wide, persuasive social campaigns from the area of breast cancer prevention.
The cerebral consequences of diabetes Paula Jankowska; Krzysztof Jankowski; Ewa Rudnicka-Drożak ...
Journal of education, health and sport,
06/2018, Letnik:
8, Številka:
7
Journal Article
Recenzirano
Odprti dostop
Introduction The number of patients suffering from diabetes mellitus is growing globally. Diabetes is a disease requiring cooperation from the patient. Numerous cases of behavior not satisfying ...doctor are interpreted as lack of subordination and willingness to adapt to medical recommendations. Problems with adherence to treatment may be a result of decrease in cognitive functions, and associated cerebral diabetes complications as stroke, structural brain changes, depression and diabetic distress. Aim The purpose of this study is to present cerebral complications and their consequences depicted in professional literature. Results Diabetes has many severe cerebral complications. Patients may experience both ischaemic and haemorrhagic stroke and ensuing disability. Moreover, diabetes is described to be a serious factor contributing development of brain structural changes. There was decrease in of gray and white matter reported to be associated with decline in cognitive functions. Diabetes is also described as cause of depression and diabetic distress. These two affective problems are very serious reasons influencing everyday activity of patients. Glycaemic control in such individuals is significantly poorer than in people not suffering from these complications. Conclusions The cerebral complications of diabetes are frequent, especially in population of elderly people. They have substantial influence on cooperation with patient, treatment adherence and its outcomes. Every situation of doctor`s dissatisfaction with the results of diabetic education, compliance and self-care activities performed by the patient should lead to investigation if he have any diabetes cerebral complications.
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