Introduction
There is significant incidence of Haemophilia in India, with second largest number of persons with Haemophilia A. 20,778 patients registered with Haemophilia Foundation of India in 2018. ...Research in India includes diagnostic studies, complications and co‐morbidities, prenatal diagnosis, inhibitor development and gene therapy. Limited is known about quality of life of these patients. Since Haemophilia leads to the loss of ‘normal lifestyle’ in young people resulting in emotional distress and depression, it is important to analyse Knowledge, Attitude and Behaviour of persons with Haemophilia.
Aim
The aim of the study is to focus on exploring the status of Haemophilia and knowledge, attitude, behaviour of adolescents and youths with haemophilia with the objectives to study 1) the current medical status of haemophilia amongst target population; 2) the knowledge, attitude and behaviour of patients with haemophilia towards their condition.
Methods
Respondents in the age group of 15–30 years, who were registered with the Hemophilia Treatment Centers of Government Hospitals/Hemophilia Societies, were interviewed. Data were collected using a structured questionnaire. The study was conducted in two different states and with respondents of two different age groups.
Findings
Most respondents suffered from severe haemophilia and co‐morbidities such as anxiety, stress, chronic pain and head‐ache. All of them felt that haemophilia interferes in leading a normal life and perceive a grim future.
Conclusion
Young people in India need technical, financial and psychological support to prevent complications related to haemophilia. While most of them take responsibility for their health, more behavioural changes need to be inducted to improve quality of life.
A new and efficient synthesis of the novel bioactive bis(benzopyrano) fused dihydropyridines is described. The conventionally developed route is a two step multicomponent condensation reaction. This ...is latter modified by a one pot microwave (MW) assisted reaction using inorganic solid support via the arylidene derivative intermediate. With this environmentally benign approach, the reaction time is brought down from hours to minutes along with a yield enhancement. Furthermore, the role of different solid supports is studied and it is concluded that the acidic alumina is the best solid support for the present investigation.
Hantzsch synthesis of N-substituted-1,4-dihydropyridines (1,4-DHP) was carried out using an environmentally benign procedure. Neat reactants were subjected to microwave irradiation (MWI) to give the ...required products in excellent yield. Appreciable results were not obtained when conventional synthesis using neat reactants was carried out. The good yield and rate enhancement observed in the case of microwave irradiation is attributed to the uniform heating effect of microwaves.Key words: 1,4-dihydropyridines (1,4-DHP), microwave irradiation (MWI), neat reaction, solid support.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The Niementowski reaction has been extended to synthesize 3-substituted/2,3-disubstituted-4(3H)quinazolinones instead of the 2-substituted derivatives. The methodology is environmentally benign and ...completely eliminates the need of solvent from the reaction. Neat reactants were cyclocondensed under microwaves to afford, in good yield, the desired product in less irradiation time as compared to the classical technique. The reaction time was reduced from hours to minutes along with yield enhancement. The rate enhancement and high yield are attributed to the coupling of solvent-free conditions with microwaves.
Rate of energy production is reflecting growth of nations and most of energy produced from the coal and natural gas-based thermal power plants (TPPs). Flue gas (point sources of emission) are main ...exhaustible form of gases that come from thermal power plants and are continuously promoting climate change and various environmental problems in global scenario. The present available technologies of flue gas treatment are energy and cost-intensive process. Among the available techniques for fixation of flue-gases at sustainable part, microalgal bio-fixation of flue gas is an alternative promising and competent technology with assurance of eco-friendly path of low energy and low-cost solution for pollution abetment with production of value added products. According to mechanism involves during photosynthetic process of microalgae, it utilizes atmospheric CO2 and CO2 from flue gases for their growth. Past, present and future treatment technologies for flue gas with their challenges are discussed. Recent experimental studies and commercially available bioreactors are very particular for bio-fixation of flue gas from thermal power plants are also reviewed with their future perspectives. The commercial viability of process with specific microalgal strains and utilized biomass for further value-added products are suggested with future limitations.
•Flue gas emits from thermal power plants consists of COx, NOx, SOx and heavy metals.•Strain selection & culturing system is important for bio-fixation of flue gas.•Closed type photobioreactors are more suitable for bio-fixation of flue gas.•Bio-fixation rate is totally depends upon the raw materials used in TPPs.•Process cost is a major challenge for bio-fixation of flue gas from TPPs.
Human C5a (
h
C5a), one of the pro-inflammatory glycoproteins of the complement system is known to undergo production hyperdrive in response to stress and infection.
h
C5a has been associated with ...the pathogenesis of many chronic and acute diseases, due to its proven ability in triggering the 'cytokine storm', by binding to its cognate receptor C5aR, expressed in myriad of tissues. Given the pleiotropic downstream function of
h
C5a, it is logical to consider the
h
C5a or its precursors as potential drug targets, and thus, we have been rationally pursuing the idea of neutralizing the harmful effect of excessive
h
C5a, by implementing the repurposing strategies for FDA-approved drugs. Indeed, the proof of principle biophysical studies published recently is encouraging, which strongly supports the potential of this strategy. Considering BSA-carprofen as a reference model system, the current study further explores the inherent conformational plasticity of
h
C5a and its effect in accommodating more than one drug molecule cooperatively at multiple sites. The data generated by recruiting a battery of experimental and computational biology techniques strongly suggest that
h
C5a can sequentially accommodate more than one raloxifene molecule with an estimated Ki ∼ 0.5 µM and Ki ∼ 3.58 µM on its surface at non-analogous sites. The study hints at exploration of polypharmacology approach, as a new avenue for discovering synergistic drug molecule pairs, or drug molecules with 'broad-range' binding affinity for targeting the different 'hot spots' on
h
C5a, as an alternative combination therapy for possible management of the 'cytokine storm'-related inflammatory diseases, like COVID19.
Communicated by Ramaswamy H. Sarma
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