This study was undertaken to evaluate the association between components defining insulin resistance and breast cancer in women.
We conducted a systematic review of four databases (PubMed-Medline, ...EMBASE, Web of Science, and Scopus) for observational studies evaluating components defining insulin resistance in women with and without breast cancer. A meta-analysis of the association between insulin resistance components and breast cancer was performed using random effects models.
Twenty-two studies (n = 33,405) were selected. Fasting insulin levels were not different between women with and without breast cancer (standardized mean difference, SMD -0.03, 95%CI -0.32 to 0.27; p = 0.9). Similarly, non-fasting/fasting C-peptide levels were not different between the two groups (mean difference, MD 0.07, -0.21 to 0.34; p = 0.6). Using individual odds ratios (ORs) adjusted at least for age, there was no higher risk of breast cancer when upper quartiles were compared with the lowest quartile (Q1) of fasting insulin levels (OR Q2 vs. Q1 0.96, 0.71 to 1.28; OR Q3 vs. Q1 1.22, 0.91 to 1.64; OR Q4 vs. Q1 0.98, 0.70 to 1.38). Likewise, there were no differences for quartiles of non-fasting/fasting C-peptide levels (OR Q2 vs. Q1 1.12, 0.91 to 1.37; OR Q3 vs. Q1 1.20, 0.91 to 1.59; OR Q4 vs. Q1 1.40, 1.03 to 1.92). Homeostatic model assessment (HOMA-IR) levels in breast cancer patients were significantly higher than in people without breast cancer (MD 0.22, 0.13 to 0.31, p<0.00001).
Higher levels of fasting insulin or non-fasting/fasting C-peptide are not associated with breast cancer in women. HOMA-IR levels are slightly higher in women with breast cancer.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Objetivos: Determinar las complicaciones perinatales que presentan las mujeres que cursan con tuberculosis (TBC) durante la gestación y la incidencia de tuberculosis congénita en nuestro hospital ...durante los años 2001 a 2009. Diseño: Estudio descriptivo observacional transversal de tipo retrospectivo. Institución: Hospital Nacional Cayetano Heredia. Participantes: Gestantes con diagnóstico de tuberculosis. Intervenciones: Ingresaron al estudio todas aquellas gestantes con diagnóstico de tuberculosis que cumplían con los criterios de inclusión.Principales medidas de resultados: Características y resultados perinatales. Resultados: La frecuencia de TBC en el HNCH fue de 5,1 casos por cada 10 000 partos. La edad media fue 25,3 años. A 43,5% el diagnóstico se les realizó durante la gestación, a 43,5% fuera de la gestación y a 3 pacientes (13%) durante el puerperio. Fue parto vaginal en 65,2% y parto abdominal en 30,4%. No se registró casos de endometritis. Un 17,4% tuvo sepsis materna y hubo un caso de muerte materna por preeclampsia severa. Se presentaron cinco casos de tuberculosis multidrogorresistente (TBC-MDR). De todos los recién nacidos, 69,6% fue adecuado para la edad gestacional y 30,4% pequeño para la edad gestacional; 17,4% fue prematuro y 21,7% tuvo peso bajo. Solo un recién nacido presentó sepsis neonatal y ninguno TBC. Conclusiones: La TBC afectó el curso de la gestación, parto y puerperio, pues entre los recién nacidos hijos de madres con tuberculosis hubo más pretérminos, pequeños para la edad gestacional y restricción del crecimiento que en la población general.Palabras clave: Tuberculosis, embarazo, puerperio, neonato.
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unrestricted use, distribution, and reproduction in any medium, provided the ...original author and source are credited.
Objective: This study was undertaken to evaluate the association between components defining insulin resistance and
breast cancer in women.
Study Design: We conducted a systematic review of four databases (PubMed-Medline, EMBASE, Web of Science, and
Scopus) for observational studies evaluating components defining insulin resistance in women with and without breast
cancer. A meta-analysis of the association between insulin resistance components and breast cancer was performed using
random effects models.
Results: Twenty-two studies (n = 33,405) were selected. Fasting insulin levels were not different between women with and
without breast cancer (standardized mean difference, SMD 20.03, 95%CI 20.32 to 0.27; p = 0.9). Similarly, non-fasting/
fasting C-peptide levels were not different between the two groups (mean difference, MD 0.07, 20.21 to 0.34; p = 0.6). Using
individual odds ratios (ORs) adjusted at least for age, there was no higher risk of breast cancer when upper quartiles were
compared with the lowest quartile (Q1) of fasting insulin levels (OR Q2 vs. Q1 0.96, 0.71 to 1.28; OR Q3 vs. Q1 1.22, 0.91 to 1.64;
OR Q4 vs. Q1 0.98, 0.70 to 1.38). Likewise, there were no differences for quartiles of non-fasting/fasting C-peptide levels (OR Q2
vs. Q1 1.12, 0.91 to 1.37; OR Q3 vs. Q1 1.20, 0.91 to 1.59; OR Q4 vs. Q1 1.40, 1.03 to 1.92). Homeostatic model assessment (HOMAIR)
levels in breast cancer patients were significantly higher than in people without breast cancer (MD 0.22, 0.13 to 0.31, p,
0.00001).
Conclusions: Higher levels of fasting insulin or non-fasting/fasting C-peptide are not associated with breast cancer in
women. HOMA-IR levels are slightly higher in women with breast cancer.
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