La monoartritis es un reto diagnóstico para el clínico, ya que es extensa la lista de patologías asociadas. En pacientes con diagnóstico establecido de enfermedad articular inflamatoria, se acepta ...que la monoartritis corresponde a la exacerbación de la enfermedad de base; sin embargo, ignorar el abordaje sistematizado de las monoartritis puede generar omisiones e implicaciones diagnósticas erróneas. En este reporte se analiza el abordaje de un caso de artritis seudoséptica, simulando un ataque agudo de artritis por urato monosódico recurrente en un paciente con retención de cuerpo extraño intraarticular.
Geothermal energy is a renewable energy source that can be found in abundance on our planet. Only a small fraction of it is currently converted to electrical power, though in recent years installed ...geothermal capacity has increased considerably all over the world. This review focuses on Enhanced Geothermal Systems (EGS), which represent a path for turning the enormous resources provided by geothermal energy into electricity for human consumption efficiently and on a large scale. The paper presents a general overview of this ever-expanding technology from its origins to the current state of the art. The Geodynamics plant in Habanero (Australia), which started up on 2 May 2013, is the first privately-run commercial EGS plant to produce electricity on a large scale. Thanks to the technological development of EGS in recent years, the future looks bright for such plants in the decades to come.
The cascading 3.21 and 4.44 MeV electric quadrupole transitions have been observed from the Hoyle state at 7.65 MeV excitation energy in C12, excited by the C12(p,p′) reaction at 10.7 MeV proton ...energy. From the proton-γ−γ triple coincidence data, a value of Γrad/Γ=6.2(6)×10−4 was obtained for the radiative branching ratio. Using our results, together with ΓπE0/Γ from Eriksen et al. Phys. Rev. C 102, 024320 (2020) and the currently adopted Γπ(E0) values, the radiative width of the Hoyle state is determined as Γrad=5.1(6)×10−3 eV. This value is about 34% higher than the currently adopted value and will impact models of stellar evolution and nucleosynthesis.
Gentamicin is an aminoglycoside antibiotic widely used against infections by Gram-negative microorganisms. Nephrotoxicity is the main limitation to its therapeutic efficacy. Gentamicin nephrotoxicity ...occurs in 10-20% of therapeutic regimes. A central aspect of gentamicin nephrotoxicity is its tubular effect, which may range from a mere loss of the brush border in epithelial cells to an overt tubular necrosis. Tubular cytotoxicity is the consequence of many interconnected actions, triggered by drug accumulation in epithelial tubular cells. Accumulation results from the presence of the endocytic receptor complex formed by megalin and cubulin, which transports proteins and organic cations inside the cells. Gentamicin then accesses and accumulates in the endosomal compartment, the Golgi and endoplasmic reticulum (ER), causes ER stress, and unleashes the unfolded protein response. An excessive concentration of the drug over an undetermined threshold destabilizes intracellular membranes and the drug redistributes through the cytosol. It then acts on mitochondria to unleash the intrinsic pathway of apoptosis. In addition, lysosomal cathepsins lose confinement and, depending on their new cytosolic concentration, they contribute to the activation of apoptosis or produce a massive proteolysis. However, other effects of gentamicin have also been linked to cell death, such as phospholipidosis, oxidative stress, extracellular calcium-sensing receptor stimulation, and energetic catastrophe. Besides, indirect effects of gentamicin, such as reduced renal blood flow and inflammation, may also contribute or amplify its cytotoxicity. The purpose of this review was to critically integrate all these effects and discuss their relative contribution to tubular cell death.
β-decay studies across N = 126 Morales, A. I.
Journal of physics. Conference series,
09/2023, Letnik:
2586, Številka:
1
Journal Article
Recenzirano
Odprti dostop
Abstract
With the advent of the first Radioactive Ion Beam facilities of new generation, the investigation of the neutron-rich side of the nuclear chart has experienced an impressive progress. ...However, the discovery and study of new nuclear species in the region around the heaviest known neutron shell closure,
N
= 126, is still one of the most coveted experimental challenges. At a slower pace, the exploitation of alternative reaction mechanisms and/or advanced instrumentation has opened the possibility to investigate the isomeric and
β
decay of new, moderately neutron-rich
N
∼ 126 nuclei. These are of relevance for the understanding of the nuclear structure below the doubly-magic
208
Pb and for their role in the synthesis of the trans-bismuth fissile elements in the
r
process. In this contribution, a general overview of the
β
-decay experiments performed at both sides of
N
= 126 is provided, with a main focus on the experiments carried out at the fragmentation facilities GSI and RIBF.
PDF
