In this Letter, comprehensive results on π±, K±, KS0, p(p¯) and Λ(Λ¯) production at mid-rapidity (0<yCMS<0.5) in p–Pb collisions at sNN=5.02 TeV, measured by the ALICE detector at the LHC, are ...reported. The transverse momentum distributions exhibit a hardening as a function of event multiplicity, which is stronger for heavier particles. This behavior is similar to what has been observed in pp and Pb–Pb collisions at the LHC. The measured pT distributions are compared to d–Au, Au–Au and Pb–Pb results at lower energy and with predictions based on QCD-inspired and hydrodynamic models.
ANTIMICROBIAL PHOTODYNAMIC THERAPY ON ORAL MUCOSITIS: A PILOT STUDY DA SILVA, VÂNIA CAVALCANTI RIBEIRO; DA MOTTA SILVEIRA, FABIANA MOURA; MONTEIRO, MARIA GABRIELA BARBOSA ...
Oral surgery, oral medicine, oral pathology and oral radiology,
January 2020, 2020-01-00, Letnik:
129, Številka:
1
Journal Article
Recenzirano
To evaluate the effect of antimicrobial photodynamic therapy (PDTa) on the treatment of chemotherapy-induced mucositis in pediatric patients.
It was a pilot study of an open, controlled, and blind ...randomized clinical trial conducted with 29 patients, with ages ranging from 10 months to 18 years, who were divided into 2 groups. Group A was submitted to PDTa with 0.01% methylene blue and red laser with 3 J energy per point; group B was submitted to photobiomodulation with wavelength of 660 nm and 1 J energy per point. The chi-square, Fisher exact, Student's t, and Mann-Whitney tests and the mixed linear regression model were used for comparison between the groups, with the maximum error admitted of 5%.
There was no difference between the groups regarding the number of sessions necessary for clinical cure of the oral lesions (P = .95) or reduction in pain (P = .26; P = .49). Within each group, however, there was significant reduction in pain (P = .03; P = .003).
PDTa could be used for control of oral mucositis in children/young patients. It was well tolerated and presented satisfactory results, the same as photobiomodulation in reducing pain associated with the mucositis.
Objective: To evaluate and compare the efficacy of photodynamic therapy and photobiomodulation in the control of chemotherapy-induced oral mucositis in pediatric patients. Study Design: A ...superiority, randomized, open, controlled, and triple-blind clinical trial consisting of 54 patients aged 10 months to 18 years and totaling 91 cases of oral mucositis were drawn for allocation into 2 groups. Group A (experimental) was subjected to photodynamic therapy (0.01% methylene blue, laser of 660 nm, 100 mW, 0.028 cm2, 3 J) and group B (control) to photobiomodulation (660 nm, 100 mW, 0.028 cm2, 1 J). For evaluating oral mucositis, the World Health Organization and Children's International Mucositis Evaluation Scale (ChIMES) scales were used, and the patients were followed up daily until clinical cure of the lesions. The χ2test, Fisher exact test, Student t test and Mann-Whitney U test, in addition to the mixed linear regression and Poisson models, were used for comparison, with the maximum error admitted of 5%. Results: There was no difference between the groups in regard to the number of sessions necessary for clinical cure of the oral lesions (P = .058), reduction in pain, and difficulty with swallowing or chewing (P> .05). Within each group, however, the reductions were significant (P< .05). Conclusion: Antimicrobial photodynamic therapy presented positive results, similar to photobiomodulation, in minimizing pain and duration of oral mucositis for pediatric patients undergoing to chemotherapy.
MACROGLOSSIA AND AFONIA ASSOCIATED WITH BURKITT’S LYMPHOMA: CASE REPORT CARVALHO, FABIANA MENEZES TEIXEIRA DE; MONTEIRO, MARIA GABRIELA LIMA BARBOSA; SOUSA, THAIS AQUINO MOREIRA DE ...
Oral surgery, oral medicine, oral pathology and oral radiology,
September 2020, 2020-09-00, Letnik:
130, Številka:
3
Journal Article
Recenzirano
A 17-year-old male sought countryside hospital with throat pain and afebrile for 8 days, being prescribed cephalexin. Due to worsening of clinical condition with lingual protrusion and progressive ...loss of voice, he returned other times to the service, when he was referred for health center. He was transferred to emergency care unit and conducted to capital hospital for drainage of retropharyngeal abscess. Patient presented dyspnea, initiating treatment with dexamethasone, with clinical improvement of the tumor, but when suspended, the tumor grew up. He was transferred to intensive care unit and submitted to a computed tomography of skull, tracheostomy, gastrostomy, and excisional biopsy of the lesion that occupied all the oropharynx. He presented cardiorespiratory arrest, seizures, and respiratory infection. Results of biopsy and immunohistochemistry diagnosed Burkitt’s lymphoma. Patient was submitted to chemotherapy with regression of the lesion and return the tongue to the normal conditions.
The production of muons from heavy flavour decays is measured at forward rapidity in proton–proton collisions at s=7 TeV collected with the ALICE experiment at the LHC. The analysis is carried out on ...a data sample corresponding to an integrated luminosity Lint=16.5 nb−1. The transverse momentum and rapidity differential production cross sections of muons from heavy flavour decays are measured in the rapidity range 2.5<y<4, over the transverse momentum range 2<pt<12 GeV/c. The results are compared to predictions based on perturbative QCD calculations.
New cyclopalladated compounds were synthesized and their antiproliferative activities against some human tumor cell lines were similar to those of cisplatin. The complexes displayed no significant ...binding with DNA and were unable to inhibit topoisomerase II activity. Studies showed that human serum albumin (HSA) can transport these compounds.
Display omitted
Metathetical reactions involving Pd(C2,N-dmpa)(μ-Cl)2 (1) and the appropriate halides/pseudohalides salts afforded cyclopalladated dimers of the type Pd(C2,N-dmpa)(μ-X)2 (dmpa = S(−) enantiomer of N,N-dimethyl-1-phenethylamine; {X = Cl (1) and N3 (2)}. Mononuclear compounds of general formulae Pd(C2,N-dmpa)(X)(lut) {X = Cl (1a) and N3 (2a)} were obtained by bridge-splitting reactions involving the corresponding Pd(C2,N-dmpa)(μ-X)2 with 2,6-lutidine (lut) in the 1:2 M ratio at room temperature. Both the cyclopalladated compounds were characterized by means of elemental analysis, FT-IR, Raman, 1H and 13C NMR spectroscopy. The antiproliferative activity of the mononuclear compounds 1a-2a was evaluated towards human glioblastoma (U251 and T98G) and melanoma cell lines (HT144 and LB373) and their IC50 values determined between 1 and 6 μM. In most cases, the cytotoxic effects of compounds 1a-2a showed to be similar to those of cisplatin (depending on the cell line), what is of utmost importance when considering treatment alternatives for these aggressive tumor types. Binding studies on the representative compound 2a towards ct-DNA, however, showed low or no affinity, suggesting that the observed cytotoxicity against the human cell lines may involve different mechanisms of action compared to that of the platinum-based chemotherapy drug. The ability of 1a to induce the inhibition of topoisomerase IIα activity has also been investigated. These cyclopalladated compounds can be transported and distributed through the body by human serum albumin (HSA), as observed by competition and computational studies with the protein. These findings are very promising and have motivated further studies for the design of new and bioactive cyclopalladated compounds for future medicinal purposes.
We present a calculation of the elliptic flow of electrons from beauty-hadron decays in semi-central Pb-Pb collisions at centre-of-mass energy per colliding nucleon pair, represented as Formula ...omitted, of 2.76 TeV. The result is obtained by the subtraction of the charm-quark contribution in the elliptic flow of electrons from heavy-flavour hadron decays in semi-central Pb-Pb collisions at Formula omitted recently made publicly available by the ALICE collaboration.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Asian rust (Phakopsora pachyrhizi) is a common disease in Brazilian soybean fields and it is difficult to control. To identify a biochemical candidate with potential to combat this disease, a new ...chitinase-like xylanase inhibitor protein (XIP) from coffee (Coffea arabica) (CaclXIP) leaves was cloned into the pGAPZα-B vector for expression in Pichia pastoris.
A cDNA encoding a chitinase-like xylanase inhibitor protein (XIP) from coffee (Coffea arabica) (CaclXIP), was isolated from leaves. The amino acid sequence predicts a (β/α)8 topology common to Class III Chitinases (glycoside hydrolase family 18 proteins; GH18), and shares similarity with other GH18 members, although it lacks the glutamic acid residue essential for catalysis, which is replaced by glutamine. CaclXIP was expressed as a recombinant protein in Pichia pastoris. Enzymatic assay showed that purified recombinant CaclXIP had only residual chitinolytic activity. However, it inhibited xylanases from Acrophialophora nainiana by approx. 60% when present at 12:1 (w/w) enzyme:inhibitor ratio. Additionally, CaclXIP at 1.5 μg/μL inhibited the germination of spores of Phakopsora pachyrhizi by 45%.
Our data suggests that CaclXIP belongs to a class of naturally inactive chitinases that have evolved to act in plant cell defence as xylanase inhibitors. Its role on inhibiting germination of fungal spores makes it an eligible candidate gene for the control of Asian rust.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
IMPORTANCE: Slower intravenous fluid infusion rates could reduce the formation of tissue edema and organ dysfunction in critically ill patients; however, there are no data to support different ...infusion rates during fluid challenges for important outcomes such as mortality. OBJECTIVE: To determine the effect of a slower infusion rate vs control infusion rate on 90-day survival in patients in the intensive care unit (ICU). DESIGN, SETTING, AND PARTICIPANTS: Unblinded randomized factorial clinical trial in 75 ICUs in Brazil, involving 11 052 patients requiring at least 1 fluid challenge and with 1 risk factor for worse outcomes were randomized from May 29, 2017, to March 2, 2020. Follow-up was concluded on October 29, 2020. Patients were randomized to 2 different infusion rates (reported in this article) and 2 different fluid types (balanced fluids or saline, reported separately). INTERVENTIONS: Patients were randomized to receive fluid challenges at 2 different infusion rates; 5538 to the slower rate (333 mL/h) and 5514 to the control group (999 mL/h). Patients were also randomized to receive balanced solution or 0.9% saline using a factorial design. MAIN OUTCOMES AND MEASURES: The primary end point was 90-day survival. RESULTS: Of all randomized patients, 10 520 (95.2%) were analyzed (mean age, 61.1 years SD, 17.0 years; 44.2% were women) after excluding duplicates and consent withdrawals. Patients assigned to the slower rate received a mean of 1162 mL on the first day vs 1252 mL for the control group. By day 90, 1406 of 5276 patients (26.6%) in the slower rate group had died vs 1414 of 5244 (27.0%) in the control group (adjusted hazard ratio, 1.03; 95% CI, 0.96-1.11; P = .46). There was no significant interaction between fluid type and infusion rate (P = .98). CONCLUSIONS AND RELEVANCE: Among patients in the intensive care unit requiring fluid challenges, infusing at a slower rate compared with a faster rate did not reduce 90-day mortality. These findings do not support the use of a slower infusion rate. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02875873
We present a calculation of the elliptic flow of electrons from beauty-hadron decays in semi-central Pb–Pb collisions at centre-of-mass energy per colliding nucleon pair, represented as sNN, of 2.76 ...TeV. The result is obtained by the subtraction of the charm-quark contribution in the elliptic flow of electrons from heavy-flavour hadron decays in semi-central Pb–Pb collisions at sNN=2.76TeV recently made publicly available by the ALICE collaboration.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
PDF
