Clinical parameters and proteins have recently been suggested as possible causes of radiotherapy (RT) resistance in cervical carcinoma (CC). The objective of the present study was to validate ...prognostic biomarkers of radiation resistance.
The present prospective study included patients undergoing RT with curative intent for histologically proven locally advanced squamous cell CC. Tissues and blood samples were systematically collected before RT initiation. Immuno-histochemistry was performed (IGF-IR α and β, GAPDH, HIF-1 alpha, Survivin, GLUT1, CAIX, hTERT and HKII). Response to radiation was assessed through tumour response 3 months after RT completion, through overall survival (OS) and through progression-free survival (PFS).
One hundred forty nine patients with a mean age of 46 years were included, with FIGO IIB (n = 53) and FIGO IIIB (n = 96) CCs. 61 patients were treated with exclusive RT + brachytherapy and 88 underwent chemo-radiotherapy + brachytherapy. Our findings suggest an association between hemoglobin level (Hb) (>11 g/dL) and 3 months complete response (p = 0.02). Hb level < 11 g/dL was associated with decreased PFS (p = 0.05) and OS (p = 0.08). Overexpression of IGF-1R β was correlated with a decreased OS (p = 0.007). Overexpression of GLUT1 was marginally correlated with reduced OS (p = 0.05). PFS and OS were significantly improved in patients undergoing chemoradiation versus exclusive radiotherapy (PFS: p = 0.04; OS: p = 0.01).
IGF-1R β overexpression and Hb level (≤11 g/dl) were associated with poor prognosis, and thus appear to be possible interesting biomarkers of radiation resistance. Our results corroborate previous pre-clinical studies suggesting IGF-1R and hypoxia to be part of the biological pathways leading to radio-resistance.
Since theorem 1 of (Elhadj and Sprott, 2012) is incorrect, some of the systems found in the article (Casas-García et al. 2016) may have homoclinic or heteroclinic orbits and may seem chaos in the ...Shilnikov sense. However, the fundamental contribution of our paper was to find ten simple, three-dimensional dynamic systems with non-linear quadratic terms that have an asymptotically stable equilibrium point and are chaotic, which was achieved. These were obtained using the Monte Carlo method applied specifically for the search of these systems.
Based on a wider systematic search on a family of 3-dimensional systems with quadratic nonlinearities, three new simple chaotic systems were found. One of them has the unusual feature of having a ...stable equilibrium point, and it is the simplest one of other chaotic flows with this property. The others have some interesting special properties.
Abstract In this paper ten new chaotic nonlinear autonomous systems are presented. These systems were found by using the Monte Carlo method and they characterized by having one of their equilibrium ...points asymptotically stable. These new systems does not present chaos in the sense of Shilnikov, but their bifurcation diagrams show a period-doubling route towards chaos. Kaplan- Yorke dimensions were also calculated, which is fractional order enclosed in a range of 2-3.
The CMS experiment, located at the Large Hadron Collider (LHC) in CERN, has a redundant muon system composed by three different gaseous detector technologies: Cathode Strip Chambers (in the forward ...regions), Drift Tubes (in the central region), and Resistive Plate Chambers (both its central and forward regions). All three are used for muon reconstruction and triggering. The CMS RPC system confers robustness and redundancy to the muon trigger. The RPC system operation in the challenging background and pileup conditions of the LHC environment is presented. The RPC system provides information to all muon track finders and thus contributing to both muon trigger and reconstruction. The summary of the detector performance results obtained with proton-proton collision at s=13 TeV during 2016 and 2017 data taking have been presented. The stability of the system is presented in terms of efficiency and cluster size vs time and increasing instantaneous luminosity. Data-driven predictions about the expected performance during High Luminosity LHC (HL-LHC) stage have been reported.
RPC upgrade project for CMS Phase II Pedraza-Morales, M.I.; Fagot, A.; Gul, M. ...
Journal of instrumentation,
05/2020, Letnik:
15, Številka:
5
Journal Article
Recenzirano
Odprti dostop
The Muon Upgrade Phase II of the Compact Muon Solenoid (CMS) aims to guarantee the optimal conditions of the present system and extend the η coverage to ensure a reliable system for the High ...Luminosity Large Hadron Collider (HL-LHC) period. The Resistive Plate Chambers (RPCs) system will upgrade the off-detector electronics (called link system) of the chambers currently installed chambers and place improved RPCs (iRPCs) to cover the high pseudo−rapidity region, a challenging region for muon reconstruction in terms of background and momentum resolution. In order to find the best option for the iRPCs, an R&D program for new detectors was performed and real size prototypes have been tested in the Gamma Irradiation Facility (GIF++) at CERN. The results indicated that the technology suitable for the high background conditions is based on High Pressure Laminate (HPL) double-gap RPC. The RPC Upgrade Phase II program is planned to be ready after the Long Shutdown 3 (LS3).
High-sensitivity double-gap phenolic resistive plate chambers (RPCs) are studied for the Phase-2 upgrade of the Compact Muon Solenoid (CMS) muon system at high pseudorapidity
η
. Whereas the present ...CMS RPCs have a gas gap thickness of 2 mm, we propose to use thinner gas gaps, which will improve the performance of these RPCs. To validate this proposal, we constructed double-gap RPCs with two different gap thicknesses of 1.2 and 1.4 mm by using high-pressure laminated plates having a mean resistivity of about 5 × 10
10
Ω-cm. This paper presents test results using cosmic muons and
137
Cs gamma rays. The rate capabilities of these thin-gap RPCs measured with the gamma source exceed the maximum rate expected in the new high-
η
endcap RPCs planned for future Phase-2 runs of the Large Hadron Collider (LHC).
In the next decades, the Large Hadron Collider (LHC) will run at very high luminosity (HL-LHC) 5×1034 cm−2s−1, factor five more than the nominal LHC luminosity. During this period the CMS RPC system ...will be subjected to high background rates which could affect the performance by inducing aging effects. A dedicated longevity program to qualify the present RPC system for the HL-LHC running period is ongoing. At the CERN Gamma Irradiation Facility (GIF++) four RPC detectors, from the spare production, are exposed to an intense gamma radiation for a dose equivalent to the one expected at the HL-LHC . The main detector parameters are under monitoring as a function of the integrated charge and the performance is studied with a muon beam. Preliminary results of the study after having collected ≈ 34% of the expected integrated charge will be presented.
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