A young man, 28 years old, was admitted to Infectious Division with transaminases over 2500 U/ml, reduced cortical activity and decerebrate posturing. A prolonged APTT, Prothrombin below 15%, very ...low levels of Factor II, V, VII (5-20%). At III by S-2238 (17%), Antiplasmin (20%) and Plasminogen(5%) by S-2251, Preltallikrein by S-2302 (5%). Fibrinogen (70mg%) but very high VIII AHF(4.5U/ml}, VIII AGN (4.0U/ml) and VIII VWF (3.8U/ml) were recorded. After 3 daily dialysis sessions with polyacrilonitrile membrane (RP 6) a marked improvement was observed. The patient awoke while prothrombin and platelet recovery took place, fibrinogen,VIII AHF and Factor V rose over normal value to 600mg%, 7.5U/ml and 3U/ml rispectively. Antiplasmin, Plasminogen, PKK showed a slow but costant improvement. Unfortunatly a venous thrombosis and sepsis set in during the 2nd day after dialysis, with a rapid decrease of platelets. Heparin infusion 1 mg/kg b.w. was infused every 6 hrs. After 15days platelet returned to normal value and VIII AHF to initial level but it was still higher (4U/ml) than normal value after 2 mounths from recovery.
