Aim
To evaluate the effectiveness of a 24‐week program of nutritional supplementation using whey protein, ingested after resistance exercise, in increasing muscle mass and physical function among ...community‐dwelling healthy older Japanese women.
Methods
We carried out a randomized controlled trial, with 81 healthy women, aged 65–80 years, allocated to three groups of 27 participants each: the exercise and protein supplementation group, the exercise only group, and the protein supplementation only group. A 24‐week program of resistance exercise, carried out twice per week, was combined with whey protein supplementation, containing 22.3 g of protein. The total protein intake for participants in all three experimental groups was adjusted to a level of at least 1.2 g/kg bodyweight/day, and more during the intervention period. Between‐group differences in the pre‐ to post‐intervention change in skeletal muscle mass and physical function were evaluated using an analysis of variance.
Results
The pre‐ to post‐intervention increase in the skeletal muscle mass index was significantly higher for the exercise only group than for the protein supplementation only group (P =0.008), and significantly higher for the exercise and protein supplementation group than for either the exercise only (P =0.007) or protein supplementation only (P <0.001) groups. Similarly, the increase in grip strength and gait speed was significantly greater for the exercise and protein supplementation group than for the protein supplementation only group (grip strength P =0.014, gait speed P =0.026).
Conclusions
Whey protein supplementation, ingested after resistance exercise, could be effective for the prevention of sarcopenia among healthy community‐dwelling older Japanese women. Geriatr Gerontol Int 2018; 18: 1398–1404.
Background and Objectives: Sarcopenia and frailty result in loss of function and independence. Sarcopenia may be a risk factor for frailty; however, risk factors for sarcopenia with frailty, and ...associated incidence of falls and poor quality of life remain unclear. We investigated the clinical characteristics and relevant factors for sarcopenia with frailty in older community-dwelling Japanese.
Methods and Study Design: This cross-sectional study included 331 Japanese community-dwelling adults aged >=60 years. We assessed falls history in the past year, health-related quality of life (HRQOL), including physical component summary (PCS) and mental component summary (MCS), age, total energy intake per ideal body weight (TEI/kg IBW), total protein intake/kg IBW, vitamin D intake, and exercise habits. Sarcopenia was determined using low hand grip strength or slow gait speed and low skeletal muscle mass index. Frailty was determined if >=3 components, such as unintended weight loss, exhaustion, low muscle strength, slow gait speed, and low physical activity were present.
Results: The prevalence of sarcopenia with frailty was 3.6%; such participants had a higher risk of recurrent falls and lower PCS and MCS scores than robust participants. Age, TEI/kg IBW, total protein intake/kg IBW, and vitamin D intake were significantly associated with risk of sarcopenia with frailty by multivariate logistic regression analysis.
Conclusions: This study showed that sarcopenia with frailty was had higher incidences of recurrent fall and poor HRQOL than robust older adults. Aging and poor energy, protein, and vitamin D intake, may be relevant factors for sarcopenia with frailty.
Background and Objectives: We evaluated the effectiveness of a 24-week nutritional ingestion program involving essential amino acid (AA) and tea catechin (TC) intake after performing resistance ...exercise in increasing the skeletal muscle mass, physical performance, and quality of life of healthy older people. Methods and Study Design: An open-label randomized controlled trial involving 84-healthy older individuals (age >=65 years) without sarcopenia, diabetes, and kidney disease, was conducted. They were allocated to the exercise (n=28), exercise and essential AA ingestion (n=28), and exercise, essential AA, and TC ingestion groups (n=28). The participants underwent a 24-week program of resistance exercise (performed twice per week) along with essential AA and TC intake (3,000 and 540 mg, respectively). Results: Six participants could not complete the intervention after randomization. After the 24-week intervention period, the exercise, essential AA, and TC ingestion groups showed an increase in the skeletal muscle mass index, one-legged balance test, and physical quality of life score (skeletal muscle mass index, p=0.004; one-legged balance test, p=0.045; physical quality of life, p=0.020). After the 24- week intervention period, the exercise and essential AA ingestion group showed an increase in the skeletal muscle mass index and physical quality of life score (skeletal muscle mass index, p=0.014; physical quality of life, p=0.041). However, the exercise group did not show an increase in the skeletal muscle mass index. Conclusions: These results suggested that resistance exercise, essential AA, and TC intake in healthy older people could improve physical performance.
Sarcopenia as a progressive and generalized skeletal muscle disorder that is associated with an increased likelihood of adverse outcomes, including falls, fractures, physical disability, and ...mortality. On the other hand, an age-related decline in muscle strength prior to the reduction of muscle mass, is proposed to be “dynapenia”. Sarcopenia and dynapenia have recently been recognized as a diabetic complications in type 2 diabetes. We firstly indicated that sarcopenia was frequently observed in 16.6% of patients with type 1 diabetes aged even over 40 years. Additionally, we recently reported that the prevalence rate of dynapenia was higher than sarcopenia in patients with type 2 diabetes. Chronic hyperglycemia accelerates accumulation of advanced glycation end products (AGEs), which causes diabetic vascular complications through oxidative stress and chronic inflammation. We also demonstrated that skin autofluorescence (AF) as a marker of AGEs, was the independent determinant for skeletal muscle mass and strength in patients with type 2 diabetes and muscle strength in type 1 diabetes. Therefore, the early diagnosis of muscle weakness is essential for patients with diabetes and sustained good glycemic control with exercise and dietary intervention might be beneficial to prevent the progression of muscle weakness in these patients.
Aims/Introduction
Advanced glycation end‐products (AGEs), which are a major cause of diabetic vascular complications, accumulate in various tissues under chronic hyperglycemic conditions, as well as ...with aging in patients with diabetes. The loss of muscle mass and strength, so‐called sarcopenia and dynapenia, has recently been recognized as a diabetic complication. However, the influence of accumulated AGEs on muscle mass and strength remains unclear. The present study aimed to evaluate the association of sarcopenia and dynapenia with accumulated AGEs in patients with type 2 diabetes.
Materials and Methods
We recruited 166 patients with type 2 diabetes aged ≥30 years (mean age 63.2 ± 12.3 years; body mass index 26.3 ± 4.9 kg/m2; glycated hemoglobin 7.1 ± 1.1%). Skin autofluorescence as a marker of AGEs, limb skeletal muscle mass index, grip strength, knee extension strength and gait speed were assessed.
Results
Sarcopenia and dynapenia were observed in 7.2 and 13.9% of participants, respectively. Skin autofluorescence was significantly higher in patients with sarcopenia and dynapenia. Skin autofluorescence was the independent determinant for skeletal muscle mass index, grip strength, knee extension strength, sarcopenia and dynapenia.
Conclusions
Accumulated AGEs could contribute to reduced muscle mass and strength, leading to sarcopenia and dynapenia in patients with type 2 diabetes.
The prevalence rates of sarcopenia and dynapenia were 7.2 and 13.9%, respectively, which seemed to be higher than those of non‐diabetic subjects in previous report from Japan. Interestingly, skin autofluorescence (AF) was significantly higher in patients with sarcopenia and dynapenia than patients without those. Skin AF was the independent determinant for sarcopenia and dynapenia.
This study examined the non-inferior efficacy of telenutrition education compared with face-to-face nutrition education in managing glycemic control in people with type 2 diabetes mellitus (T2DM). ...Participants had T2DM and a glycated hemoglobin (HbA1c) ranged 6.5-9.5%. Thirty participants were randomly assigned to either the telenutrition or face-to-face nutrition education group. During the 32-week intervention period, the participants received four sessions on nutrition education from a registered dietitian at the hospital. The telenutrition group received remote education via a videoconferencing platform. Face-to-face nutrition education was conducted using paper-based instructions. The main outcome measure was the non-inferiority of HbA1c levels in the telenutrition group compared to the face-to-face nutrition group. The non-inferiority of telenutrition education was considered valid if the intergroup difference in the mean values of the change in HbA1c had a bilateral 95% confidence interval (CI) upper limit below 0.40%. The intergroup difference in the mean HbA1c change from baseline to the fourth nutrition education session was -0.11 (95% CI -0.54-0.32) for both groups. The upper limit of the bilateral 95% CI was 0.32%, which was below the 0.40% non-inferiority margin (non-inferiority test;
= 0.011). Telenutrition education was not inferior to face-to-face nutrition education for glycemic management in people with T2DM.
Dysgeusia is not only associated with zinc deficiency but also with certain drugs or diseases, including diabetes and renal failure. It often lowers the patient’s quality of life and hinders access ...to proper nutrition. The underlying mechanism is unclear and there is a lack of awareness among patients. Here, we focused on lingual taste receptor gene expression in diabetes and elucidated the relationship between taste receptor gene expression and renal function. Forty-seven patients with diabetes and 10 healthy subjects (control group) were enrolled. Lingual foliate papillae were scraped and the derived cDNA was quantified by real-time polymerase chain reaction. Dysgeusia was assessed using SALSAVE?. All statistical analyses were performed using JMP? software 13. The expression of T1R1 and T1R2 was significantly upregulated in type 2 diabetes patients as compared with that in healthy subjects (P<0.01) but did not change in type 1 diabetes patients. T1R3 expression positively correlated and Scnn1 expression negatively correlated with estimated glomerular filtration rate, suggesting that altered taste receptor gene expression could reflect impaired renal function. Thus, alterations in T1R3 and Scnn1 expression in diabetes correlated with renal function. Taste receptor gene expression dysregulation could indicate dysgeusia associated with impaired renal function in patients with diabetes. J. Med. Invest. 69 : 120-126, February, 2022
Accumulation of advanced glycation end‐products (AGEs) is thought to contribute to muscle weakness in a diabetic animal model. Skin autofluorescence is a proposed marker for accumulation of AGEs in ...the skin. We aimed to investigate the relationship between AGEs accumulation, sarcopenia and muscle function of Japanese patients with type 1 diabetes. A total of 36 patients with type 1 diabetes participated in the present cross‐sectional study. Sarcopenia parameters (skeletal muscle mass index and knee extension strength) were compared with subcutaneous AGEs accumulation using skin autofluorescence. The prevalence of sarcopenia and impaired knee extension strength was 16.6% (men 0.0%, women 22.2%) and 47.2% (men 22.2%, women 55.6%), respectively. Knee extension strength was negatively correlated with skin autofluorescence (r² = 0.14, P < 0.05), but not with skeletal muscle mass index. In conclusion, the AGEs accumulation might be one of the reasons of impaired lower limb muscle function in Japanese patients with type 1 diabetes.
The purpose of this study is to investigate the relationship between AGE accumulations, sarcopenia and muscle function of patients with type 1 diabetes. We found that impaired muscle function in lower limb was highly observed in type 1 diabetes, and was associated with accumulation of AGE.
Aims/Introduction
To investigate the basal insulin requirement in patients with type 1 diabetes who are on multiple daily injections (MDI) and to assess the patient characteristics that affect the ...percent of total daily basal insulin dose to the total daily insulin dose (%TBD/TDD).
Materials and Methods
The subjects of this study were 67 inpatients with type 1 diabetes who were served diabetic meals of 25–30 kcal/kg standard body weight during several weeks of hospitalization. The basal insulin requirement was adjusted to keep the blood glucose level from bedtime to before breakfast within a 30 mg/dL difference. The bolus insulin dose before the meal was adjusted to keep the blood glucose level below 140 and 200 mg/dL before and 2 h after each meal, respectively. The total daily insulin dose (TDD), the percent of total daily basal insulin dose (TBD) to TDD (%TBD/TDD), and clinical characteristics were collected.
Results
The median (Q1, Q3) of TDD was 33.0 (26.0, 49.0) units, and the %TBD/TDD was 24.1 ± 9.8%. The %TBD/TDD was positively correlated with the body mass index (BMI) and negatively correlated with the age at the onset and at the examination according to a univariate analysis. However, the %TBD/TDD was dependent on the BMI (β = 0.340, P = 0.004) and the age at examination (β = −0.288, P = 0.012) according to the multiple regression analysis.
Conclusions
The average %TBD/TDD in patients with type 1 diabetes on MDI was approximately 24% under inpatient conditions. The basal insulin requirement was dependent on the BMI and the age at examination.
To investigate basal insulin requirement in patients with type 1 diabetes who are on multiple daily injection therapy (MDI), and to assess the patient characteristics, which affect the percent of total daily basal insulin dose to the total daily insulin dose (%TBD/TDD). The average of %TBD/TDD in patients with type 1 diabetes who are on MDI was approximately 24% under inpatient conditions. The basal insulin requirement was dependent on BMI and age at examination.
The objective of the present study was to investigate the correlations between serum undercarboxylated osteocalcin (ucOC) or osteocalcin (OC) concentrations and %body fat, serum adiponectin and ...free-testosterone concentration, muscle strength and dose of exogenous insulin in patients with type 1 diabetes. We recruited 73 Japanese young adult patients with childhood-onset type 1 diabetes. All participants were receiving insulin replacement therapy. The correlations between logarithmic serum ucOC or OC concentrations and each parameter were examined. Serum ucOC and OC concentrations were inversely correlated with %body fat (r = -0.319, P = 0.007; r = -0.321, P = 0.006, respectively). Furthermore, multiple linear regression analyses were performed to determine whether or not serum ucOC or OC concentrations were factors associated with %body fat. Serum ucOC and OC concentrations remained significant factors even after adjusting for gender, HbA1c, body weight-adjusted total daily dose of insulin and duration of diabetes (β = -0.260, P = 0.027; β = -0.254, P = 0.031, respectively). However, serum ucOC and OC concentrations were not correlated with serum adiponectin or free-testosterone concentrations, muscle strength or dose of exogenous insulin. In conclusion, our study demonstrates the inverse correlation between serum ucOC or OC concentrations and body fat in patients with type 1 diabetes.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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