Xeroderma pigmentosum (XP) is a rare DNA repair disorder characterized by increased susceptibility to UV radiation (UVR)-induced skin pigmentation, skin cancers, ocular surface disease, and, in some ...patients, sunburn and neurological degeneration. Genetically, it is assigned to eight complementation groups (XP-A to -G and variant). For the last 5 y, the UK national multidisciplinary XP service has provided follow-up for 89 XP patients, representing most of the XP patients in the United Kingdom. Causative mutations, DNA repair levels, and more than 60 clinical variables relating to dermatology, ophthalmology, and neurology have been measured, using scoring systems to categorize disease severity. This deep phenotyping has revealed unanticipated heterogeneity of clinical features, between and within complementation groups. Skin cancer is most common in XP-C, XP-E, and XP-V patients, previously considered to be the milder groups based on cellular analyses. These patients have normal sunburn reactions and are therefore diagnosed later and are less likely to adhere to UVR protection. XP-C patients are specifically hypersensitive to ocular damage, and XP-F and XP-G patients appear to be much less susceptible to skin cancer than other XP groups. Within XP groups, different mutations confer susceptibility or resistance to neurological damage. Our findings on this large cohort of XP patients under long-term follow-up reveal that XP is more heterogeneous than has previously been appreciated. Our data now enable provision of personalized prognostic information and management advice for each XP patient, as well as providing new insights into the functions of the XP proteins.
Understanding gravity in the framework of quantum mechanics is one of the great challenges in modern physics. However, the lack of empirical evidence has lead to a debate on whether gravity is a ...quantum entity. Despite varied proposed probes for quantum gravity, it is fair to say that there are no feasible ideas yet to test its quantum coherent behavior directly in a laboratory experiment. Here, we introduce an idea for such a test based on the principle that two objects cannot be entangled without a quantum mediator. We show that despite the weakness of gravity, the phase evolution induced by the gravitational interaction of two micron size test masses in adjacent matter-wave interferometers can detectably entangle them even when they are placed far apart enough to keep Casimir-Polder forces at bay. We provide a prescription for witnessing this entanglement, which certifies gravity as a quantum coherent mediator, through simple spin correlation measurements.
We propose an interferometric scheme based on an untrapped nano-object subjected to gravity. The motion of the center of mass (c.m.) of the free object is coupled to its internal spin system ...magnetically, and a free flight scheme is developed based on coherent spin control. The wave packet of the test object, under a spin-dependent force, may then be delocalized to a macroscopic scale. A gravity induced dynamical phase (accrued solely on the spin state, and measured through a Ramsey scheme) is used to reveal the above spatially delocalized superposition of the spin-nano-object composite system that arises during our scheme. We find a remarkable immunity to the motional noise in the c.m. (initially in a thermal state with moderate cooling), and also a dynamical decoupling nature of the scheme itself. Together they secure a high visibility of the resulting Ramsey fringes. The mass independence of our scheme makes it viable for a nano-object selected from an ensemble with a high mass variability. Given these advantages, a quantum superposition with a 100 nm spatial separation for a massive object of 10^{9} amu is achievable experimentally, providing a route to test postulated modifications of quantum theory such as continuous spontaneous localization.
ABSTRACT We use a 1D model to address photochemistry and possible haze formation in the irradiated warm Jupiter, 51 Eridani b. The intended focus was to be carbon, but sulfur photochemistry turns out ...to be important. The case for organic photochemical hazes is intriguing but falls short of being compelling. If organic hazes form, they are likeliest to do so if vertical mixing in 51 Eri b is weaker than in Jupiter, and they would be found below the altitudes where methane and water are photolyzed. The more novel result is that photochemistry turns H2S into elemental sulfur, here treated as S8. In the cooler models, S8 is predicted to condense in optically thick clouds of solid sulfur particles, while in the warmer models S8 remains a vapor along with several other sulfur allotropes that are both visually striking and potentially observable. For 51 Eri b, the division between models with and without condensed sulfur is at an effective temperature of 700 K, which is within error its actual effective temperature; the local temperature where sulfur condenses is between 280 and 320 K. The sulfur photochemistry we have discussed is quite general and ought to be found in a wide variety of worlds over a broad temperature range, both colder and hotter than the 650-750 K range studied here, and we show that products of sulfur photochemistry will be nearly as abundant on planets where the UV irradiation is orders of magnitude weaker than it is on 51 Eri b.
Abstract
We present the first results from applying the spectral inversion technique in the cloudy L dwarf regime. Our new framework provides a flexible approach to modelling cloud opacity which can ...be built incrementally as the data require and improves upon previous retrieval experiments in the brown dwarf regime by allowing for scattering in two-stream radiative transfer. Our first application of the tool to two mid-L dwarfs is able to reproduce their near-infrared spectra far more closely than grid models. Our retrieved thermal, chemical and cloud profiles allow us to estimate
$T_{\rm eff} = 1796^{+23}_{-25}$
K and
$\log g = 5.21^{+0.05}_{-0.08}$
for 2MASS J05002100+0330501, and for 2MASSW J2224438−015852 we find
$T_{\rm eff} = 1723^{+18}_{-19}$
K and
$\log g = 5.31^{+0.04}_{-0.08}$
, in close agreement with previous empirical estimates. Our best model for both objects includes an optically thick cloud deck which passes τcloud ≥ 1 (looking down) at a pressure of around 5 bar. The temperature at this pressure is too high for silicate species to condense, and we argue that corundum and/or iron clouds are responsible for this cloud opacity. Our retrieved profiles are cooler at depth and warmer at altitude than the forward grid models that we compare, and we argue that some form of heating mechanism may be at work in the upper atmospheres of these L dwarfs. We also identify anomalously high CO abundance in both targets, which does not correlate with the warmth of our upper atmospheres or our choice of cloud model, and find similarly anomalous alkali abundance for one of our targets. These anomalies may reflect unrecognized shortcomings in our retrieval model or inaccuracies in our gas phase opacities.
We show how the interference between spatially separated states of the center of mass (c.m.) of a mesoscopic harmonic oscillator can be evidenced by coupling it to a spin and performing solely spin ...manipulations and measurements (Ramsey interferometry). We propose to use an optically levitated diamond bead containing a nitrogen-vacancy center spin. The nanoscale size of the bead makes the motional decoherence due to levitation negligible. The form of the spin-motion coupling ensures that the scheme works for thermal states so that moderate feedback cooling suffices. No separate control or observation of the c.m. state is required and thereby one dispenses with cavities, spatially resolved detection, and low-mass-dispersion ensembles. The controllable relative phase in the Ramsey interferometry stems from a gravitational potential difference so that it uniquely evidences coherence between states which involve the whole nanocrystal being in spatially distinct locations.
A nitrogen-vacancy (NV(-)) centre in a nanodiamond, levitated in high vacuum, has recently been proposed as a probe for demonstrating mesoscopic centre-of-mass superpositions and for testing quantum ...gravity. Here, we study the behaviour of optically levitated nanodiamonds containing NV(-) centres at sub-atmospheric pressures and show that while they burn in air, this can be prevented by replacing the air with nitrogen. However, in nitrogen the nanodiamonds graphitize below ≈10 mB. Exploiting the Brownian motion of a levitated nanodiamond, we extract its internal temperature (T(i)) and find that it would be detrimental to the NV(-) centre's spin coherence time. These values of T(i) make it clear that the diamond is not melting, contradicting a recent suggestion. Additionally, using the measured damping rate of a levitated nanoparticle at a given pressure, we propose a new way of determining its size.
A field-deployable water vapor profiling instrument that builds on the foundation of the preceding generations of diode-laser-based differential absorption lidar (DIAL) laboratory prototypes was ...constructed and tested. Significant advances are discussed, including a unique shared telescope design that allows expansion of the outgoing beam for eye-safe operation with optomechanical and thermal stability; multistage optical filtering enabling measurement during daytime bright-cloud conditions; rapid spectral switching between the online and offline wavelengths enabling measurements during changing atmospheric conditions; and enhanced performance at lower ranges by the introduction of a new filter design and the addition of a wide field-of-view channel. Performance modeling, testing, and intercomparisons are performed and discussed. In general, the instrument has a 150 m range resolution with a 10 min temporal resolution; 1 min temporal resolution in the lowest 2 km of the atmosphere is demonstrated. The instrument is shown capable of autonomous long-term field operation - 50 days with a > 95% uptime - under a broad set of atmospheric conditions and potentially forms the basis for a ground-based network of eye-safe autonomous instruments needed for the atmospheric sciences research and forecasting communities.
Abstract Objectives Gender differences in psychotic disorder have been observed in terms of illness onset and course; however, past research has been limited by inconsistencies between studies and ...the lack of epidemiological representative of samples assessed. Thus, the aim of this study was to elucidate gender differences in a treated epidemiological sample of patients with first episode psychosis (FEP). Methods A medical file audit was used to collect data on premorbid, entry, treatment and 18-month outcome characteristics of 661 FEP consecutive patients treated at the Early Psychosis Prevention and Intervention Centre (EPPIC), Melbourne, Australia. Results Prior to onset of psychosis, females were more likely to have a history of suicide attempts ( p = .011) and depression ( p = .001). At service entry, females were more likely to have depressive symptoms ( p = .007). Conversely, males had marked substance use problems that were evident prior to admission ( p < .001) and persisted through treatment ( p < .001). At service entry, males also experienced more severe psychopathology ( p < .001) and lower levels of functioning (GAF, p = .008; unemployment/not studying p = .004; living with family, p = .003). Treatment non-compliance ( p < .001) and frequent hospitalisations ( p = .047) were also common for males with FEP. At service discharge males had significantly lower levels of functioning (GAF, p = .008; unemployment/not studying p = .040; living with family, p = .001) compared to females with FEP. Conclusions Gender differences are evident in illness course of patients with FEP, particularly with respect to past history of psychopathology and functioning at presentation and at service discharge. Strategies to deal with these gender differences need to be considered in early intervention programs.
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