Context. The flat-spectrum radio quasar 4C +71.07 is a high-redshift (z = 2.172), γ-loud blazar whose optical emission is dominated by thermal radiation from the accretion disc. Aims. 4C +71.07 has ...been detected in outburst twice by the AGILE γ-ray satellite during the period from the end of October to mid-November 2015, when it reached a γ-ray flux of the order of F(E > 100 MeV)=(1.2 ± 0.3)×10−6 photons cm−2 s−1 and F(E > 100 MeV)=(3.1 ± 0.6)×10−6 photons cm−2 s−1, respectively, allowing us to investigate the properties of the jet and the emission region. Methods. We investigated its spectral energy distribution by means of almost-simultaneous observations covering the cm, mm, near-infrared, optical, ultraviolet, X-ray, and γ-ray energy bands obtained by the GASP-WEBT Consortium and the Swift, AGILE, and Fermi satellites. Results. The spectral energy distribution of the second γ-ray flare (whose energy coverage is more dense) can be modelled by means of a one-zone leptonic model, yielding a total jet power of about 4 × 1047 erg s−1. Conclusions. During the most prominent γ-ray flaring period our model is consistent with a dissipation region within the broad-line region. Moreover, this class of high-redshift, flat-spectrum radio quasars with high-mass black holes might be good targets for future γ-ray satellites such as e-ASTROGAM.
We present the first catalog of high-confidence γ-ray sources detected by the AGILE satellite during observations performed from July 9, 2007 to June 30, 2008. Cataloged sources were detected by ...merging all the available data over the entire time period. AGILE, launched in April 2007, is an ASI mission devoted to γ-ray observations in the 30 MeV–50 GeV energy range, with simultaneous X-ray imaging capability in the 18–60 keV band. This catalog is based on Gamma-Ray Imaging Detector (GRID) data for energies greater than 100 MeV. For the first AGILE catalog, we adopted a conservative analysis, with a high-quality event filter optimized to select γ-ray events within the central zone of the instrument field of view (radius of 40°). This is a significance-limited (4σ) catalog, and it is not a complete flux-limited sample due to the non-uniform first-year AGILE sky coverage. The catalog includes 47 sources, 21 of which are associated with confirmed or candidate pulsars, 13 with blazars (7 FSRQ, 4 BL Lacs, 2 unknown type), 2 with HMXRBs, 2 with SNRs, 1 with a colliding-wind binary system, and 8 with unidentified sources.
We report the first blazar detection by AGILE. AGILE detected 3C 454.3 during a period of strongly enhanced optical emission in 2007 July. AGILE observed the source with a dedicated repointlng during ...the period 2007 July 24-30 with its two co-aligned imagers, the Gamma-Ray Imaging Detector and the hard X-ray imager Super-AGILE sensitive in the 30 MeV to 50 GeV and 18-60 keV ranges, respectively. Over the entire period, AGILE detected y-ray emission from 3C 454.3 at a significance level of 13.8 a with an average flux (E > 100 MeV) of (280 plus or minus 40) x 10 super(-5) photons cm-2, s-1. The y-ray flux appears to be variable toward the end of the observation. No emission was detected by Super-AGILE in the energy range 20-60 keV, with a 3 o upper limit of 2.3 x 10 super(-3) photons cm-2 S-1. The Y-ray flux level of 3C 454.3 detected by AGILE Is the highest ever detected for this quasar and among the most intense Y-ray fluxes ever detected from fiat-spectrum radio quasars.
Abdominal obesity and hyperinsulinemia play a key role in the development of the polycystic ovary syndrome (PCOS). Dietary-induced weight loss and the administration of insulin-lowering drugs, such ...as metformin, are usually followed by improved hyperandrogenism and related clinical abnormalities. This study was carried out to evaluate the effects of combined hypocaloric diet and metformin on body weight, fat distribution, the glucose-insulin system, and hormones in a group of 20 obese PCOS women body mass index (BMI) > 28 kg/m2 with the abdominal phenotype (waist to hip ratio >0.80), and an appropriate control group of 20 obese women who were comparable for age and pattern of body fat distribution but without PCOS. At baseline, we measured sex hormone, sex hormone-binding globulin (SHBG), and leptin blood concentrations and performed an oral glucose tolerance test and computerized tomography (CT) at the L4-L5 level, to measure sc adipose tissue area (SAT) and visceral adipose tissue area. All women were then given a low-calorie diet (1,200-1,400 kcal/day) alone for one month, after which anthropometric parameters and CT scan were newly measured. While continuing dietary treatment, PCOS women and obese controls were subsequently placed, in a random order, on metformin (850 mg/os, twice daily) (12 and 8, respectively) or placebo (8 and 12, respectively), according to a double-blind design, for the following 6 months. Blood tests and the CT scan were performed in each woman at the end of the study while they were still on treatment. During the treatment period, 3 women of the control group (all treated with placebo) were excluded because of noncompliance; and 2 PCOS women, both treated with metformin, were also excluded because they became pregnant. Therefore, the women cohort available for final statistical analysis included 18 PCOS (10 treated with metformin and 8 with placebo) and 17 control women (8 treated with metformin and 9 with placebo). The treatment was well tolerated. In the PCOS group, metformin therapy improved hirsutism and menstrual cycles significantly more than placebo. Baseline anthropometric and CT parameters were similar in all groups. Hypocaloric dieting for 1 month similarly reduced BMI values and the waist circumference in both PCOS and control groups, without any significant effect on CT scan parameters. In both PCOS and control women, however, metformin treatment reduced body weight and BMI significantly more than placebo. Changes in the waist-to-hip ratio values were similar in PCOS women and controls, regardless of pharmacological treatment. Metformin treatment significantly decreased SAT values in both PCOS and control groups, although only in the latter group were SAT changes significantly greater than those observed during the placebo treatment. On the contrary, visceral adipose tissue area values significantly decreased during metformin treatment in both PCOS and control groups, but only in the former was the effect of metformin treatment significantly higher than that of placebo. Fasting insulin significantly decreased in both PCOS women and controls, regardless of treatment, whereas glucose-stimulated insulin significantly decreased only in PCOS women and controls treated with metformin. Neither metformin or placebo significantly modified the levels of LH, FSH, dehydroepiandrosterone sulphate, and progesterone in any group, whereas testosterone concentrations decreased only in PCOS women treated with metformin. SHBG concentrations remained unchanged in all PCOS women; whereas in the control group, they significantly increased after both metformin and placebo. Leptin levels decreased only during metformin treatment in both PCOS and control groups. (ABSTRACT TRUNCATED)
Context. Known TeV sources detected by major Čerenkov telescopes are investigated to identify possible MeV-GeV γ-ray counterparts. Aims. A systematic study of the known sources in the web-based ...TeVCat catalog has been performed to search for possible γ-ray counterparts on the AGILE data collected during the first period of operations in observing pointing mode. Methods. For each TeV source, a search for a possible γ-ray counterpart that is based on a multi-source maximum likelihood algorithm is performed on the AGILE data taken with the GRID instrument from July 2007 to October 2009. Results. In the case of high-significance detection, the average γ-ray flux is estimated. For cases of low-significance detection the 95% confidence level (CL) flux upper limit is given. 52 TeV sources out of 152 (corresponding to ~34% of the analysed sample) show a significant excess in the AGILE data covering the pointing observation period. Conclusions. This analysis found 26 new AGILE sources with respect to the AGILE reference catalogs, 15 of which are galactic, 7 are extragalactic and 4 are unidentified. Detailed tables with all available information on the analysed sources are presented.
We present the AGILE-GRID (Astro-rivelatore Gamma a Immagini LEggero – Gamma-Ray Imaging Detector) monitoring of Cygnus X-3, during the period between November 2007 and July 2009. We report here the ...whole AGILE-GRID monitoring of Cygnus X-3 in the AGILE “pointing” mode data-taking, to confirm that the γ-ray activity coincides with the same repetitive pattern of multiwavelength emission and analyze in depth the overall γ-ray spectrum by assuming both leptonic and hadronic scenarios. Seven intense γ-ray events were detected in this period, with a typical event lasting one or two days. These durations are longer than the likely cooling times of the γ-ray emitting particles, implying we see continuous acceleration rather than the result of an impulsive event such as the ejection of a single plasmoid that then cools as it propagates outwards. Cross-correlating the AGILE-GRID light curve with both X-ray and radio monitoring data, we find that the main events of γ-ray activity were detected while the system was in soft spectral X-ray states (RXTE/ASM (Rossi X-ray Timing Explorer/All-Sky Monitor)count rate in the 3−5 keV band ≳ 3 counts s-1), that coincide with local and often sharp minima of the hard X-ray flux (Swift/BAT (Burst Alert Telescope) count rate ≲0.02 counts cm-2 s-1), a few days before intense radio outbursts. This repetitive temporal coincidence between the γ-ray transient emission and spectral state changes of the source turns out to be the spectral signature of γ-ray activity from this microquasar. These γ-ray events may thus reflect a sharp transition in the structure of the accretion disk and its corona, which leads to a rebirth of the microquasar jet and subsequent enhanced activity in the radio band. The γ-ray differential spectrum of Cygnus X-3 (100 MeV–3 GeV), which was obtained by averaging the data collected by the AGILE-GRID during the γ-ray events, is consistent with a power law of photon index α = 2.0±0.2. Finally, we examine leptonic and hadronic emission models for the γ-ray events and find that both scenarios are valid. In the leptonic model – based on inverse Compton scatterings of mildly relativistic electrons on soft photons from both the Wolf-Rayet companion star and the accretion disk – the emitting particles may also contribute to the overall hard X-ray spectrum, possibly explaining the hard non-thermal power-law tail seen during special soft X-ray states in Cygnus X-3.
Background Unlike chronic idiopathic intestinal pseudo‐obstruction (CIIP), severe digestive syndromes that are not characterized by episodes resembling mechanical obstruction remain poorly ...characterized. The present study compared clinical features, small bowel motility, and quality of life (QoL) in patients with CIIP or severe functional gastrointestinal disorders (SFGID), compared to irritable bowel syndrome (IBS).
Methods We enrolled 215 consecutive patients: 70 CIIP, 110 malnourished SFGID body mass index (BMI) 17.8 ± 1.8 kg m−2 and 35 non‐malnourished SFGID (BMI 22.8 ± 3.6 kg m−2).
Key Results Abnormal motor patterns that fulfilled diagnostic criteria for small bowel dysmotility were virtually absent in IBS patients, but were recorded in69 CIIP patients (98.6%), 82 malnourished SFGID patients (74.5%;), and 23 SFGID patients without malnutrition (65.7%) (P < 0.0001). CIIP patients presented more frequently abnormal activity fronts, lack of response to feeding, and hypomotility than malnourished and non‐malnourished SFGID patients (61.4%vs 42.7% and 31.4%, P < 0.05 only vs non‐malnourished SFGID; 8.6%vs 0.9% and 2.9%; 21.4%vs 0.9% and 0%, P < 0.05). Quality of life mean scores were all significantly lower in CIIP patients and malnourished SFGID patients than in IBS. Bodily pain, general health, and vitality scores were lower in CIIP also compared to non‐malnourished SFGID.
Conclusions & Inferences Chronic idiopathic intestinal pseudo‐obstruction and SFGIDs are frequently associated with small bowel dysmotility and marked derangements of QoL which are significantly more severe than in IBS and result particularly in being severe in patients with recurrent sub occlusive episodes or inability to maintain a normal body weight.
BACKGROUND & AIMS: Although gastric dysmotility and dyspeptic symptoms are often associated, their relationship remains unclear. The aim of this study was to evaluate the relationship between gastric ...emptying abnormalities and clinical features in functional dyspepsia. METHODS: In 343 patients with functional dyspepsia, the gastric emptying of solids was measured by a radioisotopic technique and four dyspeptic symptoms (epigastric pain and burning, postprandial fullness, nausea, and vomiting) were measured as absent, mild, relevant, and severe, according to their influence on patients' usual activities. RESULTS: Delayed gastric emptying was detected in 33.5% of dyspeptics. Delayed gastric emptying was particularly frequent in patients characterized by female sex, low body weight, presence of relevant and severe postprandial fullness, nausea, vomiting, and absence of relevant and severe epigastric pain. Logistic regression showed that delayed gastric emptying was invariably associated with female sex and postprandial fullness (odds ratio, 2.34; 95% confidence interval, 1.45-3.75) and vomiting (odds ratio, 4.04; 95% confidence interval, 1.30-12.54) when coded as severe and only postprandial fullness (odds ratio, 3.78; 95% confidence interval, 1.78-8.01) when coded as relevant and severe. CONCLUSIONS: Female sex, relevant and severe postprandial fullness, and severe vomiting are independently associated with delayed gastric emptying of solids in patients with functional dyspepsia seen in a referral center. (Gastroenterology 1996 Apr;110(4):1036-42)
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