This study aimed to evaluate the effects of two months of orthokeratology (OK) treatment in the accommodative response of young adult myopes. Twenty eyes (21.8 ± 1.8 years) were fitted with the ...Paragon CRT® 100 LENS to treat myopia between −1.00 and −2.00 D. Low- and high-contrast visual acuity (LCDVA and HCDVA), central objective refraction, light disturbance (LD), and objective accommodative response (using the Grand Seiko WAM-5500 open-field autorefractometer coupled with a Badal system) were measured at baseline (BL) before lens wear and after 1, 15, 30, and 60 nights of OK. Refractive error correction was achieved during the first fifty days of OK lens wear, with minimal changes afterwards. LD analysis showed a transient increase followed by a reduction to baseline levels over the first 30 nights of treatment. The accommodative response was lower than expected for all target vergences in all visits (BL: 0.61 D at 1.00 D to 0.96 D at 5.00 D; 60 N: 0.36 D at 1.00 D to 0.79 D at 5.00 D). On average, the accommodative lag decreases over time with OK lens wear. However, these differences were not statistically significant (p > 0.050, repeated-measures ANOVA and Friedman test). This shows that overnight OK treatment does not affect objectively measured the accommodative response of young, low myopic eyes after two months of treatment stabilization.
Nephrosclerosis patients are at an exceptionally high cardiovascular (CV) risk. We aimed to determine whether genetic variability represented by 38 tag-SNPs in genes of the cyclooxygenase pathway ...(PTGS1, PTGS2, PTGES, PTGES2 and PTGES3) leading to prostaglandin E2 (PGE2) synthesis, modified CV traits and events in 493 nephrosclerosis patients. Additionally, we genotyped 716 controls to identify nephrosclerosis risk associations. The addition of three variants, namely PTGS2 rs4648268, PTGES3 rs2958155 and PTGES3 rs11300958, to a predictive model for CV events containing classic risk factors in nephrosclerosis patients, significantly enhanced its statistical power (AUC value increased from 78.6 to 87.4%, p = 0.0003). Such increase remained significant after correcting for multiple testing. In addition, two tag-SNPs (rs11790782 and rs2241270) in PTGES were linked to higher systolic and diastolic pressure carriers vs. non-carriers = 5.23 (1.87-9.93), p = 0.03 and 5.9 (1.87-9.93), p = 0.004. PTGS1(COX1) rs10306194 was associated with higher common carotid intima media thickness (ccIMT) progression OR 1.90 (1.07-3.36), p = 0.029, presence of carotid plaque OR 1.79 (1.06-3.01), p = 0.026 and atherosclerosis severity (p = 0.041). These associations, however, did not survive Bonferroni correction of the data. Our findings highlight the importance of the route leading to PGE2 synthesis in the CV risk experienced by nephrosclerosis patients and add to the growing body of evidence pointing out the PGE2 synthesis/activity axis as a promising therapeutic target in this field.
Mixtures of a nonionic surfactant and non-functionalized nanohydroxyapatite (NHA) enhanced the stability of oil-in-eutectic mixture high internal phase emulsions (HIPEs). Upon ring opening ...polymerization of the eutectic mixture composed of
l
-lactide and -caprolactone, biodegradable polyHIPEs with specific cavity sizes and selective interfacial functionalization with NHA are produced.
Biodegradable macroporous polyHIPEs with specific cavity sizes and selective interfacial functionalization of the inner surface with NHA are produced.
The aim of this study was to evaluate the changes in retinal activity during orthokeratology (OK) treatment in 20 myopic eyes. Pattern electroretinography (PERG) and visual evoked potential (VEP) ...were assessed with the RETI-port/scan21 (Roland Consult, Wiesbaden, Germany). Measurements were taken at baseline (BL) and 1 night (1N), 15 nights (15N), 30 nights (30N), and 60 nights (60N) of OK lens wear. Repeated measures analysis of variance (ANOVA) and the Friedman test were used. Twenty eyes (23.20 ± 3.46 years, 70% female) with visual acuity ≤ 0.00 logMAR in post-treatment showed that despite a slight increase in retinal and cortical response amplitude, observed with both PERG and VEP, respectively, immediately after the initial treatment, these differences found were not statistically significant during the 60 days of OK treatment, despite a statistically significant increase in N95 response with PERG. This shows that retinal and cortical visual-related electrical activity is maintained or slightly increased during OK treatment.
Advanced reinforced composite structures incorporating piezoelectric sensors and actuators are increasingly becoming important due to the development of smart structures. These structures offer ...potential benefits in a wide range of engineering applications such as vibration and noise suppression, shape control and precision positioning. This paper presents a finite element formulation based on the classical laminated plate theory for laminated structures with integrated piezoelectric layers or patches, acting as sensors and actuators. The finite element model is a single layer triangular nonconforming plate/shell element with 18 degrees of freedom for the generalized displacements, and one additional electrical potential degree of freedom for each surface bonded piezoelectric element layer or patch. The control is initialized through a previous optimization of the core of the laminated structure, in order to minimize the vibration amplitude and maximize the first natural frequency. Also the optimization of the patches position is performed to maximize the piezoelectric actuators efficiency. The simulated annealing algorithm is used for these purposes. To achieve a mechanism of active control of the structure dynamic response, a feedback control algorithm is used, coupling the sensor and active piezoelectric layers or patches, and to calculate the dynamic response of the laminated structures the Newmark method is considered. The model is applied in the optimization of an illustrative adaptive laminated plate case. The influence of the position and number of piezoelectric patches, as well as the control gain, are investigated and the results are presented and discussed.
HIV-1 subtypes associate with differences in transmission and disease progression. Thus, the existence of geographic hotspots of subtype diversity deepens the complexity of HIV-1/AIDS control. The ...already high subtype diversity in Portugal seems to be increasing due to infections with sub-subtype A1 virus. We performed phylogenetic analysis of 65 A1 sequences newly obtained from 14 Portuguese hospitals and 425 closely related database sequences. 80% of the A1 Portuguese isolates gathered in a main phylogenetic clade (MA1). Six transmission clusters were identified in MA1, encompassing isolates from Portugal, Spain, France, and United Kingdom. The most common transmission route identified was men who have sex with men. The origin of the MA1 was linked to Greece, with the first introduction to Portugal dating back to 1996 (95% HPD: 1993.6-1999.2). Individuals infected with MA1 virus revealed lower viral loads and higher CD4
T-cell counts in comparison with those infected by subtype B. The expanding A1 clusters in Portugal are connected to other European countries and share a recent common ancestor with the Greek A1 outbreak. The recent expansion of this HIV-1 subtype might be related to a slower disease progression leading to a population level delay in its diagnostic.
Groundwater resources are in many parts of the world the only source for private domestic, agricultural and public water supply. Subsurface has also become major recipient of wastewater and solid ...waters especially in the developing countries. Overexploitation of coastal aquifers and pollution are among the main problems related to groundwater resources assessment and management in Santiago Island (Cabo Verde). Brackish groundwater is the only available water type in the region that is being provided to numerous parts of the Island such as Praia Baixo, Montenegro, and Charco for agriculture and human supply. Solute and isotope data obtained in different groundwater systems were used in the identification of groundwater resources degradation. In order to understand the influence of the anthropogenic activities on the water quality and the main origin of the salts in groundwater, a statistical approach (Principal Components Analyses—PCA) was performed on the physico-chemical data. The results obtained indicate water-rock interaction mechanisms as the major process responsible for the groundwater quality (mainly calcium-bicarbonate type), reflecting the lithological composition of the subsurface soil. Also, anthropogenic contamination was identified, in several points of the island. Isotopic techniques (δ²H, δ¹⁸O and ³H content) combined with geochemistry provided comprehensive information on groundwater recharge, as well as on the identification of salinization mechanisms (e.g. seawater intrusion, salt dissolution, and marine aerosols) of the groundwater systems, at Santiago Island.
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•Polyphenols rejection in the ultrafiltration of ethanolic extract was evaluated.•Two models described the permeate flux evolution during extract ultrafiltration.•Reversible layer ...growth was described by the adapted long term flux model.•The surface-renewal model predicted the cake build up on the membranes surface.
Bark from Eucalyptus globulus, a side-stream of pulp and paper industry, is a source of bioactive polyphenols that are extractable with 80/20 (v/v) ethanol/water. In this work, downstream processing of this extract was performed by ultrafiltration (UF) assessing for the first time (i) the influence of membrane type and transmembrane pressure (TMP) on the flux and permeate composition; (ii) the analysis of flux and resistances using the resistance-in-series model; (iii) permeate flux and cake build up modeling; and finally (iv) the feasibility of concentration by UF. Four membranes were selected: polyamide composite GE – 1kDa (GE 1), polyethersulfone PLEAIDE – 5kDa (P 5), polyvinylidenefluoride JW – 30kDa (JW 30), and polysulfone EW – 60kDa (EW 60). The effect of TMP on the permeation flux was evaluated, and total solids (TS), total phenolic compounds (TPC), proanthocyanidins (Pac) and formaldehyde condensed tannins (fcT) were quantified in the permeates. Data analysis showed that the experiments were performed in a region not controlled by pressure. P 5 and JW 30 membranes are more susceptible to fouling than the GE 1 and EW 60. In spite of the lowest cut-off of GE 1 membrane, it presented the lowest retention to TS, TPC and Pac, demonstrating that membrane material plays a significant role in separation. Finally, a model using classical cake-filtration theory and the surface-renewal concept successfully predicted the permeate flux and cake build up. A trade-off between permeate flux, the resistance and the retentions to TPC and Pac was established. The selected TMP was 3bar for EW 60 (retentions: TPC 14%, Pac 30%) and 5bar for JW 30, P 5 and GE 1 (retentions: TPC 66%, 66% and 58%; Pac 87%, 88% and 58%, respectively).
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