O termo DRESS (drug rash with eosinophilia and syste- mic symptoms – erupcao a droga com eosinofilia e sintomas sistemicos) surgiu em 1996, para caracterizar um tipo de reacao de hipersensibilidade ...a medicamento com caracteristicas sistemicas, que incluia erupcao cutanea grave, febre, linfadenopatia, hepatite e anormalidades hematologicas (hipereosinofilia e linfocitose atipica). Em criancas, esta sindrome e rara, muitas vezes subdiagnosticada, pois seu quadro clinico inespecifico se confunde com muitos outros diagnosticos diferenciais. Em ano de Pandemia em que muitos diagnósticos convergiam para COVID, esse relato de caso faz um diagnóstico diferencial com MIS. Por causa da raridade dessa reacao e da dificuldade e importancia de seu reconhecimento, relata-se o caso de um menino de 13 anos de idade com Síndrome de DRESS secundária a Vancomicina.
Menino admitido na UTI para tratamento de Osteomielite em membro inferior após trauma. Evoluiu com sepse clínica. Durante internação apresentou trombose venosa em sítio de acesso profundo. Iniciado anticoagulação. Persistia febre. Iniciado Vancomicina. Paciente apresentou melhora clínica sendo transferido para enfermaria. Na segunda semana do início da Vancomicina evoluiu com aumento de transaminases, erupção cutanêa importante principalmente em face. Hemograma apresentou eosinofilia e linfocitose atípica. Suspeita de COVID foi feita. Realizado PCR COVID que veio negativo. Suspenso Vancomicina. Trocado esquema antibiótico. Paciente recebeu Imunoglobulina 2g/kg com pouca melhora da lesão de face. ECO mostrava alterações agudas sugestivas de cardite. Paciente recebeu alta fazendo Clexane. No retorno ambulatorial como mantinha lesão em face foi iniciado terapia com corticoide 1mg/kg/dia. Após 30 dias anticoagulação foi suspensa e discutido com Cardiologia uso de AAS. Paciente com 2 meses de corticoide apresentou melhora de lesão cutânea que não retornou após a suspensão do corticoide.Apresentou melhora progressiva da eosinofilia. Realizado sorologia para COVID que demonstrou igG e IgM negativos. A hipótese de Reação a Vancomicina foi feita uma vez que preencheu os critérios para Sindrome de Dress – exposição a medicação, cardite, elevação de enzimas hepáticas, linfocitose atípica, eosinofilia além dos exames para COVID negativo.
In traumatology, we encounter several clinical challenges that involve extensive bone loss primarily related to trauma, conditions that can be treated with autologous grafts. A good alternative is ...the use of synthetic biomaterials as substitutes. These polymers provide a suitable environment for the growth of new bone and vascular tissue, which are essential for repair. Collagen/hydroxyapatite composites have proven to be biocompatible and to behave mechanically. Furthermore, the addition of chitosan contributes to the formation of a three-dimensional structure that permits cell adhesion and proliferation, thus improving osteogenesis. The aim of this study was to evaluate bone formation during the repair of bone defects experimentally induced in the skull of rats and grafted with a polymer blend consisting of bovine tendon collagen and chitosan combined with hydroxyapatite. Thirty animals were used for the creation of a defect in the left parietal bone and were divided into three groups of 10 animals each: a control group without biomaterial implantation, a group receiving the blend of collagen and chitosan, and a group receiving this blend combined with hydroxyapatite. Each group was subdivided and the animals were sacrificed 3 or 8 weeks after surgery. After sacrifice, the skulls were removed for macroscopic photodocumentation and radiographic examination. The samples were processed for histological evaluation of new bone formation at the surgical site. Macroscopic and radiographic analysis demonstrated the biocompatibility of the blends. Histologically, the formation of new bone occurred in continuity with the edges of the defect, with the observation of higher volumes in the grafted groups compared to control. Mineralization of sponges did not stimulate bone neoformation, with bone repair being incomplete over the experimental period. In conclusion, mineralization by the addition of hydroxyapatite should be better studied. However, the collagen/chitosan sponges used in this study are suitable to stimulate osteogenesis in cranial defects, although this process is slow and not sufficient to achieve complete bone regeneration over a short period of time.
Forest restoration is mainly based on plant-soil relationships and plant species with economic potential, but those between insects and other arthropods are also important to this reestablishment. ...The objective was to evaluate, during 24 months, the relationships between tending ants, Hemiptera phytophagous, predators and their distribution pattern (aggregated, random or uniform). The arthropods were sampled, stored and identified and their relationships and distribution patterns calculated with the BioDiversity-Pro software. The number of tending ants and phytophagous Hemiptera, Brachymyrmex sp. and Aethalion reticulatum, Cephalotes and Aleyrodidae were positively correlated. Tending ants were negatively correlated with Sternorrhyncha predators on A. auriculiformis saplings. The distribution of arthropods was aggregated, except for Teudis sp. and Cephalocoema sp., with a random pattern. The herbivores Stereoma anchoralis, Aethalion reticulatum and Tetragonisca angustula and the predators Brachymyrmex sp. and Dolichopodidae were the most abundant arthropods. The relationships between the arthropods studied on A. auriculiformis indicate that this plant, even introduced, is suitable for programs to recover degraded areas in the savannah.
The glucose-lowering independent effect of sodium glucose cotransporter-2 inhibitors (SGLT2i) on arterial wall function has not yet been clarified. This study aims to assess whether SGLT2i treatment ...can attenuate endothelial dysfunction related to type 2 diabetes mellitus (T2D) compared with glucose-lowering equivalent therapy.
In a prospective, open-label, single-center, randomized clinical trial, 98 patients with T2DM and carotid intima-media thickness above the 75th percentile were randomized 1:1 to 12 weeks of therapy with dapagliflozin or glibenclamide in addition to metformin in glucose-lowering equivalent regimens. The coprimary endpoints were 1-min flow-mediated dilation (FMD) at rest and 1-min FMD after 15 min of ischemia followed by 15 min of reperfusion time (I/R).
Ninety-seven patients (61% males, 57 ± 7 years) completed the study. The median HbA1c decreased by - 0.8 (0.7)% and -0.7 (0.95)% following dapagliflozin and glibenclamide, respectively. The first coprimary endpoint, i.e., rest FMD changed by + 3.3(8.2)% and - 1.2(7.5)% for the dapagliflozin and glibenclamide arms, respectively (p = 0.0001). Differences between study arms in the second coprimary endpoint were not significant. Plasma nitrite 1 min after rest FMD was higher for dapagliflozin 308(220) nmol/L than for glibenclamide (258110 nmol/L; p = 0.028). The resistive indices at 1 min 0.90 (0.11) vs. 0.93 (0.07); p = 0.03 and 5 min 0.93 (0.07) vs. 0.95 (0.05); p = 0.02 were higher for the glibenclamide group than for the dapagliflozin group. Plasma biomarkers for inflammation and oxidative stress did not differ between the treatments.
Dapagliflozin improved micro- and macrovascular endothelial function compared to glibenclamide, regardless of glycemic control in patients with T2DM and subclinical carotid atherosclerotic disease.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Abstract The indication of biomaterials has increased substantially in the regenerative therapy of bone defects. However, in addition to evaluating the physicochemical properties of biomaterials, the ...quality of the recipient tissue is also essential for the osseointegration of implants, as abnormalities in bone metabolism, such as gonadal hormone deficiency, can influence bone healing. This study evaluated the osteoregenerative capacity of collagen membranes derived from bovine pericardium and intestinal serosa in the repair of cranial defects in ovariectomised rats. Thirty female Wistar rats were submitted to surgical creation of a 5-mm cranial bone defect. The rats were divided into a control group (not ovariectomised) and an ovariectomised group. The non-ovariectomised group was divided into three subgroups: control (G1) in which the defect was not filled with the biomaterial, and two subgroups (G2 and G3) that received the bovine pericardium- and serosa-derived collagen membranes, respectively. The ovariectomised group was divided into the same subgroups (G4, G5, and G6). The animals were sacrificed 8 weeks after surgery. The calvaria were removed for macroscopic and radiographic photodocumentation and processed for histomorphometric analysis of bone healing at the surgical site. Macroscopic, radiological, and microscopic analyses demonstrated the biocompatibility of the implanted collagen membranes, as indicated by the absence of infiltration and signs of inflammation at the surgical site. Histologically, discrete immature bone neoformation projecting from the margins of the defect was observed at the surgical site in ovariectomised groups when compared to the non-ovariectomised groups. The volume of newly formed bone was significantly higher in the non-ovariectomised groups (G1: 7.83% ± 1.32; G2: 21.33% ± 1.96; and G3: 22.83% ± 0.98) compared to the respective ovariectomised subgroups (G4: 3.16% ± 0.75; G5: 16.83% ± 0.98; and G6: 16.16% ± 0.75), thus demonstrating the deleterious effects of ovariectomy on bone homeostasis. Higher volumes of newly formed bone were observed in the groups receiving the membrane grafts (G2, G3, G5, and G6) compared to the control groups (G1 and G4). In conclusion, the bilateral ovariectomy compromises the ability to repair bone lesions grafted with osteoconductive biomaterials as in the case of collagen membranes derived from both bovine pericardium and intestinal serosa.
.
Open and hidden heavy-flavor physics in high-energy nuclear collisions are entering a new and exciting stage towards reaching a clearer understanding of the new experimental results with the ...possibility to link them directly to the advancement in lattice Quantum Chromo-Dynamics (QCD). Recent results from experiments and theoretical developments regarding open and hidden heavy-flavor dynamics have been debated at the Lorentz Workshop
Tomography of the Quark-Gluon Plasma with Heavy Quarks
, which was held in October 2016 in Leiden, The Netherlands. In this contribution, we summarize identified common understandings and developed strategies for the upcoming five years, which aim at achieving a profound knowledge of the dynamical properties of the quark-gluon plasma.
A
bstract
Measurements of anisotropic flow coefficients with two- and multi-particle cumulants for inclusive charged particles in Pb-Pb collisions at
s
N
N
=
5.02
and 2.76 TeV are reported in the ...pseudorapidity range |
η
| < 0.8 and transverse momentum 0.2 <
p
T
< 50 GeV/
c
. The full data sample collected by the ALICE detector in 2015 (2010), corresponding to an integrated luminosity of 12.7 (2.0)
μ
b
−1
in the centrality range 0-80%, is analysed. Flow coefficients up to the sixth flow harmonic (
v
6
) are reported and a detailed comparison among results at the two energies is carried out. The
p
T
dependence of anisotropic flow coefficients and its evolution with respect to centrality and harmonic number
n
are investigated. An approximate power-law scaling of the form
v
n
(
p
T
) ∼
p
T
n
/3
is observed for all flow harmonics at low
p
T
(0.2 <
p
T
< 3 GeV/
c
). At the same time, the ratios
v
n
/
v
m
n
/
m
are observed to be essentially independent of
p
T
for most centralities up to about
p
T
= 10 GeV/
c
. Analysing the differences among higher-order cumulants of elliptic flow (
v
2
), which have different sensitivities to flow fluctuations, a measurement of the standardised skewness of the event-by-event
v
2
distribution
P
(
v
2
) is reported and constraints on its higher moments are provided. The Elliptic Power distribution is used to parametrise
P
(
v
2
), extracting its parameters from fits to cumulants. The measurements are compared to different model predictions in order to discriminate among initial-state models and to constrain the temperature dependence of the shear viscosity to entropy-density ratio.
•Establishment of reference values for trace metals in a non-previously assessed population.•Serum cooper is significantly higher in females.•Serum concentration of several metals tends to decrease ...with aging.
This study aimed to evaluate serum and urine concentrations of several trace metals of a non-directly exposed population in southern Brazil and establish reference values. Serum and urine samples were obtained from 240 volunteers (175 males and 65 females, age ranging from 18 to 74 years old). Levels of arsenic, chromium, cobalt, copper, lead, nickel, manganese and zinc were determined by means of dynamic reaction cell inductively coupled plasma mass spectrometry (DRC-ICP-MS). Comparison between genders resulted in no significant difference for all metals but serum copper, as concentrations are higher in females than males. For most metals assessed, a negative correlation between serum concentrations and age was found, but no significant correlation was found between urine concentrations and age.
Invariant differential yields of deuterons and antideuterons in pp collisions at s = 0.9, 2.76 and 7 TeV and the yields of tritons, He3 nuclei, and their antinuclei at s = 7 TeV have been measured ...with the ALICE detector at the CERN Large Hadron Collider. The measurements cover a wide transverse momentum (pT) range in the rapidity interval |y|
The azimuthal anisotropy coefficient v2 of prompt D0, D+, D∗+, and Ds+ mesons was measured in midcentral (30%-50% centrality class) Pb-Pb collisions at a center-of-mass energy per nucleon pair ...sNN=5.02 TeV, with the ALICE detector at the LHC. The D mesons were reconstructed via their hadronic decays at midrapidity, |y|