Monocyte distribution width (MDW) has been associated with inflammation and poor prognosis in various acute diseases. Chronic obstructive pulmonary disease (COPD) exacerbations (ECOPD) are associated ...with mortality. The objective of this study was to evaluate the utility of the MDW as a predictor of ECOPD prognosis. This retrospective study included patient admissions for ECOPD. Demographic, clinical and biochemical information; intensive care unit (ICU) admissions; and mortality during admission were recorded. A total of 474 admissions were included. MDW was positively correlated with the DECAF score (r = 0.184, p < 0.001) and C-reactive protein (mg/dL) (r = 0.571, p < 0.001), and positively associated with C-RP (OR 1.115 95% CI 1.076-1.155, p < 0.001), death (OR 9.831 95% CI 2.981- 32.417, p < 0.001) and ICU admission (OR 11.204 95% CI 3.173-39.562, p < 0.001). High MDW values were independent risk factors for mortality (HR 3.647, CI 95% 1.313-10.136, p = 0.013), ICU admission (HR 2.550, CI 95% 1.131-5.753, p = 0.024), or either mortality or ICU admission (HR 3.084, CI 95% 1.624-5.858, p = 0.001). In ROC analysis, a combined MDW-DECAF score had better diagnostic power (AUC 0.777 95% IC 0.708-0.845, p < 0.001) than DECAF (p = 0.023), MDW (p = 0.026) or C-RP (p = 0.002) alone. MDW is associated with ECOPD severity and predicts mortality and ICU admission with a diagnostic accuracy similar to that of DECAF and C-RP. The MDW- DECAF score has better diagnostic accuracy than MDW or DECAF alone in identifying mortality or ICU admission.
Leptin is a hormone produced and secreted mainly by adipocytes, but also by other tissues such as placenta, brain, mammary, and pituitary glands. The gastric epithelium has also been reported as a ...source of leptin in mammals. In this study we examined the presence of leptin in the stomach of non-mammalian vertebrates (trout, frog, lizard, and snake). Immunolabeling for leptin was found in the oxyntic-peptic cells of the frog and the two reptilian species studied, but not in the trout. In the trout and the lizard leptin immunoreactivity was also detected in scattered cells presenting the typical features of endocrine cells. In the trout, the frog and the snake, in addition to the epithelium, leptin immunostain was found in elements of the enteric nervous system that were also positive for VIP.
Leptin is a hormone originally identified in adipocytes. It is involved in the regulation of fat deposition and energy expenditure and in other functions, such as reproduction. The presence of leptin ...has been reported in several reproductive organs. However, few studies have addressed its expression in the ovary. Moreover, the existing information is not consistent with regard to the particular cell types responsible for leptin expression. In this work we studied the distribution of leptin in the rat ovary by immunohistochemistry (IHC) and in situ hybridization (ISH). Leptin staining was found in steroid-producing cells: thecal, luteal, and interstitial cells. The strongest signal with both techniques was found in the cytoplasm of oocytes. A weak reaction for leptin mRNA was detected in granulosa of all growing follicles, although leptin protein was found only in the mature follicle. Western blotting analysis detects a strongly reactive 16-kD band, giving further support to the presence of leptin in the rat ovary. Variations in this immunoreactive band were found throughout the estrous cycle. Localization of leptin in the ovary may contribute to a better understanding of female reproductive function.
Asymptomatic skin lesion in a black patient Caro Gutiérrez, Dolores; Floristán Muruzábal, María Uxúa; Salamanca Santamaría, Francisco Javier ...
Medicina clinica,
2013-Jun-18, Letnik:
140, Številka:
12
Journal Article
The ability to ensure continous availability of energy despite highly variable supplies in the environment is a major determinant of the survival of all species. In higher organisms, including ...mammals, the capacity to efficently store excess energy as triglycerides in adipocytes, from which stored energy could be rapidly relaeased for use at other sites, was developed.
The aim of this study was to evaluate the impact of the lack of inducible NO synthase (iNOS) on body weight and adipose tissue mass as well as on plasma leptin and adiponectin in basal conditions and ...6 h after lipopolysaccharide (LPS) administration in mice. Body weight was not different among male, six-week-old wild-type (WT) and iNOS
−/− animals. However, the amount of epididymal white adipose tissue (EWAT) in iNOS
−/− mice was significantly reduced (
P<0.05). Circulating leptin and leptin mRNA in EWAT were decreased in iNOS
−/− mice (
P<0.05 and
P<0.01, respectively). Plasma adiponectin and adiponectin mRNA were unchanged. LPS administration increased plasma leptin in both genotypes (
P<0.05). Neither genotype nor treatment changed plasma adiponectin. In summary, iNOS
−/− mice exhibited normal body weight but reduced adipose mass accompanied by hypoleptinemia. Leptin responsiveness to LPS in iNOS
−/− mutants is preserved, showing that the LPS-induced rise in leptin is independent of the presence of functional iNOS. In addition, iNOS deficiency or LPS does not influence expression and circulating levels of adiponectin.
Urgencias en ginecología oncológica Elizalde Fernández, Javier; Muruzábal Torquemada, Juan Carlos; Aguirre Gorospe, Sara ...
Anales del sistema sanitario de Navarra,
2009, 20090001, Letnik:
32, Številka:
1
Journal Article
Odprti dostop
En este trabajo se describen los signos de sospecha de neoplasia por los que la paciente acude al Servicio de Urgencias, centrándonos en el sangrado genital, la masa pélvica y el prurito vulvar. Los ...pacientes también pueden acudir por procesos resultantes de complicaciones de la enfermedad, como en el caso de la obstrucción ureteral, la carcinomatosis, la ascitis, procesos tromboembólicos, hemorragias, estreñimiento, náuseas y vómitos, obstrucción intestinal y dolor. Por último, se describen complicaciones secundarias al tratamiento como el linfocele abdominal e inguinal y la enteritis y proctitis postradioterápica.
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