We conducted a systematic review and dose–response meta-analysis of prospective studies to summarize findings on the associations between intakes of soy, soy isoflavones, and soy protein and risk of ...mortality from all causes, cancers, and cardiovascular diseases.
Online databases were systematically searched to identify relevant articles published earlier than May 2018. We applied restricted cubic splines using random-effects analysis to assess dose–response associations. Between-study heterogeneity was assessed by I2 value and Cochrane Q test. Potential publication bias was assessed by visual inspection of funnel plots and Begg regression test.
In total, 23 prospective studies with an overall sample size of 330,826 participants were included in the current systematic review and the meta-analysis. Soy/soy products consumption was inversely associated with deaths from cancers (pooled relative risk 0.88, 95% CI 0.79 to 0.99; P=0.03; I2=47.1%, 95% CI 0.0% to 75.4%) and cardiovascular diseases (pooled effect size: 0.85, 95% CI 0.72 to 0.99; P=0.04; I2=50.0%, 95% CI 0.0% to 77.6%). Such significant associations were also observed for all-cause mortality in some subgroups of the included studies, particularly those with higher quality. In addition, higher intake of soy was associated with decreased risk of mortality from gastric, colorectal, and lung cancers as well as ischemic cardiovascular diseases. Participants in the highest category of dietary soy isoflavones intake had a 10% lower risk of all-cause mortality compared with those in the lowest category. We also found that a 10-mg/day increase in intake of soy isoflavones was associated with 7% and 9% decreased risk of mortality from all cancers and also breast cancer respectively. Furthermore, a 12% reduction in breast cancer death was indicated for each 5-g/day increase in consumption of soy protein. However, intake of soy protein was not significantly associated with all-cause and cardiovascular diseases mortality.
Soy and its isoflavones may favorably influence risk of mortality. In addition, soy protein intake was associated with a decreased risk in the mortality of breast cancer. Our findings may support the current recommendations to increase intake of soy for greater longevity.
Changes in food consumption patterns during Ramadan may cause metabolic changes, but these have not been well studied. We aimed to determine food intake, glucose homeostasis, lipid profiles, and body ...composition before, during, and after Ramadan fasting.
160 healthy men were enrolled and investigated at three times (before, at the end of, and 1 month after Ramadan). Body composition was estimated by bio-impedance. Fasting blood samples were obtained for measuring fasting blood sugar (FBS), lipid profiles and insulin level. Insulin resistance (IR) was identified by the homeostatic model assessment (HOMA) of peripheral IR. Food intake was measured using a validated food frequency questionnaire before and during Ramadan. Statistical analysis was performed by SPSS 16 and P < 0.05 considered the level of significance.
Anthropometric parameters such as body weight, body mass index, and body fat percentage (BFP) as well as FBS and circulating triglycerides were all decreased significantly at the end of Ramadan compared with the same indices measured prior to Ramadan (all P < 0.001). In contrast, at the end of Ramadan, HOMA-IR was significantly elevated (P < 0.001). One month after Ramadan, these traits had all started to return to their pre-Ramadan levels, but were still disrupted. Food intake of all food groups except carbohydrates were decreased during Ramadan.
Ramadan fasting may lead to both positive and negative health effects such as a decrease in FBS, weight, BFP, and increase in LDL and IR in healthy adults. However, these effects were all transitory.
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•Melatonin, is a tryptophan derivative antioxidant which has a key role in the regulation of daily rhythms.•Melatonin indirectly improves the potential function of antioxidants ...enzymes, such as GPx, GR, and SOD.•Melatonin significantly increases total antioxidant capacity and decreases lipid peroxidation.
Oxidative stress, defined as an imbalance between pro-oxidants and neutralizing antioxidants within the body, is a growing public health concern. Oxidative stress is involved in the progression of nearly all chronic diseases. Melatonin has been suggested to reduce oxidative stress by its potential radical scavenging properties.
To determine the efficacy and safety of melatonin as a therapy for the improvement of oxidative stress parameters in randomized controlled trials.
A systematic database search using Scopus, PubMed/Medline, EMBASE, Web of Science, the Cochrane Controlled Register of Trials and clinicaltrials.gov (https://clinicaltrials.gov) for studies published up to July 2020 was conducted. We included studies which investigated the effect of supplemental melatonin compared to placebo on oxidative stress parameters in unhealthy patients. Quantitative data synthesis was conducted using a random-effects model with standard mean difference (SMD) and 95 % confidence intervals (CI). Cochrane’s Q and I2 values were used to evaluate heterogeneity.
A total of 12 randomized controlled trials (RCTs) were eligible. The meta-analysis indicated an association between melatonin intake and a significant increase in total antioxidant capacity (TAC) (SMD: 0.76; 95 % CI: 0.30, 1.21; I2 = 80.1 %), glutathione (GSH) levels (SMD: 0.57; 95 % CI: 0.32, 0.83; I2 = 15.1 %), superoxide dismutase (SOD) (SMD: 1.38; 95 % CI: 0.13, 2.62; I2 = 86.9 %), glutathione peroxidase (GPx) (SMD: 1.36; 95 % CI: 0.46, 2.30; I2 = 89.3 %), glutathione reductase (GR) (SMD: 1.21; 95 % CI: 0.65, 1.77; I2 = 00.0 %) activities, and a significant reduction in malondialdehyde (MDA) levels (SMD: -0.79; 95 % CI: -1.19, -0.39; I2 = 73.1 %). Melatonin intake was not shown to significantly affect nitric oxide (NO) levels (SMD: -0.24; 95 % CI: -0.61, 0.14; I2 = 00.0 %) or catalase (CAT) activity (SMD: -1.38; 95 % CI: -1.42, 4.18; I2 = 96.6 %).
Melatonin intake was shown to have a significant impact on improving Oxidative stress parameters. However, future research through large, well-designed randomized controlled trials are required to determine the effect of melatonin on oxidative stress parameters in different age groups and different disease types.
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•Data obtained from 5 studies with 278 subjects (145case/ 133control) were meta-analyzed.•It seems that Spirulina supplementation significantly reduces body weight.•Spirulina ...supplementation especially for obese individuals is more effective.
Evidence has suggested that Spirulina supplementation may affect anthropometric indices. Therefore, a systematic review and meta-analysis was performed to summarize published randomized clinical trials which assess the effect of Spirulina supplementation on obesity.
Pertinent studies were identified using Embase, Scopus, ISI Web of Science, PubMed and Cochrane library databases up to May 2019. Mean Differences (MD) were pooled using a random-effects model. Heterogeneity, sensitivity analysis and publication bias were reported using standard methods.
Results of 5 studies (7 treatment arms) showed a significant reduction in weight (MD: -1.56 Kg, 95% CI: -1.98 to -1.14) after Spirulina supplementation. Subgroup analysis based on health status revealed that weight change in obese subjects (MD: -2.06 Kg, 95% CI: -2.45 to -1.68) was greater than overweight participants (MD: -1.28 Kg, 95% CI: -1.62 to -0.93) following Spirulina supplementation. Also, pooled analysis showed that Spirulina supplementation led to a significant reduction in body fat percent (MD: -1.02, 95% CI: -1.49 to -0.54) and waist circumference (MD: -1.40, 95% CI: -1.40 to -1.39), but not in body mass index and waist to hip ratio.
Spirulina supplementation significantly reduces body weight, especially in obese individuals.
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•Soy products and isoflavones has been widely used as protein source and functional foods.•Soy products and isoflavones intake have been shown to exert antioxidant effects.•The ...results of our study show that soy products and isoflavones intake are effective in improving oxidative stress parameters.
Soy products and isoflavones intake have been shown to exert antioxidant effects. There are several randomized control trials (RCTs) that evaluated the effect of soy products intake on oxidative stress (OS) parameters. The aim of the present systematic review and meta-analysis was to summarize the results of RCTs evaluating the effect of soy products and isoflavones intake on OS parameters. Randomized trials that assessed the effect of soy products and isoflavones intake on OS parameters in adults were identified through searching in electronic databases: Cochrane clinical trial center, Embase, PubMed, Scopus, and Web of Sciences up to April 2020. Random effects model was used to calculate the effects sizes of soy intake on OS parameters.
Twenty-four trials with 1,852 participants were eligible and were included in the meta-analysis which measured OS parameters. Soy intake compared to control group significantly reduced MDA levels (SMD: −0.53; 95% CI: −0.86, −0.19; I2 = 88.3%), increased GSH levels (SMD: 0.51; 95% CI: 0.13, 0.88; I2 = 72.4%), SOD activity (SMD: 0.53; 95% CI: 0.08, 0.99; I2 = 84.1%), TAC (SMD: 0.54; 95% CI: 0.27, 0.82; I2 = 49.3%) and TRAP (SMD: 1.74; 95% CI: 0.82, 2.65; I2 = 81.3%) significantly compared to control group. Soy products and isoflavones intake are effective in improving OS parameters in adults compared with controls; thus, it could be a valuable advise to control OS progress in chronic diseases.
Theobromine may have beneficial effects on cardiovascular risk factors. This study aimed to find molecular effects of theobromine on lipid profile, glycemic status, inflammatory factors, and vascular ...function through a comprehensive assessment of all in vitro and in vivo studies. The search process was started at 18 July 2022. Databases including PubMed, Scopus, and Web of Science were searched to find all articles published up to 18 July 2022. Nineteen studies were included in this study. In vitro studies showed the improving effects of theobromine on inflammatory markers. Of four animal studies assessing the effect of theobromine on inflammatory markers, two reported favorable effects. Among five animal studies assessing the effects of theobromine on lipid profile, three reported improving effects on either triglyceride, total cholesterol, low- or high-density lipoprotein cholesterol. Of the three human studies, two revealed that theobromine had improving effects on lipid profile. A favorable effect of theobromine on augmentation index was also reported in two RCTs. The results for other outcomes were inconclusive. Theobromine may have favorable effects on inflammatory factors, lipid profile, and vascular function markers. However, studies with a longer duration and lower, dietary-relevant doses are required for future confirmation.
subsp.
is an important food source and a well-known medicinal plant in the Zagros Mountains of Iran. The present study aimed to investigate the effect of
extract and essential oil in ...streptozotocin-induced diabetic mice.
Different doses of hydroalcoholic extract and essential oil of
subsp.
(50, 100, and 200 mg/kg) were given to streptozotocin-induced diabetic mice in separate groups for three weeks. At the end of treatment, blood samples were collected; then, oxidative stress markers, TNF-α, and lipid profile were determined in its serum samples.
Our findings showed that the administration of
extract for three consecutive weeks significantly improved the lipid profile, oxidative stress, and inflammation process by reducing lipid peroxidation and increasing total antioxidant capacity.
This study showed that
subsp.
has antioxidant and blood lipid-lowering effects that can be used as a supplement to improve diabetes complications.
Purpose
Alternative Healthy Eating Index (AHEI)-2010, an index that determines the quality of a diet, was created to predict the risk of chronic diseases. Nevertheless, it is unclear whether this ...index can predict the risk of prostate cancer, one of the most prevalent cancers among men around the world. The study aims to investigate the association between adherence to the AHEI-2010 and the risk of prostate cancer in Iranian men.
Design/methodology/approach
The case–control study was conducted in Kermanshah, Iran in the year 2016. The study included 50 cases of Iranian men with prostate cancer and 150 healthy controls. Anthropometric indices were measured by bioelectric impedance analysis (BIA). The AHEI-2010 included 11 food components that were assessed by using a 147-item food frequency questionnaire. A multivariate logistic regression was performed to analyze the association of the AHEI-2010 (expressed as a dichotomous variable) with prostate cancer.
Findings
As per the analysis, there were no significant differences in age, body mass index (BMI) and waist-to-hip ratio (WHR) between case and control groups, statistically. After adjustment for potential confounders, the higher AHEI-2010 scores were associated with a lower risk of prostate cancer (OR AHEI > 55 vs ≤ 55 = 0.26; 95% CI: 0.11-0.63). Moreover, the Mean of AHEI scores was higher in controls than in the cases (p < 0.001).
Originality/value
The authors’ findings suggest that adherence to the dietary patterns with high scores of AHEI-2010 is associated with a reduced risk of prostate cancer, so this index may be used as an effective measure to predict prostate cancer.
Diabetes mellitus (DM) and obesity are common illnesses characterized by glucose metabolism issues and excessive weight gain. Breastfeeding is the best way to feed a newborn up to 6 months old and it ...has been shown to reduce the risk of diabetes and obesity later in life due to its nutritional properties. The purpose of this study was to investigate the effects of breastfeeding, formula feeding, and formula‐plus breastfeeding (mix‐feeding) on the anthropometric indices, metabolic variables, and the expression level of obesity and diabetes‐predisposing genes of healthy infants. A total of 150 healthy infants were enrolled in this cross‐sectional study. All infants (aged 24 months) were divided into three groups based on the type of feeding, breastfeeding, formula feeding, and mix‐feeding. The anthropometric indices, glycemic indexes, lipid profile, and the expression levels of acetyl‐coenzyme A carboxylase beta (ACACB), brain‐derived neurotrophic factor (BDNF), liver X receptor α (LXR‐α), peroxisome proliferator‐activated receptor γ (PPAR‐γ), and phosphatase and tensin homolog (PTEN) genes were measured in all infants using reverse transcription‐polymerase chain reaction (RT‐PCR) method. The anthropometric indices including weight, height, head circumference, insulin, total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C), and high‐density lipoprotein cholesterol (HDL‐C) were lower in the breastfeeding infants in comparison to other groups. As well, the expression level of the ACACB gene was significantly downregulated in breastfeeding infants, while the PPAR‐γ gene was significantly upregulated, but the expression levels of LXR‐ α, PTEN and BDNF did not change significantly across groups. Breastfeeding compared to formula feeding had positive effects on anthropometric indices, metabolic variables, and diabetes‐predisposing genes.
This study aimed to investigate the effects of breastfeeding, formula feeding, and formula‐plus breastfeeding (mix‐feeding) on the anthropometric indices, metabolic variables, and the expression level of obesity and diabetes‐predisposing genes of healthy infants. A total of 150 healthy infants were enrolled in this cross‐sectional study. Breastfeeding compared to formula feeding had positive effects on anthropometric indices, metabolic variables, and diabetes‐predisposing genes.
Ginger and its derivatives have been shown to be effective in the prevention and treatment of cancer. We undertook a systematic review to answer the question of whether ginger has a role in modifying ...the biomarkers of cancer in cell culture conditions and on colorectal cancer in randomized clinical trials. We performed a comprehensive search of the literature from Scopus, Embase, Web of Science, PubMed, Cochrane central register of controlled trials, and Cochrane database of systematic reviews. At first, all 12 papers studied the effect of ginger or its derivatives on cell culture conditions. The results of cell culture studies show that ginger has a powerful role in inducing apoptosis. In the second part, five studies of clinical trials were analyzed. By analyzing antitumor markers of clinical trials, ginger increased some anticancer markers but performed poorly in inducing some anticancer markers. This systematic review showed that the consumption of ginger extract has the potential to prevent and treat colorectal cancer but this ability is weak.
This systematic review showed that the consumption of ginger extract has the potential to prevent and treatment of colorectal cancer but this ability is weak.
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