Abstract 4900
Trisomy 8 is the most common chromosomal change in AML, as sole aberration in 5 % of cytogenetically abnormal cases and occurring together with other abnormalities in an additional 10% ...and little is known about the pathogenetic impact of trisomy 8. Most studies reported trisomy 8 in AML to be associated with intermediate risk. However, some reports have identified a poorer outcome than is usually seen in the intermediate group, considering trisomy 8 an adverse prognostic factor. More importantly, the clinical behavior and outcome of patients with trisomy 8 who are treated with hematopoietic stem cell transplantation (HSCT) is not known. We investigated the outcome in patients with trisomy 8 who were treated with HSCT.
Bone marrow conventional cytogenetic and FISH data from 110 adult AML patients was reviewed and patients divided into three cytogenetic risk groups according to the European LeukemiaNet reporting system while separating patients with trisomy 8 into another, fourth, independent group. Patients with trisomy 8 as part of a complex karyotype (complex = 3 or more abnormalities) were excluded. We also compared outcome of patients with trisomy 8 to the intermediate-risk group alone and adverse-risk group alone, respectively. The AML cohort included 62 (56%) patients treated in their first remission (CR1) while most non-CR1 AML patients were treated with HSCT in CR2. The median age of all patients was 25 years (range: 14–58).
Patients with trisomy 8 were 9 (8%). Patients with trisomy 8 showed significantly longer overall survival (OS) (P=0.02) and event-free survival (EFS) (P=0.03) as compared to patients with adverse cytogenetics. The outcome of trisomy 8-positive patients was similar to the intermediate-risk group.
This data suggests that trisomy 8 in AML is an intermediate-risk factor when patients are treated with HSCT. While we did not compare the outcome of HSCT with the outcome of trisomy 8-positive patients treated with intensive chemotherapy, most likely the cytogenetic risk of trisomy 8 for patients after HSCT is similar to their cytogenetic risk when treated with chemotherapy. Display omitted
No relevant conflicts of interest to declare.
Pure and palladium (Pd) doped Diamond-like carbon (DLC) thin films have been deposited on glass substrates by using KrF Excimer laser having 248 nm wavelength. The doping concentration of Pd in DLC ...is 0%, 0.5%, 1.0%, 1.5% and 2.0%. Internal structure, surface morphology, mechanical and electrical characteristics have been carried out by Raman spectroscopy, scanning electron microscopy (SEM), Vickers hardening and four point probes, respectively. Using Raman spectra an improved graphitic behavior of DLC has been observed with increase of Pd contents. Some nano rods were observed at the surface of pure and Pd doped DLC thin films. With increase of Pd concentration in DLC, initially there is an accumulation of particles is observed and when the doping concentration is high i.e. at 2%, cracks formation takes place. The electrical resistivity is decreased by adding Pd into DLC thin films. Further, doping of Pd decreased the hardness of films. These characteristics of Pd doped DLC with increased hardness and electrical conductivity make it potential candidate for electronic devices. Also, doping enhance the graphitic behavior, therefore this material can be used for anti-bacterial and anti- cancerous activities.
Batch adsorption technique was used to study the adsorption of cobalt on NiO. The aim of this work was to examine the effect of pH, concentration and temperature on the ion exchange removal of Co ...super(2) super(+) from aqueous solution by the NiO surface. We used Langmuir model to interpret the adsorption data. The Kurbatov-type plots were tested to determine the adsorption mechanism. The kinetics of Co super(2) super(+) adsorption on NiO was best described by film diffusion model. A well-known thermodynamic equation was used to assess the enthalpy and entropy of the system. The thermodynamic data were indicative of the spontaneous nature of the endothermic sorption process of Co super(2) super(+) onto the NiO.
Ligands sorption of ammonia, diethanolamine, and triethanolamine on the cation exchanger Amberlite IRC-50 having Cu2+, Ni2+, and Zn2+ ions was studied as a function of temperature 290−318 K and ...different initial concentrations 1−500 mmol·L-1. Sorption was found to follow the order Cu2+ > Zn2+ > Ni2+ and ammonia > diethanolamine > triethanolamine. Desorption of metal cations from the exchanger to the aqueous phase was also observed when the temperature of the system was increased. The results were explained in terms of ligand sorption and ion exchange, which were found to be dependent upon the stabilities of the complexes inside the resin and in the aqueous solution and the basicity and hydrophobicity of the ligand involved. The ratio of metal released/amine sorbed was determined which indicated two possible mechanisms of ligand sorption. The data were explained with the help of mass action law. IR studies also confirmed the presence of metal complexes and metal−amine complexes inside the resin.
Abstract
Introduction
Medical students around the world have been showing an increasing interest in Global Surgery as evident by their participation in various organizations on local and ...international levels. We set out to evaluate exposure of medical students to global surgery, modes of exposure, whether the exposure meets the needs of students, awareness of the key messages of the Lancet Commission on Global Surgery, global surgery career aspirations and barriers to said aspirations.
Methods
We developed the International Survey Of Medical students Exposure to Relevant global Surgery (ISOMERS) study, an online, international, questionnaire-based study. This survey will collect data from final year medical students across the world. The questionnaire utilises a combination of the Likert scale, multiple choice options and free text questions and will be disseminated by email and social media through the International Student Surgical Network, a global surgery student interest group with more than 5,000 members.
Results
Primary outcomes will include exposure to global surgery research, advocacy and education among medical students. We will generate simple descriptive statistics and identify determinants of exposure among medical students and subgroups (country income class and geographic region). Also, we will use multinomial regression analysis to identify confounders and significant dependent variables.
Conclusion
The ISOMERS study will identify the level of exposure to global surgery among students during medical education. An understanding of this exposure will be crucial in developing the foundation for global surgery education at the level of undergraduate medical curriculum and furthered in addressing perceived barriers to joining the global surgery workforce.
A three year old boy presented with sensory neural hearing loss since birth, Diabetes mellitus and anaemia. On investigation he was found to be suffering from thiamine responsive megaloblastic ...anaemia (TRMA) a very rare condition diagnosed in our settings.
Half and full polarization mode convertors which are monolithically integrated with semiconductor lasers are reported. A polarization mode conversion of above 40% and 88% was obtained using single ...and two back-to-back PMCs respectively.
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