The proposed 51 kton magnetized Iron Calorimeter (ICAL) detector at India based Neutrino Observatory (INO) aims to investigate atmospheric neutrino oscillations. ICAL will use approximately 29000 ...glass-based Resistive Plate Chambers (RPCs) as active detector elements, that require millions of electronic channels to be read. Therefore, a multi-channel readout Application Specific Integrated Circuit (ASIC) named as HARDROC can be considered as a possible option. The ASIC is a 64 channel analog-digital front-end chip that can read negative fast and short input signals. Each of the HARDROC channels features a current sensitive pre-amplifier coupled to the triple-branch shaper stage and then 3 low offset discriminators. A comparative performance study of the RPC detector with HARDROC ASIC and with custom electronics, based on CAEN modules and HMC pre-amplifiers, was conducted. Measurements were made on a 30cm × 30cm glass RPC detector using the cosmic rays. The purpose of this work was to compare detector performance in terms of their strip detective efficiency and count rate.
We report a robust display technology for the screening of disulfide-rich peptides, based on cDNA–protein fusions, by developing a novel and versatile puromycin-linker DNA. This linker comprises four ...major portions: a ‘ligation site’ for T4 RNA ligase, a ‘biotin site’ for solid-phase handling, a ‘reverse transcription primer site’ for the efficient and rapid conversion from an unstable mRNA–protein fusion (mRNA display) to a stable mRNA/cDNA–protein fusion (cDNA display) whose cDNA is covalently linked to its encoded protein and a ‘restriction enzyme site’ for the release of a complex from the solid support. This enables not only stabilizing mRNA–protein fusions but also promoting both protein folding and disulfide shuffling reactions. We evaluated the performance of cDNA display in different model systems and demonstrated an enrichment efficiency of 20-fold per selection round. Selection of a 32-residue random library against interleukin-6 receptor generated novel peptides containing multiple disulfide bonds with a unique linkage for its function. The peptides were found to bind with the target in the low nanomolar range. These results show the suitability of our method for in vitro selections of disulfide-rich proteins and other potential applications.
A magnetized Iron CALorimeter (ICAL) detector at the India-based neutrino observatory (INO) is used to study neutrino oscillation sensitivity using atmospheric muon neutrino source. The ICAL detector ...will be able to detect muon tracks and hadron showers produced by neutrino interactions with the iron target. We have performed precision measurement analysis for the atmospheric neutrino oscillation parameters with the muon neutrino events, generated by Monte Carlo NUANCE event generator. A marginalized
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We present a novel application of Fiber Bragg Grating (FBG) sensors in the construction and characterisation of Micro Pattern Gaseous Detector (MPGD), with particular attention to the realisation of ...the largest triple (Gas electron Multiplier) GEM chambers so far operated, the GE1/1 chambers of the CMS experiment at LHC. The GE1/1 CMS project consists of 144 GEM chambers of about 0.5 m
2
active area each, employing three GEM foils per chamber, to be installed in the forward region of the CMS endcap during the long shutdown of LHC in 2108-2019. The large active area of each GE1/1 chamber consists of GEM foils that are mechanically stretched in order to secure their flatness and the consequent uniform performance of the GE1/1 chamber across its whole active surface. So far FBGs have been used in high energy physics mainly as high precision positioning and re-positioning sensors and as low cost, easy to mount, low space consuming temperature sensors. FBGs are also commonly used for very precise strain measurements in material studies. In this work we present a novel use of FBGs as flatness and mechanical tensioning sensors applied to the wide GEM foils of the GE1/1 chambers. A network of FBG sensors have been used to determine the optimal mechanical tension applied and to characterise the mechanical tension that should be applied to the foils. We discuss the results of the test done on a full-sized GE1/1 final prototype, the studies done to fully characterise the GEM material, how this information was used to define a standard assembly procedure and possible future developments.
The CMS Collaboration plans to equip the very forward muon system with triple-GEM detectors that can withstand the environment of the High-Luminosity LHC. This project is at the final stages of R&D ...and moving to production. An unprecedented large area of several 100 m
2
are to be instrumented with GEM detectors which will be produced in six different sites around the world. A common construction and quality control procedure is required to ensure the performance of each detector. The quality control steps will include optical inspection, cleaning and baking of all materials and parts used to build the detector, leakage current tests of the GEM foils, high voltage tests, gas leak tests of the chambers and monitoring pressure drop vs. time, gain calibration to know the optimal operation region of the detector, gain uniformity tests, and studying the efficiency, noise and tracking performance of the detectors in a cosmic stand using scintillators.
We combine searches by the CDF and D0 Collaborations for the associated production of a Higgs boson with a W or Z boson and subsequent decay of the Higgs boson to a bottom-antibottom quark pair. The ...data, originating from Fermilab Tevatron pp collisions at √s = 1.96 TeV, correspond to integrated luminosities of up to 9.7 fb(-1). The searches are conducted for a Higgs boson with mass in the range 100-150 GeV/c(2). We observe an excess of events in the data compared with the background predictions, which is most significant in the mass range between 120 and 135 GeV/c(2). The largest local significance is 3.3 standard deviations, corresponding to a global significance of 3.1 standard deviations. We interpret this as evidence for the presence of a new particle consistent with the standard model Higgs boson, which is produced in association with a weak vector boson and decays to a bottom-antibottom quark pair.
We report observation of the electroweak production of single top quarks in ppover collisions at sqrts=1.96 TeV based on 2.3 fb(-1) of data collected by the D0 detector at the Fermilab Tevatron ...Collider. Using events containing an isolated electron or muon and missing transverse energy, together with jets originating from the fragmentation of b quarks, we measure a cross section of sigma(ppover --> tb + X, tqb + X) = 3.94 + or - 0.88 pb. The probability to measure a cross section at this value or higher in the absence of signal is 2.5 x 10(-7), corresponding to a 5.0 standard deviation significance for the observation.
Higgs boson studies at the Tevatron Agnew, J. P.; Annovi, A.; Bandurin, D. V. ...
Physical review. D, Particles, fields, gravitation, and cosmology,
09/2013, Letnik:
88, Številka:
5
Journal Article
Recenzirano
Odprti dostop
We combine searches by the CDF and DO Collaborations for the standard model Higgs boson with mass in the range 90- 200 GeV /c super(2) produced in the gluon-gluon fusion, WH, ZH, ttH, and vector ...boson fusion processes, and decaying in the H arrow right bb, H arrow right W super(+)W super(-), H arrow right ZZ, H arrow right tau super(+)tau super(-), and H arrow right gamma gamma modes. The data correspond to integrated luminosities of up to 10 fb super(-1) and were collected at the Fermilab Tevatron in pp collisions at radicals = 1.96 TeV. The searches are also interpreted in the context of fermiophobic and fourth generation models. We observe a significant excess of events in the mass range between 115 and 140 GeV /c super(2). The local significance corresponds to 3.0 standard deviations at mH = 125 GeV /c super(2), consistent with the mass of the Higgs boson observed at the LHC, and we expect a local significance of 1.9 standard deviations. We separately combine searches for H arrow right bb, H arrow right W super(+)W super(-), H arrow right tau super(+)t super(-), and H arrow right gamma gamma . The observed signal strengths in all channels are consistent with the presence of a standard model Higgs boson with a mass of 125 GeV /c super(2).
We present a measurement of the W boson mass using data corresponding to 4.3 fb(-1) of integrated luminosity collected with the D0 detector during Run II at the Fermilab Tevatron pp collider. With a ...sample of 1,677,394 W → eν candidate events, we measure M(W) = 80.367 ± 0.026 GeV. This result is combined with an earlier D0 result determined using an independent Run II data sample, corresponding to 1 fb(-1) of integrated luminosity, to yield M(W) = 80.375 ± 0.023 GeV.
We developed a method to produce, identify and analyze DNA fragments for the purpose of taxonomic classification. Genome profiling (GP) is a strategy that identifies genomic DNA fragments common to ...closely related species without prior knowledge of the DNA sequence. Random PCR, one of the key technologies of GP, is used to produce fragments and may be used even when there are mutations at the priming site. These fragments can then be distinguished based on the information of mobility and melting pattern when subjected to temperature gradient gel electrophoresis (TGGE). Corresponding fragments among several species, designated as commonly conserved genetic fragments (CCGFs), likely have the same genetic origin or correspond to the same gene. The criteria for identification of CCGFs has been defined and presented here. To assess this prediction, some of the fragments were sequenced and were confirmed to be CCGFs. We show that genome profiles bearing evolutionarily conserved CCGFs can be used to classify organisms and trace evolutionary pathways, among other profound applications.
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