Electronic personal dosemeters (EPD) are powerful tools for achieving ALARA (As Low As Reasonably Achievable) objectives in operational radiation protection. EPD for photons are well developed and ...their performances usually comply with relevant Standards. By contrast, a very few commercial models exist for neutrons and their energy dependence is too large for using them without pre-information on the workplace neutron spectrum. Within the INFN-based DOIN (DOsimetro Indossabile per Neutroni) project, a new EPD for neutrons was prototyped. Owing to a new patented design, a good dose response was achieved in the energy interval from thermal neutrons up to the quality of
241
Am-Be. The response is nearly isotropic and, if compared to commercial models, exhibits higher sensitivity.
FLASH radiotherapy (FRT) is a novel radiotherapy technique based on dose rates that are several orders of magnitude greater than those used in conventional radiotherapy (40 Gy/s vs. 0.5–5 Gy/min). ...FRT is still in its preclinical and early clinical stage of development. However these studies indicate that FRT is more effective in sparing normal tissues from radiation-related side effects, as compared to conventional radiotherapy. This is the so-called "FLASH effect" and was observed with multi-MeV electron beams. Before FRT is made available to humans, more basic research is needed to fully understand its radiobiology fundamentals. Meanwhile, suitable radiation sources and dosimetric tools are gradually becoming available. Within this framework, INFN-LNF developed the Unbalanced Core Detector (UCD), a novel type of electron dosimeter designed to operate in the FRT domain. UCD main characteristics are the nearly isotropic response, the independence from the electron energy, the very high radiation resistance, the linearity up to dose rates of MGy/s and the possibility to record the time evolution of a single radiation pulse. UCD was tested using 7 and 9 MeV electron beams produced with the ElectronFlash accelerator from Sordina IORT Technologies (SIT S.p.A.) in Aprilia, Italy. UCD was used to measure dose distributions in a water phantom. The results well compare to those obtained with a flashDiamond detector from PTW.
A systematic review of the published literature was conducted specifically looking at studies reporting linear dimension and angular projection data on the anatomy of the cervical pedicle (C1-C7) via ...radiography or direct measurement.
This study aimed to report a more accurate set of dimension data and identify differences based on race and gender, increasing the sample size by aggregating similar data of prior studies measuring the cervical pedicle in Asian, European/American, male, and female populations.
A wide variation in the reports of the dimensions and projections of the cervical pedicle exist partly due to the uniqueness of this structure as well as the effects of small sample sizes and variable races and genders of sample populations of previous studies.
An extensive literature search was executed, and identified articles were reviewed. A comprehensive database was constructed for synthesis of the identified studies. Subgroups were determined based on the type of population (race, gender, location of study) and radiographic or direct cadaveric measurement. Descriptive statistics were used to analyze and compare these subgroups including: means, standard deviations, and Student t test with the Bonferroni adjustment.
In total, the current study reports on 33 studies with the measurements of 1311 partial and complete cervical spines. At a 95% confidence interval statistically significant differences between races were found only at C3 and C4 levels in the pedicle axis length. Male-to-female significant differences existed only at the pedicle axis length of C5 in the Asian population, while sex differences existed in the outer pedicle width and height of C3, C4, C5, C6, and C7 in the European/American population.
The current study has found that there is no statistical difference in measuring the cervical pedicle via radiography (CT) or directly. There are more significant differences comparing the cervical pedicles of males and females in the European/American population than exists in the Asian population (specifically in pedicle width and height). There are also significant differences at C3 and C4 cervical pedicle between the Asian and European/American population (specifically in the pedicle axis length and transverse angle).
A new directional neutron spectrometer called NCT-WES (Neutron Capture Therapy Wide Energy Spectrometer) was recently developed within the INFN ENTER_BNCT project. This device constitutes a more ...compact and portable alternative to state-of-the-art directional neutron spectrometers. The device was used for the first time to characterise the near-target field produced by an accelerator-driven D–D fusion neutron source. NCT-WES operates as a “parallelised” Bonner spheres spectrometer, embedding six semiconductor-based thermal neutron detectors in a cylindrical moderator. Owing on a cylindrical collimating aperture, the device exhibits sharply directional response. To account for the non-uniform irradiation condition experienced in the near-target field, a dedicated NCT-WES response matrix was developed. The neutron spectrum at 0
∘
from the D–D neutron target, determined by means of the FRUIT unfolding code, is coherent with that previously derived with Bonner spheres. NCT-WES proved to be a promising device for angular spectrometric characterisation of neutron-emitting targets.
Mini-EUSO is part of the JEM-EUSO program and operates on board the International Space Station (ISS). It is a UV-telescope with single-photon counting capability looking at nighttime downwards to ...the Earth through a nadir-facing UV-transparent window. As part of the pre-flight tests, the Mini-EUSO engineering model, a telescope with 1/9 of the original focal surface and a lens of 2.5 cm diameter, has been built and tested. Tests of the Mini-EUSO engineering model have been made in laboratory and in open-sky conditions. Laboratory tests have been performed at the TurLab facility, located at the Physics Department of the University of Turin, equipped with a rotating tank containing different types of materials and light sources. In this way, the configuration for the observation of the Earth from space was emulated, including the Mini-EUSO trigger schemes. In addition to the qualification and calibration tests, the Mini-EUSO engineering model has also been used to evaluate the possibility of using a JEM-EUSO-type detector for applications such as observation of space debris. Furthermore, observations in open-sky conditions allowed the studies of natural light sources such as stars, meteors, planets, and artificial light sources such as airplanes, satellites reflecting the sunlight, and city lights. Most of these targets could be detected also with Mini-EUSO. In this paper, the tests in laboratory and in open-sky conditions are reported, as well as the obtained results. In addition, the contribution that such tests provided to foresee and improve the performance of Mini-EUSO on board the ISS is discussed.
A directional neutron spectrometer named NCT-WES (Neutron Capture Therapy Wide Energy Spectrometer) was developed for quality assurance of the therapeutic neutron beam in Neutron Capture Therapy ...(NCT). NCT-WES operates as a “parallelized” Bonner spheres spectrometer, embedding six semiconductor-based thermal neutron detectors in a collimated cylindrical moderator. With the objective of validating the simulation model used to derive its response matrix, irradiations in reference monoenergetic fields were performed at National Physical Laboratory (UK). As the energy distributions of neutron beams in NCT extend from keV to a few MeV, monoenergetic fields in this domain were chosen, namely 71.5 keV, 144.2 keV, 565.1 keV, 841.9 keV and 1200.4 keV. The results of the experiment confirm the correctness of the NCT-WES simulation model, within an overall uncertainty lower than ± 2%.
To efficiently treat type 1 diabetes, exogenous insulin injections currently represent the main approach to counter chronic hyperglycaemia. Unfortunately, such a therapeutic approach does not allow ...for perfectly maintained glucose homeostasis and, in time, cardiovascular complications may arise. Therefore, seeking alternative/improved treatments has become a major health concern as an increasing proportion of type 2 diabetes patients also require insulin supplementation. Towards this goal, numerous laboratories have focused their research on β‐cell replacement therapies. Herein, we will review the current state of this research area and describe the cell sources that could potentially be used to replenish the depleted β‐cell mass in diabetic patients.
More than three dozen submillisecond events of ELVES type (“elves”), which are the result of the interaction of the front of an electromagnetic pulse from a lightning discharge and the lower layer of ...the ionosphere, have been identified in the data of a UV Atmosphere orbital multichannel detector (Mini-EUSO). Each event has a characteristic annular glow pattern and occupies a significant part of the detector’s field of view, and the signal in a separate channel has an asymmetric profile with a pronounced peak. The distribution of peak times contains information about both the localization of the discharge and the altitude of the glow. In this paper, we propose a Bayesian (probabilistic) model for reconstructing ELVES events, implemented using probabilistic programming methods in PyMC-5. The capabilities of the model for determining the position of the discharge are shown using the example of several events. Methods for modifying the model to restore the discharge orientation and refine the glow height are outlined.
The CUORE Cryostat D’Addabbo, A.; Alduino, C.; Bersani, A. ...
Journal of low temperature physics,
12/2018, Letnik:
193, Številka:
5-6
Journal Article
Recenzirano
Odprti dostop
The Cryogenic Underground Observatory for Rare Events (CUORE) is a bolometric experiment for neutrinoless double-beta decay in
130
Te
search, currently taking data at the underground facility of ...Laboratori Nazionali del Gran Sasso (LNGS). The CUORE cryostat successfully cooled down a mass of about 1 ton at
∼
7
mK
, delivering a uniform and constant base temperature. This result marks a fundamental milestone in low-temperature detector techniques, opening the path for future ton-scale bolometric experiments searching for rare events. In this paper, we present the CUORE cryogenic infrastructure, briefly describing its critical subsystems.
Mini-EUSO is a high-sensitivity imaging telescope that observes the Earth from the ISS in the near ultraviolet band (290
÷
430 nm), through the nadir-facing, UV-transparent window in the Russian ...Zvezda module. The instrument, launched in 2019, has a field of view of 44
∘
, a spatial resolution on the Earth’s surface of 6.3 km and a temporal sampling rate of 2.5 microseconds. Thanks to its triggering and on-board processing, the telescope is capable of detecting UV emissions of cosmic, atmospheric, and terrestrial origin on different time scales, from a few microseconds up to tens of milliseconds. The optics is composed of two Fresnel lenses focusing light onto an array of 36 Hamamatsu Multi-Anode PhotoMultiplier Tubes, for a total of 2304 pixels. The telescope also contains two cameras in the near-infrared and visible, an 8-by-8 array of Silicon-PhotoMultipliers and a series of UV sensors to manage night-day transitions. The scientific objectives range from the observation of atmospheric phenomena lightning, Transient Luminous Events (TLEs), ELVES, the study of meteoroids, the search of interstellar meteoroids and strange quark matter, mapping of the Earth’s nocturnal emissions in the ultraviolet range, and the search of cosmic rays with energy above 10
21
eV. The instrument has been integrated and qualified in 2019, with the final tests in Baikonur prior to its launch. Operations involve periodic installation in the Zvezda module of the station with observations during the crew night time, with periodic downlink of data samples, with the full data being sent to the ground via pouches containing the data disks. Mission planning involves the selection of the optimal orbits to maximize the scientific return of the instrument. In this work, we will describe the various phases of construction, testing, and qualification prior to the launch and the in-flight operations of the instrument on board the ISS.
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