El presente artículo propone un estudio del libro como formato periodístico a través del fenómeno del periodismo narrativo en España. El libro es un formato periodístico que en nuestro país ha tenido ...poca presencia y apenas ha despertado interés. Sin embargo, una serie de circunstancias recientes ha estimulado la producción y edición de este formato. Han nacido editoriales especializadas en la publicación de obras periodísticas y junto con el surgimiento de una nueva generación de autores periodísticos narrativos han provocado un entorno de gran efervescencia. Los datos obtenidos revelan las nuevas oportunidades que tienen los periodistas para buscar otras vías de publicación, la mínima presencia del libro electrónico, así como las razones específicas de por qué utilizan el libro para publicar periodismo. La discusión muestra como el libro puede ser un excelente soporte para el periodismo y los peligros e inconvenientes a los que se enfrenta, especialmente el de la financiación.
We study existence, uniqueness and positivity conditions for a cooperative system formulated with a high order diffusion. In addition, we show and characterize the instabilities due to the high order ...diffusion for which a positivity and a comparison principle hold after rescaling. Instabilities shall be understood as the oscillatory behaviour of solutions acting as an inherent feature driven by complex exponential bundles of solutions. Firstly, a shooting method approach is used to show the existence of such instabilities. Afterwards, the existence of solutions is assessed in the self-similar approach and characterized by analytical and numerical evidences for a single equation in and for the complete system. Finally, a positive kernel is shown to exist and a sharp estimation is obtained.
Long-term adherence to antiosteoporosis medication (AOM) in the setting of a fracture liaison service (FLS) are not well known. Patients ≥ 50 with hip fracture seen in an FLS and recommended for ...treatment to prevent new fractures were analyzed. Baseline data included demographics, identification mode, previous treatment and FRAX items. Patient records were reviewed 3-8 years later, and these data were collected: (1) survival; (2) major refracture; (3) initiation of treatment, proportion of days covered (PDC) and persistence with AOM. 372 patients (mean age, 79 years; 76% women) were included. Mean follow-up was 47 months, 52 patients (14%) had a refracture (22 hip) and 129 (34.5%) died. AOM was started in 283 patients (76.0%). Factors associated with initiation of AOM were previous use of bisphosphonate (OR 9.94; 95% CI 1.29-76.32) and a lower T-score lumbar (OR 0.80; 95% CI 0.65-0.99). Persistence decreased to 72.6%, 60% and 47% at 12, 36 and 60 months. A PDC > 80% was confirmed in 208 patients (55.7%) and associated with previous use of bisphosphonate (OR 3.38; 95% CI 1.34-8.53), treatment with denosumab (OR 2.69; 95% CI:1.37-5.27), and inpatient identification (OR 2.26; 95% CI 1.18-4.34). Long-term persistence with AOM was optimal in patients with hip fracture seen at an FLS. A PDC > 80% was associated with inpatient identification and prescription of denosumab.
Abstract
Objective
To identify biomarkers of articular and ocular disease activity in patients with Blau syndrome (BS)
Methods
Multiplex plasma protein arrays were performed in five BS patients and ...eight normal healthy volunteers (NHVs). Plasma S100A12 and S100A8/9 were subsequently measured by ELISA at baseline and 1-year follow-up in all patients from a prospective multicentre cohort study. CRP was measured using Meso Scale Discovery immunoassay. Active joint counts, standardization uveitis nomenclature for anterior uveitis cells and vitreous haze by Nussenblatt scale were the clinical parameters.
Results
Multiplex Luminex arrays identified S100A12 as the most significantly elevated protein in five selected BS vs eight NHVs and this was confirmed by ELISA on additional samples from the same five BS patients. In the patient cohort, S100A12 (n = 39) and S100A8/9 (n = 33) were significantly higher compared with NHVs (n = 44 for S100A12, n = 40 for S100A8/9) (P = 0.0000004 and P = 0.0003, respectively). Positive correlations between active joint counts and S100 levels were significant for S100A12 (P = 0.0008) and S100A8/9 (P = 0.015). CRP levels did not correlate with active joint count. Subgroup analysis showed significant association of S100 proteins with active arthritis (S100A12 P = 0.01, S100A8/9 P = 0.008). Active uveitis was not associated with increased S100 levels.
Conclusion
S100 proteins are biomarkers of articular disease activity in BS and potential outcome measures in future clinical trials. As secreted neutrophil and macrophage products, S100 proteins may reflect the burden of granulomatous tissue in BS.
Hudson is one of the most active volcanoes in the Southern Andes—it had one of the largest eruptions of the 20th century in 1991 (VEI = 5) and smaller eruptions in 1971 (VEI = 3), maybe 1973, and ...2011 (VEI of 1-2). We use satellite-based interferometric synthetic aperture radar (InSAR) and thermal imagery to characterize the activity of Hudson between 2004 and 2011 and during the 2011 eruption. InSAR data show that the volcano inflated between 2004 and 2010 with a maximum change rate of between 2 and 3 cm/yr—about half of the deformation rate observed during a previous deformation episode from 1993–1999. Inversion for an inflating point source suggests magma accumulation beneath the SW part of the caldera at an average depth of 10 km. This inferred source is deeper than both the sources estimated for the magma chamber of the 1991 eruption (from petrology) and for the 1993–1999 deformation event. Also, the deformation from 2004–2010 is centered at a slightly different location and has a smaller volume change than that between 1993–1999—further indicating that there is either a large magma reservoir or several separate ones. While the deformation center is a few km from the eruption location near the caldera rim, the two are possibly linked since the predicted static Coloumb stress changes due to the inferred inflation source would encourage unclamping on potential faults in the caldera rim. We also analize nighttime satellite thermal images from MODIS and ASTER. While MODIS did not show any unambiguous evidence for hot spots, ASTER thermal imagery show that at least four months before the eruption there were locations with temperatures 7–8ºK above background. Lahars observed by helicopter overflights on 4 March 2011 and October 2011 suggest that the hotspots may have been caused by lakes or subglacial melting. There is no InSAR data available for the months immediately preceding the eruption, but the ASTER thermal imagery results may indicate an increase in geothermal activity that could have been used to forecast the eruption.
The goal of this paper is to provide analytical assessments to a fluid flowing in a porous medium with a non-linear diffusion linked to a degenerate diffusivity. The viscosity term is formulated with ...an Eyring-Powell law, together with a non-homogeneous diffusion typical of porous medium equations (as known in the theory of partial differential equations). Further, the equation is supplemented with an absorptive reaction term of Darcy-Forchheimer, commonly used to model flows in porous medium. The work starts by analyzing regularity, existence and uniqueness of solutions. Afterwards, the problem is transformed to study travelling wave kind of solutions. An asymptotic expansion is considered with a convergence criteria based on the geometric perturbation theory. Supported by this theory, there exists an exponential decaying rate in the travelling wave profile. Such exponential behaviour is validated with a numerical assessment. This is not a trivial result given the degenerate diffusivity induced by the non-linear diffusion of porous medium type and suggests the existence of regularity that can serve as a baseline to construct numerical or energetic approaches.
The goal of this study is to provide analytical and numerical assessments to a fluid flow based on an Eyring–Powell viscosity term and a Darcy–Forchheimer law in a porous media. The analysis provides ...results about regularity, existence and uniqueness of solutions. Travelling wave solutions are explored, supported by the Geometric Perturbation Theory to build profiles in the proximity of the equation critical points. Finally, a numerical routine is provided as a baseline for the validity of the analytical approach presented for low Reynolds numbers typical in a porous medium.
Provide baseline and preliminary follow-up results in a 5-year longitudinal study of Blau syndrome.
Multicenter, prospective interventional case series.
Baseline data from 50 patients from 25 centers ...worldwide, and follow-up data for patients followed 1, 2, or 3 years at the end of study enrollment. Ophthalmic data were collected at baseline and yearly visits by means of a standardized collection form.
Median age at onset of eye disease was 60 months and duration of eye disease at baseline 145 months. At baseline 38 patients (78%) had uveitis, which was bilateral in 37 (97%). Eight patients (21%) had moderate to severe visual impairment. Panuveitis was found in 38 eyes (51%), with characteristic multifocal choroidal infiltrates in 29 eyes (39%). Optic disc pallor in 9 eyes (12%) and peripapillary nodules in 9 eyes (12%) were the commonest signs of optic nerve involvement. Active anterior chamber inflammation was noted in 30 eyes (40%) at baseline and in 16 (34%), 17 (57%), and 11 (61%) eyes at 1, 2, and 3 years, respectively. Panuveitis was associated with longer disease duration. At baseline, 56 eyes (75%) were on topical corticosteroids. Twenty-six patients (68%) received a combination of systemic corticosteroids and immunomodulatory therapy.
Blau uveitis is characterized by progressive panuveitis with multifocal choroiditis, resulting in severe ocular morbidity despite continuous systemic and local immunomodulatory therapy. The frequency and severity of Blau uveitis highlight the need for close ophthalmologic surveillance as well as a search for more effective therapies.
Objectives
To evaluate the prevalence of self-perceived depression and anxiety in patients with systemic lupus erythematosus (SLE) and to explore associated factors.
Methods
Cross-sectional study of ...unselected patients with SLE (ACR-97 criteria) and controls with chronic inflammatory rheumatic diseases. Both completed the Hospital Anxiety and Depression Scale (HADS). Demographic and clinical characteristics, comorbidity, and treatments were collected, and a multivariate analysis was performed to explore factors associated with depression and anxiety in SLE.
Results
The study population comprised 172 patients and 215 controls. Women accounted for 93% of the patients with SLE. Fibromyalgia was recorded in 12.8% and a history of depression in 17%. According to HADS, 37.2% fulfilled the diagnostic criteria for depression and 58.7% those for anxiety; prevalence was similar in the controls (32.6% and 55.1%, respectively). Up to a third of patients with self-perceived depression were not receiving antidepressants. There was no concordance between a previous history of depression and current depression. In the multivariate model, current depression was associated with single marital status (OR 2.69; 95% CI: 1.17–6.42; p = .022), fibromyalgia (7.69; 2.35–30.72; p = .001), smoking (3.12; 1.24–8.07; p = .016), severity of SLE (0.76; 0.6–0.94; p = .016), and organ damage (1.27; 1.01–1.61; p = .042). Current anxiety was only associated with fibromyalgia (3.97; 1.21–17.98; p = .036).
Conclusions
Depression and anxiety are most likely underdiagnosed in SLE. Prevalence appears to be similar to that of other chronic inflammatory rheumatic diseases. Anxiety is associated with fibromyalgia, while depression is also associated with single marital status, smoking, organ damage, and severity of SLE.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, OILJ, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
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