The exploration of metabolomics and targeted segments of proteins stands as a pivotal facet of Nuclear Magnetic Resonance (NMR) analysis, furnishing valuable insights into molecular architectures and ...potential therapeutic applications. The issue of spectral congestion frequently presents challenges in ascribing distinct peaks within the confines of both one-dimensional (1D) and two-dimensional (2D) NMR spectra. Numerous strategies have been proposed to resolve specific resonances in NMR spectra differentially. Among these approaches, relaxation editing emerges as a viable solution. In the realm of relaxation phenomena within NMR, Long-Lived States (LLS) and Long-Lived Coherences (LLC) manifest as promising phenomena, offering enhanced relaxation lifetimes in comparison to the traditional longitudinal (T 1) and transverse (T 2) relaxation times for coupled nuclear spins. Notably, LLC presents a pathway to attenuate uncoupled high-intensity peaks, effectively diminishing their impact. The foundation of this technique rests upon the premise that the relaxation lifetime in the rotating frame (T 1ρ) remains smaller than T LLC . In pursuit of refining spectral assignments within complex mixtures, we introduce a new pulse sequence tailored for LLC Total Correlation Spectroscopy (LLC-TOCSY). This demonstrates efficacy in extracting LLC signals within configurations involving multiple coupled spins, thereby decluttering the spectrum and enhancing the accuracy of peak assignments. To validate the effectiveness of this method, a collection of samples was subjected to scrutiny, yielding compelling results.
Over the last two decades, numerous pulse sequences have been introduced for the excitation of long-lived spin order (LLS) in high fields. The long continuous wave (CW) or adiabatic pulses used in ...the SLIC and APSOC sequences should remind one of the spin-locking pulses that are used to induce cross-polarization (CP). Dynamics during these spin-lockings in CP experiments are explained through a geometrical formalism. However, the SLIC and APSOC sequences are described in terms of the energy-level picture or in the language of level anti-crossings. Motivated by this analogy, this work presents here a geometrical formalism for the LLS excitation by spin-locking pulses in weakly coupled systems. The formalism is similar to the one used for CP dynamics and reveals new pulse sequences involving CW or adiabatic locking. A similar formalism for the sustaining period of LLS is also provided, which reveals new features of the dynamics and suggests the usage of modulated spin-lockings for proper LLS sustaining. For strong and intermediate regimes, although a simple geometrical formalism seems infeasible, a new pulse sequence that employs a ramp-down adiabatic pulse for both LLS excitation and reconversion to observables in both these regimes is presented here. Given the similarities between LLS excitation and well-developed CP, it may be anticipated that this work would initiate the search for new LLS excitation methods and applications.
We study the efficiency of galactic feedback in the early Universe by stacking the C II 158
μ
m emission in a large sample of normal star-forming galaxies at 4 <
z
< 6 from the ALMA Large Program ...to INvestigate C II at Early times (ALPINE) survey. Searching for typical signatures of outflows in the high-velocity tails of the stacked C II profile, we observe (i) deviations from a single-component Gaussian model in the combined residuals and (ii) broad emission in the stacked C II spectrum, with velocities of |
v
|≲500 km s
−1
. The significance of these features increases when stacking the subset of galaxies with star formation rates (SFRs) higher than the median (SFR
med
= 25
M
⊙
yr
−1
), thus confirming their star-formation-driven nature. The estimated mass outflow rates are comparable to the SFRs, yielding mass-loading factors of the order of unity (similarly to local star-forming galaxies), suggesting that star-formation-driven feedback may play a lesser role in quenching galaxies at
z
> 4. From the stacking analysis of the datacubes, we find that the combined C II core emission (|
v
|< 200 km s
−1
) of the higher-SFR galaxies is extended on physical sizes of ∼30 kpc (diameter scale), well beyond the analogous C II core emission of lower-SFR galaxies and the stacked far-infrared continuum. The detection of such extended metal-enriched gas, likely tracing circumgalactic gas enriched by past outflows, corroborates previous similar studies, confirming that baryon cycle and gas exchanges with the circumgalactic medium are at work in normal star-forming galaxies already at early epochs.
In the last two decades, extending spin memory in NMR has been used for several purposes. Long-lived states (LLS) or singlet states are one of the first spin memory enhancement techniques used. LLS ...have the potential to extract structural information and intra- and intermolecular interactions of complex systems other than studying slow phenomenon. The motional regime of β-cyclodextrin (β-CD) drug inclusion complexes generally lies in the intermediate region, where ωτ c ≈ 1, and the standard methods of studying these interactions, i.e., NOE and chemical shift monitoring, suffer from insufficient output information. The sensitivity of LLS toward the environmental changes is utilized here to gain insights into the drug assemblies formed by β-CD. One can use change in relaxation of LLS to study the structural changes during complexation. The examples of β-CD with the drugs indomethacin, paracetamol, gliclazide, and CI-933 (a precursor 4-methoxybenzamide) were studied. Indomethacin, paracetamol, and 4-methoxybenzamide show strong interaction through the para-substituted benzene ring, unlike gliclazide. Relaxation of LLS in β-CD–drug complexes is modeled using standard Redfield Relaxation Theory. Computational studies performed support the experimental observations. Docking and molecular dynamics simulation provided the explanation of the relaxation properties of these drug molecules.
The South Pole Telescope (SPT) has systematically identified 81 high-redshift, strongly gravitationally lensed, dusty star-forming galaxies (DSFGs) in a 2500 square degree cosmological ...millimeter-wave survey. We present the final spectroscopic redshift survey of this flux-limited (S870 m > 25 mJy) sample, initially selected at 1.4 mm. The redshift survey was conducted with the Atacama Large Millimeter/submillimeter Array across the 3 mm spectral window, targeting carbon monoxide line emission. By combining these measurements with ancillary data, the SPT sample is now spectroscopically complete, with redshifts spanning 1.9 < z < 6.9 and a median of . We present the millimeter through far-infrared photometry and spectral energy density fits for all sources, along with their inferred intrinsic properties. Comparing the properties of the SPT sources to the unlensed DSFG population, we demonstrate that the SPT-selected DSFGs represent the most extreme infrared-luminous galaxies, even after accounting for strong gravitational lensing. The SPT sources have a median star formation rate of and a median dust mass of . However, the inferred gas depletion timescales of the SPT sources are comparable to those of unlensed DSFGs, once redshift is taken into account. This SPT sample contains roughly half of the known spectroscopically confirmed DSFGs at z > 5, making this the largest sample of high-redshift DSFGs to date, and enabling the "high-redshift tail" of extremely luminous DSFGs to be measured. Though galaxy formation models struggle to account for the SPT redshift distribution, the larger sample statistics from this complete and well-defined survey will help inform future theoretical efforts.
While several publications have focused on the intuitive role of augmented reality (AR) and virtual reality (VR) in neurosurgical planning, the aim of this review was to explore other avenues, where ...these technologies have significant utility and applicability.
This review was conducted by searching PubMed, PubMed Central, Google Scholar, the Scopus database, the Web of Science Core Collection database, and the SciELO citation index, from 1989-2021. An example of a search strategy used in PubMed Central is: "Virtual reality" All Fields AND ("neurosurgical procedures" MeSH Terms OR ("neurosurgical" All Fields AND "procedures" All Fields) OR "neurosurgical procedures" All Fields OR "neurosurgery" All Fields OR "neurosurgery" MeSH Terms). Using this search strategy, we identified 487 (PubMed), 1097 (PubMed Central), and 275 citations (Web of Science Core Collection database).
Articles were found and reviewed showing numerous applications of VR/AR in neurosurgery. These applications included their utility as a supplement and augment for neuronavigation in the fields of diagnosis for complex vascular interventions, spine deformity correction, resident training, procedural practice, pain management, and rehabilitation of neurosurgical patients. These technologies have also shown promise in other area of neurosurgery, such as consent taking, training of ancillary personnel, and improving patient comfort during procedures, as well as a tool for training neurosurgeons in other advancements in the field, such as robotic neurosurgery.
We present the first review of the immense possibilities of VR in neurosurgery, beyond merely planning for surgical procedures. The importance of VR and AR, especially in "social distancing" in neurosurgery training, for economically disadvantaged sections, for prevention of medicolegal claims and in pain management and rehabilitation, is promising and warrants further research.
ABSTRACT We present 0 4 resolution extinction-independent distributions of star formation and dust in 11 star-forming galaxies (SFGs) at z = 1.3-3.0. These galaxies are selected from sensitive ...blank-field surveys of the 2′ × 2′ Hubble Ultra-Deep Field at λ = 5 cm and 1.3 mm using the Karl G. Jansky Very Large Array and Atacama Large Millimeter/submillimeter Array. They have star formation rates (SFRs), stellar masses, and dust properties representative of massive main-sequence SFGs at z ∼ 2. Morphological classification performed on spatially resolved stellar mass maps indicates a mixture of disk and morphologically disturbed systems; half of the sample harbor X-ray active galactic nuclei (AGNs), thereby representing a diversity of z ∼ 2 SFGs undergoing vigorous mass assembly. We find that their intense star formation most frequently occurs at the location of stellar-mass concentration and extends over an area comparable to their stellar-mass distribution, with a median diameter of 4.2 1.8 kpc. This provides direct evidence of galaxy-wide star formation in distant blank-field-selected main-sequence SFGs. The typical galactic-average SFR surface density is 2.5 M yr−1 kpc−2, sufficiently high to drive outflows. In X-ray-selected AGN where radio emission is enhanced over the level associated with star formation, the radio excess pinpoints the AGNs, which are found to be cospatial with star formation. The median extinction-independent size of main-sequence SFGs is two times larger than those of bright submillimeter galaxies, whose SFRs are 3-8 times larger, providing a constraint on the characteristic SFR (∼300 M yr−1) above which a significant population of more compact SFGs appears to emerge.
Galaxies grow inefficiently, with only a small percentage of the available gas converted into stars each free-fall time. Feedback processes, such as outflowing winds driven by radiation pressure, ...supernovae, or supermassive black hole accretion, can act to halt star formation if they heat or expel the gas supply. We report a molecular outflow launched from a dust-rich star-forming galaxy at redshift 5.3, 1 billion years after the Big Bang. The outflow reaches velocities up to 800 kilometers per second relative to the galaxy, is resolved into multiple clumps, and carries mass at a rate within a factor of 2 of the star formation rate. Our results show that molecular outflows can remove a large fraction of the gas available for star formation from galaxies at high redshift.
We present high-fidelity, 30 mas (200 pc) resolution ALMA rest-frame 240 m observations of cold dust emission in three typical main-sequence star-forming galaxies (SFGs) at z ∼ 3 in the Hubble ...Ultra-Deep Field (HUDF). The cold dust is distributed within the smooth disklike central regions of star formation 1-3 kpc in diameter, despite their complex and disturbed rest-frame UV and optical morphologies. No dust substructures or clumps are seen down to 1-3 yr−1 (1 ) per 200 pc beam. No dust emission is observed at the locations of UV-emitting clumps, which lie 2-10 kpc from the bulk of star formation. Clumpy substructures can contribute no more than 1%-7% of the total star formation in these galaxies (3 upper limits). The lack of star-forming substructures in our HUDF galaxies is to be contrasted with the multiple substructures characteristic of submillimeter-selected galaxies (SMGs) at the same cosmic epoch, particularly the far-IR-bright SMGs with similarly high-fidelity ALMA observations of Hodge et al. Individual star-forming substructures in these SMGs contain ∼10%-30% of their total star formation. A substructure in these SMGs is often comparably bright in the far-infrared to (or in some cases brighter than) our typical SFGs, suggesting that these SMGs originate from a class of disruptive events involving multiple objects at the scale of our HUDF galaxies. The scale of the disruptive event found in our main-sequence SFGs, characterized by the lack of star-forming substructures at our resolution and sensitivity, could be less violent, e.g., gas-rich disk instability or minor mergers.
Abstract
We use a suite of cosmological zoom galaxy formation simulations and dust radiative transfer calculations to explore the use of the monochromatic 850
μ
m luminosity (
L
ν
,850
) as a ...molecular gas mass (
M
mol
) estimator in galaxies between 0 <
z
< 9.5 for a broad range of masses. For our fiducial simulations, where we assume that the dust mass is linearly related to the metal mass, we find that empirical
L
ν
,850
–
M
mol
calibrations accurately recover the molecular gas mass of our model galaxies and that the
L
ν
,850
-dependent calibration is preferred. We argue that the major driver of scatter in the
L
ν
,850
–
M
mol
relation arises from variations in the molecular gas-to-dust mass ratio, rather than variations in the dust temperature, in agreement with the previous study of Liang et al. Emulating a realistic measurement strategy with ALMA observing bands that are dependent on the source redshift, we find that estimating
S
ν
,850
from continuum emission at a different frequency contributes 10%–20% scatter to the
L
ν
,850
–
M
mol
relation. This additional scatter arises from a combination of mismatches in assumed
T
dust
and
β
values, as well as the fact that the SEDs are not single-temperature blackbodies. However, this observationally induced scatter is a subdominant source of uncertainty. Finally, we explore the impact of a dust prescription in which the dust-to-metals ratio varies with metallicity. Though the resulting mean dust temperatures are ∼50% higher, the dust mass is significantly decreased for low-metallicity halos. As a result, the observationally calibrated
L
ν
,850
–
M
mol
relation holds for massive galaxies, independent of the dust model, but below
L
ν
,850
≲ 10
28
erg s
−1
(metallicities
) we expect that galaxies may deviate from literature observational calibrations by ≳0.5 dex.
![The ALPINE-ALMA [C II] surv...](http://api.summon.serialssolutions.com/2.0.0/image/issn/XR4PS5YY4K/0004-6361/small "The ALPINE-ALMA [C II] survey: Star-formation-driven outflows and circumgalactic enrichment in the early Universe")
PDF
