Neste trabalho foi avaliado o efeito da argilosidade sobre as propriedades físicas de solos argilosos, com ênfase na porosidade e na permeabilidade do meio. Para isto foi utilizado o equipamento ...permo-porosímetro a gás, baseado na variação de pressão em câmara confinante, com o intuito de obter valores de porosidade efetiva e permeabilidade absoluta em sedimentos inconsolidados (solos). No procedimento foram utilizadas amostras sintéticas, usando diferentes proporções de quantidades de esferas de vidro e caulinita (argila), com a intenção de criar um padrão granulométrico das amostras a serem analisadas. Isto incluiu a preparação do invólucro da amostra e estudos da determinação das pressões e fluxos de fluidos a serem aplicados nas amostras, fundamentados em publicações científicas. Os valores obtidos de permeabilidade e porosidade foram utilizados na estimativa de outro parâmetro físico dos sedimentos, a superfície específica dos grãos através da equação de Kozeny-Carman, cujo valor da constante recomendado por outros autores é igual a 5, para fluxo em meios porosos inconsolidados. Pode-se verificar nos resultados que o permo-porosímetro a gás, pode ser utilizado com sucesso na medição das propriedades físicas de solos tanto arenosos como argilosos.
We determine lithium (Li) abundances for solar twins in the M67 open cluster to add valuable information about the correlation between Li depletion and stellar age and, then, better understand ...stellar structure and evolution. We use high resolution and good signal-to-noise ratio spectra to characterize Li depletion in three solar twins from M67, using spectral synthesis in the region of the asymmetric 6707.75 \AA \, Li I feature. The mean Li abundance value of A(Li)\(=1.6\pm0.2\) dex for our sample of M67 solar twins (our three stars plus a fourth solar twin from a previous analysis in the literature) presents Li abundance expected for its age. Also, the scatter estimated from the standard deviation of the Li abundances in this work is similar to the typical scatter found in a sample of field solar twins presented in the literature.
Folk knowledge transmitted between generations allows traditional populations to maintain the use of medicinal plants for the treatment of several diseases. In this context, the species Terminalia ...fagifolia Mart., native to Brazil, is used for the treatment of chronic and infectious diseases. Plants rich in secondary metabolites, such as this species and their derivatives, may represent therapeutic alternatives for the treatment of diseases that reduce the quality of life of people.
The aim of this study was to evaluate the antifungal and anti-inflammatory potential of aqueous fraction from ethanolic extract of T. fagifolia, with in silico study of the major compound of the fraction.
The phytochemical study of the aqueous fraction was performed by HPLC, LC/MS and NMR. The antifungal activity was evaluated against yeasts, by determination of the minimum inhibitory concentration and minimum fungicidal concentration. The effect on Candida albicans was analyzed by AFM. The antibiofilm potential against biofilms of C. albicans was also tested. The anti-inflammatory potential of the aqueous fraction was evaluated in vivo by the carrageenan-induced paw edema and peritonitis. A microglial model of LPS-induced neuroinflammation was also studied. Further insights on the activation mechanism were studied using quantum chemistry computer simulations. Toxicity was evaluated in the Galleria mellonella and human erythrocytes models.
Eschweilenol C was identified as the major constituent of the aqueous fraction of the ethanolic extract of T. fagifolia. The aqueous fraction was active against all Candida strains used (sensitive and resistant to Fluconazole) with MICs ranging from 1000 to 0.4 μg/mL. By AFM it was possible to observe morphological alterations in treated Candida cells. The fraction significantly (p < 0.05) inhibited paw edema and decreased levels of malondialdehyde induced by carrageenan. In a microglial cell model, aqueous fraction demonstrated the ability to inhibit NF-κB after induction with lipopolysaccharide. The theoretical studies showed structural similarity between eschweilenol C and indomethacin and an excellent antioxidant potential. The aqueous fraction did not present toxicity in the studied models.
The results indicate that the aqueous fraction of T. fagifolia has potential for biomedical applications with low toxicity. This finding can be attributed to the predominance of eschweilenol C in the aqueous fraction.
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Effluents from textile processes, when discarded of inappropriately, have been shown to be a major environmental concern. In this way, different methods can be used, among them adsorption is an ...economical and efficient technique in the removal of dyes. Therefore, we propose to analyze the adsorptive capacity of bacterial cellulose (CB) against effluents containing the dye Remazol Black B (RBB). CB was produced by the bacterium Gluconacetobacter hansenii and characterized by the techniques of FTIR, DRX, TGA / DTG and pH (PCZ). The RBB removal tests were initially performed at different pHs. From the best experimental condition, new tests were performed at temperatures of 30, 40, 60 and 100 ± 2 °C, 150 rpm, pH 3.5, using 0.5 g of adsorbent in the concentrations of dye from 25 to 65 mg·L-1. The kinetic study showed that the system balance was achieved in 80 minutes. The experimental data were better described by the pseudo-second order model. The equilibrium results showed that the experimental data fit the Langmuir model (qmax 17.513 mg·g-1). The thermodynamic parameters of adsorption showed that the process is exothermic, not spontaneous and also presented low system randomness. The activation energy (Ea) was 23.8 kJ·mol-1 characterizing physical adsorption. The residual water was not toxic to animal or microbial cells. Bacterial cellulose proved to be a good low-cost adsorbent, easy to acquire and which can be used in the adsorption process.
Resumo
Objetivo
O estudo visa avaliar a eficácia da recuperação intraoperatória de sangue (RIOS) na redução de hemotransfusão alogênica em pacientes submetidos à cirurgia por fratura de fêmur e ...quadril.
Métodos
Coorte prospectiva com 38 pacientes submetidos a cirurgia traumatológica para fraturas em quadril e transtrocantéricas de fêmur, divididos em dois grupos em um hospital de ensino de agosto de 2015 a fevereiro de 2017. Pacientes com qualquer enfermidade ou condição infecciosa foram excluídos do presente estudo. O grupo RIOS (19 pacientes) recebeu sangue autólogo com a utilização de Cell Saver, enquanto o grupo controle (19 pacientes) recebeu apenas sangue alogênico, quando necessário.. Grupos comparados em relação ao gênero, idade na cirurgia, escala da Sociedade Americana de Anestesiologistas (ASA) (I, II ou III), uso intraoperatório da RIOS, volume sanguíneo reinfundido pela RIOS, parâmetros hematimétricos pré- e pós-operatórios, volume intra e pós-operatório de sangue alogênico transfundido. Dados processados no software SPSS Statistics for Windows, Versão 20.0 (IBM Corp, Armonk, NY, EUA).
Resultados
Sem diferenças significativas entre os grupos com as variáveis: idade, gênero e ASA. Percebeu-se que os valores finais de hemoglobina e hematócrito (no 1° dia de pós-operatório) foram mais elevados no grupo que utilizou o dispositivo (
p
< 0,05). Não houve redução significativa da transfusão alogênica intra e pós-operatória no grupo RIOS em comparação ao controle.
Conclusões
O presente estudo constatou que a RIOS não foi eficaz em reduzir a transfusão alogênica no intra e pós-operatório de pacientes submetidos à cirurgia de fêmur transtrocantérica e de quadril.
Abstract
Objective
The present study aims to evaluate the efficacy of blood cell salvage (CS) as a method of reducing allogeneic blood transfusion in patients submitted to transtrochanteric femoral and hip surgeries due to injury.
Methods
Prospective cohort of 38 patients from a school hospital submitted to hip or trochanteric surgeries and divided into two groups from August 2015 to February 2017. Patients with any malignancy or infectious condition were excluded from the study. Cell savage group (19 patients) received autologous blood using cell saver, whereas control group (19 patients) received just allogeneic blood, if needed. Red blood cell parameters, blood transfusion requirements, and clinical and surgical characteristics, such as age, gender, ASA scale and type of surgery, were compared both preoperatively and postoperatively. Data was processed in SPSS 20.0.
Results
There were no differences in the clinical parameters studied (age, gender and ASA scale). Red blood cell parameters on the first day postoperative were higher in the cell savage group (
p
< 0.05). No significant reduction of intraoperative and postoperative allogeneic blood transfusion requirements was found.
Conclusion
This study found that CS was not effective in reducing intraoperative and postoperative allogeneic blood transfusion requirements in patients submitted to transtrochanteric femoral and hip surgery.
The leaves of
were subjected to physicochemical analysis, such as ion content, extractives, and structural molecules. The hexanic, ethanolic and ethyl acetate extracts were submitted to phytochemical ...analyzes by GC-MS, HPLC-MS, and spectrophotometry. In addition, antioxidant (DPPH, ABTS and TAA methods) potential, antimicrobial (MIC method) action, cytotoxicity and immunostimulant activity (flow cytometry analysis) were performed. The extracts showed a moderate antioxidant capacity and revealed the presence of several metabolites, mainly phenols, such as caffeic acid, p-coumaric acid and luteolin. The ethyl acetate and ethanolic extracts showed antifungal activity. In addition, the extracts did not affect splenocytes viability at 12.5 μg/mL and promoted the production of IL-6, IL-10, IL-17 and TNF-α cytokines.
extracts showed antifungal and antioxidant activity and were able to induce immunostimulatory action in splenocyte cultures
.
Lemon gum (LG) obtained from Citrus × latifolia in Brazil was isolated and characterized. In addition, gum biocompatibility was evaluated in vitro and in vivo by Galleria mellonella and mice model. ...The cytotoxicity against tumor cells was also evaluated. The ratio of arabinose:galactose: rhamnose:4-OMe-glucuronic acid was 1:0.65:0.06:0.15. Small traces of protein were detected, emphasizing the isolate purity. Molar mass was 8.08 × 105 g/mol, with three different degradation events. LG showed antiproliferative activity against human prostate adenocarcinoma cancer cells, with percentage superior to 50 %. In vivo toxicity models demonstrated that LG is biocompatible polymer, with little difference in the parameters compared to control group. These results demonstrate advance in the study of LG composition and toxicity, indicating a potential for several biomedical and biotechnological future applications.
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•Lemon gum (LG) obtained from Citrus × latifolia in Brazil.•LG is a arabinogalactan with more selective cytotoxicity for PC3 cells.•LG is non-toxic in Galleria mellonella and in Swiss mice.•LG is a promising polymer for biomedical and biotechnological applications.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic hit almost all cities in Brazil in early 2020 and lasted for several months. Despite the effort of local state and municipal ...governments, an inhomogeneous nationwide response resulted in a death toll amongst the highest recorded globally. To evaluate the impact of the nonpharmaceutical governmental interventions applied by different cities—such as the closure of schools and businesses in general—in the evolution and epidemic spread of SARS-CoV-2, we constructed a full-sized agent-based epidemiological model adjusted to the singularities of particular cities. The model incorporates detailed demographic information, mobility networks segregated by economic segments, and restricting bills enacted during the pandemic period. As a case study, we analyzed the early response of the City of Natal—a midsized state capital—to the pandemic. Although our results indicate that the government response could be improved, the restrictive mobility acts saved many lives. The simulations show that a detailed analysis of alternative scenarios can inform policymakers about the most relevant measures for similar pandemic surges and help develop future response protocols.
The Commission on Science and Information Technology (CTCI) of the Brazilian Astronomical Society (SAB) is tasked with assisting the Society on issues of astronomical data management, from its ...handling and the management of data centres and networks, to technical aspects of the archiving, storage and dissemination of data. In this paper we present a summary of the results of a survey recently conducted by the Commission to diagnose the status of several data-related issues within the Brazilian astronomical community, as well as some proposals derived therefrom.
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