This study aimed to investigate the ion pair association values and association parameters of nano MnSO4 in water and methanol-water mixtures (20 % and 40 % methanol by mass percentage) at varying ...temperatures (298.15, 303.15, 308.15, and 313.15 K) using the conductometric technique. Additionally, the parameters for complex formation between nano MnSO4 and glycylglycine as a ligand were determined. The focus was on elucidating the thermodynamic formation parameters for the nano Mn2+-glycylglycine interaction, with particular emphasis on comparing the 1: 1 and 1: 2 (M: L) complexes to understand the complexation behavior more comprehensively. The results indicated that the complexation process was spontaneous, as evidenced by negative ΔGf (formation free energy change) values, which increased with temperature, highlighting the enhanced spontaneity of the process. The findings provide valuable insights into designing new materials and procedures by enhancing our understanding of the complexation behavior of nano MnSO4 with ligands like glycylglycine, thus contributing to advancements in various applications such as chemical synthesis, medicines, and environmental remediation. By elucidating the thermodynamic aspects of these interactions, the study aimed to provide valuable information that could be utilized in practical applications and further research endeavors.
Display omitted
This study investigated the physicochemical properties of the interaction of indomethacin and copper chloride using the electrical conductance measurement in methanol, ethanol, and their binary ...mixture with water at room temperature (298.15 K), to determine the solvation behavior, redox behavior, and kinetics. The association parameters were computed using the Fuoss-Hsia-Fernández-Prini and Fuoss-Shedlovsky models. The standard Gibbs energy for association (ΔGoA), Walden product (Λoηo), and hydrodynamic radii (RH) were calculated to study the interaction of indomethacin and copper chloride. On the other hand, cyclic voltammetry examines the electrochemical redox behavior of copper chloride using a gold electrode and its interactions with indomethacin. Results showed changes in peak potentials and currents density in the presence of indomethacin, indicating alterations in redox behavior and reaction rates. Overall, this research can be valuable in understanding the electrochemical properties and potential applications of indomethacin and copper chloride, as well as in developing new drugs or therapeutic agents, which could have has implications in various fields, including drug development, electrochemistry, and materials science.
•The study investigated the physicochemical properties of the interaction between indomethacin and copper chloride.•The electrical conductance in different solvents was determined to provide information about the solvation behavior, redox behavior, and kinetics of the system using the Fuoss-Shedlovsky and Fuoss-Hsia-Fernández-Prini models.•The cyclic voltammetry study revealed changes in the electrochemical redox behavior of CuCl2 in the presence of indomethacin, indicating potential applications in drug development and materials science.•Overall, this research can have significant implications in various fields.
Spectral interference through the presence of uninformative variables, excess reagents, and complications in the refinement of the analyte signal is common in the quest to identify complex species in ...real samples. Therefore, an economical green, facile, and sensitive strategy has been developed for Cu2+ detection using the anionic surfactant sodium dodecylsulphate- (SDS-) assisted dual-wavelength β-correction spectrophotometric strategy combined with the chromogenic reagent zincon (ZI). The low limits of detection (LOD) and quantification (LOQ) of Cu2+ using ordinary (single wavelength) spectrophotometry were 0.19 (3.02) and 0.63 (10.0) μgmL−1, and these values were improved to 0.08 (1.27) and 0.26 μgmL−1 (4.12 μM)) using β-correction (dual wavelength) spectrophotometry, respectively. The LOD and LOQ were improved from 0.08 (1.27) and 0.26 (4.12) μgmL−1 to 0.02 (0.32) and 0.08 μgmL−1 (1.27 μM) using SDS-assisted dual-β-correction spectrometry, respectively. Ringbom, s, and the corrected absorbance (Ac) versus Cu2+ concentration plots were linear over the concentration range 1.10–2.4 (17.4–38.1) and 0.50–2.40 μgmL−1 (7.94–38.1 μM), respectively. Sandell’s sensitivity index of 3.0 × 10−3 μg/cm2 was achieved. The selectivity was further confirmed via monitoring the impact of common diverse ions and surfactants on the corrected absorbance. Total determination and Cu2+ speciation in water were favorably implemented and validated by ICP-OES at 95% (P=0.05). Satisfactory Cu2+ recoveries in tap (92.2–98.0%) and mineral (105–111.0%) water samples were achieved. The sensing system is simple, reliable, sensitive, and selective for Cu2+ detection.
Nickel peroxide nanoparticles (NPNPs) were prepared and characterized using various techniques including transmission electron microscope (TEM), scan electron microscope (SEM), energy dispersive ...spectrometer (EDS), X-ray diffraction (XRD), and FTIR spectra. The aqueous basic catalytic system NiSO4·6H2O/NaOCl/NaOH (pH = 14) was investigated for the catalytic dehydrogenation of benzylamine and parasubstituents to their corresponding nitriles at room temperature. The obtained results confirmed the formation of NiO2 nanocrystalline particles with a size of 20 nm. Benzylamine with electron-donating groups showed higher yields of nitriles compared to electron-withdrawing groups. The mechanism involved in the in situ generated NiO2 nanoparticles dehydrogenating benzylamine to benzonitrile, with the produced NiO converting back to NiO2 nanoparticles through the excess of NaOCl.
This study aimed to investigate the ion pair association values and association parameters of nano MnSO
in water and methanol-water mixtures (20 % and 40 % methanol by mass percentage) at varying ...temperatures (298.15, 303.15, 308.15, and 313.15 K) using the conductometric technique. Additionally, the parameters for complex formation between nano MnSO
and glycylglycine as a ligand were determined. The focus was on elucidating the thermodynamic formation parameters for the nano Mn
-glycylglycine interaction, with particular emphasis on comparing the 1: 1 and 1: 2 (M: L) complexes to understand the complexation behavior more comprehensively. The results indicated that the complexation process was spontaneous, as evidenced by negative ΔG
(formation free energy change) values, which increased with temperature, highlighting the enhanced spontaneity of the process. The findings provide valuable insights into designing new materials and procedures by enhancing our understanding of the complexation behavior of nano MnSO
with ligands like glycylglycine, thus contributing to advancements in various applications such as chemical synthesis, medicines, and environmental remediation. By elucidating the thermodynamic aspects of these interactions, the study aimed to provide valuable information that could be utilized in practical applications and further research endeavors.
Spectral interference through the presence of uninformative variables, excess reagents, and complications in the refinement of the analyte signal is common in the quest to identify complex species in ...real samples. Therefore, an economical green, facile, and sensitive strategy has been developed for Cusup.2+ detection using the anionic surfactant sodium dodecylsulphate- (SDS-) assisted dual-wavelength β -correction spectrophotometric strategy combined with the chromogenic reagent zincon (ZI). The low limits of detection (LOD) and quantification (LOQ) of Cusup.2+ using ordinary (single wavelength) spectrophotometry were 0.19 (3.02) and 0.63 (10.0)μ gmLsup.-1, and these values were improved to 0.08 (1.27) and 0.26μ gmLsup.-1 (4.12μ M)) using β -correction (dual wavelength) spectrophotometry, respectively. The LOD and LOQ were improved from 0.08 (1.27) and 0.26 (4.12)μ gmLsup.-1 to 0.02 (0.32) and 0.08μ gmLsup.-1 (1.27μ M) using SDS-assisted dual-β -correction spectrometry, respectively. Ringbom, s, and the corrected absorbance (Asub.c) versus Cusup.2+ concentration plots were linear over the concentration range 1.10-2.4 (17.4-38.1) and 0.50-2.40μ gmLsup.-1 (7.94-38.1μ M), respectively. Sandell's sensitivity index of 3.0×10sup.-3μ g/cmsup.2 was achieved. The selectivity was further confirmed via monitoring the impact of common diverse ions and surfactants on the corrected absorbance. Total determination and Cusup.2+ speciation in water were favorably implemented and validated by ICP-OES at 95% (P=0.05). Satisfactory Cusup.2+ recoveries in tap (92.2-98.0%) and mineral (105-111.0%) water samples were achieved. The sensing system is simple, reliable, sensitive, and selective for Cusup.2+ detection.
To assess the diagnostic accuracy of magnetic resonance imaging (MRI) in evaluating patello-femoral instability as a cause of anterior knee pain (AKP) and its predisposing factors.
55 knees of 50 ...adult patients below 40 years complaining of AKP underwent MRI between February 2013 and February 2015. The patients were analyzed prospectively for the presence of bone, hyaline cartilage and soft-tissue abnormalities, as well as anatomic variants that may contribute to patello-femoral maltracking or impingement abnormalities. Our results were compared to those of the arthroscopic and mini open exploration procedures.
In the 55 knees analyzed for patello-femoral instability cartilaginous injuries were found in 58%, with an MRI sensitivity of 88%, disruption of the medial patello-femoral ligament (MPFL) in 31% with an MRI sensitivity 84%, joint morphology abnormalities in 74.5% of patients, bone edema in 27% of patients and Hoffa’s fat pad edema in 30 patients (55%). MRI had a sensitivity of 84% and accuracy of 81% in determining the injury site and pattern.
MRI is reliable imaging modality in identifying the risk factors that may contribute to the development of patello-femoral maltracking or impingement permitting individual tailored treatment.
OBJECTIVES:The objective of this study was to evaluate and compare the outcome of the crossed and the lateral pin configurations in the management of supracondylar humeral fractures in children in ...the hands of junior trainees.
DESIGN:Prospective randomized controlled trial.
SETTING:Level I Trauma Center.
PATIENTS:Sixty children with supracondylar humeral fractures. The mean age was 5.1 years (1.5–9 years). The minimum follow-up period was 6 months, with no patients lost to follow up.
INTERVENTION:Thirty patients were managed by crossed and 30 by the lateral method. All surgeries were performed by junior trainees in their first 3 years of training.
MAIN OUTCOME MEASUREMENTS:Postoperative stability, ulnar nerve injury, range of motions, and pin tract infection.
RESULTS:The crossed configuration was stable in all the patients, whereas the lateral method was less stable in 20% of the cases because the distal fragment rotated in 5 patients and posteriorly displaced in 1 patient. The difference was statistically significant with a P value of 0.031. Ulnar nerve neurapraxia occurred in 1 patient from the lateral group and it recovered in the fourth month, whereas no ulnar nerve injury occurred in the crossed configuration group. Two patients in the lateral group lost approximately 100 of elbow flexion.
CONCLUSIONS:This prospective randomized controlled trial showed that the crossed pin configuration method provided more stability than the lateral pin configuration, especially, in the hands of junior trainees in their first 3 years of training, and the difference was statistically significant.
LEVEL OF EVIDENCE:Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
•Clinical value of expanded NIHSS over NIHSS.•Cut off value for baseline expanded NIHSS for prediction of poor outcome.•A higher median expanded NIHSS than NIHSS in posterior circulation ...stroke.•Expanded NIHSS ought to be a practical scale in posterior circulation stroke.
The NIHSS is used routinely but has drawbacks. One of them is its inefficiency in detecting all signs of posterior circulation strokes. Since its declaration as a possible substitute for NIHSS in posterior circulation strokes in 2016; the expanded NIHSS (e-NIHSS) has not been paid much attention.
The current study assesses clinically the value of e-NIHSS over NIHSS in posterior circulation strokes as regards the percentage of cases with different/higher scores, the significance of such scoring on management decisions, the weight of baseline e-NIHSS as a prognostic tool on 90 days functional outcome and its cut off value.
The current longitudinal observational study was conducted on 79 cases after formal written consent who presented with posterior circulation strokes and confirmed by brain imaging.
In Comparison to NIHSS; the e-NIHSS score was higher in 36 cases at baseline and in 30 cases on discharge. The e-NIHSS median was two points higher at baseline and 24 h and was one point higher on discharge P < 0.001. A baseline moderate/moderate-severe was more common with e-NIHSS (n 50, 63.3%). In terms of 90 days outcome; a less favorable outcome (>2) was evident in cases with different scoring (e-NIHSS > NIHSS) indicating more sensitivity of e-NIHSS in prognosing 90 days outcome. ROC curve showed 82% sensitivity and 81% specificity with a significant area under the curve (=0.858) on scoring ≥ 8 in e-NIHSS.
e-NIHSS is diagnostically and prognostically relevant tool in posterior circulation strokes and ought to be considered in future guidelines.
PDF
