Abstract Aim To investigate the effects of uncomplicated vaginal delivery and epidural analgesia on fetal acid–base parameters in women with gestational diabetes (GDM) compared with controls. Methods ...A retrospective case–control study of 142 women with gestational diabetes and 284 controls. To evaluate the effect of diabetes and analgesia on acid–base status correcting for potential confounders we used ordered logistic equations including quartiles of fetal arterial acid–base parameters collected at birth as outcomes and categories of diabetes and epidural analgesia as explanatory variables. Results In the GDM group cord base deficit (−2.63 mmol/l, interquartile range IQR = 4.2 to −0.65 mmol/l vs. −1.9 mmol/l, IQR = −3.3 to −0.2 mmol/l, p = 0.009, odds ratio (OR) = 1.51, 95% confidence interval (CI) = 1.04–2.18) was lower and concentration of calcium higher (1.49 mmol/l, IQR = 1.42–1.56 mmol/l vs. 1.47 mmol/l, IQR = 1.41–1.51 mmol/l, p = 0.009, OR = 1.69, 95% CI = 1.12–2.56) compared with controls. Epidural analgesia in the GDM group was associated with reduced cord concentration of glucose (84.0 mg/dl 4.7 mmol/l, IQR = 70–103.3 mg/dl vs. 92.5 mg/dl 5.1 mmol/l, IQR = 76.5–121.8 mg/dl, p = 0.004), lactate (2.65 mmol/l (IQR = 1.80–4.20) vs. 3.70 mmol/l (IQR = 2.90–5.55 mmol/l), p = 0.002) and less pronounced base deficit (−2.05 mmol/l, IQR = −3.90 to −0.17 mmol/l vs. −2.8, IQR = −5.57 to −1.05 mmol/l, p = 0.01, OR = 0.7, 95% CI = 0.49–0.99). Conclusions In uncomplicated pregnancies and deliveries, well-controlled gestational diabetes mellitus has potentially significant detrimental effects on fetal acid–base status at birth. Epidural analgesia reduces cord arterial glucose and lactates.
The present work describes a novel and efficient synthetic method of ruthenium monosubstituted-phthalocyanine complexes and its application against cancer cell lines. It allows find relationship of ...subcellular localizations and cytotoxicity. Display omitted
•Synthesis of a ruthenium monosubstituted-phthalocyanine complex.•In vitro cytotoxicity assays on cancer cells show complexes possible tumoricidal role.•Confocal microscopy analysis on cancer cells was used to investigate cellular uptake.•Subcellular localization is dependent on phthalocyanine substituent.
Due to be launched in late 2021, the Imaging X-ray Polarimetry Explorer (IXPE) is a NASA Small Explorer mission designed to perform polarization measurements in the 2–8 keV band, complemented with ...imaging, spectroscopy and timing capabilities. At the heart of the focal plane is a set of three polarization-sensitive Gas Pixel Detectors (GPD), each based on a custom ASIC acting as a charge-collecting anode.
In this paper we shall review the design, manufacturing, and test of the IXPE focal-plane detectors, with particular emphasis on the connection between the science drivers, the performance metrics and the operational aspects. We shall present a thorough characterization of the GPDs in terms of effective noise, trigger efficiency, dead time, uniformity of response, and spectral and polarimetric performance. In addition, we shall discuss in detail a number of instrumental effects that are relevant for high-level science analysis—particularly as far as the response to unpolarized radiation and the stability in time are concerned.
Objectives
To evaluate and compare clinical and histological changes after ridge preservation procedures with those of spontaneous healing.
Materials and Methods
Ninety patients were enrolled in the ...present randomized controlled clinical trial and underwent single‐tooth extraction in the premolar/molar areas. Thirty sites were grafted with collagenated cortico‐cancellous (coll), 30 sites with cortical (cort) porcine bone and 30 sites underwent natural healing. Primary (vertical and horizontal bone changes after 3 months) and secondary outcomes (histomorphometric after 3 months) were evaluated at implant placement.
Results
The vertical bone changes at the grafted sockets were significantly (p < 0.0001) lower (0.30 mm for cort group and 0.57 mm for coll group) when compared to non‐grafted sockets (2.10 mm for nat group). Moreover, the width reduction of the coll (0.93 mm) and cort (1.33 mm) groups was significantly lower (p < 0.0001) than the non‐grafted group (3.60 mm). The analysis of subgroups attested that when premolar and molar sites were compared, the buccal bone loss appeared to be dependent both on tooth position and grafting material employed.
Conclusion
The ridge preservation procedures had significantly better outcomes when compared to natural healing. The biomaterials did not differ for maintenance of bone width; even though, the bone height seemed to be better preserved with the cortical porcine bone.
Purpose: The aim of this study was to evaluate crestal bone resorption and bone apposition resulting from immediate post‐extraction implants in the canine mandible, comparing a conditioned ...sandblasted acid‐etched implant surface with a non‐conditioned standard sandblasted implant surface.
Material and methods: In this experimental study, third and fourth premolars and distal roots of first molars were extracted bilaterally from six Beagle dog mandibles. Each side of the mandible received three assigned dental implants, with the conditioned surface (CS) on the right side and the non‐conditioned surface (NCS) on the left. The dogs were sacrificed at 2 (n=2), 4 (n=2) and 12 weeks (n=2) after implant placement.
Results: The microscopic healing patterns at 2, 4 and 12 weeks for both implant types (CS and NCS) yielded similar qualitative bone findings. The mean crestal bone resorption was found to be greater for all implants with NCS (2.28±1.9 mm) than CS (1.21±1.05 mm) at 12 weeks. The mean percentage of newly formed bone in contact with implants was greater in implants CS (44.67±0.19%) than with the NCS (36,6±0.11%). There was less bone resorption with the CS than the NCS.
Conclusion: The data show significantly more bone apposition (8% more) and less crestal bone resorption (1.07 mm) with the CS than with the NCS after 12 weeks of healing. This CS can reduce the healing period and increase bone apposition in immediate implant placements.
To cite this article:
Calvo‐Guirado JL, Ortiz‐Ruiz AJ, Negri B, López‐Marí L, Rodriguez‐Barba C, Schlottig F. Histological and histomorphometric evaluation of immediate implant placement on a dog model with a new implant surface treatment. Clin. Oral Impl. Res. 21, 2010; 308–315. doi: 10.1111/j.1600‐0501.2009.01841.x
Self-efficacy has been shown to be a predictor of many health-related behaviors, including the practice of pelvic floor exercises with a focus on prevention or cure.
To describe the process of ...construction and the psychometric properties of the scale of self-efficacy for the practice of pelvic floor exercises (EAPEAP).
A cross-sectional study of validation was carried out with 81 from community and 96 postpartum women, 54.8% of them complained of urinary leakage. An exploratory factor analysis and internal consistency analysis was performed. To check predictive capacity, we analyzed the adherence at 3 months post - intervention and compared the scores of self-efficacy between adherent and non-adherent women. Reliability was analyzed by split half procedure.
The instrument showed α=0.923, and revealed three factors: performance expectation considering the action, performance expectation considering the preparation for action and outcome expectations. These factors accounted for 65.32% of the total variance. The instrument was able to differentiate between women who adhere and have not adhered to the exercises (U=352, p=0.013) and there was strong correlation between the two halves of the instrument (rho=0.889, p<0.001).
The scale is a valid and reliable tool to measure self-efficacy to practice pelvic floor exercises.
Aim The aim of the present study was to evaluate the stability and osseointegration of zirconia dental implants modified by femtosecond laser vs. zirconia implants with sandblasted surface.Materials ...and methods A total of 48 dental implants were used in this study. After the extraction of premolars (P2, P3, P4) and molars (M1), and 2-months healing period, implants were randomly inserted in both sides of the lower jaw of 6 American Foxhound dogs: 16 zirconia implants with sandblasted surface on endosseous portion (Control Group), 16 zirconia implants with sandblasting and laser modification of the endosseous neck portion only (Test Group A), and 16 zirconia implants with sandblasting and laser modification over the whole endosseous portion (Test Group B). Stability was evaluated by Periotest, while osseointegration was evaluated by Bone-to-implant contact (BIC) assessed by histomorphometry at 1 and 3 months after surgery.Results All implants were stable; Periotest® values (PTV) for Control Group were -5.75 ± 0.22; for Group A -6.125 ± 0.26 and for Group B -7.625 ± 0.27. BIC was greater for group B implants at both 1 and 3 months. No differences between the Control Group and Group A over the examined time periods were detected.Conclusion The present results suggested that the surface treatment of zirconium implants by femtosecond laser increases implant stability and bone to implant contact.
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