We report direct-detection constraints on light dark matter particles interacting with electrons. The results are based on a method that exploits the extremely low levels of leakage current of the ...DAMIC detector at SNOLAB of 2–6×10−22 A cm−2. We evaluate the charge distribution of pixels that collect <10e− for contributions beyond the leakage current that may be attributed to dark matter interactions. Constraints are placed on so-far unexplored parameter space for dark matter masses between 0.6 and 100 MeV c−2. We also present new constraints on hidden-photon dark matter with masses in the range 1.2–30 eV c−2.
We report a measurement of the ionization efficiency of silicon nuclei recoiling with sub-keV kinetic energy in the bulk silicon of a charge-coupled device (CCD). Nuclear recoils are produced by ...low-energy neutrons (<24 keV) from a Sb124−Be9 photoneutron source, and their ionization signal is measured down to 60 eV electron equivalent. This energy range, previously unexplored, is relevant for the detection of low-mass dark matter particles. The measured efficiency is found to deviate from the extrapolation to low energies of the Lindhard model. This measurement also demonstrates the sensitivity to nuclear recoils of CCDs employed by DAMIC, a dark matter direct detection experiment located in the SNOLAB underground laboratory.
We present direct detection constraints on the absorption of hidden-photon dark matter with particle masses in the range 1.2-30 eV c^{-2} with the DAMIC experiment at SNOLAB. Under the assumption ...that the local dark matter is entirely constituted of hidden photons, the sensitivity to the kinetic mixing parameter κ is competitive with constraints from solar emission, reaching a minimum value of 2.2×10^{-14} at 17 eV c^{-2}. These results are the most stringent direct detection constraints on hidden-photon dark matter in the galactic halo with masses 3-12 eV c^{-2} and the first demonstration of direct experimental sensitivity to ionization signals <12 eV from dark matter interactions.
We present results of a dark matter search performed with a 0.6 kg d exposure of the DAMIC experiment at the SNOLAB underground laboratory. We measure the energy spectrum of ionization events in the ...bulk silicon of charge-coupled devices down to a signal of 60 eV electron equivalent. The data are consistent with radiogenic backgrounds, and constraints on the spin-independent WIMP-nucleon elastic-scattering cross section are accordingly placed. A region of parameter space relevant to the potential signal from the CDMS-II Si experiment is excluded using the same target for the first time. This result obtained with a limited exposure demonstrates the potential to explore the low-mass WIMP region (<10 GeV c−2) with the upcoming DAMIC100, a 100 g detector currently being installed in SNOLAB.
This study evaluated the effects of antimicrobial photodynamic therapy (aPDT) in the alveolar repair of rats with major risk factors for bisphosphonate-related osteonecrosis of the jaws (BRONJ). ...Senile rats received 0.45 ml of vehicle (VEH and VEH/aPDT) or 0.45 ml of zoledronate (ZOL and ZOL/aPDT) every three days for seven weeks. After three weeks of treatment, the first lower left molar was extracted. VEH/aPDT and ZOL/aPDT were submitted to aPDT on the extraction site at 0, 2 and 4 days postoperatively. Euthanasia was performed 28 days postoperatively and the extraction site was evaluated by clinical, histological, histometric, histochemical and immunohistochemical analysis. ZOL showed tissue repair impairment; lower percentage of newly formed bone tissue (NFBT); higher percentage of non-vital bone tissue (NVBT); fewer mature collagen fibers and increased immunolabeling for tumor necrosis factor (TNFα), interleukin (IL)-1β and IL-6. ZOL/aPDT showed clinical and histological characteristics of the extraction site, percentage of NFBT and percentage of mature collagen fiber similar to VEH. Percentage of NVBT and immunolabeling for inflammatory cytokines in ZOL/aPDT was lower than in ZOL. Immunolabeling for tartarato-resistant acid phosphatase (TRAP) was lower in ZOL and ZOL/aPDT. aPDT in the dental extraction site improves tissue repair process and prevents the occurrence of BRONJ-like lesions after tooth extraction.
•Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a serious adverse effect of therapies with anti-resorptive drugs.•BRONJ is a difficult to treat condition.•Antimicrobial photodynamic therapy (aPDT) was effective, safe and able to prevent the occurrence of BRONJ-like lesions in rats.
Abstract This study evaluated the impact of peri-implant treatment in the salivary levels of Colony stimulator factor-1 (CSF-1), S100A8/A9 and S100A12 in patients having mucositis or ...peri-implantitis. As a secondary aim, we analysed the correlation between the salivary and peri-implant crevicular fluid (PICF) levels. Forty-seven patient, 27 having mucositis (mean age 63.11+-7.78) and 20 having peri-implantitis (61.25+-7.01) participated in the study. Clinical parameters, probing pocket depth, clinical attachment level, % of plaque and bleeding on probing were evaluated. Unstimulated whole saliva was collected from all patients, while PICF was collected only from a patient's subgroup (n=20). Samples were collected before and 3 months after peri-implant treatment. Enzyme-linked immunosorbent assays determined levels of CSF-1, S100A8/A9 and S100A12. Clinical parameters improved and salivary levels of CSF-1 and S100A8/A9, but not S100A12, reduced significantly after treatment in both groups. No significant correlation was found in the salivary and PICF levels of the same molecule. In conclusion, the treatment of peri-implant disease significantly improved the clinical parameters and reduced the salivary levels of CSF-1 and S100A8/A9. The salivary expressions of CSF-1, S100A8/A9 and S100A12 did not correlate with their own expression in PICF.
This paper summarizes the status and the recent measurements from the Pierre Auger Observatory. The energy spectrum is described and its features discussed. We report searches for anisotropy of ...cosmic ray arrival directions on large scales and through correlation with catalogues of celestial objects. We also present the search for anisotropies in the data without the use of astronomical catalogues. The first measurement of the proton-air cross section around 1018eV is discussed. Finally, the mass composition is addressed with measurements of the variation of the depth of shower maximum with energy and with the muon density at ground.
The guidelines on allergic rhinitis aim to update knowledge about the disease and care for affected patients. The initiative called “Allergic Rhinitis and its Impact on Asthma”, initially published ...in 2001 and updated in 2008 and 2010, has been very successful in disseminating information and evidence, as well as providing a classification of severity and proposing a systemized treatment protocol. In order to include the participation of other medical professionals in the treatment of allergic rhinitis, it is important to develop algorithms that accurately indicate what should and can be done regionally.
To update the III Brazilian Consensus on Rhinitis – 2012, with the creation of an algorithm for allergic rhinitis management.
We invited 24 experts nominated by the Brazilian Association of Allergy and Immunology, Brazilian Association of Otorhinolaryngology and Head and Neck Surgery and Brazilian Society of Pediatrics to update the 2012 document.
The update of the last Brazilian Consensus on Rhinitis incorporated and adapted the relevant information published in all “Allergic Rhinitis and its Impact on Asthma” Initiative documents to the Brazilian scenario, bringing new concepts such as local allergic rhinitis, new drugs and treatment evaluation methods.
A flowchart for allergic rhinitis treatment has been proposed.
As diretrizes sobre rinite alérgica visam atualizar os conhecimentos sobre a doença e os cuidados para com esses pacientes. A iniciativa designada “Rinite Alérgica e seu Impacto na Asma”, cujo relatório inicial foi publicado em 2001 e atualizada em 2008 e 2010, tem sido muito bem sucedida na disseminação de informações e evidências, bem como na formulação da classificação de gravidade e proposta de sistematização do tratamento. Entretanto, visando a participação de outros profissionais médicos no atendimento da rinite alérgica, é importante o desenvolvimento de algoritmos que indiquem com precisão o que deve e pode ser feito regionalmente.
Atualizar o III Consenso Brasileiro sobre Rinites-2012, com elaboração de algoritmo para conduta da rinite alérgica.
Foram convidados 24 especialistas indicados pelas Associação Brasileira de Alergia e Imunologia, Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial e Sociedade Brasileira de Pediatria para atualização do documento de 2012.
A atualização do último Consenso Brasileiro sobre Rinites, incorporou e adaptou para a realidade brasileira as informações relevantes publicadas em todos os documentos da Iniciativa “Rinite Alérgica e seu Impacto na Asma”, trazendo novos conceitos como a rinite alérgica local, novos medicamentos e métodos de avaliação de tratamento.
Proposto um fluxograma de tratamento para a rinite alérgica.
We present the design, implementation and data taking performance of the MIcrowave Detection of Air Showers (MIDAS) experiment, a large field of view imaging telescope designed to detect microwave ...radiation from extensive air showers induced by ultra-high energy cosmic rays. This novel technique may bring a tenfold increase in detector duty cycle when compared to the standard fluorescence technique based on detection of ultraviolet photons. The MIDAS telescope consists of a 4.5m diameter dish with a 53-pixel receiver camera, instrumented with feed horns operating in the commercial extended C-Band (3.4–4.2GHz). A self-trigger capability is implemented in the digital electronics. The main objectives of this first prototype of the MIDAS telescope – to validate the telescope design, and to demonstrate a large detector duty cycle – were successfully accomplished in a dedicated data taking run at the University of Chicago campus prior to installation at the Pierre Auger Observatory.
•The MIDAS objective is to detect ultra high energy cosmic rays using microwaves.•GHz radiation could provide a powerful alternative to current detection methods.•The MIDAS prototype explores the potential of the microwave technique.
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