"A unique collection of letters from a member of the YWCA on her first world tour in the 1930s, Letters from Clara tells one woman's story of adventure and danger on the eve of World War II. Despite ...limited financial means, Clara Pagel was richly resourceful and used the YWCA network to find work and places to live in the Far East, along the way meeting other women also working their way around the world. As Clara described in letters to her YMCA friends back home, her sojourn was filled with museums and world-famous landmarks, as well as typhoons, bombings, and earthquakes. These experiences are described in over one hundred pages of letters, annotated throughout by Janet Newman. Upon Clara's return to the United States in 1939, she enrolled at the University of Chicago and earned an MBA at the age of forty-six. This is the story of a remarkable woman on an unexpected but fulfilling journey to learn about the world and herself"--.
`This is an illuminating and topical study, which skilfully blends together theoretical and empirical analysis in search of the "citizen-consumer". It should become a key text for all with an ...interest in public service reform and the "choice" agenda, as well as consumerism and citizenship′ - Ruth Lister, Professor of Social Policy, University of Loughborough Political, popular and academic debates have swirled around the notion of the citizen as a consumer of public services, with public service reform increasingly geared towards a consumer society. This innovative book draws on original research with those people in the front-line of the reforms - staff, managers and users of public services - to explore their responses to this turn to consumerism. Creating Citizen-Consumers explores a range of theoretical, political, policy and practice issues that arise in the shift towards consumerism. It draws on recent controversies about choice to examine the tensions of modernising public services to meet the demands of a consumer society. The book offers a fresh and challenging understanding of the relationships between people and services, and argues for a model based on interdependence, respect and partnership rather than choice. This original book makes a distinctive contribution to debates about the future of public services. It will be of interest to those studying social policy, cultural studies, public administration and management across the social sciences, as well as for those working in public services. John Clarke is a Professor of Social Policy at the Open University. Janet Newman is a Professor of Social Policy at the Open University. Nick Smith is a Research Officer in the Personal Social Services Research Unit at the University of Kent. Elizabeth Vidler is a Project Officer in the Faculty of Social Sciences at the Open University.
Louise Westmarland is a Lecturer in Criminology at the Open University.
This paper offers an engagement with theoretical deficits in some uses of neoliberalism as an explanatory concept. It draws on theories of ideology, of governmentality and of assemblage to offer ...alternative conceptions of the relationship between neoliberalism and its others, and to illuminate the ambiguous and contradictory role of local governments in the UK in processes of neoliberalisation. The paper develops an analysis of local governments as strategic actors in the 'landscapes of antagonism' generated by current cycles of economic, political and governance change, and argues for more attention to be paid to the relationship between theory, politics and critique.
Moving beyond MARCO Rosa, Nicholas; Watkins, Christopher J; Newman, Janet
PloS one,
03/2023, Letnik:
18, Številka:
3
Journal Article
Recenzirano
Odprti dostop
The use of imaging systems in protein crystallisation means that the experimental setups no longer require manual inspection to determine the outcome of the trials. However, it leads to the problem ...of how best to find images which contain useful information about the crystallisation experiments. The adoption of a deeplearning approach in 2018 enabled a four-class machine classification system of the images to exceed human accuracy for the first time. Underpinning this was the creation of a labelled training set which came from a consortium of several different laboratories. The MARCO classification model does not have the same accuracy on local data as it does on images from the original test set; this can be somewhat mitigated by retraining the ML model and including local images. We have characterized the image data used in the original MARCO model, and performed extensive experiments to identify training settings most likely to enhance the local performance of a MARCO-dataset based ML classification model.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The Machine Recognition of Crystallization Outcomes (MARCO) initiative has assembled roughly half a million annotated images of macromolecular crystallization experiments from various sources and ...setups. Here, state-of-the-art machine learning algorithms are trained and tested on different parts of this data set. We find that more than 94% of the test images can be correctly labeled, irrespective of their experimental origin. Because crystal recognition is key to high-density screening and the systematic analysis of crystallization experiments, this approach opens the door to both industrial and fundamental research applications.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Thinking Like a Leaf Newman, Janet
Journal of New Zealand literature,
01/2017, Letnik:
35, Številka:
35:1
Journal Article
Recenzirano
In her most recent poetry collection Ocean and Stone, Dinah Hawken writes polemically against human degradation of the environment:
The ocean is an open sewer. So far it takes what it gets: toxins, ...dead zones, blasts, oil, blooms, waste, drugs, radiation ...
Enzymes expressed by highly salt-tolerant organisms show many modifications compared with salt-affected counterparts including biased amino acid and lower α-helix content, lower solvent accessibility ...and negative surface charge. Here, we show that halotolerance can be generated in an enzyme solely by modifying surface residues. Rational design of carbonic anhydrase II is undertaken in three stages replacing 18 residues in total, crystal structures confirm changes are confined to surface residues. Catalytic activities and thermal unfolding temperatures of the designed enzymes increase at high salt concentrations demonstrating their shift to halotolerance, whereas the opposite response is found in the wild-type enzyme. Molecular dynamics calculations reveal a key role for sodium ions in increasing halotolerant enzyme stability largely through interactions with the highly ordered first Na(+) hydration shell. For the first time, an approach to generate extreme halotolerance, a trait with broad application in industrial biocatalysis, in a wild-type enzyme is demonstrated.
The development of new biocatalysts using ancestral sequence reconstruction is reported. When applied to an ω-transaminase, the ancestral proteins demonstrated novel and superior activities with ...eighty percent of the forty compounds tested compared to the modern day protein, and improvements in activity of up to twenty fold. These included a range of compounds pertinent as feedstocks in polyamide manufacture.
This book rethinks the public, public communication and public action in a globalising and mediated world. It develops novel theoretical perspectives for investigating the formation of publics, ...focusing on four overlapping processes: claiming publics; personalising publics; mediating publics; and becoming public. Using fascinating case studies, Rethinking the public offers a rich set of methodological resources on which other researchers can draw and foregrounds the need to interrogate the boundaries between theory, research and politics. It is ideal reading for higher level undergraduate and masters programmes in politics, geography, public policy, sociology, social policy, public administration and cultural studies.
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