A novel series of dual NK(1)/NK(2) receptor antagonists, based on the 2-oxo-(1,4'-bipiperidine) template, has been prepared. Compound 10R is a potent dual NK(1)/NK(2) antagonist and demonstrates ...excellent in vivo activity and good oral plasma levels in the dog.
In response to previous articles concerning pedophilia and the label of mental illness, the authors express their own opinions on pedophilia, human sexuality, and mental illness.
A novel series of dual NK
1/NK
2 receptor antagonists, based on the 2-oxo-(1,4′-bipiperidine) template, has been prepared. Compound
10R is a potent dual NK
1/NK
2 antagonist and demonstrates ...excellent in vivo activity and good oral plasma levels in the dog.
A novel 2-oxo-(1,4′-bipiperidine) oxime
10R, which is a potent dual NK
1/NK
2 inhibitor in vitro and in vivo and exhibits an improved pharmacokinetic profile, has been identified.
Carbonation conversion of aqueous sodium2sulfur to gaseous hydrogen2sulfide for the production of elemental sulfur is found to be kinetically viable. It is likely that the absorption of carbon ...dioxide would be one of the rate-limiting step(s).
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