Objective: To investigate the anti-inflammatory and analgesic effects of Solanum procumbens on complete Freund's adjuvant-induced arthritis rat models. Methods: We isolated and identified five ...compounds in the ethanol-soluble Solanum procumbens extract (SP) with anti-inflammatory effects, including ursolic acid, β-sitosterol, hexadecanoic acid, cis-vaccenic acid, and vanillic acid. Additionally, we investigated the anti-inflammatory effects of SP on rheumatoid arthritis symptoms, including paw volumes, local temperatures, withdrawal latency, and mechanical withdrawal threshold at the hind paw and white blood cell (WBC) number from complete Freund's adjuvant-induced arthritis rat models. Results: We have successfully established a complete Freund's adjuvant-induced arthritis rat model at a low dose (1 mg/mL). SP extract significantly reduced paw volumes (P<0.05), prolonged withdrawal latencies (P<0.05), decreased local temperature, and increased the mechanical withdrawal threshold (P<0.05), but only SP extract at the dose of 300 mg/kg significantly decreased WBC numbers. Conclusions: SP extract could be a potential medication candidate with anti-inflammatory effects for arthritis, but it requires further investigation into the mechanism of the SP and its effectiveness on other models as well as clinical trials.
This paper proposes a novel online control method for Hybrid Active Power Filter with Injection Circuit (IHAPF). It includes two closed-control loops. The lower closed-control loop contains a ...conventional PI controller and IHAPF model, while the upper closed-control loop is composed of predictive neural network model, optimization adjustor using generalized predictive control criterion (GPC) and IHAPF model. The purpose of the upper closed-control loop is to find a set of optimal PI parameters for the lower closed-control loop. Compared to the conventional PI control method, the simulation and experimental results show that the proposed control method has the advantages of shorter response time, able to online control very well and very effective in reducing harmonics.
