A single nerve block provides excellent analgesia in a short time, but rebound pain after the nerve block disappears has attracted researchers' attention. The aim of this study is to evaluate the ...effect of perineural dexamethasone on rebound pain after sciatic nerve block and femoral nerve block in patients undergoing unicompartmental knee arthroplasty (UKA).
In a double-blinded fashion, We recruited 72 patients undergoing UKA, each of whom received sciatic and femoral nerve block. Patients were randomly assigned to two groups (n=36): X (ropivacaine only) and D (ropivacaine combined with dexamethasone). The primary outcome was the incidence of rebound pain. The secondary outcomes were rebound pain score, the duration of rebound pain, the duration of nerve block, pain score, sufentanil consumption and rescue analgesic, patient-controlled intravenous analgesia, distance walked, sleep quality score, C-reactive protein levels, and adverse effects.
Compared with group X, the incidence of rebound pain in group D was higher, the rebound pain score was higher and the duration of nerve block was prolonged (P<0.05). At 12, 16, and 20 hours postoperatively, the pain scores at rest in group D was lower. At 32 and 36 hours postoperatively, the pain scores at rest in group D was higher (P<0.05). Moreover, patients in group D had lower levels of C-reactive protein after surgery (P<0.05).
Addition of dexmedetomidine to ropivacaine for UKA effectively prolonged the duration of nerve block and decreased c-reactive protein levels, but increased the incidence of rebound pain and rebound pain score, and had no beneficial effects on the postoperative analgesia.
To explore the difference in tumor-infiltrating lymphocytes (TILs) and programmed death-ligand (PD-L1) in primary hepatocellular carcinoma (HCC) and its adjacent tissues, and to evaluate their effect ...on HCC prognosis.
Liver cancer and paracancerous tissue samples were collected from 72 patients who underwent radical hepatectomy between December 15, 2017 and January 9, 2019. Flow cytometry was used to detect the distribution of TILs and PD-L1, analyze the correlation between the expression of CD8/CD3 and PD-L1 and clinical-pathological parameters, and evaluate their effect on the prognosis of HCC patients.
The distribution proportion of CD3+T cells, CD4+T cells, and PD-L1 in liver cancer were significantly higher than in paracancerous tissues, while the distribution proportion of CD8+T cells was significantly lower (all P<0.05). In HCC, the distribution proportion of CD8+T cells was related to tumor size and stage, while the PD-L1 expression was related to the tumor stage only (all P < 0.05). Univariate analysis showed that tumor differentiation, TNM stage, expression of CD8/CD3, and PD-L1 in tumor tissue were related to disease-free survival (DFS)(P < 0.05); multivariate Cox regression analysis showed that tumor differentiation, TNM stage, CD8/CD3, and PD-L1 expression were independent influencing factors of postoperative DFS (P < 0.05). Kaplan-Meier survival curve analysis showed that the DFS of CD8/CD3 high expression group was significantly higher than that of the low expression group, and the DFS of PD-L1 low expression group was significantly higher than that of the high expression group (all P < 0.05).
There are significant differences in the distribution of TILs and PD-L1 in HCC and paracancerous tissues. The expression of CD8/CD3 and PD-L1 in tumor-infiltrating lymphocytes in HCC may help evaluate the immunological indexes of prognosis after radical resection of HCC and to further the study of immunotherapy in patients with HCC.
Based on the conversion and alloying reactions, antimony sulfide (Sb2S3) with a theoretical discharge specific capacity of 946 mAh g−1 is a hopeful anode material for lithium/sodium ion batteries. ...Nevertheless, the poor electronic conductivity of Sb2S3 and the serious volume expansion during alloying reaction bring about the rapid capacity fading, which severely hinder its practical application. The design of morphology/structure and/or combining with carbon materials is the common strategies to address these issues. Herein, a simple electrospinning technology coupled with hydrothermal reaction is employed to synthesize the Sb2S3/carbon-silicon oxide (Sb2S3/CS) nanofibers for the first time. The obtained Sb2S3/CS nanofibers show superior lithium/sodium storage properties. Specifically, the Sb2S3/CS electrode maintains a high discharge specific capacity of 566 mAh g−1 under 200 mA g−1 after 200 cycles in lithium-ion batteries. For sodium storage, the Sb2S3/CS electrode obtains a discharge specific capacity of 321 mAh g−1 under 200 mA g−1 over 200 cycles. One-dimensional Sb2S3/CS nanofibers with good electronic conductivity accelerate the transport of ions and electrons, and effectively buffer the volume change of Sb2S3 nanoparticles during electrochemical reaction process, bringing about the excellent electrochemical properties.
•Sb2S3/CS nanofibers were synthesized by electrospinning and hydrothermal method.•The formation of Sb2S3/CS is reducing SbOx to Sb and transforming Sb to Sb2S3.•The fine 1D fiber structure can facilitate the transport of ions and electrons.•The Sb2S3/CS nanofibers have excellent lithium and sodium storage properties.
Lead (Pb) discharged from rural industries poses a significant threat to the environment and human health. Algal-bacterial aerobic granular sludge (A-B AGS) is a promising alternative for sewage ...treatment with high efficiency and good settleability. In this study, Pb(II) biosorption using fresh A-B AGS was investigated for the first time. The important role of extracellular polymeric substances (EPS) was revealed with the involved mechanisms being clarified. The desorbents for Pb recovery from Pb-loaded A-B AGS were also screened. Results showed that A-B AGS has an excellent maximum Pb adsorption capacity of 72.4 mg·g−1 at pH 6.0. EPS plays an important role in keeping microbial activity, Pb bonding, and providing metal ions (Ca, Na and Mg) for Pb ion exchanges. Electrostatic interaction, ion exchange, and bonding to functional groups may occur orderly in the Pb biosorption process and the formation of pyromorphite (Pb5(PO4)3Cl) contributes to Pb biosorption. About 66 % of the adsorbed Pb was accumulated in the A-B AGS microbial cells. Na2EDTA (0.05 M) can recover 60.3 % of the loaded Pb with the highest microbial activity of granules being remained. All the findings will provide the theoretical basis for the large-scale application of A-B AGS to bioremediate Pb(II)-containing wastewater.
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•Fresh algal-bacterial aerobic granular sludge (A-B AGS) as a novel adsorbent for Pb(II) removal.•A-B AGS shows an excellent Pb(II) biosorption capacity of 72.4 mg·g−1.•EPS functions in keeping microbial activity, Pb bonding, and governing ions exchange.•Both physicochemical and biological effects are involved in Pb biosorption.•Na2EDTA desorbs 60.3 % of Pb with the highest microbial activity remaining in A-B AGS.
Multiple RNA processing events including transcription, mRNA splicing, and export are delicately coordinated by the TREX complex. As one of the essential subunits, DDX39B couples the splicing and ...export machineries by recruiting ALYREF onto mRNA. In this study, we further explore the functions of DDX39B in handling damaged DNA, and unexpectedly find that DDX39B facilitates DNA repair by homologous recombination through upregulating BRCA1. Specifically, DDX39B binds to and stabilizes BRCA1 mRNA. DDX39B ensures ssDNA formation and RAD51 accumulation at DSB sites by maintaining BRCA1 levels. Without DDX39B being present, ovarian cancer cells exhibit hypersensitivity to DNA-damaging chemotherapeutic agents like platinum or PARPi. Moreover, DDX39B-deficient mice show embryonic lethality or developmental retardation, highly reminiscent of those lacking BRCA1. High DDX39B expression is correlated with worse survival in ovarian cancer patients. Thus, DDX39B suppression represents a rational approach for enhancing the efficacy of chemotherapy in BRCA1-proficient ovarian cancers.
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•The SnS2/C nanofibers are prepared by electrospinning for the first time.•During one-step calcination process, N and S are doped in the carbon nanofibers.•The SnS2/C nanofibers ...electrode shows superior sodium storage performance.
In this work, tin disulfide (SnS2) embedded in nitrogen and sulfur dual-doped carbon (denoted as SnS2/NSDC) nanofibers are synthesized using a facile electrospinning technique for the first time. The exterior of the nanofibers is decorated through the SnS2 nanosheet, and the interior of carbon nanofibers is embedded with SnS2 nanoparticles. Benefit from the unique structure and morphology, SnS2/NSDC nanofibers show excellent electrochemical performance. In Na half-cell, SnS2/NSDC nanofibers electrode show superior cycling performance and the capacity remains at 380.1 mAh g−1 at 500 mA g−1 after 200 cycles. Not only that, a capacity of 310.6 mAh g−1 still was obtained when the applied current density even increased to 4000 mA g−1, which reveals good rate performance of the SnS2/NSDC nanofibers electrode. In Na full-cell, SnS2/NSDC nanofibers electrode also show good sodium storage performance, which retained 213.4 mAh g−1 capacity after 50 cycles when cycling at 50 mA g−1. The excellent sodium storage performance indicates that the SnS2/NSDC nanofibers are one of the promising anode materials for high-performance sodium-ion batteries.
Nitrogen-doped TiO
2
–C composite nanofibers (TiO
2
/N–C NFs) were manufactured by a convenient and green electrospinning technique in which urea acted as both the nitrogen source and a pore-forming ...agent. The TiO
2
/N–C NFs exhibit a large specific surface area (213.04 m
2
g
−1
) and a suitable nitrogen content (5.37 wt%). The large specific surface area can increase the contribution of the extrinsic pseudocapacitance, which greatly enhances the rate capability. Further, the diffusion coefficient of sodium ions (
D
Na+
) could be greatly improved by the incorporation of nitrogen atoms. Thus, the TiO
2
/N–C NFs display excellent electrochemical properties in Na-ion batteries. A TiO
2
/N–C NF anode delivers a high reversible discharge capacity of 265.8 mAh g
−1
at 0.05 A g
−1
and an outstanding long cycling performance even at a high current density (118.1 mAh g
−1
) with almost no capacity decay at 5 A g
−1
over 2000 cycles. Therefore, this work sheds light on the application of TiO
2
-based materials in sodium-ion batteries.
SnS/C nanofibers membrane (SnS/C NFM) has been synthesized by low-temperature vulcanization from SnO2/C nanofiber membrane (SnO2/C NFM), which is obtained via electrospinning using commercial nano ...SnO2 as raw material followed by high-temperature carbonization. This method not only forms the high conductivity and stable carbon fiber skeleton in high temperature but also avoids the losing of tin source. The self-standing SnS/C NFM shows outstanding electrochemical properties as anode for sodium-ion batteries (SIBs) without adding any conductive agent and binder. Additionally, it exhibits much better performance compared to SnO2/C NFM and nano SnO2 particles. After 200 cycles at 200 mA g−1, it can provide high capacity of 324 mA h g−1 (up to 84.8% capacity retention rate), and also display a good rate performance. Such superb electrochemical performance can be attributed to the interconnection of the 3D conductive network to enhance the electrical conductivity of SnS, and effectively suppress the aggregation of SnS particles during the cycling process. Therefore, the self-standing SnS/C NFM is considered as promise anode materials for sodium-ion batteries.
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•The SnS/C NFM can be directly used as self-standing anode of sodium ion battery.•The SnS/C NFM has a 3D carbon fiber conductive network, which facilitates enhanced conductivity.•Under the moderate experimental conditions, the conversion of SnO2 strong covalent bond to SnS ion bond was realized.•The self-standing SnS/C NFs electrode present excellent electrochemical performance in SIBs.
Layer-by-layered SnS2/graphene (LL-SnS2/G) hybrid nanosheets are fabricated via a simple ball-milling of SnS2 nanoplates obtained through hydrothermal treatment and commercial graphene. When assessed ...as anode materials for LIBs, LL-SnS2/G shows a high initial reversible capacity of 696.27 mAh g−1 with a high initial coulombic efficiency (74.16%) at 200 mA g−1, and negligible capacity fading over 180 cycles. Moreover, LL-SnS2/G also has an excellent rate capability, which delivers a high capacity of 567.78 mAh g−1 at 2000 mA g−1. Benefits from synergism between SnS2 nanoplates with high specific capacity and graphene, the graphene increases the conductivity of SnS2, buffers the volume change during lithiation/de-lithiation processes, and provides an effective physical barrier between the active materials and the electrolyte to suppress the shuttle effect of polysulfides formed during de-lithiation processes. LL-SnS2/G shows excellent electrochemical performance and is a promising anode material candidate for lithium ion batteries.
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•Layer-by-layered SnS2/graphene (LL-SnS2/G) hybrid nanosheets was firstly prepared via a simple ball-milling method.•The unique layer-by-layered structure of LL-SnS2/G is favorable to the fast diffusion of Li+ and electrons.•The LL-SnS2/G shows remarkable cycling performance and outstanding rate capability.
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