The inert two-Higgs-doublet Model (i2HDM) is a well-motivated minimal consistent dark matter (DM) model, but it is rather challenging to test at the LHC in the parameter space allowed by relic ...density and DM direct detection constraints. This is especially true when considering the latest XENON 1T data on direct DM searches, which we use here to present the best current combined limit on the i2HDM parameter space. In this analysis, we present prospects to advance the exploitation of DM monojet signatures from the i2HDM at the LHC, by emphasising that a shape analysis of the missing transverse momentum distribution allows one to sizably improve the LHC discovery potential. For a key element of our analysis, we explore the validity of using an effective vertex, ggH, for the coupling of the Higgs boson to gluons using a full one-loop computation. We have found sizeable differences between the two approaches, especially in the high missing transverse momentum region, and incorporated the respective K-factors to obtain the correct kinematical distributions. As a result, we delineate a realistic search strategy and present the improved current and projected LHC sensitivity to the i2HDM parameter space.
A
bstract
We perform a statistical combination of the ATLAS and CMS results for the search of a heavy resonance decaying to a pair of vector bosons with the
s
=
8
TeV datasets collected at the LHC. ...We take into account six searches in hadronic and semileptonic final states carried out by the two collaborations. We consider only public information provided by ATLAS and CMS in the HEPDATA database and in papers published in refereed journals. We interpret the combined results within the context of a few benchmark new physics models, such as models predicting the existence of a W′ or a bulk Randall-Sundrum spin-2 resonance, for which we present exclusion limits, significances,
p
-values and best-fit cross sections. A heavy diboson resonance with a production cross section of ∼4-5 fb and mass between 1.9 and 2.0 TeV is the exotic scenario most consistent with the experimental results. Models in which a heavy resonance decays preferentially to a WW final state are disfavoured.
The aim of the current project was to characterize the luteal vascularity and the plasma concentrations of progesterone (P4), prolactin (PRL) and 13,14-dihydro-15-keto-PGF2α (PGFM) in mares with ...luteal disturbances during early and mid-diestrus. In Experiment 1, twenty-one mares were treated with 2 mL of 0.9% NaCl, or 1 mg Dinoprost, or 10 mg Dinoprost on day two after ovulation (Control-D2, 1/10PGF-D2 and PGF-D2 groups, respectively; n = 7 mares/group). In Experiment 2, similar treatments were performed eight days post-ovulation using a different cohort of 21 mares (Control-D8, 1/10PGF-D8 and PGF-D8 groups, respectively; n = 7 mares/group). Blood samples were collected hourly and power-Doppler examinations of the corpus luteum (CL) were performed every 6 h from H0 (moment immediately before treatment) to H48. Data collection was also done once a day from D0 (day of ovulation) to D20. In Experiment 1, the PGF-D2 and 1/10PGF-D2 groups had lower increase of plasma concentration of P4 until H48 and reduced maximum P4 concentrations on D8-D11 than mares from the Control-D2 group. However, no differences among groups were detected for luteal vascularity during early and mid-diestrus. In Experiment 2, complete and partial luteolysis were detected in mares from the PGF-D8 and 1/10PGF-D8 groups, respectively. Luteal vascularity and plasma P4 concentrations differed among Control-D8, PGF-D8 and 1/10PGF-D8 groups on H48. Partially regressed CLs (1/10PGF-D8 group) generated more Doppler signals than completed regressed CLs (PGF-D8 group) between D10 and D13. In both experiments, a transient increase in PRL activity was observed in parallel to the PGFM pulse in mares receiving 1 or 10 mg Dinoprost. The use of prostaglandin on D2 at conventional or 1/10 of the dose impaired the luteal development in mares. Moreover, the low dose of prostaglandin lead to partial regression of mature CLs. The blood supply was reduced in partially regressed CLs, but not in CLs undergoing impaired luteogenesis.
•A single prostaglandin treatment on day two after ovulation reduced the maximum production of P4 during diestrus.•Impaired luteogenesis did not affect the vascularity of mid-cycle CLs.•The vascularity was reduced in CLs undergoing partial luteolysis during mid-diestrus.•Partially regressed CLs did not rebound to normality.•The use of Doppler ultrasonography was efficient to detect partially regressed CLs.
With the successful control of rabies transmitted by dogs in Brazil, wild animals have played a relevant epidemiological role in the transmission of rabies virus (RABV). Bats, non-human primates and ...wild canines are the main wild animals that transmit RABV in the country. It is worth highlighting the possibility of synanthropic action of these species, when they become adapted to urban areas, causing infections in domestic animals and eventually in humans. This work aimed to evaluate the circulation of RABV in the Pedra Branca Forest, an Atlantic Forest area, located in the state of Rio de Janeiro, Southeast Brazil. Saliva and blood samples were obtained from 60 individuals of eight species of bats, captured with mist nets, and 13 individuals of callitrichid primates, captured with tomahawk traps. Saliva samples were subjected to Reverse Transcription Polymerase Chain Reaction (RT-PCR), targeting the RABV N gene, with all samples being negative. Blood samples of all animals were submitted to the Rapid Fluorescent Focus Inhibition Test (RFFIT) to detect neutralizing antibodies (Ab) for RABV. Six bat samples (8%) were seropositive for RABV with antibody titers greater than or equal to 0.1 IU/mL. The detection of Ab but not viral RNA indicates exposure rather than current RABV transmission in the analyzed populations. The results presented here reinforce the importance of serological studies in wildlife to access RABV circulation in a region.With the successful control of rabies transmitted by dogs in Brazil, wild animals have played a relevant epidemiological role in the transmission of rabies virus (RABV). Bats, non-human primates and wild canines are the main wild animals that transmit RABV in the country. It is worth highlighting the possibility of synanthropic action of these species, when they become adapted to urban areas, causing infections in domestic animals and eventually in humans. This work aimed to evaluate the circulation of RABV in the Pedra Branca Forest, an Atlantic Forest area, located in the state of Rio de Janeiro, Southeast Brazil. Saliva and blood samples were obtained from 60 individuals of eight species of bats, captured with mist nets, and 13 individuals of callitrichid primates, captured with tomahawk traps. Saliva samples were subjected to Reverse Transcription Polymerase Chain Reaction (RT-PCR), targeting the RABV N gene, with all samples being negative. Blood samples of all animals were submitted to the Rapid Fluorescent Focus Inhibition Test (RFFIT) to detect neutralizing antibodies (Ab) for RABV. Six bat samples (8%) were seropositive for RABV with antibody titers greater than or equal to 0.1 IU/mL. The detection of Ab but not viral RNA indicates exposure rather than current RABV transmission in the analyzed populations. The results presented here reinforce the importance of serological studies in wildlife to access RABV circulation in a region.
Purpose
Bariatric surgery (BS) promotes carotid intima-media thickness (C-IMT) regression as early as 6 months post-surgery. To verify whether C-IMT regression occurs even earlier, we aimed at the ...effect of Roux-en-Y gastric bypass (RYGBP) and biliopancreatic diversion (BPD) on C-IMT 1–2 months and 12 months post-surgery.
Subjects/Methods
Prospective trial. BS was performed on 109 patients either with (RYGBP = 42; BDP = 40) or without type 2 diabetes (RYGBP = 27). Healthy volunteers served as control group. Follow-up: baseline, 1–2 months, 12 months post-surgery. Endpoints: changes (∆) in C-IMT, weight, body mass index, fat mass, waist and neck circumferences, blood pressure, HbA1c, glucose, insulin, insulin sensitivity HOMA-IR; OGIS, from meal tolerance test, lipids, C-reactive protein, leptin, adiponectin, MCP-1.
Results
All surgery subgroups had similar levels of ∆-C-IMT. C-IMT in the pooled surgery group reduced from mean (95% confidence interval) 0.81 (0.77–0.84) mm to 0.66 (0.63–0.69) mm,
p
< 0.001 −17.1 (−20.4 to −13.8)% at 1–2 months, and to 0.63 (0.59–0.66) mm,
p
< 0.001 −21.8 (−25.3 to −18.4)% at 12 months post-surgery. ∆-C-IMT 1–2 months and 12 months post-surgery correlated to baseline C-IMT, and with ∆-leptin at 1–2 months, but not at 12 months post-surgery. In linear regression analysis, ∆-leptin and baseline C-IMT were predictors of ∆-C-IMT 1–2 months post-surgery.
Conclusions
A remarkable C-IMT regression occurred as early as 1–2 months after BS in obese patients either with or without type 2 diabetes, which was associated to the early reduction in leptin, (at least partially) independent of weight loss. Whether this is a causative or correlative association needs further investigation.
Hydroxypropyl methylcellulose (HPMC) E4M chains are crosslinked with citric acid and ethylenediaminetetraacetic acid (EDTA), resulting in adsorbent sponges (SpE4M), which are impregnated with ...magnetic nanoparticles (SpE4M‐mag) for the adsorption of 17 α‐ethinyl estradiol (EE). The characterization of SpE4M and SpE4M‐mag characterization includes X‐ray microcomputer tomography (Micro‐CT), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) vibrational spectroscopy, elemental analysis, inductively coupled plasma optical emission spectrometry (ICP‐OES), and X‐ray diffraction (XRD). SpE4M and SpE4M‐mag present porosities of 72±6 % and 80±7 %, respectively, and outstanding stability in water, in the pH range 4 to 8, and in alcohols, alkanes, and acetone. The compressive moduli of SpE4M and SpE4M‐mag amount to 2.75 and 4.37 MPa, respectively. The adsorption of 17 α‐ethinyl estradiol (EE), an estrogenic pollutant, on SpE4M and SpE4M‐mag follows the pseudo‐first‐order kinetic model. The EE removal capacity by SpE4M is 78±5 %, which is twice that presented by SpE4M‐mag. The new sponges are recovered successfully either by flotation or by an external magnet, and can be recycled five times keeping 80 % of their initial removal capacity after the fifth cycle, disclosing their potential for environmental remediation.
Water remediation: The estrogenic water pollutant 17 α‐ethinyl estradiol is removed successfully by using hydroxypropyl methylcellulose sponges and their magnetic counterparts. These sponges can be recovered easily from water by flotation or magnets. They can be recycled at least five times without significant efficiency loss (see figure).
•FSH treatment alters endometrial histomorphometry in prepubertal gilts.•Changes in uterine morphology do not occur from 140 to 160 d of age in prepubertal gilts.•Ovarian preantral follicles are not ...responsive to FSH treatment in prepubertal gilts.
This study investigated the effect of age and follicle stimulating hormone (FSH) treatment on the estradiol (E2) plasma concentration, ovarian follicle development, endometrial histomorphometry, and ultrasonographic parameters of the ovaries and uterus in prepubertal gilts. Thirty-five prepubertal gilts were grouped according to age (140 or 160 d), and within each age, gilts were allotted to receive 100 mg of FSH (treated; G140 + FSH n = 10 and G160 + FSH n = 7) or saline solution (control; G140 + control n = 10 and G160 + control n = 8). The total dose of FSH was divided into 6 similar doses administered every 8 h (days 0–2). Before and after FSH treatment, blood sample was collected, and transabdominal scanning of the ovaries and uterus was performed. Twenty-four hours after the last FSH injection, the gilts were slaughtered and their ovaries and uterus were processed for histological and histomorphometric analysis. The histomorphometric parameters of the uterus differed (P < 0.05) between prepubertal gilts at 160 d and 140 d of age. Moreover, changes (P < 0.05) in uterine and ovarian ultrasound images occurred between 140 and 160 d of age. Age and FSH treatment did not affect (P > 0.05) E2 plasma concentrations. Follicle stimulating hormone treatment did not affect (P > 0.05) the early stage of folliculogenesis in the prepubertal gilts; however, the number of early atretic follicles decreased (P < 0.05) after the FSH treatment. Follicle stimulating hormone administration increased (P < 0.05) the number of medium follicles and decreased (P < 0.05) the number of small follicles in 140 and 160 d old gilts. In the endometrium, luminal/glandular epithelium height and glandular diameter increased (P < 0.05) after FSH treatment. Thus, injections of 100 mg of FSH stimulate the endometrium epithelium and induce follicular growth to a medium follicle size without affecting the preantral stages in prepubertal gilts; also, the uterine macroscopic morphometry does not change from 140 to 160 d of age.
Environmental temperatures influence ectotherms’ physiology and capacity to perform activities necessary for survival and reproduction. Time available to perform those activities is determined by ...thermal tolerances and environmental temperatures. Estimates of activity time might enhance our ability to predict suitable areas for species’ persistence in face of climate warming, compared to the exclusive use of environmental temperatures, without considering thermal tolerances. We compare the ability of environmental temperatures and estimates of activity time to predict the geographic distribution of a tropical lizard, Tropidurus torquatus. We compared 105 estimates of activity time, resulting from the combination of four methodological decisions: 1) how to estimate daily environmental temperature variation (modeling a sinusoid wave ranging from monthly minimum to maximum temperature, extrapolating from operative temperatures measured in field or using biophysical projections of microclimate)? 2) In which temperature range are animals considered active? 3) Should these ranges be determined from body temperatures obtained in laboratory or in field? And 4) should thermoregulation simulations be included in estimations? We show that models using estimates of activity time made with the sinusoid and biophysical methods had higher predictive accuracy than those using environmental temperatures alone. Estimates made using the central 90% of temperatures measured in a thermal gradient as the temperature range for activity also ranked higher than environmental temperatures. Thermoregulation simulations did not improve model accuracy. Precipitation ranked higher than thermally related predictors. Activity time adds important information to distribution modeling and should be considered as a predictor in studies of the distribution of ectotherms. The distribution of T. torquatus is restricted by precipitation and by the effect of lower temperatures on their time of activity and climate warming could lead to range expansion. We provide an R package ‘Mapinguari’ with tools to generate spatial predictors based on the processes described herein.
The BINGO project Fornazier, Karin S. F.; Abdalla, Filipe B.; Remazeilles, Mathieu ...
Astronomy and astrophysics (Berlin),
08/2022, Letnik:
664
Journal Article
Recenzirano
Context.
Observing the neutral hydrogen distribution across the Universe via redshifted 21 cm line intensity mapping constitutes a powerful probe for cosmology. However, the redshifted 21 cm signal ...is obscured by the foreground emission from our Galaxy and other extragalactic foregrounds. This paper addresses the capabilities of the BINGO survey to separate such signals.
Aims.
We show that the BINGO instrumental, optical, and simulations setup is suitable for component separation, and that we have the appropriate tools to understand and control foreground residuals. Specifically, this paper looks in detail at the different residuals left over by foreground components, shows that a noise-corrected spectrum is unbiased, and shows that we understand the remaining systematic residuals by analyzing nonzero contributions to the three-point function.
Methods.
We use the generalized needlet internal linear combination, which we apply to sky simulations of the BINGO experiment for each redshift bin of the survey. We use binned estimates of the bispectrum of the maps to assess foreground residuals left over after component separation in the final map.
Results.
We present our recovery of the redshifted 21 cm signal from sky simulations of the BINGO experiment, including foreground components. We test the recovery of the 21 cm signal through the angular power spectrum at different redshifts, as well as the recovery of its non-Gaussian distribution through a bispectrum analysis. We find that non-Gaussianities from the original foreground maps can be removed down to, at least, the noise limit of the BINGO survey with such techniques.
Conclusions.
Our component separation methodology allows us to subtract the foreground contamination in the BINGO channels down to levels below the cosmological signal and the noise, and to reconstruct the 21 cm power spectrum for different redshift bins without significant loss at multipoles 20 ≲
ℓ
≲ 500. Our bispectrum analysis yields strong tests of the level of the residual foreground contamination in the recovered 21 cm signal, thereby allowing us to both optimize and validate our component separation analysis.
We analyze the potential of the Fermilab Tevatron and CERN Large Hadron Collider (LHC) to study anomalous quartic vector--boson interactions (photon photon Z Z) and (photon photon W+ W-). Working in ...the framework of SU(2)_L X U(1)_Y chiral Lagrangians, we study the production of photons pairs accompanied by (e+e-), (e nu), and jet pairs to impose bounds on these new couplings, taking into account the unitarity constraints. We compare our findings with the indirect limits coming from precision electroweak measurements as well as with presently available direct searches at LEPII. We show that the Tevatron Run II can provide limits on these quartic limits which are of the same order of magnitude as the existing bounds from LEPII searches. LHC will be able to tighten considerably the direct constraints on these possible new interactions, leading to more stringent limits than the presently available indirect ones.
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