Background
Application of fluoride mouthrinse before an acidic challenge may decrease enamel erosion. This paper compares the efficacy of stannous (SnF2) and sodium (NaF) fluoride when facing single ...and multiple erosive cycles in vitro.
Methods
Human enamel samples (N = 60) were randomly assigned to groups testing SnF2 and NaF mouthrinses (225 p.p.m.) and a water control. Samples were allocated into subgroups testing one or five erosive cycles. Samples were immersed in test solution for 1 min prior to citric acid immersion (0.3%, pH 3.2, 10 min), and the cycle repeated either one or five times. Analysis was done using profilometry and microhardness change.
Results
After one cycle, SnF2 resulted in least step height followed by NaF and water (1.3 μm (0.63), 2.3 μm (0.39), 4.3 μm (0.41) respectively; P < 0.0001). After five cycles SnF2 continued to reduce step height but pre‐application of NaF was no different to water (4.6 μm (0.7), 10.5 μm (1.1) and 11.1 μm (0.38) respectively; P < 0.0001). There were no statistical differences in microhardness change between fluorides. After one erosive cycle, fluoride application resulted in statistically softer enamel compared with water.
Conclusions
Both SnF2 and NaF reduced erosion after one cycle. After five cycles, SnF2 continued to offer protection whereas NaF was statistically comparable with water. Softening of enamel may not imply less erosion has occurred.
This investigation aimed to compare the protective role of saliva against erosion and attrition challenges.
Polished enamel and dentine samples (n = 160) were prepared and randomly assigned to either ...the saliva or saliva-free group (n = 40 enamel and n = 40 dentine/group). Within each subgroup, they were allocated to four subgroups: negative control (deionized water exposure 10 min), erosion (0.3% citric acid 10 min), attrition (120 S of 300 g force), or combined erosion/attrition (0.3% citric acid 10 min then 120 S of 300 g force). Experimental cycles were repeated three times. Data analysis was performed using SPSS.
The mean and standard deviation (SD) of step heights produced by the attrition and erosion/attrition groups in enamel in the saliva-free group were 5.6 µm (2.4) and 13.4 µm (2.8), respectively, while they were 2.4 µm (3.8) and 12.9 µm (3.5) in the saliva group, with no significant difference between the saliva and saliva-free groups. For dentine, the corresponding step heights were 25.2 µm (5.5) and 35.9 µm (7.9) for the saliva-free group, but 21.8 µm (5.3) and 27.3 µm (6.4) for the saliva group (p < 0.001).
There was a trend that saliva decreased wear, but this was only statistically significant for erosion/attrition dentine wear.
Aberrant expression of cyclin D1 protein is a common feature of breast cancer. However, the CCND1 gene encodes two gene products, cyclin D1a and cyclin D1b, which have discrete mechanisms of ...regulation and impact on cell behavior. A polymorphism at nucleotide 870 in the CCND1 gene, rs603965, influences the relative production of the encoded proteins and can impart increased risk for tumor development. Here, the impact of both the G/A870 polymorphism and cyclin D1b protein production on breast cancer risk, disease phenotype and patient outcome was analysed. In a large multiethnic case-control study, the G/A870 polymorphism conferred no significant risk for breast cancer overall or by stage or estrogen receptor (ER) status. However, the cyclin D1b protein was found to be upregulated in breast cancer, independent of cyclin D1a levels, and exhibited heterogeneous levels in breast cancer specimens. High cyclin D1a expression inversely correlated with the Ki67 proliferation marker and was not associated with clinical outcome. In contrast, elevated cyclin D1b expression was independently associated with adverse outcomes, including recurrence, distant metastasis and decreased survival. Interestingly, cyclin D1b was particularly associated with poor outcome in the context of ER-negative breast cancer. Thus, specific cyclin D1 isoforms are associated with discrete forms of breast cancer and high cyclin D1b protein levels hold prognostic potential.
Abstract In childhood chronic illness, family communication can impact the child's and parents' psychosocial well-being. However, little is known about family communication in the context of epilepsy ...in childhood. The aim of this systematic review was to identify the existing evidence available on communication strategies adopted by families living with childhood epilepsy, including; the facilitators, barriers and challenges experienced by families when choosing to communicate, or not, about epilepsy; and the consequences of this communication. Papers published in the English language prior to March 2015 were identified following a search of six electronic databases: PubMed, MEDLINE, Web of Science, PsycINFO, CINAHL, and Scopus. Studies were included if they involved a sample of parents of children with epilepsy or children/young people with epilepsy (0–18 years of age) and used qualitative, quantitative, or mixed methods. Following a comprehensive search and screening process, 26 studies were identified as eligible for inclusion in the review. No studies identified specific communication strategies adopted by families living with childhood epilepsy. Some studies found that talking about epilepsy with family members had positive consequences (e.g., communication as an effective coping strategy), with no negative consequences reported in any of the studies. The main barrier to communication for parents was an unwillingness to use the word “epilepsy” because of the perceived negative social connotations associated with the health condition. For children with epilepsy, barriers were as follows: parental desire to keep epilepsy a secret, parents' tendency to deny that the child had epilepsy, parental overprotection, and parents' tendency to impose greater restrictions on the child with epilepsy than on siblings without epilepsy. Future research investigating the communication strategies of families living with epilepsy is needed in order to create effective communication-based interventions for discussing epilepsy within the home.
We present our analyses of 15months of Kepler data on KIC10139564. We detected 57 periodicities with a variety of properties not previously observed all together in one pulsating subdwarf B (sdB) ...star. Ten of the periodicities were found in the low-frequency region, and we associate them with nonradial g modes. The other periodicities were found in the high-frequency region, which are likely p modes. We discovered that most of the periodicities are components of multiplets with a common spacing. Assuming that multiplets are caused by rotation, we derive a rotation period of 25.6 ± 1.8d. The multiplets also allow us to identify the pulsations to an unprecedented extent for this class of pulsator. We also detect l ≥ 2 multiplets, which are sensitive to the pulsation inclination and can constrain limb darkening via geometric cancellation factors. While most periodicities are stable, we detected several regions that show complex patterns. Detailed analyses showed that these regions are complicated by several factors. Two are combination frequencies that originate in the super-Nyquist region and were found to be reflected below the Nyquist frequency. The Fourier peaks are clear in the super-Nyquist region, but the orbital motion of Kepler smears the Nyquist frequency in the barycentric reference frame and this effect is passed on to the sub-Nyquist reflections. Others are likely multiplets but unstable in amplitudes and/or frequencies. The density of periodicities also makes KIC10139564 challenging to explain using published models. This menagerie of properties should provide tight constraints on structural models, making this sdB star the most promising for applying asteroseismology. To support our photometric analysis, we have obtained spectroscopic radial-velocity measurements of KIC10139564 using low-resolution spectra in the Balmer-line region. We did not find any radial-velocity variation. We used our high signal-to-noise average spectrum to improve the atmospheric parameters of the sdB star, deriving Teff=31859K and logg=5.673dex. PUBLICATION ABSTRACT
In this paper, we show that method of mode identification using combined multicolour photometry and spectroscopy can be successfully applied to the pulsating subdwarf B star Balloon 090100001. The ...method constrains the spherical degree, ℓ. We confirm that the dominant mode is radial and we show that for some other modes the method provides values of ℓ consistent with the observed rotationally split triplet. Moreover, we derive a radius variation of 1.7 per cent for the dominant mode. The identification opens the possibility for constraining the internal structure of the star by means of seismic methods.
It is generally acknowledged that hormones are implicated in socioemotional behavior, yet little is known about the role of hormones in the context of emotion regulation. The aims of the present ...review and meta-analysis were to review and synthesize the available evidence pertaining to the effect of emotion regulation instructions on hormones, and to investigate whether this effect varies according to: type of hormone, context (e.g., emotion-induction procedure), emotion regulation characteristics (e.g., emotion regulation strategy), and presence and type of psychiatric disorder. PubMed, PsycINFO, and CINAHL were searched for experimental studies assessing the effect of instructed emotion regulation on levels of hormones (i.e., testosterone, cortisol, oxytocin, estradiol, and vasopressin) in physically healthy adults. The literature search yielded 17 relevant studies, 16 investigating cortisol and one investigating testosterone. Of these, 12 cortisol studies had eligible data for the meta-analysis. The results of the meta-analysis indicated no statistically significant effect of receiving an emotion regulation instruction compared with receiving no instruction on the cortisol response to subsequent emotion induction (g = −0.05, p = .48). However, within-person comparisons of change from an unregulated response to a regulated response indicated a significant change in cortisol levels (g = 0.18, p = .03) consistent with the specified regulation goal (i.e., either up- or downregulation). No statistically significant effects were found in subgroup meta-analyses conducted according to context, emotion regulation characteristics or psychiatric disorders. Taken together, the findings indicate that emotion-induction procedures are associated with increases in cortisol that may subsequently return to equilibrium regardless of emotion-regulation instructions. Based on the large gaps in research (e.g., few studies investigated other hormones than cortisol, few studies included self-report measures of emotions) identified in the present review, we conclude that the effect of emotion regulation on hormones remains poorly understood.
CRD42020157336.
•Research on the effect of emotion regulation on hormones has focused on cortisol.•Emotion regulation does not influence cortisol responses to emotion induction.•Psychological confounders have received little attention in the reviewed research.•The effect of emotion regulation on hormones remains poorly understood.
Summary Introduction A large number of children with spina bifida develop a neuropathic bladder and this group of patients still forms the largest group of children who require urological management. ...Although there are published guidelines on the management of the neuropathic bladder, they are not specific to children. It is unsurprising, therefore, that the initial investigation, assessment and management of children with spina bifida vary considerably. The 2014 British Association of Paediatric Urologists (BAPU) meeting was devoted to the management of the neuropathic bladder. The aim was to produce a consensus on the appropriate investigation and management of a child with a neuropathic bladder. Methods and Materials A questionnaire was devised and the members were polled on their current practice. Six paediatric urology fellows presented an evidence-based literature review on different aspects of the neuropathic bladder. At the end of the session, the members of the organisation present were polled again using the same questions. Results The BAPU felt that the use of urodynamics in the neuropathic bladder should be selectively determined by clinical parameters. Regarding CIC, the group was evenly split between universal use or only when poor emptying was established. Oxybutinin was the first-line anticholinergic of choice. Most paediatric urologists routinely used Botox and were happy to use it repeatedly. The surgical intervention most frequently employed was determined to be an ileocystoplasty, with most surgeons deferring the need for surveillance cystoscopy until at least 10 years after surgery. Conclusion It was felt that a consensus statement is not a guideline or a way to establish best practice; however, it serves as a way of surveying current practice and providing a benchmark for clinicians involved in the management of these patients.
We present six years of new radial velocity data from the Anglo-Australian and Magellan Telescopes on the HD 73526 2:1 resonant planetary system. We investigate both Keplerian and dynamical ...(interacting) fits to these data, yielding four possible configurations for the system. The new data now show that both resonance angles are librating, with amplitudes of 40degrees and 60degrees, respectively. We then perform long-term dynamical stability tests to differentiate these solutions, which only differ significantly in the masses of the planets. We show that while there is no clearly preferred system inclination, the dynamical fit with i = 90degrees provides the best combination of goodness-of-fit and long-term dynamical stability.
Objective To assess charting, risk assessment and treatment-planning of tooth wear between recently qualified and experienced dentists in general dental practice.Design Service evaluation.Setting ...Multi-setting evaluation of three mixed NHS/Private general dental practices in North-East London.Methods The clinical notes of new patient examinations on dentate adults presenting from the 1 October 2016 to 31 December 2016 were audited collecting data on tooth wear charting, risk assessment and treatment planning. Data were analysed using descriptives, chi square and logistic regressions in SPSS. Significance was inferred at p <0.05.Results Foundation dentists and experienced dentists performed 85 and 200 new patient examinations, respectively, during the evaluation period. Tooth wear was charted for 48% of those attending foundation dentists and 5% of those attending experienced dentists. Diet was assessed in 50.6% of patients examined by foundation dentists and 1.0% of patients examined by experienced dentists. Foundation dentists were more likely to chart tooth wear, risk assess and preventively manage tooth wear compared to experienced dentists (p <0.001).Conclusion This service evaluation highlights that improvements are required in recording, risk assessing and preventive treatment planning of erosive tooth wear. Experienced dentists were less likely to risk assess tooth wear and less likely to provide preventive treatment. Experienced GDPs may benefit from re-training in this area.