Objectives: over the years a device has been developed, the Magnetic Mallet, which allows a very high control and stability of the applied forces, able to perform procedures that were the safest ...possible for the patient and the surgeon himself. The handpiece has been designed so that different shock waves are emitted according to the type of surgery, with the possibility of inserting different inserts according to the technique/procedure that is being applied. The Magnetic Mallet can be used in different surgical procedures; Dental extractions, implant placement, implant site preparation (osseodensification), maxillary sinus lift procedures or crestal expansion procedures. Materials and methods: In the following clinical case, the extraction of element 2.7 is conducted with the simultaneous insertion of two implant fixtures in place 2.6 and 2.7 and simultaneous regenerative therapy. The implant in site 2.6 was positioned with a traditional method, with the help of the implant motor, while the post-extraction implant in site 2.7 was inserted with the use of the Magnetic Mallet. Results: At one week the sutures were removed and the tissues showed good healing. The patient is then placed in a maintenance and follow-up program to monitor healing after some time.
The advent of new assisted design software in combination with computed tomography (CT) has increased the possibility of rehabilitating edentulous jaws with implant-supported fixed prostheses, ...allowing flapless surgery and immediate loading even in the presence of critical bone volume. Aim: The aim of the present study is to demonstrate how the use of advanced technologies supported by specific software allows the design and execution of optimal implant surgery while going on to decrease what could be intra- and postoperative risks.
Working landscapes need at least 20% native habitat Garibaldi, Lucas A.; Oddi, Facundo J.; Miguez, Fernando E. ...
Conservation letters,
March/April 2021, 2021-03-00, 20210301, 2021-03-01, Letnik:
14, Številka:
2
Journal Article
Recenzirano
Odprti dostop
International agreements aim to conserve 17% of Earth's land area by 2020 but include no area‐based conservation targets within the working landscapes that support human needs through farming, ...ranching, and forestry. Through a review of country‐level legislation, we found that just 38% of countries have minimum area requirements for conserving native habitats within working landscapes. We argue for increasing native habitats to at least 20% of working landscape area where it is below this minimum. Such target has benefits for food security, nature's contributions to people, and the connectivity and effectiveness of protected area networks in biomes in which protected areas are underrepresented. We also argue for maintaining native habitat at higher levels where it currently exceeds the 20% minimum, and performed a literature review that shows that even more than 50% native habitat restoration is needed in particular landscapes. The post‐2020 Global Biodiversity Framework is an opportune moment to include a minimum habitat restoration target for working landscapes that contributes to, but does not compete with, initiatives for expanding protected areas, the UN Decade on Ecosystem Restoration (2021–2030) and the UN Sustainable Development Goals.
There is clear association between the intensity of the acute inflammatory response during acute myocardial infarction (AMI) and adverse prognosis after AMI. Interleukin‐1 (IL‐1) is a ...pro‐inflammatory cytokine released during AMI and involved in adverse remodeling and heart failure (HF). We describe a study to evaluate the safety and efficacy of IL‐1 blockade using an IL‐1 receptor antagonist (anakinra) during the acute phase of ST‐segment elevation myocardial infarction (STEMI). The Virginia Commonwealth University–Anakinra Remodeling Trial‐3 (VCU‐ART3; http://www.ClinicalTrials.gov NCT01950299) is a phase 2, multicenter, double‐blinded, randomized, placebo‐controlled clinical trial comparing anakinra 100 mg once or twice daily vs matching placebo (1:1:1) for 14 days in 99 patients with STEMI. Patients who present to the hospital with STEMI within 12 hours of symptom onset will be eligible for enrollment. Patients will be excluded for a history of HF (functional class III–IV), severe valvular disease, severe kidney disease (stage 4–5), active infection, recent use of immunosuppressive drugs, active malignancy, or chronic autoimmune/auto‐inflammatory diseases. We will measure the difference in the area under the curve for C‐reactive protein between admission and day 14, separately comparing each of the anakinra groups with the placebo group. The P value will be considered significant if <0.025 to adjust for multiple comparisons. Patients will also be followed for up to 12 months from enrollment to evaluate cardiac remodeling (echocardiography), cardiac function (echocardiography), and major adverse cardiovascular outcomes (cardiovascular death, MI, revascularization, and new onset of HF).
Aims
Grasslands are among the largest ecosystems in the world and store up to 30% of the global reserves of carbon. Decomposition processes have a crucial role in maintaining carbon balance, but few ...studies have investigated the heterogeneity of this process at small scale, especially in alpine ecosystems. We aimed at investigating the interactions between decomposition and environmental heterogeneity at microscale (i.e. elevation gradient <1 m) in a subalpine grassland on the western Italian Alps characterised by the presence of parallel hummock and hollow areas.
Methods
In the study area we monitored microenvironmental drivers (soil temperature and soil water content), plant distribution and decomposition. The latter was studied through a litter bags approach followed by elemental analysis,
13
C NMR and FT-IR spectroscopies.
Results
Microtopography exerted a direct and indirect control over litter decomposition by affecting plant species distribution and microclimatic conditions. The different elemental and biochemical properties of plants, interacting with microtopography, led to a higher decomposition rate of forb than grass litter, and in hollow than in hummock areas. The observed differences were both quanti- and qualitative.
Conclusions
Decomposition processes bridge the gap between plant community structure and ecosystem functioning, determining a feedback mechanism that maintains ecosystem heterogeneity at the microscale.
Cognitive post‐acute sequelae of SARS‐CoV‐2 (PASC) can occur after mild COVID‐19. Detailed clinical characterizations may inform pathogenesis. We evaluated 22 adults reporting cognitive PASC and 10 ...not reporting cognitive symptoms after mild SARS‐CoV‐2 infection through structured interviews, neuropsychological testing, and optional cerebrospinal fluid (CSF) evaluations (53%). Delayed onset of cognitive PASC occurred in 43% and associated with younger age. Cognitive PASC participants had a higher number of pre‐existing cognitive risk factors (2.5 vs. 0; p = 0.03) and higher proportion with abnormal CSF findings (77% vs. 0%; p = 0.01) versus controls. Cognitive risk factors and immunologic mechanisms may contribute to cognitive PASC pathogenesis.
Colorectal cancer (CRC) is a leading cause of cancer death worldwide, and its incidence is correlated with infections, chronic inflammation, diet, and genetic factors. An emerging aspect is that ...microbial dysbiosis and chronic infections triggered by certain bacteria can be risk factors for tumor progression. Recent data suggest that certain bacterial toxins implicated in DNA attack or in proliferation, replication, and death can be risk factors for insurgence and progression of CRC. In this study, we recruited more than 300 biopsy specimens from people undergoing colonoscopy, and we analyzed to determine whether a correlation exists between the presence of bacterial genes coding for toxins possibly involved in CRC onset and progression and the different stages of CRC. We also analyzed to determine whether CRC-predisposing genetic factors could contribute to bacterial toxins response. Our results showed that CIF toxin is associated with polyps or adenomas, whereas pks+ seems to be a predisposing factor for CRC. Toxins from
as a whole have a higher incidence rate in adenocarcinoma patients compared to controls, whereas
toxin does not seem to be associated with pre-cancerous nor with cancerous lesions. These results have been obtained irrespectively of the presence of CRC-risk loci.
Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive cancer with marked resistance to chemotherapeutics without therapies. The tumour microenvironment of iCCA is enriched of ...Cancer-Stem-Cells expressing Epithelial-to-Mesenchymal Transition (EMT) traits, being these features associated with aggressiveness and drug resistance. Treatment with the anti-diabetic drug Metformin, has been recently associated with reduced incidence of iCCA. We aimed to evaluate the anti-cancerogenic effects of Metformin in vitro and in vivo on primary cultures of human iCCA. Our results showed that Metformin inhibited cell proliferation and induced dose- and time-dependent apoptosis of iCCA. The migration and invasion of iCCA cells in an extracellular bio-matrix was also significantly reduced upon treatments. Metformin increased the AMPK and FOXO3 and induced phosphorylation of activating FOXO3 in iCCA cells. After 12 days of treatment, a marked decrease of mesenchymal and EMT genes and an increase of epithelial genes were observed. After 2 months of treatment, in order to simulate chronic administration, Cytokeratin-19 positive cells constituted the majority of cell cultures paralleled by decreased Vimentin protein expression. Subcutaneous injection of iCCA cells previously treated with Metformin, in Balb/c-nude mice failed to induce tumour development. In conclusion, Metformin reverts the mesenchymal and EMT traits in iCCA by activating AMPK-FOXO3 related pathways suggesting it might have therapeutic implications.
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