Context.
We present results from the first recorded stellar occultation by the large trans-Neptunian object (174567) Varda that was observed on September 10, 2018. Varda belongs to the ...high-inclination dynamically excited population, and has a satellite, Ilmarë, which is half the size of Varda.
Aims.
We determine the size and albedo of Varda and constrain its 3D shape and density.
Methods.
Thirteen different sites in the USA monitored the event, five of which detected an occultation by the main body. A best-fitting ellipse to the occultation chords provides the instantaneous limb of the body, from which the geometric albedo is computed. The size and shape of Varda are evaluated, and its bulk density is constrained using Varda’s mass as is known from previous works.
Results.
The best-fitting elliptical limb has semi-major (equatorial) axis of (383 ± 3) km and an apparent oblateness of 0.066 ± 0.047, corresponding to an apparent area-equivalent radius
R
′
equiv
= (370±7) km and geometric albedo
p
v
= 0.099 ± 0.002 assuming a visual absolute magnitude
H
V
= 3.81 ± 0.01. Using three possible rotational periods for the body (4.76, 5.91, and 7.87 h), we derive corresponding MacLaurin solutions. Furthermore, given the low-amplitude (0.06 ± 0.01) mag of the single-peaked rotational light-curve for the aforementioned periods, we consider the double periods. For the 5.91 h period (the most probable) and its double (11.82 h), we find bulk densities and true oblateness of
ρ
= (1.78 ± 0.06) g cm
−3
,
ɛ
= 0.235 ± 0.050, and
ρ
= (1.23 ± 0.04) g cm
−3
,
ɛ
= 0.080 ± 0.049. However, it must be noted that the other solutions cannot be excluded just yet.
ABSTRACT
We report the results of the stellar occultation by (UII) Umbriel on 2020 September 21. The shadow crossed the USA and Canada, and 19 positive chords were obtained. A limb parameter ...accounted for putative topographic features in the limb fittings. Ellipse fittings were not robust – only upper limits were derived for the true size/shape of a putative Umbriel ellipsoid. The adopted spherical solution gives radius = 582.4 ± 0.8 km, smaller/close to 584.7 ± 2.8 km from Voyager II. The apparent ellipse fit results in a true semi-major axis of 584.9 ± 3.8 km, semi-minor axis of 582.3 ± 0.6 km, and true oblateness of 0.004 ± 0.008 for a putative ellipsoid. The geometric albedo was pV = 0.26 ± 0.01. The density was ρ = 1.54 ± 0.04 g cm−3. The surface gravity was 0.251 ± 0.006 m s−2 and the escape velocity was 0.541 ± 0.006 km s−1. Upper limits of 13 and 72 nbar (at 1σ and 3σ levels, respectively) were obtained for the surface pressure of a putative isothermal CO2 atmosphere at T = 70 K. A milliarcsecond precision position was derived: α = 02h30m28${_{.}^{\rm s}}$84556 ± 0.1 mas, δ = 14o19′36″.5836 ± 0.2 mas. A large limb parameter of 4.2 km was obtained, in striking agreement with opposite Southern hemisphere measurements by Voyager II in 1986. Occultation and Voyager results indicate that the same strong topography variation in the surface of Umbriel is present on both hemispheres.
We report the results of the stellar occultation by (UII) Umbriel on September 21st, 2020. The shadow crossed the USA and Canada, and 19 positive chords were obtained. A limb parameter accounted for ...putative topographic features in the limb fittings. Ellipse fittings were not robust - only upper limits were derived for the true size/shape of a putative Umbriel ellipsoid. The adopted spherical solution gives radius = 582.4 +/- 0.8 km, smaller/close to 584.7 +/- 2.8 km from Voyager II. The apparent ellipse fit results in a true semi-major axis of 584.9 +/- 3.8 km, semi-minor axes of 582.3 +/- 0.6 km and true oblateness of 0.004 +/- 0.008 for a putative ellipsoid. The geometric albedo was pV = 0.26 +/- 0.01. The density was rho = 1.54 +/- 0.04 g cm-3. The surface gravity was 0.251 +/- 0.006 m s-2 and the escape velocity 0.541 +/- 0.006 km s-1 . Upper limits of 13 and 72 nbar (at 1 sigma and 3 sigma levels, respectively) were obtained for the surface pressure of a putative isothermal CO2 atmosphere at T = 70 K. A milliarcsecond precision position was derived: RA = 02h 30m 28.84556s +/- 0.1 mas, DE = 14o 19' 36.5836" +/- 0.2 mas. A large limb parameter of 4.2 km was obtained, in striking agreement with opposite southern hemisphere measurements by Voyager II in 1986. Occultation and Voyager results indicate that the same strong topography variation in the surface of Umbriel is present on both hemispheres.
We present results from the first recorded stellar occultation by the large trans-Neptunian object (174567) Varda that was observed on September 10\(^{\rm th}\), 2018. Varda belongs to the ...high-inclination dynamically excited population, and has a satellite, Ilmar\"e, which is half the size of Varda. We determine the size and albedo of Varda and constrain its 3D shape and density. Thirteen different sites in the USA monitored the event, five of which detected an occultation by the main body. A best-fitting ellipse to the occultation chords provides the instantaneous limb of the body, from which the geometric albedo is computed. The size and shape of Varda are evaluated, and its bulk density is constrained, using Varda's mass known from previous works. The best-fitting elliptical limb has semi-major (equatorial) axis of \((383 \pm 3)\)km and an apparent oblateness \(0.066\pm0.047\) corresponding to an apparent area-equivalent radius \(R'_{\rm equiv}= (370\pm7)\)km and geometric albedo \(p_v=0.099\pm 0.002 \) assuming a visual absolute magnitude \(H_V=3.81\pm0.01\). Using three possible rotational periods for the body (4.76h, 5.91h, and 7.87h), we derive corresponding MacLaurin solutions. Furthermore, given the low-amplitude (\(0.06\pm0.01\)) mag of the single-peaked rotational light-curve for the aforementioned periods, we consider the double periods. For the 5.91h period (the most probable) and its double (11.82h), we find bulk densities and true oblateness of \(\rho=(1.78\pm0.06)\) g cm\(^{-3}\), \(\epsilon=0.235\pm0.050\) and \(\rho=(1.23\pm0.04)\) g cm\(^{-3}\), \(\epsilon=0.080\pm0.049\). However, it must be noted that the other solutions cannot be excluded just yet.
RADIAL-VELOCITY STANDARD STARS BEAVERS, W. I.; EITTER, J. J.; KETELSEN, D. A. ...
Publications of the Astronomical Society of the Pacific,
10/1979, Letnik:
91, Številka:
543
Journal Article
Recenzirano
Observations obtained during the first three years of observation with the Fick Observatory photoelectric radial-velocity spectrometer have been employed to select a set of 200 velocity standard ...stars brighter than 7th magnitude of spectral types from late F to early M. All velocities have been reduced to the Lick Observatory system.
Intra-tumor heterogeneity (ITH) is a mechanism of therapeutic resistance and therefore an important clinical challenge. However, the extent, origin, and drivers of ITH across cancer types are poorly ...understood. To address this, we extensively characterize ITH across whole-genome sequences of 2,658 cancer samples spanning 38 cancer types. Nearly all informative samples (95.1%) contain evidence of distinct subclonal expansions with frequent branching relationships between subclones. We observe positive selection of subclonal driver mutations across most cancer types and identify cancer type-specific subclonal patterns of driver gene mutations, fusions, structural variants, and copy number alterations as well as dynamic changes in mutational processes between subclonal expansions. Our results underline the importance of ITH and its drivers in tumor evolution and provide a pan-cancer resource of comprehensively annotated subclonal events from whole-genome sequencing data.
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•Pan-cancer resource of comprehensively annotated intra-tumor heterogeneity (ITH)•ITH is pervasive across cancers and shows cancer type-specific patterns•Branching phylogenies are common•Dynamic changes in mutational processes between subclonal expansions
Dentro et al. provide a comprehensive annotation of intra-tumor heterogeneity and its drivers in cancer evolution.
The discovery of drivers of cancer has traditionally focused on protein-coding genes
. Here we present analyses of driver point mutations and structural variants in non-coding regions across ...2,658 genomes from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium
of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). For point mutations, we developed a statistically rigorous strategy for combining significance levels from multiple methods of driver discovery that overcomes the limitations of individual methods. For structural variants, we present two methods of driver discovery, and identify regions that are significantly affected by recurrent breakpoints and recurrent somatic juxtapositions. Our analyses confirm previously reported drivers
, raise doubts about others and identify novel candidates, including point mutations in the 5' region of TP53, in the 3' untranslated regions of NFKBIZ and TOB1, focal deletions in BRD4 and rearrangements in the loci of AKR1C genes. We show that although point mutations and structural variants that drive cancer are less frequent in non-coding genes and regulatory sequences than in protein-coding genes, additional examples of these drivers will be found as more cancer genomes become available.
In cancer, the primary tumour's organ of origin and histopathology are the strongest determinants of its clinical behaviour, but in 3% of cases a patient presents with a metastatic tumour and no ...obvious primary. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we train a deep learning classifier to predict cancer type based on patterns of somatic passenger mutations detected in whole genome sequencing (WGS) of 2606 tumours representing 24 common cancer types produced by the PCAWG Consortium. Our classifier achieves an accuracy of 91% on held-out tumor samples and 88% and 83% respectively on independent primary and metastatic samples, roughly double the accuracy of trained pathologists when presented with a metastatic tumour without knowledge of the primary. Surprisingly, adding information on driver mutations reduced accuracy. Our results have clinical applicability, underscore how patterns of somatic passenger mutations encode the state of the cell of origin, and can inform future strategies to detect the source of circulating tumour DNA.
Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly understood, with ...limited comprehension of its associations with specific mutational processes, non-coding driver genes and evolutionary features. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumour types, we quantify hypoxia in 1188 tumours spanning 27 cancer types. Elevated hypoxia associates with increased mutational load across cancer types, irrespective of underlying mutational class. The proportion of mutations attributed to several mutational signatures of unknown aetiology directly associates with the level of hypoxia, suggesting underlying mutational processes for these signatures. At the gene level, driver mutations in TP53, MYC and PTEN are enriched in hypoxic tumours, and mutations in PTEN interact with hypoxia to direct tumour evolutionary trajectories. Overall, hypoxia plays a critical role in shaping the genomic and evolutionary landscapes of cancer.
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